text:
Abadansi bamunye okunye okuhle ngesikhathi sekhefu ukuqedela izingubo zethu. Njengama-moccasins, esikhulume ngawo muva nje, lezi zicathulo ezicaba zisinikeza induduzo enkulu osukwini lwethu nosuku.
Ngezinsuku ezishisa kakhulu sisengakwazi ukugqoka abadansi bethu ngezinyawo ezingenalutho. Yize, ngaphambi kokuzikhipha ekhabethe, kuzoba yinto evamile ngathi ukuthi sizisebenzise ngamasokisi amancane. Futhi ukuqedela zonke izinhlobo zokugqoka, ngama-jeans aphrintiwe, amalokwe noma iziketi.
Abadansi bangama- izicathulo ezilula nezikhululekile. Okungenani iningi, ngaphandle kwamamodeli angenaso isithende esincane. Lokhu akukhona okunconyelwa kakhulu ukuhamba amabanga amade, noma kunjalo kushiwo okufanayo ngamaflip-flops futhi kukhona labo abangahamba umhlaba wonke nabo. Kepha masingaphambuki.
Ngemibala engathathi hlangothi futhi enqunu, Abadansi baba umlingani osebenzisekayo ukuqedela izingubo zethu. Siyabathanda enamajini nejazi elide noma ijazi lemvula, inhlanganisela engaphandle komgwaqo engasebenza amahora angama-24 ngosuku. Ungakhetha futhi ihembe elisikiwe kanye nesethi ye-cardigan, efanelekile ngalesi sikhathi sonyaka.
Uma kukhona umuntu owazi ukusebenzisa kabi le nhlanganisela ngokuphelele, kunjalo Anouk Yve, ozogula ngokubona izingubo zakhe eBezzia. Ungavuma okuncane noma okuncane kokuthandayo naye kepha ungumthombo omuhle wokhuthazo uma kukhulunywa dala izingubo eziyisisekelo usuku lwethu lwanamuhla.
Ungahlanganisa nabadansi nge izingubo ezinamaphethini neziketi, ukufeza isitayela esinemimoya yothando efana naleyo Van y UMaria Ruiz. Uzodinga kuphela i-blazer noma i-cardigan kumathoni angathathi hlangothi ukuqedela ukubukeka kwakho. Ngabe ufuna okuthile okuhlelekile futhi okuyingozi? UJenny Walton unokhiye. Dare ngesiketi esibe nombala onesibindi bese usihlanganisa ne-ballerinas ehlukile, ngeke ungaboni!


c: text/html

text:
Izici eziyinhloko
- Isicacisi somsebenzi esinamandla
- Ukuphrinta kwamamethrikhi okunemba kakhulu
- Ukusekelwa kwezinhlobo ezahlukahlukene zamagrafu (imisebenzi, parametric, polar)
- Izilungiselelo zokubuka ezenziwe ngezifiso (imigqa, izimbazo, igridi)
- Ukusekela ukuthekelisa ku-BMP, PNG naku-SVG
- Ikuvumela ukuthi ulondoloze iseshini ngefomethi ye-XML
- Zoom ukwesekwa
- Masidwebe okuphuma koku-1 nokwesibili nokuhlanganiswa komsebenzi
- Ukusekelwa kwezimo ezichazwe ngumsebenzisi nemingcele
- Amathuluzi amaningi angeziwe wemisebenzi yokudweba: thola amanani aphezulu nobuncane, thola inani le-Y bese ugcwalisa indawo phakathi komsebenzi ne-Y eksisi.
Ukufakwa
Ubuntu
sudo apt-get ukufaka kmplot
I-Arch Linux
pacman -S kdeedu-kmplot
abanye
Njengoba i-Kmplot iyingxenye yezinhlelo zokusebenza zemfundo ze-KDE, kungenzeka ukuthi isivele itholakale ezinqolobaneni ezisemthethweni ze-distro oyikhethile.
Imininingwane engaphezulu: I-Kmplot

robotstxt: allowed

filter: keep


text:
Viladomat rural -Paissa Era-LaNou
Umbungazi ovelele
I-i-villa ephelele ibungazwe ngu-Albert
Izivakashi ezingu- 7, amakamelo okulala 3, imibhede engu-6, Amagumbi okugeza angu-2
Ikhaya lonke
I-villa izoba ngeyakho wedwa.
Ukuhlanza Okwenziwe Ngcono
Lo mbungazi uzibophezele enqubweni yokuhlanza ethuthukisiwe yezinyathelo ezingu-5 ye-Airbnb.
Indawo yokubhukuda
Izivakashi zivame ukusesha le sevisi ethandwayo
Umbungazi osemnkantsh'ubomvu
U-Albert unokuphawula okungu-87 kwezinye izindawo.
Lokho ozokuthola kule ndawo
Ikhishi
I-Wifi
Ukupaka mahhala ngaphakathi endaweni
Indawo yokubhukuda
Ubhavu wamanzi ashisayo
Izilwane ezifuyiwe zivunyelwe
I-TV
Umshini wokuwasha
Ayitholakali: i- I-alamu ye-carbon monoxide
Ayitholakali: i- I-alamu yesimoko
5.0 out of 5 stars from 5 reviews
Inhlanzeko
Ukunemba
Ezokuxhumana
Indawo
Ngena
Inani
Lapho uzobe ukhona
La Nou de Bergudà, Barcelona, i-Spain
- Ukubukeza okungu-92
- Ubuwena buqinisekisiwe
- Umbungazi ovelele
Hi, I'm Albert. We are happy to show you our marvellous Masia of the XIV Century. We, Meritxell and Albert, wait for you at ViladomatRural. Our small village La Nou de Bergueda is in the middle of the Catllaras mountains and you' ll be able to do a lot of excursions walking or in a bike!!
Hi, I'm Albert. We are happy to show you our marvellous Masia of the XIV Century. We, Meritxell and Albert, wait for you at ViladomatRural. Our small village La Nou de Bergueda is…
UAlbert Ungumbungazi ovelele
Ababungazi Abahamba Phambili banesipiliyoni, ababungazi bezinga eliphezulu abazinikele ekuphatheni izivakashi ngendlela ekhethekile.
- Inombolo yepholisi: PCC-000942
- Izilimi: English, Español
- Izinga lokuphendula: 80%
- Isikhathi sokuphendula: kungakapheli usuku
Ukuze uvikele ukukhokha kwakho, ungalokothi uthumele imali noma uxhumane nabantu ngaphandle kwewebhusayithi ye-Airbnb noma i-app.
Izinto okufanele uzazi
Imithetho yendlu
Ngena: Kushintshashintsha nezimo
Isikhathi sokuphuma: 11:00
Ayikho imicimbi noma izenzakalo
Izilwane ezifuywayo zivunyelwe
Ezempilo & ukuphepha
Uzibophezele enqubweni yokuhlanza ethuthukisiwe ye-Airbnb. Veza okwengeziwe
Iziqondiso ze-Airbnb zokuziqhelelanisa komphakathi kanye nezinye ezihlobene ne-COVID-19 ziyasebenza
I-alamu ye-carbon monoxide ayibikwangwa Veza okwengeziwe
I-alamu yesimoko ayibikwangwa Veza okwengeziwe
Inqubomgomo yokukhansela
Hlola ezinye izinketho ezise- La Nou de Bergudà namaphethelo
Ezinye izindawo zokuhlala e- La Nou de Bergudà:


text:
Namuhla siyaqhubeka nesethu iposi lesishiyagalolunye nepenultimate ku- Abaphathi bamawindi (Abaphathi beWindows - WM, ngesiNgisi), lapho sizobuyekeza khona okulandelayo 5, kusuka ohlwini lwethu lwe 50 okuxoxwe ngaphambilini.
Ngaleyo ndlela, ukuqhubeka nokwazi izici ezibalulekile zazo, njengokuthi, ingabe zikhona noma cha amaphrojekthi asebenzayo, ukuthi Uhlobo lwe-WM yibo, okungokwabo izici eziphambili, futhi zifakwa kanjani, phakathi kwezinye izici.
Kuyafaneleka ukukhumbula ukuthi uhlu oluphelele lwabaphathi bamawindi abazimele nabondliwayo of a Imvelo yedeskithophu Ngokuqondile, kutholakala kokuthunyelwe okuhlobene okulandelayo:
Futhi uma kwenzeka ufuna ukufunda ifayili lethu le- okuthunyelwe kwangaphambilini okuhlobene Lapho i-WM yangaphambilini ibuyekeziwe, okulandelayo kungachofozwa izixhumanisi:
- 2BWM, 9WM, AEWM, Afterstep futhi Awesome
- IBerryWM, iBlackbox, iBSPWM, iByobu neCompiz
- I-CWM, i-DWM, i-Enlightenment, i-EvilWM ne-EXWM
- I-Fluxbox, i-FLWM, i-FVWM, iHaze neHerbstluftwm
- I3WM, IceWM, Ion, JWM ne-MatchBox
- I-Metisse, i-Musca, i-MWM, i-OpenBox ne-PekWM
- I-PlayWM, iQtile, iRatpoison, iSawfish neSpectrwm
- I-Steamcompmgr, iStumpWM, iShukela, iSwayWM ne-TWM
Inkomba
Ama-WM amanye ama-5 weLinux
I-UltimateWM
Incazelo
Ngokuya ngewebhusayithi yayo esemthethweni, ichazwa njenge:
“I-WM entsha enethemba lokuba yi-GUI ephelele ngokuzayo, yingakho ibizwa manje I-Unix Desktop Environment Project (UDE). Iphrojekthi ayisebenzisi noma yimiphi imitapo yolwazi ekhethekile efana ne-QT noma i-GTK +. Isebenzisa kuphela indinganiso ye-Xlibs, ukuyigcina ishesha, ilula futhi ivikele ukuncika. I-UltimateWM noma i-UDE ine-Look'n'Feel yasekuqaleni, akuyona nje enye ikhophi yesikhombimsebenzisi somsebenzisi sokuphathwa kwewindi esaziwa kakhulu "sakudala".".
Izici
- Iphrojekthi engasebenzi: Umsebenzi wokugcina utholwe cishe eminyakeni eyisithupha edlule.
- I-Tipo: Ukunqwabelana.
- Inikeze ukusetshenziswa okuphezulu kwesikhala sesikrini, ukuzinza, nokusetshenziswa kwemithombo ephansi kakhulu.
- Yenzelwe ukuthi isetshenziswe kahle kakhulu ngemuva kwesigaba sokufunda esifushane.
- Ibingenayo ibha yomsebenzi noma iphaneli yedeskithophu noma okulinganayo. Futhi amafasitela ayengenayo ibha yesihloko ngakho-ke ayengenazo izinkinobho zokuvala, ukukhulisa usayizi, ukufaka isithombe noma ukukhulisa amawindi emaphethelweni amawindi. Lezi zinkinobho zathathelwa indawo yimenyu ebizwa ngokuthi i-hexagonal noma i-honeycomb evele lapho umsebenzisi echofoza onqenqemeni lwewindi.
- Ukusebenzisana komsebenzisi kusebenze ngokuphelele ngokusebenzisa izinkinobho ezihlukile zamagundane emingceleni yewindi kanye nesizinda sedeskithophu, ngenxa yalesi sizathu, ukusetshenziswa kahle kwe-UDE kungenzeka kuphela kusetshenziswa igundane elinezinkinobho ezintathu, ngoba linikeza ukusekelwa kuphela eyisisekelo kakhulu kuzinqamuleli zekhibhodi.
Ukufakwa
Ukulanda nokufaka noma eminye imininingwane, okulandelayo kunikwe amandla isixhumanisi. Futhi lokhu okunye isixhumanisi Uma kunesidingo
I-VTWM
Incazelo
Ngokuya ngewebhusayithi yayo esemthethweni, ichazwa njenge:
"Umphathi Wewindi Olula Futhi Osebenzayo Wesistimu Ye-X Window".
Izici
- Iphrojekthi engasebenzi: Umsebenzi wokugcina utholwe eminyakeni engaphezu kwengu-5 edlule.
- I-Tipo: Ukubeka phansi.
- Inikeze amabha wamatayitela, amawindi amile, izinhlobo ezahlukahlukene zokuphathwa kwezithonjana, imisebenzi ye-macro echazwe ngumsebenzisi, ukugxila kwekhibhodi yokuchofoza kanye nesikhombi, kanye nokubopha izinkinobho ezibekiwe zomsebenzisi nezinkomba.
- Kwakwenziwa kaningi ngaphambili njengeklayenti lokugcina elilayishiwe, ukuze kuthi lapho lenziwa ngale ndlela, lapho liphuma, isikhathi somsebenzisi sinqanyulwe.
- Ngokuzenzakalelayo, inikeze ngohlelo lokusebenza windows elizungezwe umngcele onebha yesihloko phezulu. Ibha yesihloko ebiqukethe igama lewindi, indawo engunxande ekhombisa ukuthi iwindi lithola okokufaka kwekhibhodi, namabhokisi womsebenzi amathathu aziwa ngokuthi "izinkinobho zebha yesihloko."
- Ukucindezela inkinobho kubha yesihloko nomcibisholo obheke phansi kuyo kuveze imenyu eneminye imisebenzi eminingi engasetshenziswa efasiteleni.
Ukufakwa
Le WM ebuyekeziwe ivame ukutholakala ezinqolobaneni eziningi ezihlukile I-GNU / Linux Distros, ngaphansi kwegama le- iphakethe "vtwm"Ngakho-ke, kuya ngomphathi wephakeji osetshenzisiwe, wokuqhafaza noma wokugcina, ingafakwa kalula. Imininingwane engaphezulu ngale WM ingatholakala kokulandelayo isixhumanisi noma lokhu okunye isixhumanisi.
Wayland
Incazelo
Ngokuya ngewebhusayithi yayo esemthethweni, ichazwa njenge:
“Umphathi we-Window noMqambi ophelele futhi oqinile owenzelwe njenge-Linux X Server yesimanje, enhle futhi elula, ngakho-ke kulula ukuyakha nokuyigcina. Ngakho-ke, kulindeleke ukuthi izindawo eziqinile zeDeskithophu, ezifana ne-GNOME ne-KDE, zikusebenzise ngokugcwele nangokucacile nangokukodwa esikhathini esizayo esiseduze ".
Izici
- Iphrojekthi esebenzayo: Umsebenzi wokugcina utholwe ngaphansi nje kwenyanga edlule.
- I-Tipo: Ukuzimela.
- Inikeza ukuqedwa kwamaqiniso amaningi anzima ukunikeza umsebenzi olula kakhulu. Kusebenza ngokulula ngokwenza isitaki sehluzo. Kungakho-ke futhi futhi elawula nomsebenzi wokwenziwa.
- Ingqikithi yayo kuyiprotocol yomqambi ukukhuluma namakhasimende abo kanye nokuqaliswa komtapo wezincwadi we-C waleyo protocol. Umqambi kungaba iseva yokubonisa ezimele esebenza kumadivayisi wokufaka we-Linux kernel ne-evdev, uhlelo lokusebenza lwe-X, noma iklayenti leWayland uqobo.
- Ibuye inikeze ukuqaliswa kwesethenjwa kweWeston ngaphakathi kokusebenza kwayo njengomqambi. I-Weston ingasebenza njengeklayenti le-X noma ngaphansi kwe-Linux KMS futhi ithunyelwe namanye amaklayenti wedemo. Umqambi kaWeston umqambi omncane futhi osheshayo futhi ulungele amacala amaningi okusetshenziswa afakiwe futhi ashumekiwe.
Ukufakwa
Le WM ebuyekeziwe ivame ukutholakala ezinqolobaneni eziningi ezihlukile I-GNU / Linux Distros, ngaphansi kwegama le- "xwayland" iphakhejiNgakho-ke, kuya ngomphathi wephakeji osetshenzisiwe, wokuqhafaza noma wokugcina, ingafakwa kalula. Imininingwane engaphezulu ngale WM ingatholakala kokulandelayo isixhumanisi.
Wingo
Incazelo
Ngokuya ngewebhusayithi yayo esemthethweni, ichazwa njenge:
"Imenenja yeWindi ebhalwe ngokuphelele ngolimi lokuhlelwa kweGo".
Izici
- Iphrojekthi esebenzayo: Umsebenzi wokugcina utholwe eminyakeni engaphezu kwengu-2 edlule.
- I-Tipo: Amandla.
- Inakho konke ukuncika kwayo, kusukela ekuxhumaneni no-X kuya ekudwebeni umbhalo kumawindi, kubhalwe kuGo. Futhi, ikakhulukazi i-ICCCM ne-EWMH iyahambisana.
- Inezici ezimbili okuthi uma zihlanganisiwe zehlukaniswe kwabanye abaphathi bamawindi: Ukusekelwa kwezinqubomgomo zokubekwa kwamawindi, okuhambisana nama-Wiling we-Tiling and Stacking. Futhi ukusetshenziswa okukodwa kwezindawo zokusebenza ngomqaphi ngamunye, okuvumela umqaphi ngamunye ukuthi abonise indawo yakhe yokusebenza, ezimele kwezinye iziqaphi.
- Kuyinto okulungisekayo ngokweqile. Lokhu kufaka ukuxhumanisa inombolo enkulu yemiyalo ekuchofozeni izinkinobho noma ukucindezela kwegundane, ukuhlobisa iwindi, nokusetha izingwegwe ezivuthayo kuye ngesethi yezimo zomdlalo. Konke ukumiswa kwenziwa kusetshenziswa ifomethi yefayela le-INI ngokusekelwa kokufaka okulula okuguqukayo. Akukho ukusetshenziswa kwamafayela weXML, akukho lutho olungabuyiswa kabusha, futhi akukho mibhalo esetshenziswayo.
Ukufakwa
Ukulanda nokufaka noma eminye imininingwane, okulandelayo kunikwe amandla isixhumanisi.
I-WM2
Incazelo
Ngokuya ngewebhusayithi yayo esemthethweni, ichazwa njenge:
“Umphathi wamawindi omncane kakhulu weX X Window System".
Izici
- Iphrojekthi engasebenzi: Umsebenzi wokugcina utholwe cishe eminyakeni engaphezu kwengu-9 edlule.
- I-Tipo: Ukunqwabelana.
- Inikeze amandla okwenza hambisa amawindi azungeze isikrini, ushintshe usayizi wamawindows ngokuvundlile nangokuqondile, fihla amafasitela, ubuyisele amawindi afihliwe, futhi usule amawindi.
- Inikeze ngohlaka oluhle efasiteleni ngalinye eliphethwe, kepha alunikanga ngezithonjana, ukumiswa, amadeskithophu abonakalayo, amamenyu ezimpande anwebekayo, namabha wamathuluzi, phakathi kwezinye izinto.
Ukufakwa
Le WM ebuyekeziwe ivame ukutholakala ezinqolobaneni eziningi ezihlukile I-GNU / Linux Distros, ngaphansi kwegama le- iphakethe "wm2"Ngakho-ke, kuya ngomphathi wephakeji osetshenzisiwe, wokuqhafaza noma wokugcina, ingafakwa kalula. Imininingwane engaphezulu ngale WM ingatholakala kokulandelayo isixhumanisi.
Note: Khumbula ukuhlola amawebhusayithi asemthethweni we-WM ngayinye ukuze wazi ukuthi afana kanjani ngokubukeka, ngoba, ngakunye, kunezifanekiso-skrini ezivuselelwe ngokuvamile ukubukeka kwazo okubonakalayo.
Isiphetho
Siyethemba lokhu "okuthunyelwe okuwusizo okuncane" mayelana nalezi ezi-5 ezilandelayo
«Gestores de Ventanas», ezimele kunoma iyiphi
«Entorno de Escritorio»ubizile I-UltimateWM, i-VTWM, iWayland, iWingo, i-WM2, yiba nentshisekelo nokusetshenziswa okuhle, kwayo yonke
«Comunidad de Software Libre y Código Abierto» kanye negalelo elikhulu ekusabalalisweni kwemvelo emangalisayo, enkulu futhi ekhulayo yezicelo ze
«GNU/Linux».
Futhi ukuthola eminye imininingwane, unganqikazi njalo ukuvakashela noma yikuphi Umtapo wolwazi oku-inthanethi njengoba I-OpenLibra y I-JedIT ukufunda izincwadi (ama-PDF) ngalesi sihloko noma ezinye izindawo zolwazi. Okwamanje, uma ukuthandile lokhu
«publicación», ungayeki ukuyaba nabanye, ku- Amawebhusayithi ayizintandokazi, iziteshi, amaqembu, noma imiphakathi zokuxhumana nabantu, okungcono mahhala futhi evulekile njenge I-mastodon, noma ukuphepha nokuyimfihlo kwangasese yocingo.
Noma mane uvakashele ikhasi lethu lasekhaya ku- KusukaLinux noma ujoyine iSiteshi esisemthethweni Yocingo kusuka ku-DesdeLinux ukufunda nokuvotela lokhu noma ezinye izincwadi ezithakazelisayo ku-
«Software Libre»,
«Código Abierto»,
«GNU/Linux» nezinye izihloko ezihlobene ne-
«Informática y la Computación»kanye
«Actualidad tecnológica».


text:
Iziboshwa zinelungelo lokuxhumana nokuhlinzekwa ngabameli
UMbatha ngumhleli nomhluzi wezindaba kwelaboHlanga.
Abantu abatokile noma ababoshiwe banamalungelo athile ngaphansi koMthethosisekelo wezwe. Elinye lalawa malungelo ngelithi umuntu oboshiwe noma otokile angakwazi ukuxhumana nommeli amfisayo futhi kumele aziswe ngaleli lungelo ngokushesha ngokulandela iSigaba 35(2)(b) soMthethosisekelo.
Ngaphezu kwalokho, uma oboshiwe engakwazi ukukhokhela ummeli, kuchaza ukuthi ukungabi naye umuntu ozokumela kungaholela ekutheni kungabi khona nobulungiswa uma sekuqulwa icala. Yingakho umbuso kumele uhlinzeke ummeli kumuntu oboshiwe noma otokile futhi kube umbuso ozokhokha izindleko zakho konke lokho. Ukumelwa emacaleni kuyinto ebalulekile eNingizimu Afrika, futhi kuyaziwa ukuthi abantu ababoshiwe nabatokile kungenzeka ukuthi abaqeqeshiwe kwezomthetho okungasho ukuthi uma bebuzwa umbuzo noma benxuswa ngamaphoyisa ukuba babambisane nabo bangaphenduli ngendlela. Ukuba khona kommeli kubalulekile ukwenza isiqiniseko sokuthi leli lungelo liyalandelwa futhi liyavikelwa.
Uma umuntu eboshwa kuba yinto ejwayelekile ukuthi anikwe ithuba lokuxhumana nommeli wakhe. Lowo muntu anganikezwa ucingo esiteshini samaphoyisa ukuba axhumane nesihlobo esithile sona esingaxhumana nommeli, noma yena angakwazi ukuxhumana nommeli ngqo. Inhloso yalo mbhalo ukucacisa ukuthi ilungelo lokumelwa lidinga ukubhekisiswa ikakhulukazi kubhekwe nokuthi ukumeleleka kuyatholakala ngokushesha. Enye inhloso yalo mbhalo ukucacisa ukuthi oboshiwe angakwazi nokuzitholela ummeli ngokuthi angene ngqo enkundleni yokubheka nakuGoogle njengokubalula koMthethosisekelo.
Uma siqhathanisa iCanadian Charter and Freedoms, lona wumthethosivivinywa okuMthethosisekelo wezwe futhi uqinisekisa amalungelo ezepolitiki nawesintu kuwona wonke umuntu waseCanada. ISigaba 10(b) seCanadian Charter of Rights and Freedom sibalula ukuthi wonke umuntu waseCanada unelungelo lokuthola ukwelulekwa kwezomthetho nokwaziswa ngawo wonke amalungelo akhe.
Uma siza eNingizimu Afrika, uMthethosisekelo wakuleli iSigaba 35(2)(b) uthi wonke umuntu unelungelo lokukhetha, lokuxhumana nommeli futhi aziswe ngaleli lungelo ngokushesha. Ngaphezu kwalokho iSigaba 73(1) somthetho iCriminal Procedure Act 51 wezi-1977 sithi, “Umuntu oboshiwe okungaba ukuthi unewaranti noma akanayo, unelungelo lokuthola usizo lommeli noma umeluleki wezomthetho kusuka ngesikhathi eboshwa. Indlela okubekwa ngayo ilungelo loboshiwe noma otokile ezindaweni ezimbili zithi azifane nangendlela ezichazwa ngayo.
Ecaleni langowezi-2013 eNkantolo Yesiunda i-Alberta eCanada elaliphakathi kukaR noMcKay ngaleso sikhathi owesilisa oneminyaka yobudala eli-19 waboshwa ngecala lokushayela ephuzile. Ngesikhathi amaphoyisa efika naye esiteshini izinto zakhe okuhlanganisa nomakhalekhukhwini kwase kuvalelwe esiteshini.
Owayeboshiwe wanikwa ithuba lokubheka izinombolo ebhukwini elinezinombolo okuyibhuku elifanayo neYellow Pages lapha eNingizimu Afrika. Wayenxuswa ukuba asebenzise ilungelo lakhe lokuxhumana nommeli. Wayezitshela ukuthi unikezwe ithuba elilodwa lokuba athinte ummeli. Emuva kokushaya ucingo kanye ummangalelwa wayengakalutholi usizo lommeli. Ecaleni lakhe waveza ukuthi wasebenzisa uGoogle ukubheka inombolo yommeli, futhi akazange akubone kuzomsiza ukubheka izinombolo zamahhala.
Inkantolo yabe isibheka udaba lokuthi ukukwazi ukuthola inombolo yamahhala nokuthola uYellow Pages (waseCanada) kungalinganiswa njengemizamo yokusiza oboshiwe akwazi ukuxhumana nommeli Inkantolo yanquma ukuthi ngokunganiki oboshiwe ilungelo lokuthola i-inthanethi kuwukwephula ilungelo elikuMthethosisekelo. Leli cala linokuningi okuhlabahlosile futhi kuningi okungenza lilandelwe ngoba impilo yabantu emhlabeni isincike kakhulu ezinkundleni zokuxhuanana.
Isinqumo esakhishwa ecaleni likaR v MacCay eCanada, sashiya imibuzo ngokwaseNingizimu Afrika ukuthi ngokwesimo sakhona nokulandela uMthethosisekelo ngabe umuntu oboshiwe noma otokile uyawathola yini amalungelo okufuna ummeli kuGoogle ngokulandela iSigaba 35(2)(b). Ukuphendula lo mbuzo ukuchaza uMthethosisekelo kusemqoka. Ecaleni eladuma likaS v Makwanyane and Another 1995, uMthethosisekelo akumele ubhekwe wodwa eceleni, kodwa kumele kubhekwe nomlando wokusungulwa kwawo.


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Espoo
I-Espoo idolobha lase-Uusimaa eFinlandi. Abantu abangaba ngu-280,000 bahlala e-Espoo. Esikhathini sendawo edolobheni (lapho u-Espoo engowakhe khona) kunabakhileyo abangaphezu kwesigidi. I-Espoo yiyona idolobha lesibili elikhulu kunawo wonke eFinland. Omakhelwane balo yiVihti, Nurmijärvi, Vantaa, Helsinki, Kirkkonummi, noKauniainen ngaphakathi kwe-Espoo.
I-Espoo yidolobha elikhulu kunazo zonke eFinland. U-Espoo uphinde waziwa ngeNokia, inkampani ye-Fortum yamandla, i-Angry Birds, inkampani yemidlalo ye-Rovio nezinye izinkampani eziningana zobuchwepheshe, iNuuksio National Park kanye ne-campus ye-Otaniemi, lapho kukhona khona amakolishi ayisithupha e-Aalto University. I-Espoo ibuye ibe nezindawo ezinkulu zokuthutha impahla emazweni aseNordic, isikhungo se-Ämmässuo yokwelashwa kwemfucuza, lapho kunezindawo ezingaphezu kuka-1.1 million nezakhamuzi zokudoba ezigcinwa emadolobheni aseHelsinki.


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Le 1 isibambo sendawo yokugezela ompompi 2320201 inezinzuzo eziningi.Igcina amanzi futhi inedizayini enhle.Kungashiwo ukuthi kuyincomo yokuqala ekhishini nakompompi bendawo yokugezela.
Ukuzikhipha komkhiqizo:
Isikulufu esiqiniselwe ekugcineni kwethumbu Sink Sink noma Basin for 1-Hole Isethaphu; Ukuphakama: 11 ″; Ukufinyelela kwe-Spout: 7 ″; Usayizi weHole: 1.4 ”(Sicela Uhlole Ubungako Bembobo yakho ngaphambi koku-oda).
Ompompi for Toilet & Bath: isikulufu esiqiniselwe ekugcineni kwethumbu usinki noma umcengezi, ingasetshenziswa yokugezela kanye nekhishi, arc Ephakeme futhi 360-degree ukuphotha iyasiza kosinki ababili uma wenza imisebenzi yokwandisa.
Isiteji Sensimbi Yekhishi Engagxiliwe I-Nickel engu-Stainless: ibekwazi ukukwazi ukuklwebheka kwansuku zonke nokugqwala, insimbi engenasici, nomzimba wensimbi we-zinc, onzima futhi oqinile, ofanele ikhaya, ukugeza, ikhishi, ihhotela, indawo yokudlela, ifulethi, indawo yokuhlala kanye nokunye.
I-Hardware Hardware: i-hucai hose hose enkulumweni yaseMelika ngombhalo wokuphepha, ama-valves angenayo ama-drip, kanye ne-spout engaphakathi nendawo yokuqinisekisa indawo efanelekile Yamanzi, Yonke imishini yokufaka iseyinsimbi engenasici, engenasidina futhi engaxuthiwe.
UBUDLELWANE NGESIKHATHI SEKUPHAKATHI KWAMAKHAYA: kumbozwe izinsuku ezingama-90 zokubuya kwamahhala kanye newaranti yempilo yonke!
SICELA UXHUMANE EMAIL❤service@wowowfaucet.com


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Ingabe ufile ubeka ngokumelene nokuguga? Yebo, isidakamizwa sokulwa nokuguga akungabazeki ukuthi kuyindlela ethembekile kakhulu yokuguqula iwashi lakho lezinto eziphilayo. Hlola izici ezibucayi zeNicotinamide Mononucleotide (NMN), indima yayo ku-senescence, nokuthi ungathola kanjani ukwelashwa.
Thumela ngokushesha uphenyo: Oxhumana nathi
Isingeniso
Ukukhula ubudala akugwemeki. Kodwa-ke, kunamandla okuguqula inqubo yokuguga ngokusebenzisa I-Nicotinamide Mononucleotide. Bamba amahhashi akho ngoba ngizokunika ulwazi olunzulu ukuthi imilingo ihlanganiswe kanjani ngaphakathi kwamaseli omuntu.
Izinwele ezimhlophe zilingana nokuhlakanipha!
Le nkolelo kungenzeka ukuthi yiyona nto engcono kakhulu ozoxoxa ngayo enkulu. Noma kunjalo, ukumomotheka kwakho kuyobe kuphila isikhathi esifushane uma uqala ukuqaphela imibimbi yonke isikhumba sakho. Ngaphezu kwalokho, ukuguga kuyathinta kokubili imisebenzi engokwenyama nangokwengqondo.
Ake sibhekane nakho. I- anti-ukuguga okhilimu ebusweni nokuhlinzwa kwezimonyo bekulokhu kuyinto kuleli khulu leminyaka elihlakaniphile. Okudingayo ukwazi ukuthi lezi zinqubo zesikhashana futhi kungenzeka ukuthi zidale imiphumela emibi.
Ngokuvamile, kufanele ulwa nokuguga ngokuqala ukuqonda izinqubo zamaselula nezomzimba ezidlala indima ezimweni ezihlobene nobudala. Emva kwalokho, kuba lula ukucubungula izindlela zokulwa ne-senescence. I-Nicotinamide Mononucleotide yokuguga isebenza ukubuyisela ubusha.
Sonke sifuna ukukhula ngobubele, kwesokudla? Lokhu, okuyiqiniso kungase kungabonakali lapho umzimba wakho uqhubeka u buthakathaka, futhi ugcina ube umshini wezinhlobo zezinhliziyo zenhliziyo, i-Alzheimer's, ukulahlekelwa inkumbulo nokuningi.
I-Nicotinamide Mononucleotide engaqondakali (i-NMN)
Ngakho-ke, yikuphi ukuphikisana ngakho konke mayelana neNicotinamide Mononucleotide? Ake ngichaze.
I-NMN ikhona kokubili ama-alpha (a) namafomu we-beta (B). Nokho, i-B-NMN ifomu elisebenza kakhulu. Le nucleotide ephilayo iphakathi kwe-biosynthesis ye-nicotinamide adenine dinucleotide noma i-NAD +.
Le nhlanganisela ngokwemvelo ikhona ku-avocado, utamatisi, ikhukhamba, i-cabbages, i-broccoli, nenkomo yenkomo eluhlaza. E-laboratory, itholakala njenge-nicotinamide mononucleotide bulk powder.
Ngendlela yayo eluhlaza, ibonisa inombolo ye-CAS, 1094-61-7. Isakhi sivela ekuphenduleni phakathi kwe-nucleoside, njenge-nicotinamide riboside neqembu le-phosphate.
Ezifundweni ezandulela ukwelashwa, ukusebenza kweNicotinamide Mononucleotide kumagundane kukhombisile ukuthi kuyasiza emisebenzini yamaselula yamakhemikhali, ukuphathwa kwesifo i-Alzheimer's, isifo sikashukela esihlobene nobudala, izinkinga ezivela ngenxa yokukhuluphala, kanye nokuvikela isifo senhliziyo. Phezu kwayo yonke le misebenzi yokwenziwa kwemithi ehlotshaniswa neNicotinamide Mononucleotide, okutholwe okuyisisekelo esikhulu ukuzibandakanya kwayo emisebenzini yokulwa nokuguga.
Emzimbeni womuntu, i-NMN ingumthombo omkhulu wamandla ngaphakathi kwamaseli. Njengoba ukhula, amandla eselula ancipha ngenxa yamazinga aphansi we-nicotinamide mononucleotide nokunciphisa okulandelayo kwe-NAD +. Ukulawula i-NMN kuzoguqula inqubo futhi ibuyisele imali.
(1) I-NMN iyimfihlakalo kanjani?
Le mithi elwa nokuguga ihamba njengombani kusuka esiswini iye ekujikelezeni kwegazi. Emizuzwini embalwa, zizobe sezinyuselwe egazini. Ngalesi sizathu, kuyacaca ukuthi kungahle kungabi khona ukuphendula kwamakhemikhali okwenzeka endleleni yama-molecule.
Ijubane elididayo lenze abacwaningi baphetha ngokuthi kungenzeka kube khona umthuthi, okwenza kube lula ukulethwa kukaphethiloli wamaseli. Isibonelo, u-Imai nabangane bakhe baqala ukuthola impendulo ngocwaningo lwakhe lwakamuva olushicilelwe ngoJanuwari 7, 2019.
Ngokuguga, umzimba usebenzisa i-NAD + engaphezulu kunalokho ongakwenza. Noma ngabe usebenzisa kangakanani i-nicotinamide mononucleotide, inqubo isazoba ukuchitha isikhathi inqobo nje uma ingekho i-molecule yokusiza ukuthuthwa kwayo. Qhubeka upheqa ukuze uveze umthuthi ongaqondakali ozoxazulula ama-90% ezinkinga zokuguga.
(2) I-Nicotinamide Mononucleotide Structure Formula
(3) Imininingwane ye-Nicotinamide Mononucleotide
Thumela ngokushesha uphenyo: Oxhumana nathi
I-Nicotinamide Mononucleotide ne-NAD +
Bobabili I-Nicotinamide Mononucleotide ne-NAD + yizici eziphawulekayo zokukhiqizwa kwamafutha emaselula.
I-NMN ingaphakathi phakathi kwe-biosynthesis ye-Nicotinamide adenine dinucleotide (i-NAD +). Into esebenza njenge-substrate ye-enzyme ethize njenge-nicotinamide mononucleotide adenylyltransferase, eguqulela ku-NAD + emzimbeni womuntu. Phezu kokuchichima, lesi sakhi sishintsha ku-nicotinamide. Kamuva, ihlangana nesinye isenzo esithintekayo esithinta i-nicotinamide phosphoribosyltransferase (NAMPT) eyenza i-NMN.
Lezi zimvukuzane ezimbili zihlangene kangangokuthi ukungabi khona kwanoma yikuphi kubo kuzothinta omunye. Thatha, isibonelo, uma amazinga we-NMN ewa ngezansi kakhulu, mhlawumbe ngenxa ye-senescence, ubungakanani be-NAD + buzokwehla.
Njengoba ukhula, ezinye izinto ze-enzymatic zivame ukudla i-NAD + ngaphezu komzimba ongakwazi ukukhiqiza uphethiloli. Ama-nurtua, i-NADase, ne-poly-ADP-ribose polymerase (PARP) ziyingxenye ye-enzymes, eshisa i-NAD + eholele ekuqondeni kwayo.
Nokho, ukwehla kwamapayipi kagesi akuyona okungahleliwe. Thatha, isibonelo, impendulo ye-enzymatic ehlanganisa i-PARP usizo ekulungiseni i-DNA ewonakele. Futhi, ama-sirerisi adlala indima ebalulekile ekuthuthukiseni umzimba wamagciwane.
Yize kukhona ubudlelwane bemithi phakathi kwalawa ma-biomarker amabili, awusoze waqondisa ngqo i-NAD + ohlelweni. Ngendlela engenzeka ngayo, imiphumela emibi ngeke ibekezeleleke. Isibonelo, umthamo omkhulu ubonakala ngokukhathala, ukukhathazeka nokuqwasha. Ngaphezu kwalokho, le nhlanganisela ayikwazi ukungena kalula nge-plasma ulwelwesi.
(1) Indlela Yokuthwala
The anti-ukuguga i-Nicotinamide Mononucleotide iyatholakala njengesidakamizwa somlomo. Ukwamukela kwawo ngaphakathi kwodonga lwamathambo futhi kuhlelo lokujikeleza luqala cishe ngemizuzu emithathu. Nge-15th min, konke kuzobe sekuthathiwe. Ucwaningo olunzulu olwenziwe ngu-Imai nabacwaningi asebenza nabo luthola ukuthi kukhona iprotheni esheshisa leli zinga lokumunca ngokushesha.
Lapho kufakwa izicubu, i-NMN iguqulela ibe yi-NAD + ukuze igcinwe kalula. Inqubo ye-metabolism ingathatha isigamu sehora. Ukuhlushwa kwe-NAD + kuvame kakhulu emisipha yamathambo, izicubu ezimhlophe ze-adipose, isibindi, ne-cortex. Kodwa-ke, ukuphathwa kwesikhathi eside kweNicotinamide Mononucleotide kwaphakamisa izinga le-NAD + kwezinye izitho ezifana nezicubu ezibomvu ze-adipose.
(2) I-NMN Biosynthetic Pathways
Ngaphakathi kwamaseli we-mammalian, kunezindlela ezintathu ezihlukene zokuxilisa umzimba ezikhokhela ukulahlekelwa kwe-NAD +.
① I-De Novo Pathway
I-De Novo igama elithiLain, elisho ukuthi "kusukela ekuqaleni." Lapha, i-nucleotides itholakala ku-tryptophan noma i-nicotinic acid, ephuma kakhulu ekudleni kwe-NMN.
Kule ndlela, ukulandelana komsebenzi wezinto eziphilayo kubangela ukwakheka kwe-nicotinic acid mononucleotide, i-nicotinic acid adenine dinucleotide, futhi ekugcineni i-NAD + elindeleke kakhulu. I-De Novo ikhiqiza mayelana ne-15% yephethri yeselula yonke.
② I-Salvage Pathway
Lapha, indlela ivuselela i-nucleosides lapho kwenzeka khona i-DNA. Ilandisa ngaphezu kwe-80% yenani le-NAD + eliphelele, elidinga umzimba womuntu ngemisebenzi yeselula. Umzila uvuselela kokubili i-nicotinic acid ne-nicotinamide ukuze kwenziwe i-NAD + entsha.
I-Nicotinate phosphoribosyltransferase ishesha ukubunjwa kwe-nicotinic acid mononucleotide kusuka ku-nicotinic acid. Ngemuva kwalokho, i-nicotinamide mononucleotide adenylyltransferase i-1 ivuselela i-adenylation yomkhiqizo ophumela ku-nicotinic acid adenine mononucleotide, futhi ekugcineni ibe yi-NAD +.
Umsebenzi weNMN kumuntu uncike kule ndlela.
③ Ukuguqulwa kwe-NR
I-Nicotinamide Riboside ingenye isandulela se-NAD +. Phezu kwe-phosphorylation phambi kwe-nicotinamide riboside kinase, i-biomarker ikhiqiza i-NMN ngaphambi kokuba iphenduke enye inguquko ye-enzymatic ibe yi-NAD +.
Umlando we-NAD + ne-NMN kuCwaningo
Phakathi neminyaka, ukutadisha kanye nokusetshenziswa kokwelapha kwe-nicotinamide adenine dinucleotide kanye nabangaphambili bayoba yilo lonke ukufutheka. Nokho, kufanele uqaphele ukuthi lezi anti-aging izithako ziye zaqhutshwa kabanzi ocwaningweni kusukela phakathi kwe-1900s.
Ku-1906, izazi zokuqala zathi i-NAD + yashesha izinga lokuvutshelwa emvubelo. Ngemva kwalokho, ezinye izazi ze-biochemists zalandelana ngokuzihlukanisa njenge-nucleotide.
Ngokucwaninga kwakhe ku-1937, uConrad Elvehjem wathola ukuthi i-nicotinamide ne-nicotinic ngamavithamini nama-precursors we-NAD +. Kamuva, wathola ukuthi laba ababili banganciphisa i-pellagra ezinja. Isizathu siwukuthi amazinga we-nicotinic acid ne-nicotinamide ayephansi kakhulu kubantu ababhekene nalesi sifo.
Ngo-1963, iqembu lososayensi lasungula ukuthi iNicotinamide Mononucleotide isebenza kumagundane izokhuthaza ama-enzyme ancike kwi-DNA, abaluleke kakhulu ekwandiseni ukusebenza kwamaselula. Eminyakeni emibili kamuva, abanye abacwaningi baveza izindlela ze-NAD + zamakhemikhali ezibandakanya i-tryptophan ne-nicotinic acid.
Kusukela ngaleso sikhathi, izazi ze-biochemists ziye zaqhubeka zibonisa isithakazelo ku-NMN no-NAD + ucwaningo. Kule nkathi, ukugxila okubaluleke kakhulu kulokhu kubaluleka kwalokhu izidakamizwa zokulwa nokuguga ngokuphila isikhathi eside nokunciphisa izinkinga ezihlobene nobudala.
Ukucwaninga kwakamuva kweNicotinamide Mononucleotide Kusebenza kumaMice
Kunezinhlobo ezingenakubalwa ezihlotshisiwe ezihlotshaniswa ezihlokweni ze-murine ezibonisa izinzuzo zokwelapha zeNicotinamide Mononucleotide (1094-61-7).
Ake sigxile kwabambalwa, abaye baba nomthelela wokuguqula isimo se-biochemistry.
(1) Ngokusho kukaSinclair, i-NAD + iyisithombo sobusha
UDkt. Sinclair kanye nozakwabo baye banyathelisa izingcezu zocwaningo eziningana mayelana nekhono le-nicotinamide mononucleotide ne-NAD + ekuguquleni ukuguga. Ngokusho kocwaningo lwakhe lwe-2013, uSinclair kanye neqembu bathola ukuthi amagundane ase-22 ezinyanga ezinhlanu ezithatha i-NMN ngezinsuku eziyisithupha abonise ukuthuthukiswa komthamo wamascle, umzimba kanye nokukhuthazela.
Kamuva ephepheni lokucwaninga le-2016, leli qembu liqinisekise ukuthi i-NMN inezinzuzo ezifanayo njengokuzivocavoca. Esikhundleni sokugijima esitokisini nsuku zonke, usengathola imiphumela efanayo uma usebenzisa izithako ze-Nicotinamide Mononucleotide esikhundleni salokho.
Ngokwale Harvard Geneticist, the Umsebenzi we-NMN kumuntu ihambisana nokuqinisa ukugeleza kwegazi kulabo abagijimi asebekhulile nabalandeli.
(2) Izicelo zokugaya izimpahla ukuthi i-NMN iyanciphisa ukunciphisa umzimba ngokwemigodi ekhulile
Ngokubhekisela kwisifundo se-2016, uMills et al. bathola ukuthi ukwelashwa kwe-NMN kuzokwenqabela ukuncipha kokubili kokusebenza komzimba nokuzivikela kwamagundane endala. Ekupheleni kwalesi sengezo se-NMN ucwaningo, amagundane abhalise ukwanda kokuvezwa kwamaseli omzimba, ukwanda kwe-lymphocytic, nokuncipha kuma-neutrophils.
Phambilini, e2011, uMills, Yoshino, no-Imai basebenzise amamodeli wamagundane ukuqinisekisa indima ye-NAD + ekwelapheni isifo sikashukela esibangelwa ukudla kanye nobudala. Kwesinye futhi isifundo se-2016, wajoyina izandla nabanye abacwaningi abasungula ukuthi ukwengezwa kwe-NMN kuzomelana nengcindezi ye-oxidative kanye nokungasebenzi kahle kwemithambo kumagundane amadala.
(3) Izifo Zama-Alzheimer's NmN (AD) ku-Murine Models
Ngo-2015, uLong et al. uphenye umphumela we-NMN ekushodweni kokuphefumula kwe-mitochondrial kumagundane ane-Alzheimer's. Ithimba liqaphele ukuthi ukwelashwa kwe-NMN kwakwazi ukwelapha i-etiology ye-AD, kufaka phakathi i-OCR ephansi (amazinga okusetshenziswa komoya-mpilo), ukwehla kwe-NAD +, kanye nokungajwayelekile kwe-mitochondria.
Ngo-2016, uWang nabalingani bakhe bashicilela ucwaningo lwabo, baphetha ngokuthi lezi anti-ukuguga izidakamizwa zilwa nokukhubazeka kwengqondo nokuqonda, okuvela ku-B-amyloid (AB) oligomer. Le protein ye-AB ine-neurotoxic futhi inesibopho sokwakhiwa kwamacwecwe ebuchosheni beziguli ze-AD. U-Wang et al. uphethe ngokuthi ukuphathwa kwe-NMN kumagundane kuholele ekwehleni kwama-oligomers e-AB, ngaleyo ndlela kukhulisa imisebenzi yokuqonda.
Ngemuva kocwaningo lwango-2017, uHou nozakwabo bathola ukuthi ukwesekwa kwe-NAD + kunciphise ukukhiqizwa kwama-oligomers e-B-amyloid. Ngemuva konyaka, uYao nethimba lakhe basungula ukuthi iNicotinamide Mononucleotide inciphisa ukuqoqwa kwe-AB kanye nokulahleka kwe-synaptic kumamodeli we-AD-Tg murine.
(4) I-NMN ne-Cardio-ukuvikelwa
Ngokusho kokushicilelwa kuka-2014 ngu-Yamamoto nozakwabo, I-NMN ivikela inhliziyo ekulimaleni kwe-ischemic nasekuphindisweni kabusha. Ngaphambi kwalolu cwaningo, u-Yamamoto wayeyingxenye yeqembu lika-2012, elathola ukuthi i-NAD + ibala ukukhuluphala okubangelwa ukudla ekudleni kwamagundane.
Ngo-2016, uDe Picciotto et al. futhi ozakwabo bamakhemikhali ekilasini bafunda umphumela wokwengeza kwe-NMN ekusebenzeni kwemithambo yegundane eliguga. Kusukela kulokho okushiwo, i-nicotinamide mononucleotide ibonakale isebenza ngempumelelo ekubuyiseleni ukungasebenzi kahle kwemithambo, ukucindezeleka okwenziwe nge-oxidative, nokwehla kwe-elastin.
(5) Ukutholakala Emgwaqweni Omusha Wezakhi Zamafutha Amaseli Shin-Ichiro Imai
Ecwaningweni lwakamuva, iqembu labososayensi eliholwa ngu-Imai lathola futhi lahlukanisa lo mthumeli oyimfihlakalo we-NMN emasethini.
Lolu cwaningo lwe-NMN lokungeza luqale litholakale ngoJanuwari 2019 ku Uhlobo lweMetabolism. U-Imai wasungula ukuthi iphrotheni ethile, i-Slc12a8, inesibopho sokuguqulwa okusheshayo kwe-NMN ku-NAD + futhi ukuyithuthela esitokisini. Le enzyme ibaluleke kakhulu kubantu abadala kunokuba abantu abasha noma abanempilo.
Kuzo zonke izifundo ezandulela ukwelashwa, ososayensi bezocwaningo bazoncibilikisa izinyathelo ezaziwayo ze-nicotinamide mononucleotide powder ngobuningi emanzini ngaphambi kokuzinikeza amagundane.
Thumela ngokushesha uphenyo: Oxhumana nathi
Izinzuzo ezivela eNicotinamide Mononucleotide (NMN)
I-NMN inemisebenzi eminingi yokwelapha nemiphumela yezokwelapha emzimbeni womuntu. Ngaphansi kweminyaka eyishumi, ososayensi baye banikezela isikhathi sabo sokutadisha zonke izinzuzo zeNicotinamide Mononucleotide kufaka phakathi izindlela ezichaza ukuguga kanye nezifo ezihlobene nobudala.
Ake sihlole izinzuzo zekhompiyutha ohlelweni lomuntu.
(1) Ukwehlisa i-Cellular Lifespan
Kuze kube sekuqaleni kwe-21st ikhulu leminyaka, izazi zinezizathu ezanele zokumemezela ukuguga njengenqubo engenakuguqulwa. Noma kunjalo, le mbono isuke ingenalutho ngenxa yokutholakala kokunciphisa anti-aging izithako njengoNicotinamide Mononucleotide.
I-NMN isemvelo-eyenzeka emangqamuzaneni omuntu futhi ibhekene ne-biosynthesis ye-NAD + nokukhiqizwa kwamandla. Njengoba usuguga, lezi zinhlanganisela ezimbili zihlaziya futhi ziholela ekulawulweni kwamaseli ase-stem. Khumbula, leyunithi esebenzayo idinga uphethiloli okwanele okwanele ukuphindaphinda njalo, ngakho-ke, ukuwa kuyokwehlisa isikhathi sokuphila kwamaselula.
Ukulawula izidakamizwa eziphikisayo zokulwa nokuguga ezifana ne-NMN kuzoguqula inqubo bese iphuza indlela yokuguga.
(2) Ukusekela Amanqanaba Ezinsizwa ZamaNtsha aseNtsha
Imvelaphi eyinhloko yezifo eziningi ezihlotshaniswa nokuguga kuncipha kuze kube sezingeni leselula. Ukunciphisa ukukhiqizwa kwamandla ngaphakathi kwamaseli kuyinhloko enkulu yezinkomba zokuguga.
Ukuba yisandulela se-NAD +, i-NMN inendima okufanele idlale ekulondolozeni amazinga aphezulu wezamandla we-mitochondria yeseli. Ukuguga kuzobangela ukuthi ukwehla kwe-NAD + kungabikho. Ngenxa yalokho, inqubo yokuguga isikhashana iholela ekuthuthukiseni izifo eziguga.
Ukudonsa emanzini wamandla eselula ngaphakathi kwezitho ezibalulekile ezinjengezinthambo, imithambo yegazi, izinso, isibindi, noma ama-pancreas njalo kuphazamisa impilo engokwenyama nangokwengqondo. Kungenxa yalesi sizathu ukuthi izifo ezinjenge-ischemia, izimo zenhliziyo, ukwehluleka kwezinso, ukuphazamiseka kwe-neurodegenerative, nabanye ukudubula.
Isixazululo esikahle ngokwengeza somzimba I-Nicotinamide mononucleotide ne-NAD + ephathwa ngaphandle nge-NMN. Lezi imishanguzo yokulwa nokuguga inikeza ukuqasha okusha kokuphila kumaseli asebekhulile, azobe esebukeka njengobusha.
(3) Ukwenza ngcono ukujikeleza kwegazi
Enye yezinguquko ezenzeka ngesikhathi eside kunciphisa izinga lemithambo yegazi ngaphakathi komzimba wamamamalia. Ngakho-ke, uhlelo lokujikeleza luhamba kahle kakhulu lapho luthwala izakhi, oksijini, ukushisa, noma ukususa imfucuza ezivela ezithombeni. Njengoba lesi simo siqhubeka, siphuthuma ngokuhamba kwesikhathi esiholela ekufakeni izifo ezinesikhathi eside.
I-Nicotinamide Mononucleotide ngokuqondile ingabangela ukukhiqizwa kwemithambo yegazi. Ngivumele ngichaze. I-compound yenza inamba ye-NAD +, ephinde isebenze iphrotheni ye-sirtuin deacetylase (SIRT1).
Ngakolunye uhlangothi, i-SIRT1 i-diacetylates i-lysine izinsalela ezisiza ekukhiqizeni ama-radicals mahhala e-oxygen. Le ndlela ilwa nokucindezeleka okwenziwe nge-oxidative, ukufinyelwa kabusha, noma ukulimala kwe-ischemic. Ezimweni ezijwayelekile, umzimba ngokwawo uzokuphikisana nokusekela ischemia nezimo ezihlobene ngokusebenzisa ischemic preconditioning (IPC). I-IPC izobe isenza ukugqugquzela ukukhiqizwa kwe-SIRT1.
Ungakwazi ukuphatha i-NMN ngaphambi komcimbi we-ischemic noma ngesikhathi sokubonakaliswa kwayo. Ngaphambi kokuba kwenzeke, le nhlanganisela inikeza i-cardio-protection ngokukhulisa ukukhiqizwa kwe-ATP ngokusebenzisa i-glycolysis.
Endabeni ye-Ischemia, usengasebenzisa iNicotinamide Mononucleotide njengoba izodala i-acidosis futhi idale ukungasebenzi kahle kwe-mitochondrial; yingakho, kuqinisekisa ukuvikelwa kohlelo lwezinhliziyo.
(4) I-Muscle Endurance
Ngabe ulindeleni lapho ukugeleza kwegazi kwehla? Yebo, umbuso uzoholela ekulahlekelweni kwesisindo semisipha. Akungabazeki ukuthi uzobona ukuthi abantu abadala abanakho ukusebenza okuncane, ukukhuthazela okuphansi, ukunganyakazi, nokukhathala kakhulu ngaso sonke isikhathi.
Okunye kokutholwa okuqhekezayo nguDkt.Sinclair kwakugxile ekusebenzeni kweNMN ekukhuliseni amandla emisipha. Ngokuya nge-2013 yakhe kanye nezifundo zakamuva ze-2018, amagundane amadala avezwe ukwelashwa kwe-NMN kwezinsuku eziyisikhombisa aba namandla emzimbeni futhi asebenza njengabalingani babo abancane.
Amandla omzimba kanye nokukhuthazela kwamagundane amadala (izinyanga ezingu-30 ezindala) zazifana nezingane ezineminyaka emihlanu ubudala. Lezi zinsuku zifaniswa neminyaka eyi-70 kanye ne-20 kubantu. Kusukela ekutholeni, ungenza ukuthi iNMN isebenze kubantu uqinisekile njengokufa.
(5) Ukulwa nezifo ze-Neurodegenerative
Ubuchopho bunjenge-powerhouse yesistimu yakho. Lesi sici singase sibe isizathu sokuthi kungani ama-medics azohlala ethembela emisebenzini yobuchopho lapho ememezela isikhathi sokufa.
Ukunciphisa amazinga we-NAD + ebuchosheni kuphazamisa impilo yokuqonda phakathi kwabantu asebekhulile. Ukuphathwa kwe-NMN kusheshisa ukukhiqizwa kwe-NAD, ngakho-ke, ukuvikela imisebenzi ye-neural.
Izifundo eziningi zifakazela ukuthi uNicotinamide Mononucleotide inenzuzo ukuqonda, ukushaya unhlangothi, nokuvimbela ukulahleka kwememori, okuvame kakhulu lapho umuntu esemdala. Ngokufingqiwe, lokhu anti-ukuguga ibhekwa ibhekele ukugcinwa kwama-neurons.
I-NMN ihlose ikakhulukazi i-etiology yanoma yisiphi isimo sezinzwa esinikeziwe. Ngokwesibonelo, I-Alzheimer's isifo senzeka ngenxa yokwehla kwe-NAD +, isilinganiso esiphansi sokusetshenziswa komoya-mpilo ebuchosheni, nokungajwayelekile kwe-mitochondrial. Ukwandisa inani le-NMN kuzinto zokubala zomzimba yonke le miphumela.
Ngokuya ngocwaningo olushicilelwe ngo-2012, iNicotinamide Mononucleotide izokuphatha kahle ukulinyazwa kwe-intracerebral, okuvame ukuholela ekushayweni unhlangothi. Amagundane amadala abengaphansi kwesilinganiso se-NMN abhalise intuthuko enkulu ekukhiqizweni kwe-intracerebral NAD +. Lezi zinhlobo zocwaningo zazinokuvikelwa okuphezulu ekulweni nesifo se-ischemic, ukufa kwe-neural, nokuvuvukala kwemizwa.
(6) I-Metabolism Ethuthukisiwe Ebudala
Abacwaningi abaningana baye bacwaninga futhi bafakazela ukuthi i-NMN ikhuthaza ukubekezelelana kwe-glucose ngenkathi kukhuliswa umthamo weshukela kumagundane asekhulile ngokudla okuncane. Lolu cwaningo lusetshenziselwa abantu asebekhulile abahlakulela isifo sikashukela noma ngenxa yeshukela eliphakeme noma ukudla okunomsoco. Ukwengeza, ukudla okunomsoco oholela kuma-insulin ukumelana.
I-Nicotinamide Mononucleotide igcina ukukhiqizwa okukhulu kwe-NAD +, okuyinto ekunciphiseni ukuvuvukala ehlobene yobudala ngenkathi ngcono ukusebenza kwe-insulin ezinhlanganweni amafutha.
(7) Ukwelashwa kwesifo sikashukela
Abantu abanesifo sikashukela sohlobo II bahlala bekhombisa ukumelana ne-insulin. Lesi sici singenxa yokuwa kwe-NAD +. Ngenxa yalokhu, amaseli aba nengcindezi ye-oxidative nokuvuvukala. Uma usemncane, umzimba uzozivuselela ngemisebenzi ethile yomzimba engapheli. Kodwa-ke, ngokuguga, amazinga e-NAD + ancipha ezithombeni ezisekela impilo njengemisipha yamathambo, isibindi, ubuchopho namanyikwe.
Okunye okunikela ngesifo sikashukela esihlobene nobudala ukudla okunamafutha amaningi. Inani elingajwayelekile lamafutha agcwele livimbela i-biosynthesis ye-NAD +. Ngenhloso yokufakazela ukusebenza kweNicotinamide Mononucleotide ekwelapheni isifo sikashukela esidala kanye nokudla, uYoshino nozakwabo basebenzise izinhlobo ezimbili zamagundane.
Ngemuva kokwenza umthamo wansuku zonke we-NMN izinsuku ezicishe zibe yishumi, izazi zathola ukuthi amagundane, ayephekwa ngokudla okunamafutha amaningi, aqopha ukungabekezelelani kwe-insulin. Ngakolunye uhlangothi, amagundane esifo sikashukela akhombisa ukuthuthuka okukhulu kwe-hyperlipidemia.
(8) Ukuguqula ukuguga
Izinkinga zempilo ezingapheli njalo zihambisana nenqubo yokuguga. Njengoba umzimba uhamba nezinguquko eziningana zomzimba, ezinye zezinhlelo zamaselula zenzeka ukuba zibuyele emuva. Ngokwesibonelo, cabanga ukuthi amazinga we-nicotinamide adenine dinucleotide ancipha ezithombeni eziningi, okuholela ekunciphiseni kokukhiqizwa kwamandla nge-mitochondrion yeseli.
Ukuguga kusetha izinto ezihlukahlukene ezifana nokulimaza kwe-DNA ngenxa yama-molecule angakhulumi, ukucindezeleka kwe-vascular oxidative, nezinye izinkinga eziyinkimbinkimbi. Uyazi ukuthi kwenzekani? Yebo, kune-protein yokulungisa i-DNA (PARP1) ohlelweni lwesintu. Uma kwenzeka umonakalo we-DNA, i-NAD + izovuselela le phrotheni ukuze ilungise iseli eliphathekayo.
Ucwaningo oluningana luye lwavela nezinzuzo ze-nicotinamide mononucleotide ekugugeni. Isibonelo, uMills nozakwabo basebenzise amamodeli wamagundane ukuphenya umphumela wokwehla komzimba kwe-NMN ngeminyaka.
Esicwaningweni, abacwaningi baphawula ukuthi ukuphathwa kwesikhathi eside kwezokwelapha kwaholela ekwenzeni ukuguqulwa kwamagciwane okweqile ngaphakathi kwesibindi, imisipha yamathambo kanye nezicubu ze-adipose. Ngaphezu kwalokho, ukutholakala okuqinisekisile ukuthuthukisa ukukhulumisana kwamasosha omzimba, ukwanda kwama-lymphocytes, nokusebenza kwama-leukocytes.
Esinye isici sokuguga kungukuthi kukhona izindawo ezinemibala ekhanyayo ku-fundus ye-eye. Lesi simo kanye nokwehliswa kwamathambo nokuhluleka ukukhiqiza izinyembezi kuye kwacwaningwa ngokugcwele ezindongeni. Ososayensi baqaphele ukuthi amagundane, abeka ukwelashwa kwe-NMN ngenyanga ye-12, abe nayo yonke imibandela engenhla iguqulwa.
Ubude besikhathi yisona sizathu esenza abantu Thenga i-Nicotinamide Mononucleotide.
(9) Ukwelashwa kokukhuluphala
Kubantu asebekhulile, i-NMN inganciphisa kuze kufike ku-10% yesisindo somzimba sokuqala ngaphandle kokuthola indawo emaphakathi phakathi kokudla nokukhula. Indlela yokwelapha yokukhuluphala nesifo sikashukela ihambisana. Amazinga aphansi we-NAD + aletha ukukhubazeka kwamamithachondrial; ngakho-ke, ukwehla ekukhiqizweni kwe-ATP.
Ukukhuluphala kunciphisa amandla okuba mitochondria ekwenzeni amandla we-ATP amangqamuzana. Uma usuphethe i-Nicotinamide Mononucleotide, lesi sidakamizwa sizothuthukisa ukungahambisani kwe-glucose neminye imisebenzi ye-metabolic ephathelene nokukhuluphala.
Uma kukhulunywa ngokuthuthukisa ukugeleza kwegazi, i-NMN yokwelashwa okhuluphele yenza ngokufana nokuzivocavoca umzimba. Iphilisi elilodwa lingafana nokusebenzisa umshini wokunyathelisa nsuku zonke. Kodwa-ke, umehluko uza emazingeni wokuqukethwe kwe-NAD + ezithweni zomzimba. Ngenkathi iNicotinamide Mononucleotide inyusa i-NAD + kuzo zombili izicubu zesibindi nezemisipha, ukuzivocavoca umzimba kuphela kwakha inhlanganisela ngaphakathi kwemisipha.
Ingabe i-Nicotinamide Mononucleotide (i-NMN) Ngempela isebenza Kubantu?
Yebo, lo kungaba umbuzo wamanje okhalayo ekhanda lakho. Kunoma ikuphi, lonke ucwaningo kanye nezifundo ze-Preclinical ezigxile kuNicotinamide mononucleotide naseNAD + bezilokhu zikhombe amamodeli we-murine.
Uma unokubhuka mayelana nokusebenza komsebenzi we-NMN kubantu, nansi konke okudingeka ukwazi. UDkt. David Sinclair, umcwaningi ophezulu, kanye ne-geneticist eHarvard University ungomunye wabamukeli be-NMN.
USinclair uyavuma ukuthi uthatha isengezo. Kuze kube manje, isazi asikaze sibhale noma yimiphi imiphumela emibi ye-nicotinamide mononucleotide. Ngokuphambene nalokho, uthi uzizwa emncane ngengqondo ebukhali. Ama-Hangovers nama-jet lags manje sekuyisikhathi esedlule kuye. Ubuye aqinisekise ukuthi ubaba wakhe, osevile eminyakeni engamashumi ayisikhombisa, naye uthatha isengezo.
Ukwengeza, uDkt. Sinclair usebenzise ukwelashwa njengesivivinyo sokuqala eBrigham naseBhedlela labesifazane. Unamasu okuqhubeka nokuhlola ukwesekwa kubantu abadala asebekhulile. Nakuba isifundo sakhe sesigaba esisodwa sesiphelile, usazokwenza incwadi esemthethweni. USinclair waqala isigaba sesibili salesi sitholampilo Ukwengeza kwe-NMN ucwaningo e 2018.
Izivivinyo zemitholampilo
Esifundweni somtholampilo esifanele i-1st Ngo-Juni 2020, abacwaningi bafuna ukusungula ushintsho kobuzwe kanye nemisebenzi ye-beta-cell ne-NMN ukwengezela kubantu. Izazi zivela eWashington University School of Medicine naseKeio University School of Medicine eTokyo.
Ekulingweni komuntu okwenziwe ku-2016 eKeio University, izazi zazibheke ukuhlola ukuphepha kwe-NMN kubantu abadala abanempilo. Esigabeni sesibili esiqhubekayo, inhlangano efanayo, eholwa nguShin-Ichiro, iphhenya ukuphathwa kwe-NMN yesikhathi eside. Ngaphezu kwalokho, ithimba lifuna ukuhlola imingcele ehlobene nemithi-syndrome, i-NMN kinetics, nomphumela wezidakamizwa ku-glucose metabolism.
Esifundweni se-2017 emtholampilo yiYunivesithi yaseWashington, ababambiqhaza bahlanganisa abesifazane be-50 abaneminyaka engu-55 kuya ku-75 iminyaka. Leli qembu lafakwa esilinganisweni nsuku zonke se-250mg se-NMN amasonto ayisishiyagalombili. Nakuba babeyizifo ezinempilo, laba besifazane babenezinhlanzi eziphakeme zegazi, i-triglyceride ne-BMI. Ucwaningo alukakapheli.
Njengamanje, azikho izincwadi eziqinisekisa ukusebenza kwe-NMN kumuntu. Kodwa-ke, kufanele ulinde ngoba kukhona okuphekayo futhi izivivinyo zomtholampilo zingathembisa.
Indlela Yokusebenzisa i-Nicotinamide Mononucleotide (i-NMN) Yokulwa nokuguga?
Uma ubheka ukuthenga i-nicotinamide mononucleotide, kunezinto ezimbalwa okudingeka wazi.
Ungathatha nje ukwelashwa njengesithasiselo sokudla ngoba singakaze sithole imvume yokugcina ye-FDA ukuze ibe yisidakamizwa somuthi.
Izinga lokulinganisa phakathi kwe-25mg ne-300mg kuye ngezinzuzo zezempilo ofuna ukuzifeza. Noma kunjalo, abanye abantu bavuma ukuthatha ku-1000mg ngosuku. Thatha, isibonelo, uDkt. Sinclair uthatha i-750mg / usuku. Ngaphandle kwalokho, uqinisa lo mbuso nge-resveratrol ne-metformin.
Kuhlolwa kwe-NMN emitholampilo, iningi labacwaningi babezobeka izihloko zabo ohlwini lwamanani we-100mg kuya ku-250mg.
I-Oral vs. Okulinganiselwe
Uma ufuna ukwandisa ukutholakala kwemvelo kwalesi sengezo, kufanele uthenge amaphilisi e-Nicotinamide Mononucleotide ekuphathweni kwezilinganiso. Ukuthatha izidakamizwa ngomlomo kunciphisa inani elithintekayo ezinhlakeni. Isizathu siwukuthi sibhekana nokugaya umzimba nokudakalisa njengoba sidlula ngendlela yokugaya nesibindi.
I-NMN eyingqayizivele ingena ngqo egazini ngaphandle kwezingcingo. Izinga lokungenisa le ndlela yokudiliva cishe izikhathi ezinhlanu ngaphezu kokuphathwa komlomo. Kulesi simo, kuzodingeka ukwandise umthamo wokwenza isiphakamiso sokuqala se-metabolism esibindi. Uma ucabanga ukuthi ucwaninga, ungadinga i-nicotinamide mononucleotide i-powder bulk ukuze ugcwalise isifundo.
I-Effect Side Of Nicotinamide Mononucleotide Okufanele Uyazi
Okujwayelekile kufana nalokho okukhonjiswe yi-niacinamide kanye neminye imiphumela emibi ye-vitamin B3 compoundnicotinamide mononucleotide. Kodwa-ke, iningi labantu aliziboneli nakancane. Isibonelo, usosayensi ocwaningayo ophakeme waseHarvard University uyavuma ukuthi uthatha i-NMN, kepha akazange abone noma yimiphi imiphumela yokungqongqoza.
Kuze kube manje, kuzo zonke i-Nicotinamide Mononucleotide etholakalayo isebenza ngamagundane, akukho datha ekhombisa ukuthi kukhona noma yimiphi imiphumela emibi e-murine models. Akekho umcwaningi orekhodile uphawu olubi kokubili kokuphathwa kwe-NMN emfushane nesikhathi eside.
Abanye abantu bangase babone lokhu okulandelayo okungalungile;
- I-nausea
- Ukuvota
- isiyezi
- Isisu sithukuthele
- Uhudo
- Ukusabela okwenziwe okwenziwe okwenziwe okwenziwe okwehla okufana ne-itchiness, imihlathi, noma imfucumfucu
Ezimweni ezingavamile, imiphumela emibi ye-nicotinamide mononucleotide ingaba nzima kangangokuthi kufanele ufune ukuhlolwa kwezempilo ngokushesha. Ukukhuluma ngezinkinga ezimbalwa, ukuphefumula, ukushaya kwenhliziyo okungavamile, ukuhlanza okuqhubekayo, isikhumba esikhuphuka, nokulahlekelwa kwesifiso kungenye yezimpawu ezinzima.
Izimo
Kuze kube manje, ukuvivinywa kokwelashwa kuye kwagxila kubantu abadala abanempilo ebangeni lobudala le-45 kuya ku-75 iminyaka. Ngenxa yalesi sizathu, amaqembu alandelayo kufanele aqaphele ngaphambi kokulawula ama-NMN anti-aging supplements.
- Omama abakhulelwe nabahlengikazi
- Abantu abanomlando we-hypersensitivity ku-NMN
- Iziguli ezithatha imithi yezifo ezingapheli
Thumela ngokushesha uphenyo: Oxhumana nathi
Ngingayitholaphi I-Anti-Aging Drugs-Nicotinamide Mononucleotide (NMN)?
(1) Imithombo Yokudla ye-NMN
Cishe wenza ingxabano ngokuthi kungani kufanele uthenge iNicotinamide Mononucleotide lapho ungakuthola kalula ekudleni okuthile. Ake ngichaze kafushane ukuthi kungani lokhu okungeziwe kudingekile.
Njengoba i-NAD + inqamuka emzimbeni ngenxa yokuguga, amaseli ngeke akwazi ukulwa nomphumela. Kuleli phuzu, ukhetho lwakho kuphela lungase lusebenzise izithasiselo ze-NMN. Abahlengikazi bazokukhuthaza ukuba uthathe ukudla okune-NMN okucebile njenge-broccoli, amakhowe, i-edamame noma ama-shrimp. Noma kunjalo, lokhu kudla kuzokhipha kuphela ngaphansi kwe-5% yalokho umzimba wakho odinga.
U-FDA uncoma ukuthi noma yimuphi umuntu udinga cishe i-560mg ye-NMN ngosuku. Uma ucabanga ukuthi uzothola ukwesekwa kusuka ku-broccoli, kuzodingeka udle ama-1500 amakhilogremu afanayo.
(2) Ama-NMN Supplements
The i-nicotinamide mononucleotide i-powder eningi iyatholakala ukuthengiswa ezitolo eziningi zokwelapha nezidakamizwa noma laboratories. Uma ufuna ezinye ucwaningo lwakho, ungenza umyalelo wenqwaba, okuza nezintengo ezishisiwe futhi ukukhishwa kwamacala okuthumela.
Ukwenza ukuthengwa kwe-inthanethi kwe-NMN kungagcini nje kuphela ngesikhathi sakho kodwa futhi kunikeza isiteji esihle kakhulu sokuqhathanisa amanani ahlukene. Uma ungewona umcwaningi, usengathenga i-Nicotinamide Mononucleotide Izithako ukuze uzisebenzise. Ngaphambi kokwenza umyalelo, qiniseka ukuthi umkhiqizo webanga lokudla.
Isifinyezo
Kuzwakala kungenangqondo ukufakazela ukuthi i-NMN yandisa isikhathi sokuphila kwabantu. Noma kunjalo, lokhu kufaka kuphelile. Isizathu sokufa phakathi kwabantu asebekhulile kubangelwa izifo ezibangelwa ukudala, okuvela ngenxa yemisebenzi yamaselula empofu.
The ukulwa nokuguga i-Nicotinamide Mononucleotide kuphela inyathelo ekuthuthukiseni ukulethwa kwamafutha emzimbeni futhi kukhulise ukusebenza kwamaseli. Isebenza ngokunciphisa i-NAD +, okuvame ukwehla njengoba sikhula.
Ukusebenzisa ama-crams ebusweni bokuguga, ama-moisturizers, ama-sunscreens, noma ukuqala umzimba ngokudla okunempilo kungashintsha ubuso bakho kuphela. Kodwa-ke, udinga ukuqonda imbangela ebangela ukucindezeleka ukuguga ukubhekana nabo ngabanye. I-Nicotinamide mononucleotide iguqula inqubo yokuguga ngokulungisa i-DNA eyonakalisiwe, ivikela ubuchopho, isimiso senhliziyo, ukuthuthukisa imisebenzi yemisipha, nokuthuthukisa ukukhuthazela.
Uma ufuna nicotinamide mononucleotide bulk powder, hlola nathi futhi ujabulele amanani angobungane.
Okubhekwayo
- Izigayidi, KF, Yoshino, J., Yoshida, S., et al. (I-2016). Ukulawulwa Kwesikhathi Eside Kokuphela Kwe-Nicotinamide Mononucleotide Kunciphisa Ukuguga Kwemvelo Ehlanganiswa Nokwemvelo Kwezinsana. I-Cell Metabolism.
- UJoshino, J., Mills, KF, Imai, SI, noJoon, MJ (2011). I-Nicotinamide Mononucleotide, i-NAD + ephakathi, isebenzisa i-Pathophysiology ye-Diet- kanye ne-Diabetes Ekhulelwe Ngayo Emantwini. I-Cell Metabolism.
- Yamamoto, T., Byun, J., Zhai P., Ikeda, Y., Oka, S., noSadoshima, J. (2014). I-Nicotinamide Mononucleotide, isiPhakathi seNAD + Synthesis, ivikela Inhliziyo kusuka Ischemia nokuphinda kufakwe kabusha.
- Sinclair, DA, Uddin, GM, Youngson, NA, noMorris, MJ (2016). Hlola kuya eNhloko Ukuqhathaniswa Ukwelashwa Kwesikhathi Esifishane Nesandulela seNAD + iNicotinamide Mononucleotide (NMN) kanye namaviki ayisithupha Wokuzivocavoca Emagundeni Ase-Obese Abesifazane.
- Imai, S., Yoshino, J., Mills, KF, Grozio, A., et al. (2019) I-Slc12a8 yi-Nicotinamide Mononucleotide Transporter. Uhlobo lweMetabolism.
- De Picciotto, NE, Mills, KF, Imai, S., Gano, LB, et al. (I-2016). I-Nicotinamide Mononucleotide iguqula ukukhubazeka kwe-Vascular nokucindezeleka okuxubile ngamagundane asegugile.
- Yao, Z., Gao, Z., Yang, W., noJia, P. (2017). I-Nicotinamide Mononucleotide ivimbela ukuvuselelwa kwe-JNK ukuguqula izifo ze-Alzheimer.
- Hou, Y., Wang, Y., Zhang, Y., Lautrup, S., et al. (I-2018). I-NAD + I-Supplementation ihlanganisa izici ze-Alzheimer Key kanye ne-DNA Impendulo yokulimala ku-AD entsha ye-Mouse Model ne-Introduced DNA Repair Repair.
- RAW I-NICOTINAMIDE MONONUCLEOTIDE (NMN) UPHAWU (1094-61-7).


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Muva nje i-intanethi iyacasuka kakhulu ukuzwa ukuthi umlingisi usetshenziswe kakhulu yisitudiyo. Usuku lwehora le-12 olugcwele ukumenyezelwa lulungile kithi shlub emhlabeni sisebenza ama-non gigs, kepha abalingisi abaphoqeleka ukuthi basebenze inqwaba yamahora futhi bathethiswe ngumqondisi wabo bayisitha somphakathi esiyinombolo eyodwa. Yebo, i-intanethi isizocasuka kakhulu futhi kufanele kanjalo kuJean-Claude Van Damme ukuxoshelwa… ukuthola lokhu… ukuphelelwa amanzi emzimbeni futhi ucishe ufe.
Njengamanje, iningi lethu liyazi ukuthi uJean-Claude Van Damme ekuqaleni wayezodlala i- nomzingeli. Uhlobo lwakhe lomzingeli omkhulu lwalunokubukeka okuhluke kakhulu. Ukubukeka kwakujwayele ukubukeka kuyizinambuzane kakhulu njengokuphikisana nalokho okwaba yikho. UKevin Walker Hall wagcina ethathe indima ye- nomzingeli futhi wenza indima yabalingiswa.
UVan Damme ubelokhu esho njalo ukuthi ukuzibandakanya kwakhe kule filimu bekungubusuku obunzima. Wayehlala enamanzi emzimbeni futhi egula esethiwe ngenxa yesudi nokushisa okumangalisayo kwehlathi.
nomzingeli Umlingisi uBill Duke ukhulume noMurder Master Music wathi inkanyezi ayenayo empeleni isenkingeni enkulu yokuphelelwa ngamanzi emzimbeni.
Sasisehlathini lasePuerto Vallarta nasePalenque isikhathi eside. Angazi noma uyayazi le ndaba noma cha, kepha uMdli owabona ukuthi wayengeyena uMdliwayo wokuqala. UPredator wokuqala wayeyisidalwa esincane kakhulu futhi babezobeka imiphumela ekhethekile emzimbeni wakhe ngemuva kokukhiqizwa. Ngakho-ke wayegqoke isudi yokuntshontsha futhi bamfaka ezintanjeni yena wandiza phezulu ezihlahleni izintambo zakhe zazingemuva ngathi uyandiza. Ubesedlulile emhlabeni kabili ngenxa yokuphelelwa ngamanzi, futhi umkhiqizi weza kuye wathi, 'Uma uzophinde udlule futhi, ngizokuxosha.' Futhi umfana wathi, 'Angidlulisi ngenhloso! Ngiphelelwe ngamanzi emzimbeni! ' Umdidiyeli uthe, 'Ungaphinde udlule futhi.' Kudlula amasonto amabili, bese umfana edlula emhlabeni. Uphrojusa uyahamba uyomxosha. Lowo muntu kwakunguJean-Claude Van Damme. ” UDuke utshele uMurder Master Music.
Ungakucabanga ukuxoshwa ngenxa yokuxoshwa emzimbeni? Kuyamangalisa.
Ekugcineni kusebenze kahle kuVan Damme. U-dude uqhubeke waba yinkanyezi enkulu yokulwa nobuciko bokulwa. Ngakho-ke, nginesiqiniseko sokuthi usesimweni esidlule sesigaba esidlulile. Futhi, ungacabanga ukuthi uma ukuthi nomzingeli isudu bekuyiyona ebisetshenziswa? Cishe bekungeke kube yi-smash hit ukuthi yaba.
Ucabangani ngohlobo lokuqala lwesudi yeVan Damme? Sazise esigabeni sokuphawula.


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Ngubani owabhala yiphi incwadi? – Nini? IThestamente elisha
18.02.2014
eVlayhede
Kubabhali bezincwadi zeThestamente elisha kekho namunye owazi uJesu ngamehlo.
Kwasekwedlule iminyaka engamashumi amane uJesu abulawa ngenkathi kuqalwa kubhalwa incwadi evangeli lokuqala – ivangeli ngokukaMakhu -, kwathi kuqambe kuqalwa kubhalwa elokugcina – ivangeli ngokukaJohani -, kwase kuhlangene engamashumi ayisikhombisa afa.
Nantu uhlelo lwezincwadi eziseThestamenteni elisha ngokwelamana kwazo kanye nomzamo wokutholisisa ukuthi ngobani abazibhala1:
Ingosi: ezisematheni 5274 Asebevakashile


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*Abomanyano wenhlanganiso ezimela izisebenzi zikahulumende we Zimbabwe Confederation of Public Sector Trade Unions (ZCPSTU bathi amalunga abo akasanelisi ukuya emsebenzini ngakho, ezoqala ukusebenza insuku ezimbili kuphela ngeviki kusukela mhla ka 12 Mabasa kuwonalo umnyaka ka 2021.
*Abantwana bezikolo ezintathu zesiaba seMatabeleland South basuswe emphakathini ngemva kokutholakala belegcikwane le coronavirus.
*Obengumyeni weNdlovukazi yeNgilandi, uQueen Elizabeth, uPrince Phillip kasekho.
*Sizalethulela okwenzakale emthethwandaba namuhla.
*KuWoza Friday namuhla silomculi werhumba uUrgent Ncube leqembu lakhe leNtunungwe Masters bephethe idlalade labo elitsha elilesihloko esithi ‘Batshintshi’nhiziyo.


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Entire new apartment with stunning view
4.89Umbungazi ovelele
I-iyunithi yokuqasha ephelele ibungazwe ngu-Stella
Izivakashi ezingu- 3, ikamelo lokulala 1, imibhede engu-2, Igumbi lokugezela elilodwa
Ikhaya lonke
Ifulethi izoba ngeyakho wedwa.
Ukuhlanza Okwenziwe Ngcono
Lo mbungazi uzibophezele enqubweni yokuhlanza ethuthukisiwe yezinyathelo ezingu-5 ye-Airbnb.
Indawo enhle
Izivakashi ezingu-90% zakamuva zinikeze indawo isilinganiso sezinkanyezi ezingu-5.
Okokuzithokozisa kokungena okuhle kakhulu
Izivakashi ezingu-95% zakamuva zinikeze inqubo yokungena isilinganiso sezinkanyezi ezingu-5.
Lokho ozokuthola kule ndawo
Ukubukeka kwechibi
Izintaba
Ikhishi
I-Wifi
Ukupaka okungakhokhelwa egalaji emagcekeni – isikhala esiyi-1
Izilwane ezifuyiwe zivunyelwe
Izincwadi zezingane namathoyizi
I-Hair dryer
Ayitholakali: i- I-alamu ye-carbon monoxide
Ayitholakali: i- I-alamu yesimoko
4.89 out of 5 stars from 62 reviews
Inhlanzeko
Ukunemba
Ezokuxhumana
Indawo
Ngena
Inani
- Ukubukeza okungu-74
- Ubuwena buqinisekisiwe
- Umbungazi ovelele
I felt in love with great-dane dogs 36 years ago. I like travelling and doing exibitions with my dog. I love reading and learning about different cultures.
Phakathi nokuhlala kwakho
I live in the same building but in a separate apartment, I'm always reachable for any information. I speak Italian, German, English and French, Spanish "un poquito". I live with my beautiful dog, three lovely cats and a turtle in the garden. If you are worried about the pets, I guarantee that they are always living with me.
I live in the same building but in a separate apartment, I'm always reachable for any information. I speak Italian, German, English and French, Spanish "un poquito". I live with my…
UStella Ungumbungazi ovelele
Ababungazi Abahamba Phambili banesipiliyoni, ababungazi bezinga eliphezulu abazinikele ekuphatheni izivakashi ngendlela ekhethekile.
- Izilimi: English, Français, Deutsch, Italiano
- Izinga lokuphendula: 100%
- Isikhathi sokuphendula: kungakapheli ihora
Ukuze uvikele ukukhokha kwakho, ungalokothi uthumele imali noma uxhumane nabantu ngaphandle kwewebhusayithi ye-Airbnb noma i-app.
Izinto okufanele uzazi
Imithetho yendlu
Ngena: 15:00 - 00:00
Isikhathi sokuphuma: 11:00
Akufanelekile ezinsaneni (ezingaphansi kuka-2)
Akubhenywa
Ayikho imicimbi noma izenzakalo
Izilwane ezifuywayo zivunyelwe
Ezempilo & ukuphepha
Uzibophezele enqubweni yokuhlanza ethuthukisiwe ye-Airbnb. Veza okwengeziwe
Iziqondiso ze-Airbnb zokuziqhelelanisa komphakathi kanye nezinye ezihlobene ne-COVID-19 ziyasebenza
Asikho isiqwashisi se-carbon monoxide
Asikho isiqwashisi sentuthu
Inqubomgomo yokukhansela
Hlola ezinye izinketho ezise- Cademario namaphethelo
Ezinye izindawo zokuhlala e- Cademario:


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Ukuphupha abantu esebafa imvamisa kusho izinto ezimbi. Uma bevuka bephila futhi kusho ukuthi kungenzeka ukuthi kunenkathazo ezayo kuwe. Uma behlobene nawe kusho ukuthi kufanele uyeke ukwenza izinto ezimbi kungenjalo uzoyithola usenkingeni.
Uma uphupha omunye wabantu bakini abangasekho emhlabeni, lokho kusho ukuthi basuke benomyalezo abafuna ukuwudlulisa kulabo abasaphilayo. Kuyenzeka bakhale ngokuthi balambile, lapho-ke kusuke kumelwe kwenziwe umsebenzi kuhlatshwe imbuzi, inkomo noma izinkukhu ukuze badle.


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Uma ngempela ufuna ukuhlobisa ingadi isitshalo sakho, okuyinto ukujabulisa iso unyaka wonke, kubalulekile ukuba banake imbali ezifana bloodroot. Ukutshala nokunakekela musa okungadala ubunzima ngisho balimi imfundamakhwela, futhi zonke izinto ezazikukhathaza bebakhohliwe uma bayokwazisa izimbali zayo ezincane kodwa amahle kakhulu. entwasahlobo cinquefoil flower embhedeni kuhlobisa izimila yayo aminyene, esikhathini kusuka July kuya ku-August sezihlahla embozwe emhlophe, pink izimbali ophuzi. Ekwindla isitshalo futhi enhle kakhulu, amaqabunga ayo ujike egolide, futhi ebusika ngenxa amahlumela ngesikele sokuthena iqhwa ukulunguza obomvu.
Uma ufuna ukuthola izimbali kanye flower kwendle kakhulu, kuyoba nje indlela bloodroot. Ukutshala nokunakekela isiphakamiso yokuthola indawo efanelekayo. On ukuthi kuyakuba kanjani yimpumelelo kuxhomeke ekutheni lesi sitshalo singagxila engadini yakho. Emvelweni, kukhona izinhlobo eziningi kakhulu imibala, basuke kubhekwe lapho kwazalelwa khona eMpumalanga Ekude, e-Europe kanye neNyakatho yeMelika. Njengoba bloodroot uthanda amanzi, likhula futhi kuba izindawo omnandi futhi manzi eduze imizimba amanzi. Indlu Kufanele ngizame nokuzala zonke izimo ukuthi sesiseduze endaweni yazo yemvelo.
Izingadi Russian cinquefoil ezivamile Nepal. Ngiyajabula ukuthi kusukela ekuqaleni kuka-July no-cishe kuze kube sekupheleni kuka-August, obomvu noma izimbali amnyama-pink. Kukhona izinhlobo ezimbili: "Nkosazana Wilmotte" futhi "Floris". Lena nzalo enhle kakhulu, inflorescences ukunakwa okunethezeka. Futhi okudume kakhulu cinquefoil izihlahlana ezingasetshenziswa ukubekezelela ukugunda izinwele, imibala egqamile ujabule, umuzwa omkhulu egqumeni alpine. Lolu hlobo isetshenziselwe ukudala Hedges. Potentilla kwesiliva futhi ngezinye izikhathi atholakala izingadi, it has a encane kakhulu izimbali ukukhanya yellow. Kodwa ukubaluleka kwalo akukho leso sikhalo, ngakho amandla okwelapha izitshalo.
Into enzima kakhulu - ukuthola indawo lapho ubanjwe bloodroot. Ukutshala nokunakekela adinga ukuvundiswa gqwa, Ukukhipha futhi ayakhala nokhula. Imbali uthanda ilanga, kodwa ngesikhathi esifanayo ngaphansi imisebe ngqo luphola futhi buyabuna. Emthunzini likhula kancane kakhulu futhi awukwazi eziqhakaza, ngakho cinquefoil amasudi penumbra. I nzima kakhulu ukuba alandise Florists nge cinquefoil pink, ngoba liyisihlalo ezingezwakali kakhulu. Lezi izinhlobo zikhula kahle ezindaweni efudumele.
Etshalwe for isitshalo unomphela kangcono kakhulu entwasahlobo. Ukuze wenze lokhu, wemba cishe kwesigamu imitha ukujula. Njengoba bloodroot uthanda calcium, kufanele wafaka abakhwabanisi amatshe e-limestone. Khona-ke wathela ungqimba elincane emhlabeni nge humus nesihlabathi, ibekwe yisithombo futhi wambozwa inhlabathi asele. Inhlabathi kumele ugcwalise kahle, ngoba uyakuthanda kakhulu umswakama bloodroot. Ukutshala futhi Care ukuthambisa njalo, ukugwema omiswe umhlabathi akukwazi kunoma isiphi isimo. Kuyadingeka ukuba banakekele umqhele zalesi sihlahla, cut yayo njalo ngonyaka. Le nqubo kangcono entwasahlobo cinquefoil uma abalimalanga. Ukwakha isihlahla uqweqwe izimbali, kuwufanele wonke uzuza ngoba ngonyaka usike ngumuntu wesithathu. Futhi ungakhohlwa mayelana nesicelo kukamanyolo amaminerali kanye Ukuhlakula ukhula.


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I-Russia izophinda iqale insizakalo yomoya namanye amazwe ayisishiyagalolunye, kufaka phakathi iBahamas, i-Iran, i ...
Isigaba - Switzerland Izindaba Ezintsha
Izindaba eziqabulayo ezivela eSwitzerland - Ukuvakasha & Nezokuvakasha, Imfashini, Ezokuzijabulisa, Ezokupheka, Amasiko, Imicimbi, Ezokuphepha, Ezokuphepha, Izindaba, Namathrendi.
ISwitzerland izindaba zokuhamba nezokuvakasha zabahambi nabachwepheshe bezokuvakasha. Izindaba zakamuva zokuhamba nezokuvakasha eSwitzerland. Izindaba zakamuva kwezokuphepha, amahhotela, izindawo zokungcebeleka, okuhehayo, izinkambo nokuhamba eSwitzerland. Imininingwane yeZurich Yokuhamba. ISwitzerland yizwe elinezintaba laseCentral Europe, ikhaya lamachibi amaningi, amadolobhana kanye neziqongo eziphakeme ze-Alps. Amadolobha alo aqukethe izindawo zokuhlala zasendulo, ezinezimpawu ezifana nenhlokodolobha yaseBern's Zytglogge clock tower kanye nebhuloho lesonto likaLucerne lokhuni. Izwe laziwa futhi ngezindawo zalo zokungcebeleka zokushushuluza nemizila yokuhamba izintaba. Ukubhanga kanye nezezimali yizimboni ezibalulekile, futhi amawashi aseSwitzerland noshokoledi adume umhlaba wonke.
Kuqubuke udlame olunodlame eSwitzerland ngenxa yamaphasiphothi e-COVID-19
Amaphoyisa aseBern aqinise isakhiwo sephalamende futhi asebenzisa izinganono zamanzi, izinyembezi nezinye izinhlamvu zenjoloba ...
Vakashela iSwitzerland entsha: Amahhotela Aqhutshwa Amarobhothi awadingi Migwaqo ...
Kube ilukuluku, amathuba okuxhumana nabantu, izingxoxo zokuhweba ezaletha abanikazi bamahhotela nabangaphezu kwekhulu ...


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uZinhle wase Dubazane
Kepha nansi insizwa thizeni ngemuva ezimboze ngelikhulu ijazi leli wena owazibonela umantshingelana evikela amakhaza ebusuku, ungathi kwayilo lithi, 'ngizokufudumeza uyoze uthi tshilo tshilo sengivuthiwe', simile insizwa yinde le, ukuthi iyoke imuphendule okanye isondele kuye uZinhle phinde!. Kungenzeka phela ukuthi iyazi ngayo le ntokazi, phela kuyaziwa ukuthi uZinhle yi mbokodo yoqobo kalingenwa!, uma in case nje me nsizwa wo! Ingazisola mame. "Vela ekukhanyeni-ke, shono okudingayo kimi, kusukela ngesonto eledlule ulokhe ungilandela ebumnyameni. Awuzivezi ngani ukuthi ungubani?." Kuphinda yena belu uZinhle. Iphenduke nge Jun and insizwa icele kwele mpunzi, iphinda lapho evele ngakhona. "Mana, yima lapho bo!, angizukwenza lutho ubalekelani manje?, uxolo!", 'gxa!, gxa!, gxa', izigi zale nsizwa iya kosithela, hhowu inyamalale!. A sale enkemile unyaka Shobane. Athi nhla phansi nali ipheshana elimhlophe elilotshwe okuthile. Alivule, mamo! Linetshe elncanyana elinamathele kanye no myalezo omfushane. Wo laze lafana nelo mfula wangakithi edubazane nalitshe, ngabagcina nini nje?,abantwana bami bona", usho nje uZinhle zicwebile. Afunde umyalezo, akusiwo amagama angakho kulotshwe nje ukuthi : 'KHUMBULA'. Heqe uvalo! , "engabe?, hhayi akukwazi". Simudle isazela aze aphimise, "hhayi! Ngibuyela kubantabami kusasa lokhu ezintatha, akukho ndlovu yasindwa ngu mboko wayo." Cosi Cosi iyaphela.


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Ukwahlulela Kuqala Endlini KaNkulunkulu
Okukhethiwe okukule ncwadi konke kungamazwi akhulunywa nguNkulunkulu uSomandla ngenxa yomsebenzi Wakhe wokwahlulela ezinsukwini zokugcina, athathwe encwadini ethi Izwi Livela Lisenyameni. Kungamaqiniso okudingeka ukuthi wonke umuntu ofuna futhi ohlola umsebenzi kaNkulunkulu ezinsukwini zokugcina awathole ngokuphuthumayo, kukhethelwe ukuthi kwenze bonke abalangazelela ukubonakala kukaNkulunkulu bezwe iphimbo Lakhe ngokushesha okukhulu. Amazwi kaNkulunkulu akule ncwadi ayilokho uMoya oNgcwele akusho emabandleni njengoba kuphrofethwe eNcwadini yesAmbulo. La mazwi kaNkulunkulu amanje awubufakazi obuhle kakhulu ngokubonakala Kwakhe nomsebenzi Wakhe, futhi awubufakazi obuhle kakhulu ngeqiniso elithi uKristu uyindlela, iqiniso, nokuphila. Sethemba ukuthi bonke abalindele ukufika kweNkosi futhi abalangazelela ukubonakala kanye nomsebenzi kaNkulunkulu bazokwazi ukuyifunda le ncwadi.
Amazwi kaKristu
1Amazwi KaKristu Ekuqaleni—Isahluko 1
2Amazwi KaKristu Ekuqaleni—Isahluko 2
3Amazwi KaKristu Ekuqaleni—Isahluko 3
4Amazwi KaKristu Ekuqaleni—Isahluko 5
5Amazwi KaKristu Ekuqaleni—Isahluko 15
6Amazwi KaKristu Ekuqaleni—Isahluko 88
7Amazwi KaKristu Ekuqaleni—Isahluko 103
8Amazwi KaNkulunkulu Aya Emhlabeni Uwonkana—Isahluko 4
9Amazwi KaNkulunkulu Aya Emhlabeni Uwonkana—Isahluko 5
10Amazwi KaNkulunkulu Aya Emhlabeni Uwonkana—Isahluko 6
11Amazwi KaNkulunkulu Aya Emhlabeni Uwonkana—Isahluko 8
12Amazwi KaNkulunkulu Aya Emhlabeni Uwonkana—Isahluko 10
14Amazwi KaNkulunkulu Aya Emhlabeni Uwonkana—Isahluko 12
16Amazwi KaNkulunkulu Aya Emhlabeni Uwonkana—Isahluko 26
17Amazwi KaNkulunkulu Aya Emhlabeni Uwonkana—Isahluko 29
18Yimuphi Umqondo Okumele Abakholwayo Bawubambe
19Umuntu Okhohlakele Akakwazi Ukumela UNkulunkulu
20Ukukhonza Kwenkolo Kumele Kususwe
21Ekukholweni Kwakho KuNkulunkulu Kumele Ulalele UNkulunkulu
22Izithembiso Kulabo Abaphelelisiwe
24Indlela Yokukhonza Ngokuvumelana Nentando KaNkulunkulu
25Mayelana nokusebenzisa kukaNkulunkulu umuntu
27Umbuso Weminyaka Eyinkulungwane Usufikile
28Kumele Wazi Ukuthi UNkulunkulu Wokoqobo NguNkulunkulu Uqobo
29Ukwazi Umsebenzi kaNkulunkulu Namhlanje
30Ngabe Umsebenzi KaNkulunkulu Ulula Njengoba Umuntu Ecabanga?
31Umele Ukuphilela Iqiniso Njengalokhu Ukholelwa KuNkulunkulu
32Ukunqenqeza Kwemidumo Eyisikhombisa—Okuyisiprofetho Sokuthi Ivangeli Lombuso Lizosabalala Ligcwale Umhlaba Wonke
33Umehluko Obalulekile Phakathi KukaNkulunkulu Ongumuntu Kanye Nabantu Abasetshenziswa UNkulunkulu
34Okholweni, Umuntu Kumele Agxile Eqinisweni—Ukwenza Isiko Lenkolo Akulona Ukholo
35Yilabo Abazi Umsebenzi KaNkulunkulu Namuhla Kuphela Abangasebenzela UNkulunkulu
36Yazi Umsebenzi Wakamuva KaNkulunkulu Bese Ulandela Ezinyathelweni Zakhe
37UNkulunkulu Uyabaphelelisa Labo Abasenhliziyweni Yakhe
38Labo Abalalela UNkulunkulu Ngenhliziyo Yeqiniso Bayozuzwa Ngokuqinisekileyo NguNkulunkulu
39INkathi Yombuso YiNkathi Yezwi
40Konke Kuyafezeka Ngezwi LikaNkulunkulu
41Labo Abapheleliswayo Kumele Bacwengwe Kuqala
42Ukubhekana Nezilingo Ezibuhlungu Kuphela Okungakwenza Wazi Ubuhle BukaNkulunkulu
43Ukuthanda UNkulunkulu Kuphela Okuwukukholwa KuNkulunkulu Ngeqiniso
44Inkulumo Emfishane Mayelana Nombhalo Othi “Umbuso Weminyaka Eyinkulungwane Usufikile”
45Yilabo Abazi UNkulunkulu Kuphela Abangafakaza NgoNkulunkulu
46Indlela UPetru Amazi Ngayo UJesu
47Labo Abathanda UNkulunkulu Bayophila Phakathi Kokukhanya Kwakhe Ingunaphakade
48Umsebenzi KaMoya ONgcwele Nomsebenzi KaSathane
49Isixwayiso Kulabo Abangalenzi Iqiniso
51Bonke Abantu Abangamazi UNkulunkulu Bangabantu Abaphikisana NoNkulunkulu
52Umbono Womsebenzi KaNkulunkulu (1)
53Umbono Womsebenzi KaNkulunkulu (2)
54Umbono Womsebenzi KaNkulunkulu (3)
55Imfihlakalo Yokuba Senyameni (1)
56Imfihlakalo Yokuba Senyameni (2)
57Imfihlakalo Yokuba Senyameni (3)
58Imfihlakalo Yokuba Senyameni (4)
59Ukuba Sesimweni Somuntu Okubili Kuphelelisa Ukubaluleka Kokuba Sesimweni Somuntu
60Ingabe UZiqu Zintathu Into Ekhona?
61Iqiniso Langaphakathi Lomsebenzi Wokunqoba (1)
62Iqiniso Langaphakathi Lomsebenzi Wokunqoba (3)
63Iqiniso Langaphakathi Lomsebenzi Wokunqoba (4)
64Ungakunaka Kanjani Ukuthunywa Kwakho Kwesikhathi Esizayo?
65Kuyini Ukuqonda Kwakho Izibusiso?
66Kuthini Ukuqonda Kwakho UNkulunkulu?
67Okushiwo Ukuba Umuntu Woqobo
69Uma Amaqabunga Awile Ebuyela Ezimpandeni Zawo, Uzozisola Ngabo Bonke Ububi Obenzile
70Akekho Umuntu Osenyameni Ongabalekela Usuku Lolaka
71Umsindisi Usebuyile “Esefwini Elimhlophe”
72Umsebenzi Wokusabalalisa IVangeli Umsebenzi Futhi Wokuhlenga Umuntu
73Umsebenzi ENkathini Yomthetho
74Indaba Eyiqiniso Ngomsebenzi Wenkathi Yokuhlengwa
75Kumele Wazi Ukuthi Sonke Isintu Sithuthuke Kanjani Kuze Kufike Esikhathini Samanje
76Okumayelana Namagama Nokuthi Ungubani
77Kufanele Nibeke Eceleni Izibusisio Zesikhundla Futhi Niqonde Intando KaNkulunkulu Yokuletha Insindiso Kumuntu
78Umuntu Ochaze UNkulunkulu Ngokwemibono Yakhe Angazithola Kanjani Izambulo ZikaNkulunkulu?
79UNkulunkulu Anganeliswa Kuphela Yilabo Abamaziyo Nabazi Umsebenzi Wakhe
80Umehluko Phakathi Kwenkonzo KaNkulunkulu Osesimweni Somuntu Kanye Nomsebenzi Womuntu
81UNkulunkulu UyiNkosi Yayo Yonke Indalo
82Impumelelo Noma Ukwehluleka Kuncike Endleleni Umuntu Ayihambayo
83Umsebenzi KaNkulunkulu Kanye Nomsebenzi Womuntu
84Ukwazi Izigaba Ezintathu Zomsebenzi KaNkulunkulu Kuyindlela Yokwazi UNkulunkulu
85Isintu Esikhohlakele Siyidinga Ngokwengeziwe Insindiso KaNkulunkulu Osesimweni Somuntu
86Ingqikithi Yenyama Ehlalwe UNkulunkulu
87Umsebenzi KaNkulunkulu Nokwenza Komuntu
88Ingqikithi KaKristu Ukuthobela Intando KaBaba Osezulwini
89Ukubuyisela Impilo Ejwayelekile Yomuntu Nokumhambisa Endaweni Emangalisayo Okuphokophelwe Kuyo
90UNkulunkulu Nomuntu Bayongena Ndawonye Ekuphumuleni
91Ngesikhathi Ubona Umzimba KaJesu KaMoya, UNkulunkulu Uyobe Esenze Izulu Nomhlaba Kabusha
92Labo Abangahambisani NoKristu Impela Bangabaphikisana NoNkulunkulu
93Baningi Ababiziweyo, Kepha Bayingcosana Abakhethiweyo
94Kufanele Ufune Indlela Yokufanelana NoKristu
95Ingabe Uyikholwa Leqiniso KuNkulunkulu?
96UKristu Wenza Umsebenzi Wokwahlulela Ngeqiniso
97Ingabe Bewazi? UNkulunkulu Wenze Into Enkulu Phakathi Kwabantu
98UKristu Wezinsuku Zokugcina Kuphela Onganika Umuntu Indlela Yokuphila Ingunaphakade
99Lungisa Izenzo Ezinhle Ezanele Ukulungiselela Isiphetho Sakho
103Iziphambeko Ziyoholela Umuntu Esihogweni
104Kubaluleke Kakhulu Ukuqonda Isimo SikaNkulunkulu
105Indlela Yokwazi UNkulunkulu Osemhlabeni
106Inkinga Enkulu Kakhulu: Ukukhaphela (1)
107Inkinga Enkulu: Ukukhaphela (2)
108Kumele Ubhekisise Izenzo Zakho
109UNkulunkulu Ungumthombo Wokuphila Komuntu
110Ukububula KukaMninimandla Onke
111Ukubonakala KukaNkulunkulu Kulethe Inkathi Entsha
112UNkulunkulu Wengamela Phezu Kwesiphetho Sesintu Sonke
113Ukwazi UNkulunkulu Kuyindlela Eya Ekumesabeni UNkulunkulu Nokudeda Kokubi
114Ukubona Ukubonakala KukaNkulunkulu Ekwahluleleni Nasekusoleni Kwakhe


text:
UMongameli wesikhombisa wakwele Zambia, uMnu Hakainde Hichilema namhla ugcotshwe ukuthatha intambo zombuso emkhosini owenzelwe enkundleni eyeNational Heroes Stadium, esigodlweni salelo lizwe eseLusaka. Ele Zimbabwe belimelwe nguMongameli Emmerson Mnangagwa lomkhokheli weMDC Alliance, uMnu Nelson Chamisa.
Ukungena kuka Hichilema esikhundleni sekulethe ithemba kwamanye amazwe awezwekazi leAfrica, lokuba balakho ukukhipha uhulumende oncindezela uzulu ngoba encintise kwaze kwaba kahlanu andubana anqobe kukhetho.
Ekhuluma emkhosini wokugcotshwa kwakhe uMongameli Hichilema uthe iZambia ifundise amazwe wonke omhlaba ukuba amandla ezombusazwe asebantwini, esithi kuzamele uhulumende wakhe atshiyane lombuso kantando kayiphikiswa.
“Amandla kasiwo ethu, ngawabantu, abantu be Zambia. Kuyathabuthisa ukuba namhlanje ngokwesithathu selokhe abantu be Zambia baguqula ohulumende, saba labo hulumende abatsha”
UMongameli Hichilema uthe uzazame ngazo zonke indlela ukuqeda ubuyanga eZambia esithi uzakwenza lokhu ngokuqakathekisa ubudlelwano be Zambia lamanye amazwe womhlaba.
Ummeli we Hwange Central engowe MDC Alliance uMnu Daniel Molokele uthe bazazama ngendlela zonke ukulandela isibonelo esihle sokwenziwe libandla ebeliphikisa eleUPND elinqobileyo eZambia kukhetho luka 2023 e Zimbabwe.
“Asengamhlophe athe nke, thina njengo makhelwane siyaziqhenya ngalokho esikubone kusenzakala e Lusaka. Siyawubona umzekeliso wakho omuhle sizazama ngamandla ethu onke ukuba siwulandele”
UMnu Baster Magwizi omunye wabalwa impi ye nkululeko, owahlala isikhathi eside ekwele Zambia, uncome uMnu Edgar Lungu ngokuvuma ukudedela uHichilema.
“Kuyisifundo kwamanye amazwe, abanjengabakithi ukuthi intando kazulu kayiphikiswa ikakhulu mayelana ngamalungelo abo”
Kodwa omsekeli womsebenzi kubandla le ZANU PF kuhlangothi lwabatsha uMnu Mabutho Moyo uthi abamabandla aphikisayo eZimbabwe bangaziyengi ngokwenzakale eZambia.
“Lokho okwenzakale e Zambia kakusoze kwenzakala e Zimbabwe. IZANU PF libandla elikhulu kakhulu. Kakusoze kwaba le nguquko yaloluhlobo ngoba e Zambia vele kulamabandla amancane”
Abanye abakade besemkhosini weZambia bagoqela uMongameli Cyril Ramaphosa wele South Africa, uMongameli Uhuru Kenyata wele Kenya, uMongameli Mokgweetsi Masisi wele Botswana, Lazarus Chakwera
owe Malawi, abameli benkokheli yamazwe angentshonalanga, labenhlanganiso eye Common Wealth.
Uhambo lukaHichilema belungalula ukuze afinyelele intambo zombuso ngoba wahlukunyezwa okwesikhathi eside etshaywa, ebotshelwa amacala okubazelwa okugoqela isehlakalo sokubotshelwa ukwephula umthetho womgwaqo ngo mnyaka ka 2017 kodwa lelo cala lacina lisiba ngelokufuna ukugenqula uMongameli Ernest Lungu.
Kodwa kusenzakalo esimangalise abanengi, uHichilema yena owayesazakala njengesitha selizwe phansi kukahulumende ka Lungu, unqobe okulesisindo kukhetho olwenziwa mhlaka 12 Ncwabakazi.
Lokhu sokulethe idlabuzane lethemba kwele Zimbabwe ukuthi mhlawumbe isimo singaguquka phakathi kukaMnangagwa loChamisa kukhetho olulandelayo lomnyaka ka2023.


text:
Charmant gîte à 15 min du Futuroscope
Umbungazi ovelele
I-i-guesthouse ephelele ibungazwe ngu-Cindy
Izivakashi ezingu- 3, ikamelo lokulala 1, imibhede engu-2, Igumbi lokugezela elilodwa
Ikhaya lonke
I-guesthouse izoba ngeyakho wedwa.
Ukuhlanza Okwenziwe Ngcono
Lo mbungazi uzibophezele enqubweni yokuhlanza ethuthukisiwe yezinyathelo ezingu-5 ye-Airbnb.
Indawo enhle
Izivakashi ezingu-95% zakamuva zinikeze indawo isilinganiso sezinkanyezi ezingu-5.
Okokuzithokozisa kokungena okuhle kakhulu
Izivakashi ezingu-100% zakamuva zinikeze inqubo yokungena isilinganiso sezinkanyezi ezingu-5.
Lapho uzolala khona
Igumbi
Umbhede omkhulu ongu-1
Ikamelo lokuphumula
1 umbhede wosofa
Lokho ozokuthola kule ndawo
Ukubukeka kweshashalazi lokungena endaweni
Ukubuka ingadi
Ikhishi
I-Wifi
Ukupaka okungakhokhelwa emagcekeni – izikhala ezingu-2
Kuyimfihlo ubhavu oshisayo
I-HDTV ene- Fire TV, I-Netflix
Imahhala umshini wokuwasha – Kuyunithi
Igceke elingemuva Kuyimfihlo – Kunothango oluphelele
Ayitholakali: i- I-alamu ye-carbon monoxide
5.0 out of 5 stars from 23 reviews
Inhlanzeko
Ukunemba
Ezokuxhumana
Indawo
Ngena
Inani
- Ukubukeza okungu-23
- Ubuwena buqinisekisiwe
- Umbungazi ovelele
J'habite à Colombiers avec mon conjoint , dans un petit village au cœur de la campagne. Nous adorons les voyages, découvrir de belles régions et toujours en quête pour trouver des sites et des endroits à faire partager à notre fils. Sans oublier la gastronomie et les loisirs comme le canoë et les randos. J'adore aussi la décoration d'intérieur et le Home Staging et le jardinage. Nous adorons aussi les animaux. L’accueil, les échanges , la communication et mon sens relationnel, sont des qualités que j’aime faire partager à mes voyageurs.
J'habite à Colombiers avec mon conjoint , dans un petit village au cœur de la campagne. Nous adorons les voyages, découvrir de belles régions et toujours en quête pour trouver des…
Phakathi nokuhlala kwakho
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UCindy Ungumbungazi ovelele
Ababungazi Abahamba Phambili banesipiliyoni, ababungazi bezinga eliphezulu abazinikele ekuphatheni izivakashi ngendlela ekhethekile.
- Izilimi: English, Français
- Izinga lokuphendula: 100%
- Isikhathi sokuphendula: kungakapheli ihora
Ukuze uvikele ukukhokha kwakho, ungalokothi uthumele imali noma uxhumane nabantu ngaphandle kwewebhusayithi ye-Airbnb noma i-app.
Izinto okufanele uzazi
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Ngena: 17:00 - 21:00
Isikhathi sokuphuma: 11:00
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Izilwane ezifuywayo azivunyelwe
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Ezempilo & ukuphepha
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Iziqondiso ze-Airbnb zokuziqhelelanisa komphakathi kanye nezinye ezihlobene ne-COVID-19 ziyasebenza
Asikho isiqwashisi se-carbon monoxide
Indawo yokubhukuda/ubhavu wamanzi ashisisiwe ongenasango noma ongakhiywa
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Inqubomgomo yokukhansela
Hlola ezinye izinketho ezise- Colombiers namaphethelo
Ezinye izindawo zokuhlala e- Colombiers:


text:
Lapha ngizokwabelana ngolunye lwezinhlelo zokusebenza ezivikeleke kakhulu ze-E-Wallet. Empeleni ngikhuluma nge-PayMaya Apk manje ongayilanda ngokusebenzisa isixhumanisi esinikezwe ngezansi.
Kukhawulelwe esifundeni esithile engizokwabelana ngaso futhi ekubuyekezweni. Ungaqhubeka ngokwazi ngezici eziyisisekelo zohlelo lokusebenza ngemuva kokufunda konke lokhu kubuyekezwa.
Yini i-PayMaya Apk?
Okuqukethwe
I-PayMaya Apk i-e-wallet ongayisebenzisa ukwengeza imidlalo, ukudlulisa izimali, ukufaka imali, nokunye okuningi. Inikeza ikhadi elibonakalayo kulabo abafuna ukuthenga ku-inthanethi. Ungaba futhi nenketho yokubhuka amathikithi endiza online ngokusebenzisa indlela yayo yokukhokha ephephile.
Into enhle ukuthi ungayilanda mahhala futhi inikeze izinsizakalo ngemali eshibhile. Ungakwazi phezulu noma ukuthenga i-UC yePUBG Mobile bese uthola inani elingenamkhawulo lamadayimane we-Mobile Legends Bang Bang. Noma kukhona eminye imidlalo eminingi ongayengeza.
Ingesinye sezikhwama ezivikeleke kakhulu ePhilippines. Ngakho-ke, ngokuyisisekelo, yenzelwe abantu basePhilipines. Ungalanda futhi ujoyine uhlelo lokusebenza ukudlulisa izimali zakho ku-akhawunti yakho yasebhange. Ngakho-ke, ngalolu hlelo lokusebenza, ungakusebenzisa lokho ukuthengiselana okuku-inthanethi.
Uzothola inketho yokukhokha kulezo zitolo noma ezitolo ezinkulu ezisekela ama-ATM noma amakhadi asebhange. Ngakho-ke, ungaxhuma noma ulungiselele ikhadi lakho elilukhuni le-PayMaya kuhlelo lokusebenza bese wenza izinkokhelo. Ungaqhubeka uphathe ibhalansi yakho neminye imininingwane.
Uma wabelana nge-SMS ne-imeyili izaziso zokuthengiselana noma zomsebenzi ngamunye. Ngakho-ke, ngalokho, ungagcina ibhalansi yakho nesikhwama sakho semali kuphephile kubaduni nakubantu ongabazi. Zama ezinye izikhwama zemali njenge Thola uDana futhi I-Bajaj Wallet kepha lezi zisebenza ezifundeni ezahlukahlukene.
App Yokuxhumana
Izici Key
Nawa amaphuzu abalulekile engidinga ukuwabelana nawe. Ngoba ngineqiniso lokuthi iningi labantu lifuna ukwazi ukuthi i-PayMaya Apk inikezani. Ngakho-ke, ngakho-ke ngizochaza ezinye zezinto ezibaluleke kakhulu kuwe. Lezi yizici ezilandelayo.
- Kumahhala ukulanda kumakhalekhukhwini we-Android.
- Ungenza ukuthengiselana ngamanani ashibhile.
- Dlulisela imali kwamanye ama-akhawunti asebhange.
- Thenga ku-inthanethi.
- Khokha izikweletu.
- Ungakhokha ezitolo nasezitolo ezinkulu ezisekela ama-ATM namakhadi asebhange.
- Bhuka amathikithi endiza online.
- Kuphephile futhi uthole ukushintshwa kwe-SMS.
- Phezulu kwemidlalo eminingi oyidlalayo ePhilipine.
- Isibonisi esilula nesisebenziseka kalula.
- Futhi okuningi okuningi.
Izithombe-skrini zohlelo lokusebenza
Ungayilanda kanjani futhi uyisebenzise i-PayMaya Apk?
Ukuze uzuze ku-PayMaya App, udinga ukulanda i-Apk yayo bese uyifaka efonini yakho. Lapha kuleli khasi, uzothola izixhumanisi ezimbili eziqondile kuqala eyodwa inikezwa ekuqaleni kuthi eyesibili inikezwe ekugcineni.
Ngakho-ke, ungasebenzisa noma yiziphi izixhumanisi ukuthola i-Apk. Ngemuva kwesikhathi ungathepha kulelo fayela bese ulifaka efonini yakho. Manje udinga ukwethula lolo hlelo lokusebenza efonini yakho bese unikeza zonke izimvume eziceliwe.
Chofoza inkinobho yokubhalisa uma uyisebenzisa okokuqala. Bese unikeza yonke imininingwane edingekayo. Manje usungahambisa imininingwane bese uqinisekisa i-akhawunti yakho.
amazwi okugcina
Lokho konke kusuka kulokhu kubuyekezwa lapho ngike ngazama ukukwazisa ngePayMaya Apk. Uma unesifiso, ungasilanda ngokusebenzisa isixhumanisi esinikezwe ngezansi. Kuyinto inguqulo yakamuva futhi esemthethweni yohlelo lokusebenza.


text:
QF3725 Ishidi lokufaka uphawu lwe-asbestos
Imininingwane yomkhiqizo
Amathegi womkhiqizo
Izici zomkhiqizo
● Ukushisa okuphezulu kungu-300℃
● Ukucindezela okukhulu kokusebenza kungu-3.0MPa
● Ukumelana nokushisa okuhle kakhulu, ukuqina nokubekwa uphawu
● AI-nti-adhesion nokunye ukwelashwa kwendawo
● I-asbestosi - ukuqinisekiswa kwamahhala ngumzimba ochwepheshe
● Ukudlulisa isitifiketi se-ROHS ngenhlangano yobungcweti
Isicelo somkhiqizo
Ukufaka amanzi kuketshezi olufana nezinhlobo ezahlukahlukene zamafutha, umoya, amanzi, umhwamuko, njll.
Isetshenziswa njenge-gasket yezimoto, izithuthuthu, imishini, uphethiloli-chemistry, njll.
Kunconywa ngokukhethekile njengezinto ze-gasket zezimoto nezithuthuthu.
Osayizi abajwayelekile
(L) × (W) (mm): 1290 × 1280/3840 × 1290/3840 × 2580
Ubukhulu (mm): 0.3 ~ 3.0
Usayizi weshidi okhethekile nobunye ubukhulu bosayizi kwisicelo samakhasimende.
Ukusebenza ngokomzimba
Amazwi: 1. Idatha ebonakalayo engenhla isuselwa kusisindo esingu-1.5mm.
2. Uma unanoma imuphi umbuzo ekukhetheni imikhiqizo, sicela uxhumane nathi ngqo.


text:
ISENGEZO
Ngubani UMikhayeli Ingilosi Enkulu?
ISIDALWA somoya esibizwa ngokuthi nguMikhayeli akukhulunywa ngaso kanengi eBhayibhilini. Kodwa lapho okukhulunywa ngaso khona, siyabe sisenza okuthile. Ebhukwini likaDanyeli, uMikhayeli ulwa lezingilosi ezimbi, encwadini kaJuda uxabana loSathane njalo kuSambulo ulwa loDeveli lamadimoni akhe. UMikhayeli wenza okuhambelana lebizo lakhe elitsho ukuthi “Ngubani onjengoNkulunkulu?” ngokuvikela ubukhosi bukaJehova kanye lokulwa lezitha zikaNkulunkulu. Kodwa ungubani uMikhayeli?
Abanye abantu balamabizo amabili kumbe adlula lapho. Ngokwesibonelo, inhloko yomuzi uJakhobe yayibizwa langokuthi ngu-Israyeli, njalo umphostoli uPhethro wayebizwa langokuthi nguSimoni. (UGenesisi 49:1, 2; UMathewu 10:2) Ngendlela efananayo, iBhayibhili litshengisa ukuthi uMikhayeli ngelinye ibizo likaJesu Khristu engakezi emhlabeni lalapho esebuyele ezulwini. Ake sibone izizatho eziseBhayibhilini ezenza sitsho njalo.
Ingilosi Enkulu. ILizwi likaNkulunkulu likhuluma ngoMikhayeli ‘ingilosi enkulu.’ (UJuda 9) Nanzelela ukuthi uMikhayeli ubizwa ngokuthi uyingilosi enkulu. Lokhu kutshengisa ukuthi yinye kuphela ingilosi enjalo. Kanti njalo eBhayibhilini ukuthi ‘ingilosi enkulu’ kusetshenziswa ebunyeni hatshi ebunengini. Isikhundla sengilosi enkulu sisetshenziswa kuJesu. Mayelana leNkosi uJesu Khristu evusiweyo, u-1 KwabaseThesalonika 4:16 uthi: “INkosi uqobo izakwehla ivela ezulwini, ngelizwi elikhulu, ngelizwi lengilosi enkulu.” Yikho-ke ilizwi likaJesu lichazwa njengelizwi lengilosi enkulu. Umbhalo lo utshengisa ukuthi uJesu nguye ingilosi enkulu uMikhayeli.
Umkhokheli Webutho. IBhayibhili lithi: ‘UMikhayeli lezingilosi zakhe balwa lomgobho lezingilosi zawo.’ (ISambulo 12:7) Yikho-ke, uMikhayeli nguMkhokheli webutho lezingilosi ezithembekileyo. ISambulo laso sithi uJesu unguMkhokheli webutho lezingilosi ezithembekileyo. (ISambulo 19:14-16) Umphostoli uPhawuli laye uyiqamba ngendlela ecacileyo “iNkosi uJesu” kanye ‘lezingilosi zayo ezilamandla.’ (2 KwabaseThesalonika 1:7) Ngakho iBhayibhili likhuluma ngoMikhayeli “lezingilosi zakhe” liphinde likhulume ngoJesu ‘lezingilosi zakhe.’ (UMathewu 13:41; 16:27; 24:31; 1 UPhetro 3:22) Kulengqondo-ke ukuthi siphethe ngokuthi akula omunye umuntu obizwa ngokuthi nguMikhayeli ngaphandle kukaJesu Khristu esesikhundleni sakhe ezulwini. Lokhu kungenxa yokuthi eLizwini likaNkulunkulu akulandawo etshengisa ukuthi kulamaqembu amabili amabutho ezingilosi ezithembekileyo ezulwini, elinye elikhokhelwa nguMikhayeli lelinye elikhokhelwa nguJesu. *
^ indima 1 Ukuze uthole okunengi okutshengisa ukuthi ibizo elithi Mikhayeli ngeleNdodana kaNkulunkulu khangela ibhuku elithi Insight on the Scriptures Volume 2, amakhasi 393-394, elidindwe ngoFakazi bakaJehova.