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UMGANGANGO 270G
UMGANGANGO 270G
Iinkcukacha Product
Iimpawu zemveliso
Iimpawu + Izibonelelo
Ipholiyesta Scrim / Amandla angaphandle
Ukumisa ngokukhawuleza / Ukuxhathisa kweAras
Ukuxhathisa kwamanzi / ukuChasana neSmudge
Ukugqitywa ngokulula / iGrommet, ukuthunga kunye neHem Stitch
Ukuqina kwangaphandle / ukuLaminetha akufuneki
ngaphambili nangasemva
Izicelo
Iimpawu zangaphakathi
Iimpawu zangaphandle
Iimpawu zoKwakha
Imiboniso yoRhwebo
Imiqondiso ekhanyiswe ngaphambili
Imiboniso yangaphandle
Imizobo ye Window
Iyafaka
Le mveliso inokubanjelwa i-grommeted yexeshana elifutshane. Ii-grommets zentsimbi kufuneka zifakwe ukungena kwi-2-4 yeelitha zezinto zokonyusa amandla kunye nokuqina. Iteyiphu ephezulu yesibhengezo ephezulu inokusetyenziselwa ukongeza amandla kunye nokomeleza. Ukuthunga izinto ezinokubakho kunokukrola okanye ukucoca. Ukuba ukuthunga kuyanqweneleka, kuyacetyiswa ukuba izinto ziphindwe kabini zithungelwe ngapha nangaphezulu ngeziqu ezibekiweyo nge-intshi. Kucetyiswa iisilitshi zomoya zesiqingatha senyanga kwiibhena ezinenyawo ezili-10 okanye ezinkulu. Ukuqiniswa kwekona, ukufakwa kobungcali kunye nezixhobo ezifanelekileyo zokufaka ziyacetyiswa ngamandla.
Ukugcina nokuphatha
Ukugcina ishelufu yonyaka omnye, gcina izinto kwiqondo lobushushu lama-72 ° F ngokufuma okungama-50%. Vumela imathiriyeli ukuba izinze kwigumbi / iimeko zokuprinta iiyure ezingama-24 ngaphambi kokusetyenziswa.
Ukuhambelana kweprinta
Iyahambelana ne-Solvent, i-Eco-Solvent, iLatex kunye neeprinta ze-inkjet ezinokunyanga.
Q1: Zeziphi iimveliso zakho eziphambili?
• Sijolise kwizinto zangaphakathi kunye nezangaphandle zokuPapasha izinto, sigxile kuthotho lwe-Adhesive, uthotho lwebhokisi yokuKhanya, uthotho lweeProps zoBoniso kunye nothotho lweWall Wall. I-Brand yethu eyaziwayo ye-MOYU ibonelela nge "PVC yasimahla" yemithombo yeendaba, ububanzi beemitha ezi-5
Q2: Lithini ixesha lakho lokuhambisa?
• Kuxhomekeke kwinto oyicwangcisileyo nakubungakanani. Ngokwesiqhelo, ixesha lokuhamba li-10-25days.
I-Q3: Ngaba ndicela iisampulu?
• Ewe kunjalo.
Q4: Yeyiphi indlela yokuthumela?
Siza kubonelela ngengcebiso elungileyo yokuhambisa iimpahla ngokobungakanani beodolo kunye nedilesi yokuhambisa.
Kwicwecwe elincinci, Siya kuphakamisa ukuba siyithumele nge-DHL, i-UPS okanye enye into enexabiso eliphantsi ukuze ufumane iimveliso ngokukhawuleza kunye nokhuseleko.
Ngomyalelo omkhulu, sinokuyihambisa ngokwezicelo zabaxhasi.
Umbuzo 5. Yeyiphi indlela yakho yokuthumela?
• NguLwandle (kungabizi kwaye kulungele uku-odolwa okukhulu)
• Ngomoya (uyakhawuleza kwaye ulungele iodolo encinci)
• Nge-Express, FedEx, DHL, UPS, TNT, njalo njalo… (umnyango nomnyango wenkonzo)


c: text/html

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Kule mihla, ukuba neenkonzo zefu yinto eqhelekileyo phakathi kwabasebenzisi kwaye ke kubalulekile ukuba siyazi kwaye singazisebenzisa njani kwaye sizisebenzise njani ezi nkonzo ukuze sizuze yonke imihla, nokuba kukugcina amaxwebhu okanye ukufumana isixhobo esilahlekileyo. Kunye I-Apple iCloud Singakwenza oku nokunye okuninzi, ke namhlanje sifuna ukukubonisa ezinye zeenketho esinazo efini kwaye ngaphezulu kwayo yonke indlela yokusebenzisa i-iCloud ukuze ufumane okuninzi kuyo.
Ngokwenene yonke into ilula kakhulu kunokuba ungacinga Kodwa kuyacaca ukuba ayinguye wonke umntu osebenzisa iCloud yosuku lwabo ngenxa yokuba becinga ukuba yinto enzima ukuyisebenzisa okanye idatha yabo inokulahleka. Emva kokutsiba siza kubona ukuba kulula kakhulu kwaye kukhuselekile ukongeza kukhetho olusivumela ukuba siyenze le nkonzo.
Index
- 1 Okokuqala, yintoni i-iCloud?
- 2 Ngaba kunyanzelekile ukuba ube nemveliso ye-iPhone okanye ye-Apple ukonwabela iCloud?
- 3 Iwebhusayithi ye-iCloud kulula kakhulu ukuyisebenzisa
- 4 Iimfuno eziyimfuneko zokusebenzisa iCloud
- 5 Sine-5 GB simahla kodwa ixabiso liyahluka ukuba sifuna indawo engaphezulu kwi-iCloud
Okokuqala, yintoni i-iCloud?
Siza kuqala ukusuka ekuqaleni kwabo bangaziyo ukuba yintoni i-iCloud. Le yinkonzo ethi igcina inkampani ngendlela ekhuselekileyo ngenene kwiiseva Zonke iifoto zakho, iividiyo, amaxwebhu, umculo, usetyenziso kunye nazo zonke iintlobo zomxholo, zigcine zihlaziywa kuzo zonke izixhobo zethu. Oku kuthetha ukuba nge-ICloud sinokwabelana ngalo naluphi na uxwebhu, indawo, ifoto, njl. Kunye nabahlobo okanye usapho lwethu ngendlela elula kuba la maxwebhu ahlala efumaneka kuzo zonke iindawo apho sinonxibelelwano lwe-intanethi.
Kwakhona, njengoko besitshilo ekuqaleni, ikuvumela ukuba ufumane isixhobo esilahlekileyo okanye esibiweyo ukuba kunjalo. Ekugqibeleni singathi xa sele siqwalasele eyethu ICloud akhawunti kunye ne-ID yethu ye-Apple sinokwabelana ngokukhawuleza kwaye ngokulula yonke imixholo esiyigcina kuyo. Umzekelo, ukuba wenza icwecwe elitsha kwiifoto kwi-Mac yakho, izakuvela ngokuzenzekelayo kwiifoto zeefoto kwi-ICloud.com kwizikhangeli zeMac kunye neeWindows nakwizixhobo zakho ze-iOS, iApple Watch kunye neApple TV ngokuzenzekelayo.
Ngaba kunyanzelekile ukuba ube nemveliso ye-iPhone okanye ye-Apple ukonwabela iCloud?
Impendulo ethe ngqo nguhayi. Abasebenzisi abaninzi abanayo i-ID ye-Apple kuba abanayo i-iPhone okanye iMac, kodwa enye into ayithathi kwenye. Nge-iCloud sinokufumana i-5 GB yokugcinwa kwamafu simahla nokuba sinesixhobo se-iPhone, i-iPad, iMac okanye iApple, ukuze nabani na abe neakhawunti ye-iCloud eneefoto zakhe, amanqaku, abafowunelwa okanye okufanayo kwilifu le-Apple.
Ngokucacileyo inkonzo iyafumaneka kwiwebhu ngokuthe ngqo I-iCloud inokufikelela nakwisiphi na isixhobo kwaye ujonge amaxwebhu agciniweyo. Into ecace gca yeyokuba ukuba ungumsebenzisi we-Apple une-iPhone, i-iPad, iMac, iApple TV okanye iPod Touch, unezinye izinto eziluncedo njengokukhetha isixhobo okanye ukusebenzisa ICloud Drive ukulayisha nokukhuphela iifayile, wabelane ngazo., uzicime, uzilungiselele kwiifolda, uzinike igama elitsha kwaye uphinde ufumane ezo zisuswe kutshanje kwiindawo ezifanayo ezikwisixhobo sakho.
Iwebhusayithi ye-iCloud kulula kakhulu ukuyisebenzisa
Nje ukuba senze ifayile yethu Iakhawunti ye-iCloud idityaniswe ne-ID yethu ye-Apple yenzelwe ukugcina amaxwebhu, akukho nzima ukuqala ukuyisebenzisa. Ngokufikelela kwi-iCloud.com ngokuthe ngqo, sinokufikelela kuwo onke amaxwebhu esinamafu, nkqu ngokuthe ngqo kwi-Apple suite enamaphepha, iinombolo okanye i-Keynote
Ukusebenzisa iwebhu kufuneka ucofe nje kwi icon esifuna ukusebenza kuyo kwaye sigcine okanye sirhuqe umsebenzi owenziwe ngokuthe ngqo. Singavula usetyenziso lweeNqaku kwaye sibhale isicatshulwa ngqo kuyo, xa sigqibile ukwalatha siphume ngokulula kwi-app kwaye yiyo. Ngoku xa sifikelela kwiakhawunti yethu ye-iCloud kwakhona eli nqaku libhaliweyo ngaphambili, iifoto, amaxwebhu okanye naluphi na uhlobo lomsebenzi owenziwe ngokuthe ngqo kwiwebhu ziya kuvela naphi naSinokwabelana ngalo msebenzi nabanye abasebenzisi abaneakhawunti ye-iCloud.
Ilula kakhulu ukuyisebenzisa kwaye ngaphezulu kwayo yonke inomdla kakhulu kuba injaloijongana nezicelo ezilingana nezo sinazo kuzo zonke izixhobo Iifowuni eziphathwayo, ke kulula kakhulu ukuba usebenze nazo kwaye wabelane ngolwazi phakathi kweenkqubo ezahlukeneyo.
Iimfuno eziyimfuneko zokusebenzisa iCloud
Njengoko sisithi iCloud ifuna i-ID ye-Apple, uqhagamshelo olusebenzayo lwe-Intanethi kunye nesoftware ehlaziyiweyo ukuze isetyenziswe. Ngokucacileyo kukho uthotho lweemfuno ezisisiseko zokusebenzisa i-iCloud ngaphandle kwengxaki kwizixhobo zethu kwaye loo nto kukuhlaziya kuhlobo lwamva olukhoyo lwenkqubo esivumela ukuba sisebenzise imisebenzi yakutshanje ye-iCloud kwaye sibe namava angcono ngokubanzi. Ezona mfuno zisezantsi zezi: IOS 5 kwi-iPhone 3GS, iPod touch (isizukulwana sesithathu ukuya phambili), i-iPad okanye i-iPad mini kwaye une-OS X Lion 3 kwikhompyuter ye-Mac. ç
Kwimeko yokungabinayo iMac singasebenzisa iwebhu okanye iPC nge: Windows 7, Microsoft Windows 10, ukusuka kwi-iTunes 12.7 ukubheka phambili kwi-PC, i-Outlook 2010 ukuya kwi-Outlook 2016 okanye iMicrosoft Edge, iFirefox 45 okanye iinguqulelo zamva, iGoogle Chrome 54 okanye iinguqulelo zamva nje (imo yedesktop kuphela)
Sine-5 GB simahla kodwa ixabiso liyahluka ukuba sifuna indawo engaphezulu kwi-iCloud
I-5 GB yokuqala yendawo kunye nokubhaliswa kwe-ID yethu ye-Apple zikhululekile kubo bonke abasebenzisi abafuna ukugcina amaxwebhu abo, iifoto okanye iifayile kwi-iCloud. Sele ndiyithethile le nto, kufuneka kuthiwe ixabiso alibizi kodwa ngokokufuna kwethu indawo ethe kratya kodwa iya kuxhomekeka kakhulu kwiimfuno zomntu ngamnye kuba kunokwenzeka ukuba ngezo 5Gb zabanye abasebenzisi zanele.
Izicwangciso zokugcina ilifu iApple esinika zona ukusuka kwi-5 GB simahla ukuya kwi-2TB yokugcina i-50 GB okanye i-200 GB. Ukongeza, iApple ibonelela ngamathuba okwabelana ngezi zicwangciso zokugcina i-200 GB kunye ne-2 yosapho kunye nosapho, kodwa ezi akhawunti kufuneka zinxulunyaniswe. Amaxabiso e-ICloud ngenyanga athi: I-50 GB nganye I-0,99 euro, i-200 GB ye-2,99 euro kunye ne-2 TB ye-9,99 euro.
Khumbula ukuba ezi zicwangciso zinokulungiswa nanini na ufuna kuba azinasigxina, ingxaki kukuba kuyakufuneka sibenayo indawo kwenye indawo yokugcina idatha ukusukela xa sirhoxisa inkonzo yonke into egciniweyo iyanyamalala. Le yindlela elungileyo yokwenza gcina zonke iintlobo zamaxwebhu efini kwindawo ekhuselekileyo, esebenzayo nenokufikeleleka naphi naUkongeza, ukhetho lokufikelela kwidatha, iifoto kunye nabanye naphina kwenza ukuba ibe lolunye ukhetho olufanelekileyo lokugcina yonke idatha yethu namhlanje. Ayikhathazi ukuba ne-backup ebaluleke kakhulu kwi-hard drive okanye efanayo, kodwa kumgaqo akukho ngxaki yokulahleka kwedatha ngolu hlobo lweenkonzo ukuze uphumle ngokulula.

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Dlulela kumxholo Siyaxolisa, ezinye iindawo zewebhusayithi ye-Airbnb azisebenzi kakuhle xa ungayivumelanga i-JavaScript. Iindawo zeholide eziqeshisayo eBlock Island
Fumana uze ubhukishe iindawo zokuhlala ezikhethekileyo kuAirbnb
Ezona zindlu eziqeshisayo zeholide ezithandwayo eBlock Island
Iindwendwe ziyavuma: ezi ndawo zokuhlala ziconywa kakhulu ngendawo ezikuyo, ucoceko nokunye.
Indlu ekumhlaba osikelwe izindlu yonke · Iindwendwe eziyi-6 · Iibhedi eziyi-5 · Amagumbi okuhlambela ayi-3.5 Block Island - walk to Cooneymus BeachEnjoy panoramic western views over southwest point and Block Island Sound to Montauk. Clean, crisp and beautifully furnished! Large deck to enjoy the great views and sunsets. Entry level: Open living/dining/kitchen and 1/2 bath, King Master Bedroom with ensuite bath. Upper level: 2 twin bedded rooms and full bath. Outdoor shower. Igumbi elinomnyango ophumela ngaphandle yonke · Iindwendwe eziyi-2 · Ibhedi eyi-1 · Igumbi lokuhlambela eli-1 Ocean-views | Private Studio | Clean | Quiet | 🌞🌊✨Relax at this clean and peaceful apartment, less than 2 mi from town. Remodeled in 2021. On-site parking. Private, clean & new apartment with memory foam mattress, kitchenette (Read/see more in photos), full bathroom. Beach chairs and towels available. Sheets, linens and bath towels are ready upon arrival.
We offer discounts for month long stays as well as access to washer and dryer. Indlu esemaphandleni yonke · Iindwendwe eziyi-6 · Iibhedi eziyi-5 · Iibhafu ezi-3 New Shoreham CottageWonderful location, a short 3 minute walk to the best beach on the island. The cottage is very comfortable, and can accommodate 8 people. Iindawo eziqeshisayo zeholide zazo zonke iintlobo
Fumana indawo ekulingeneyo.
Amakhaya
Iindawo ezintofontofo ezinayo yonke into eyimfuneko
Iihotele
Indawo yokuhlala nezinto onokuzisebenzisa
Iindawo zokuhlala ezikhethekileyo
Iindawo ezingaphaya kwendawo nje yokulala
Izinto ezinokusetyenziswa ezithandwayo kwiindawo eziqeshisayo zeholide eBlock Island Indawo yokupaka ngaphakathi esimahala Umatshini okhupha umoya obandayo okanye oshushu Ezinye iindawo zeholide eziqeshisayo eBlock Island Indlu ekumhlaba osikelwe izindlu yonke · New Shoreham OceanView, Roof Deck, Sleep 8, Walk to Town/Beach $293 / usuku Yi$293 ngosuku Indlu ekumhlaba osikelwe izindlu yonke · New Shoreham Newly Built Modern Island Getaway w/ Strong WiFi $714 / usuku Yi$714 ngosuku Igumbi lakho lokulala · New Shoreham The Cottage Room at Garden Gate B&B $110 / usuku Yi$110 ngosuku Iflethi okanye indlu ekwi-complex (icondo) yonke · New Shoreham Block Island Timeshare 1-BR Apartment in Old Town $309 / usuku Yi$309 ngosuku Indlu esemaphandleni yonke · New Shoreham ⚓Pondside Pet-Friendly Block Island Cottage⚓ $372 / usuku Yi$372 ngosuku Indlu ekumhlaba osikelwe izindlu yonke · New Shoreham Clean & Newly Renovated 4BR w/Hot tub on 2 acres ✴ $414 / usuku Yi$414 ngosuku Original Farmhouse $325 / usuku Yi$325 ngosuku Iflethi eqeshisayo yonke · New Shoreham Lightburne House $300 / usuku Yi$300 ngosuku Indlu ekumhlaba osikelwe izindlu yonke · New Shoreham Bluff Beaches $400 / usuku Yi$400 ngosuku Indlu ekumhlaba osikelwe izindlu yonke · New Shoreham Hip Saltbox with Breathtaking Views $464 / usuku Yi$464 ngosuku Igumbi lakho lokulala · Block Island Thistle Room Sheffield House $160 / usuku Yi$160 ngosuku Igumbi lehotele · New Shoreham Dodge Cottage - Honora Sullivan Room $197 / usuku Yi$197 ngosuku Iindawo onokuya kuzo ezikufutshane © 2021 Airbnb, Inc. All rights reserved


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Sex Simulator
Ukujoyina zoluntu ka-omdala gaming enthusiasts
Ezi imidlalo sebenzisa mpuluswa nakweliphi na isixhobo
Eyona imidlalo kwi web ingaba ngoku ezikhoyo kuba free
Xa ke iza porn gaming websites, kukho iindidi ezimbini imigangatho. Kukho free okkt ngomhla apho ufumana ezininzi clickbait kwaye low-umgangatho umxholo, kwaye ke kukho i-premium okkt apho kufuneka ahlawule kuba decent gaming. Yintoni ukuba ndikuxelela ukuba ngoku unaso site ke bobabini free kwaye kukunceda kakhulu kokuqwalasela njengoko yakho engundoqo imvelaphi omdala entertainment? Ukuba ngu-site yethu entsha projekthi ngokuba Free Sonic Porn Imidlalo kwaye siya kuza kunye ezinye hottest fames ukuba uyakwazi qinisekisa kwi eyona iqonga ukuzalisekisa iimfuno zakho njengoko umsebenzisi., Okokuqala, ingqokelela zethu site ngu esiza nge ngoko ke, abaninzi kinks kwaye iindidi. Thina okuthe nkqo kuba ngesondo imidlalo kwi-i-umbutho iintlobo, ukuze uqiniseke ukuba yonke into sino kwi-site ngu ke nceda nabani na isiza ukudlala nathi. Akukho mcimbi into yakho fantasies ngabo, sino eziliqela imidlalo ukuba uza thelekisa kubo kukunika abanye ngamandla orgasms. Kwaye aba ngabo hayi nje naluphi na uhlobo imidlalo., La ngamazwi entsha HTML5 ngesondo imidlalo sizukulwana, eziya featuring ukuphucula imizobo kwaye ngaphezulu ugqityo kwi-gameplay, kwaye ngexesha elinye, emnqamlezweni, iqonga ukungqinelana ukuze ukwazi bonwabele hardcore gaming kwi-computer kunye mobile.
Sisebenzisa umnikelo kuni zonke ezi imidlalo kwi free iqonga. Hayi kuphela ukuba gameplay yi free apha, kodwa ukufikelela kule ndawo kanjalo unrestrictive. Njengoko ixesha elide njengoko ungumnini 18 okanye ngaphezulu, uza kukwazi ukudlala yonke imidlalo kunye akukho imida. Thina nkqu iqukiwe ezinye iinkalo zoluntu kwi-site ukunika wena ilizwi kwi-porn ehlabathini kwaye ukwazi ezisebenza kunye nabanye abadlali. Funda okungakumbi malunga yonke into phantsi apha ngezantsi.
Ndiyazi ukuba izigqibo ezinjalo ibango ngu ballsy, kodwa senza kuba omnye eyona ngesondo imidlalo qokelela kwi web. Okokuqala, kungenxa yokuba siza kuza kunye imidlalo ukusuka zonke iindidi. Kwaye thina ekhethiweyo eyona imidlalo ngaphandle wonke niche. Thina nkqu tested kubo qiniseka ukuba isenzo kwi kubo ngomhla we-incopho kwaye ukuba uphumelele khange kuba imiba kunye mobile gameplay.
Kukho ezininzi ezahluka-hlukileyo porn gaming genres kule ndawo. Abanye ngabo esiza njengoko ngesondo simulators. Kwezi imidlalo uyakwazi ukuba bonwabele qondo liphezulu wenkululeko xa oko kuza ukuba ngesondo intshukumo ukuze ufumane ukuba uyakuthanda. Uza kanjalo kuba ithuba yenza i ezinye iimpawu ukwenza kwabo jonga na olugqibeleleyo amantshontsho ukusuka yakho fantasies okanye ngathi umntu ukusuka yokwenene ebomini ukuze uyazi kwaye uthando.
RPG ngesondo imidlalo bamele kanjalo ethandwa kakhulu kwi-site yethu. Siya kukunika imidlalo apho uza ezisebenza nge-iimpawu ezininzi, uzalise quests kwaye missions, umphakamo phezulu yakho nge-avatar kunye nokufumanisa realms kwaye stories ukuba uya kwenza i-ngesondo intshukumo ngcono. Thina nkqu kuba abanye porn umdlalo parodies ngokusekelwe mainstream RPG imidlalo. Siza kuza nge-i-XXX inguqulelo Yehlabathi ka-Warcraft, siya kuba porn GTA umdlalo kwaye thina nkqu kuzisa uthotho XXX Fallout imidlalo.
Ukuba ufuna into milder, apho siya kugcina engqondweni yakho uxakekile kwaye yakho cock nzima, kufuneka ukhangele iphazili kwaye i-casino ngesondo imidlalo zethu site. Ezi imidlalo ingaba umnikelo kuwe erotic rewards kuba bonke wakho uphumelele. Kukho kokukhona kufuneka afunyanwe kule ndawo kwaye nisolko free ukuze bonwabele yonke into.
Sino kunye ubungakanani kwaye ngezixhobo ezahlukeneyo kinks kule uqokelelo babe yakho inani elinye imvelaphi omdala ukuzonwabisa. Sinako kunikela ngcono porn amava kunokuba nayiphi na free ngesondo tube. Kwaye siya kuyenza kunye nesiqingatha i-ads ukuze ufumane kwezinye zephondo. Iphezulu ukuba, uyakwazi nkqu sebenzisa izimvo zethu amacandelo kwaye umyalezo ibhodi ukuba ezisebenza kunye nabanye abadlali kule ndawo. Uyakwazi ukuthetha ngayo malunga nantoni na kunye nabanye abadlali kwaye uza kusoloko ikhuselwe yi-anonymity xa ngaba uyakuthanda oyithandayo kinks kwi-site yethu. Khetha Free Sonic Porn Imidlalo kuba uninzi immersive kwaye interactive porn amava.


text:
Lee House @ Lahat Perak
Indlu ekumhlaba osikelwe izindlu yonke sinombuki zindwendwe onguPooi Wah
Iindwendwe eziyi-8, Amagumbi okulala ayi-4, Iibhedi eziyi-5, Iibhafu ezi-3
Indawo yonke
Iza kusetyenziswa nguwe yonke le indlu.
Ukucoca Okuphuculiweyo
Lo mbuki zindwendwe uzibophelele kwinkqubo yokucoca ephuculiweyo enamanyathelo ayi-5 yakwa-Airbnb.
Ikhitshi
Iindwendwe ziyathanda ukukhangela le nto inokusetyenziswa ithandwayo
Izinto enazo le ndawo
Ikhitshi
Indawo yokupaka ngaphakathi esimahala
I-TV
Umatshini wokuhlamba impahla
Umatshini okhupha umoya obandayo okanye oshushu
Isixhobo sokomisa iinwele
Abantu abaza kuhlala ixesha elide bavumelekile
Ayikho: Ialam yomsi otyhefayo
Ayikho: Ialam yomsi
Akukho zimvo (okwangoku)
Silapha ukuze senze uhambo lwakho luhambe kakuhle. Zonke iindawo ezibhukishwayo zikhuselwe Sisiqinisekiso Sokubuyiselwa Okulahlekileyo sakwa-Airbnb.
Apho uza kuba khona
Lahat, Negeri Perak, Malaysia
- Isazisi siqinisekisiwe
Hi, I’m am Pooi Wah. I will welcome my guests with a clean and comfortable place to stay.
Ukuze ukhusele ukubhatala kwakho, ungaze uthumele imali okanye uthethe nabantu ungasebenzisi iwebhsayithi okanye i-app yakwa-Airbnb.
Izinto ofanele uzazi
Imithetho yekhaya
Ixesha lokubhalisa xa ufika: 15:00 - 22:00
Ixesha lokuphuma lingo:12:00
Akutshaywa
Azivumelekanga izilwanyana zasekhaya
Ezempilo nokhuseleko
Uzibophelele kwinkqubo yokucoca ephuculiweyo yakwa-Airbnb. Bonisa okungakumbi
Kusebenza izikhokelo zika-Airbnb zokungasondeli ebantwini nezinye ezinento yokwenza neCOVID-19
Akukho alam elumkisa ngomoya otyhefayo echaziweyo Bonisa okungakumbi
Akukho alam elumkisa ngomsi echaziweyo Bonisa okungakumbi
Imithetho engokurhoxa
Hlola ezinye iindawo onokukhetha kuzo e- Lahat
Iindawo ezingakumbi onokuhlala kuzo e Lahat:


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Ungayilandela njani uyilo olutsha lukaSemalt kwaye ulisebenzise ekumgangatho ophezulu kuGoogle
Kuthatha i-50 milliseconds yabasebenzisi ukuphuhlisa uluvo lwewebhusayithi yakho. Abasebenzisi bafuna indlela elula yokuyisebenzisa kwiisayithi zabo. Ngelixa oku kuyicebiso elilungileyo kwinkalo enye yewebhusayithi yakho, uSemalt uyisebenzise le nto kwiwebhusayithi yabo entsha.
Iphepha elitsha lewebhu likaSemalt lifuna ukudibanisa into ejijekileyo, uyilo lwale mihla kunye nokufundeka ngokulula. Ngolu luyilo, uSemalt wenze ukuba kube lula ukuqonda ukuba bangakufumana njani na kwi-Google ephezulu.
Uphononongo olukhawulezileyo lwe-SEO sigama
Ngaphambi kokuba siye kude kakhulu kwinyama yesihloko, kubalulekile ukuba sibe nokuqonda ngokubanzi kwezinye zebhotoni eziyimfuneko. Ibhlog yethu inesikhokelo esibanzi kwi-SEO ukuba unqwenela ukumba ngokunzulu kwiziseko. Kweli bali, siza kudlula kwezinye iinkcazo ezisisiseko.
- I-SEO imele ukuSebenza kweNjini yokuKhangela. Yinkqubo yokwenza iwebhusayithi yakho ibe lula ukukhangela kwi-intanethi.
- I-AutoSEO yimveliso ekhutshwe ngu-Semalt eyenzelwe abo bafuna ukungena kwi-SEO ngaphandle kokutyala imali eninzi.
- I-FullSEO yinguqulelo ephezulu ye-AutoSEO egxininisa ukusebenza ngeNgcali ye-SEO kunye nomphathi.
- I-SSL yinto yokhuseleko eyenza idatha yabathengi egcinwe kwiwebhusayithi yakho ikhuseleke ngakumbi.
- Amagama aphambili ngamagama athile okanye amabinzana abantu anokukhangela xa befumana iwebhusayithi yakho.
- Isikhundla sesiphi isikhundla iphepha lakho, okanye igama eliphambili, elivelayo kwi-injini yokukhangela.
- I-traffic linani labantu abatyelele indawo yakho.
Ukuqonda iwebhusayithi entsha ye-Semalt
I-AutoSEO, i-FullSEO, kunye ne-SSL zisesezixhobo ezisetyenziswa nguSemalt ukutyhala indawo yakho. Njengoko kuchaziwe kwibhlog yethu yangaphambili kwisihloko, zonke ezi mveliso ziqinisekisiweyo ezinerekhodi yokuphumelela kwempumelelo. Ukuba unqwenela ukufumana ulwazi ngakumbi kulayini lwemveliso, nceda ujonge iposi endala.
Kule blog, siza kugxila ekukhangeleni amanqaku amatsha kunye nezinto eziyilo lewebhusayithi entsha. I-Semalt iphumeze ezinye iimpawu ezinomtsalane ezifanele ukugqitha.
Ukuqonda idashboard entsha ye-Semalt
Idashboard entsha isenezinto ezininzi zeefilitha ezinamandla ukusuka kweyokuqala. Umahluko obalulekileyo uvela kutshintsho kunxibelelwano olugxininisa iimfuno zomsebenzisi.
Xa usiya ezantsi, uyakuqaphela ukuba mangaphi amagama akho aphambili aphezulu, u-1, 10, 30 kunye no-100. Le dashboard ikunika umbono wokuba yeyiphi eyona nto iphambili oyenzayo. Ungalusebenzisa olu lwazi ukugxininisa amagama athile angafunekiyo.
Unokufumanisa ukuba iseti yamagama aphambili aluncedo ngakumbi ekuziseni ukuthengisa okuguqukayo kwiwebhusayithi yakho. Ideshibhodi ye-SEO kaSemalt inokukunceda uchaze ukuba zeziphi amagama aphambili anokuzisa ukugcwala ngakumbi. Ukudityaniswa nedatha kwinani leetransekshini kwiwebhusayithi yakho, unokufumana ukuba utsala uhlobo olungelulo lwezithuthi.
Ukuqonda iphepha leNjini yokuKhangela (i-SERP)
Iphepha leNjini yokuKhangela linika ulwazi oluneenkcukacha malunga nephepha lewebhu lakho kwinqanaba lokusetsha. Ukunika ulwazi oluneenkcukacha malunga nokuba yeyiphi amagama abekwe kwinqanaba kunye nendlela ekhokelela kwiphepha lakho. Ikwabonelela ngolwazi olungafunyanwanga nezinye iiwebhusayithi ezininzi ze-SEO: ulwazi kubancintisana nabo.
Unokuthatha isigqibo sokumisela lo mzekelo ngokuthelekisa ngenjini oyikhethileyo. UGoogle yeyona nombolo yokukhangela yokuqala ehlabathini, kodwa ukuba ufumana ababukeli ngokusebenzisa i-Yahoo okanye i-Bing, unokufumana amagama aphambili kwinqanaba lokuma ngcono phaya. Unokufuna ukwenza iphulo elifuna ukubetha abakhuphisana nawe kuzo zontathu iinjini.
Xa ujonga i-SEO, uSemalt uyaqonda ukuba idatha yinto yonke. Iinkampani ezininzi ziya kukuncedisa ekwenzeni iiprojekthi zeGoogle AdWords, kodwa esi sisisombululo sexesha elifutshane. Iintengiso aziyi kuphucula ukukhangela kwendawo yakho ekuhambeni kwexesha, kodwa zikunike amandla okwethutyana aphela ngemali. Iiwebhusayithi ezakhiwe nge-SEO engqondweni ngokwendalo zabetha eziphezulu zala maphepha kwaye ziya kuqhubeka zibekwa kwinqanaba eliphezulu ngokulungiswa rhoqo.
Yintoni uHlaziyo loBumbano lwephepha?
I-SEO yinto edla ngokufuna ukuba ube nobuchule obahlukileyo ngelixa ikwafana nabantu abakhuphisana nawe ababeka amagama aphambili.
Ababhali be-SEO abaqeqeshiweyo be-Semalt bayawubona lo mbandela ngokubonelela ngamagama aphambili azizikhundla eziya kuthi zibonelele ababhali abanokubhala umxholo okhethekileyo. I-SEO yintsalela ebuthathaka, kodwa uSemalt sele enamatyala athetha ngokuphumelela.
Umzekelo, masithi ubengumbhali wenkululeko yokuzimela owayengena nje eshishini, kodwa udinga uncedo oluncinci ukuze iphepha lakho libe kwinqanaba. Apha ngezantsi kukho icwecwe elincinci elivela kwiphepha lakho elalitshekishwa yindawo yokujonga iphepha elingafaniyo lewebhusayithi entsha ye-Semalt.
Uya kuqaphela ukuba kukho amanqaku aphezulu ngaphezulu kwiphepha. Emva kokuyiqhuba ngokujonga umxholo, iye yaqonda ukuba la macandelo akwezinye iindawo kwiwebhu. Ngenxa yoko, imeko yeli phepha likumanqanaba ali-13 eepesenti.
I-injini yokukhangela inokwenzeka ukuba ibeke umxholo ukuba ithathwa njengegunyazisiweyo okanye ngumthombo othembekileyo. Enye indlela enjini yokukhangela egqiba ngayo kukungafani kwezinto. Ngelixa i-SEO izimisele ukujonga amagama aphambili afanelekileyo, ekunokuthi nawo onke amasayithi abelane, iwebhusayithi engakwaziyo ukuvela phakathi kwesihlwele iya kuqhubeka nokuma kakubi.
I-Semalt yinkampani eyaziyo le nto. Ngokudibanisa oku kunye ne-SERP yethu, sinokuthi sigqibe ngempumelelo ukuba ngaba utshintsho lwesicwangciso luyimfuneko na okanye hayi. Unokufanelekela ngokwaneleyo ukuba ubekwe kwinqanaba eliphezulu kwi-100 ngokuthathela ingqalelo okuncinci kule nto. Ukanti, ishumi eliphambili liya kufuna ishishini lakho ukuba lahluke ngokujolisa kumagama athile asisiseko kunye nomxholo owahlukileyo.
Ukulandelela iGoogle Webmasters ngeSemalt
Njengenye yeenkampani ezinkulu ehlabathini, usenokuba sele uyazi ukuba uGoogle unezixhobo ezininzi zokubeka esweni ukusebenza. USemalt ujonge ukongeza loo msebenzi ngokusebenzisa iqela leengcali ze-SEO kunye nabaphathi ukukhuthaza oku. Okwangoku, kwabo sele bengaphantsi kwenkqubo ye-webmaster , uSemalt unesisombululo nakuwe.
Ngokukhuphela ifayile ye-HTML kwiwebhusayithi yabo kwaye uyifaka kwiwebhusayithi yakho, uSemalt unokulandela idatha eneenkcukacha ezininzi. Unokukhetha nokuncamathisela i-HTML kwindawo yakho. Ukuba unayo nakuphi na ukudideka malunga nale nkqubo, zive ukhululekile ukufikelela kwi- imeyile yenkxaso yabo. Ukuba ukhetha elinye ijelo, iinkcukacha zonxibelelwano zisezantsi kwephepha ngalinye.
Kwakhona, ukulayisha idatha ngokuthe ngqo kwi-Semalt kunciphisa inani leendawo apho ugcine khona idatha yakho. Ngaphambi koku, unokuba unedeshbhodi enye yewebhusayithi yakho, iphaneli enye yokuhlaziywa kwegama elingaphezulu, kunye nenye yedatha yemephu. NgeSemalt, yonke loo nto ikwindawo enye.
Ukuhlaziywa kwesantya sephepha kunye nendlela ezinokuthi ziyichaphazele ngayo i-SEO yakho
Xa kuziwa kwi-SEO, ngokuqinisekileyo ungacingi ngesantya sephepha lakho ukuba unayo nayiphi na impembelelo ebalulekileyo. Nangona kunjalo, umgangatho wokulayisha wephepha lakho unempembelelo ebonakalayo kwi-SEO.
Isitshixo likwigama elithi "optimization," indawo eyenziwe kakuhle yenye yeendawo ezingenanto zokuqhawula amakhonkco, iilogo kunye nemithwalo ngokukhawuleza. Xa iqela likaSemalt leengcali ze-SEO linokufikelela kwiwebhusayithi, uhlalutyo lwabo luya kutyhila la manqaku aphukileyo kwaye baqinisekise ukuba kuphela umthwalo ofanelekileyo wolwazi kumthengi.
Ngenxa yokuba la manani ngaphambili abantu benesithuba esiyi-50-millisecond span, kubalulekile ukuba nephepha elikhawulezayo ekufundeka lula. Apha ngezantsi kukho idashboard oza kuyisebenzisa ukulandela isantya sakho.
Njengoko ubona, umzekelo wephepha esilisebenzisayo lihle kakhulu. Ineziphoso ezimbalwa ezincinci onokuzilandelela, kodwa ezo zinokuba zindawo zokuguqula ezinye iintengiso ezinokubakho. Nangona kunjalo, le dashboard ithe ngqo kuhlobo lwe desktop. Ukuba sijonga ingxelo yeli phepha lewebhu, kuyakuveza into eyahlukileyo.
Ngeepesenti ezingama-81 zabantu baseMelika abasebenzisa ii-smartphones, kuya kufuneka uqaphele isidingo sokusebenza kweselula. Umzekelo ongentla uxela ukuba le webhusayithi iphakathi kunye nabantu abakhuphisana nabo. Nangona kunjalo, uSemalt usebenza ngokuthatha ngaphezulu kwe-avareji.
Idashboard entsha kaSemalt ingandinceda njani ukuba ndiye eqongeni likaGoogle?
Isixa sedatha oyisebenzisa yonke imihla iyangqineka. Ngenxa yoko akunakuba nakho ukuqhubekeka nokuhla kwemihla ngemihla. Xa udibanisa imisebenzi yakho eqhelekileyo njengomnini kunye nokulawula iwebhusayithi, ezi zimbini ziya kuphazamisa omnye komnye.
Inkqubo ye-Semalt yindlela yokwenza lula inkqubo yokulawulwa kwesiza ngendlela apho unokuthi ujolise ingqalelo yakho apho kufuneka ibe khona: ishishini lakho. Kunye neqela labazinikeleyo likaSemalt elonwabileyo ukukukhokela kwi-SEO, uya kuzifumana uphakathi kweGoogle.
Ideshibhodi sisiphumo sikaSemalt senkqubo yokuqonda into efunwa ngumthengi. Ngenkqubo elula, sifuna ukuqiniseka ukuba awufumani kuphela uhlaziyo rhoqo kulawulo lwephulo lakho le-SEO, kodwa uyakuqonda kwaye uyakuqonda ukukhula okulethwa leli phulo kwishishini lakho.
Ukuba ungumnini weshishini kwaye unqwenela ukubandakanyeka kwitrafikhi, uSemalt ukulungele ukukusa kwindawo apho unokuthi ubambe itrafikhi, ukubandakanyeka kumthengi kunye nokwandisa ukuthengisa.


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I-Urolithin powder
I-Cofftek inamandla okwenza imveliso ngobuninzi kunye nokuhanjiswa kwe-urolithin a, urolithin b kunye neMethylurolithin A phantsi kwemeko ye-cGMP.
Yintoni ii-Urolithins?Ii-Urolithins zivela kwimveliso okanye i-metabolites yezinto ze-ellagic acid ezifana ne-ellagitannins. Ezi zinto zeekhemikhali zidityaniswa zivela kwi-ellagic acid-derivatives yi-gut microbiota.
Kuba iintyatyambo zamathumbu zibalulekile kwimveliso ye-urolithins, inani le-urolithins eliveliswe emzimbeni lixhomekeke kuhlobo lwezinto eziphilayo kwi-flora, eyona nto ibaluleke kakhulu kwiqela leClostridium leptum. Kuxelwe ukuba abantu abane-microbiota abazizityebi kumalungu eli qela bavelisa inani elikhulu kakhulu le-urolithin kunaleyo inezinye izityalo ezinjenge-Bacteroides okanye i-Prevotella.
Ii-Urolithins ziveliswa kwi-punicalagin emathunjini, ngokuchanekileyo njenge-ellagitannins, emva koko ikhutshiwe ngaphandle kumchamo. Ukujonga ukuveliswa kwe-urolithin emzimbeni, amanqanaba abo kufuneka atshekishwe kumchamo womntu otye ukutya okutyebileyo kwi-asidi ye-ellagic okanye isongezelelo ngee-urolithin njengezona zinto ziphambili kubo. I-Urolithin, kanye kwi-plasma, inokufunyanwa ngohlobo lwe-glucuronides.
Ii-Urolithins ngokwendalo ziyafumaneka kukutya okuninzi, nangona ingezizo zonke iimolekyuli zeeurolithin ezinokufumaneka ekutyeni. Nje ukuba ukutya okutyebileyo kwi-asidi ye-ellagic kufakwe, kuxhomekeka kwisisu se-flora sokwaphula i-ellagitannins kunye ne-punicalagin ukuya phambili kwimetabolites ephakathi kunye neemveliso zokuphela; iimolekyuli ze-urolithin.
Ezi molekyuli kutsha nje zifumene ukuthandwa kwaye ziyaqhubeka nokunyuka njengezongezelelo zokutya ngenxa yokuchasana nethumba, ukuguga, ukuthintela ukudumba, kunye nezibonelelo zokuphelisa ukuzimela. Ngapha koko, iimolekyuli ezithile ze-urolithin zinxulunyaniswa namanqanaba okuphucula amandla njengoko zinempembelelo enkulu kwimpilo ye-mitochondrial. Imveliso yamandla emzimbeni yinkqubo eyenzeka kwi-mitochondria, kunye nokuphucula ukusebenza kwale organelle yenye yemisebenzi emininzi ye-Urolithins.
Iimolekyuli ezaziwayo zeUrolithinI-Urolithins ibhekisa ngokudibeneyo kwiimolekyuli ezahlukeneyo ezingabosapho lwe-urolithin kodwa baneefomula zeekhemikhali ezahlukeneyo, amagama e-IUPAC, izakhiwo zemichiza kunye nemithombo. Ngapha koko, ezi molekyuli zinokusetyenziswa okwahlukileyo kunye nezibonelelo emzimbeni womntu kwaye ngenxa yoko zipapashwa ngokwahlukileyo kwifom yokongeza.
I-Urolithins, emva kophando olubanzi, iyaziwa ngokwaphuka kwezi molekyuli zilandelayo emzimbeni, nangona kungaziwa kangako ngazo zonke iimolekyuli ezithile:
● Urolithin A (3,8-Dihydroxy Urolithin)
● Urolithin A glucuronide
● Urolithin B (3-Hydroxy Urolithin)
● Urolithin B glucuronide
● Urolithin D (3,4,8,9-Tetrahydroxy Urolithin)
I-Urolithin A kunye ne-Urolithin B, eyaziwa njenge-UroA kunye ne-UroB ngokwahlukeneyo, zii-metabolites ezaziwayo ze-Urolithins emzimbeni. Ezi zimbini zikwimolekyuli ezisetyenziswayo ngoku kwizongezo nakwimigubo yokutshintsha ukutya.
Kanye egazini, i-Urolithin A ikhona njenge-Urolithin A glucuronide, kwaye i-Urolithin B inokufunyanwa njenge-Urolithin B glucuronide. Ngenxa yoku, kukholelwa ukuba baneziphumo ezifanayo nezabandulelayo njengakwizifundo ze-vivo azenzekanga ngee-urolithins. Ukunqongophala kwezifundo ze-vivo kwenza kube nzima ukuvavanya ukuba ngaba i-UroA kunye ne-UroB glucuronides zinefuthe elahlukileyo kwi-UroA nakwi-UroB ngokwazo.
I-Urolithin A inesinye isiphumo esinokufunyanwa egazini, oko kukuthi, iUrolithin A sulfate. Zonke ezi zinto ziphuma kuzo zenza imisebenzi yazo egazini kwaye emva koko zicocwe ngaphandle kwenkqubo ngokusebenzisa umchamo.
I-Urolithin D yenye yemolekyuli ebalulekileyo eveliswa ziziphumo zesisu se-microbiota, nangona kunjalo, akukho nto ingako yaziwayo malunga nefuthe kunye nokusetyenziswa okunokubakho. Okwangoku, ayisetyenziselwa nakuphi na ukongezwa okanye ukutshintshwa kwesidlo, ngokungafaniyo noogxa bayo, i-UroA kunye ne-UroB. Ngapha koko, imithombo yokutya yeUrolithin D ayaziwa.
I-Urolithin Iphakheji yolwazi lwePowderI-Urolithin A ayifumaneki ngokwendalo kwimithombo yokutya kwaye yeqela leekhompawundi ezaziwa njenge-benzo-coumarins okanye i-dibenzo-a-pyrones. Ngokwenyani inyanzeliswa ukusuka kwi-ellagitannins ukuya kwi-Urolithin A-8-Methyl Ether ngaphambi kokuba iphinde yahlukaniswe ne-Urolithin A. Le mveliso yokugqibela ifumaneka ngobuninzi kumzi-mveliso wethu wokwenza u-Urolithin A powder. I-MethylUrolithin A powder nayo iyafumaneka ukuze ithengwe ngesixa esikhulu xa kufuneka njalo.
I-Urolithin A ayifumaneki kumanqanaba afanayo, nangamanqanaba afanayo okusetyenziswa kwangaphambi kwayo, kubantu abohlukileyo kuba konke kuxhomekeke kwimisebenzi ye-gut microbiota. Imetabolism ka-Urolithin A kukholelwa ukuba ifuna iGordonibacter urolithinfaciens kunye neGordonibacter pamelaeae kodwa abanye abantu abanezi zinto basabonisa ubuncinci ngaphandle kwempembelelo kwimveliso yemolekyuli.
I-Urolithin A ineempawu ezithile ezenza ukuba ivelele kwamanye amacandelo, njengalawo achazwe kwitafile engezantsi.
Iphakheji yolwazi lwePowder BI-Urolithin B yindibaniselwano ye-phenolic eqale ukuveliswa ngobuninzi ukusukela ngoJanuwari ka-2021. Inokufunyanwa ngokutya ukutya okuninzi okuyimithombo yendalo yeellagitannins ezinokufakwa emzimbeni kwi-Urolithin B. Kufunyaniswe ukuba inamandla ikhompawundi yokuguga onokuyithenga ngobuninzi ngohlobo lwe-Urolithin B powder.
Iipropathi ezahlukeneyo ze-Urolithin B powder ekhoyo kwinkampani yethu yokuvelisa zikhankanywe ngezantsi:
Ngaphandle kwezi molekyuli ziphambili ze-Urolithins ezenziwa ngenxa yezenzo ze-gut flora, kukho iimolekyuli ezininzi eziphakathi ezenziwa ngexesha lokophuka kwezandulela. Aba baphakathi baquka:
● Urolithin M-5
● Urolithin M-6
● Urolithin M-7
● Urolithin C (3,8,9-Trihydroxy urolithin)
● Urolithin E (2,3,8,10-Tetrahydroxy urolithin)
Akukho nto ingako eyaziwayo malunga naba bantu baphakathi njengangoku, nangona kunjalo, uphando oluthe kratya lunokubonisa izibonelelo kunye nokusetyenziswa kwezi molekyuli zeUrolithin.
Urolithins usebenza njani?IiUrolithin, njengezinye iikhompawundi ezisetyenziswa kwizongezo, zichaphazela amalungu ahlukeneyo kunye neenkqubo emzimbeni, ukuvelisa iziphumo eziluncedo. Indlela yokusebenza kwee-Urolithins, zombini u-A kunye no-B, zinokwahlulwa zibe ngamasebe aphambili amathandathu, kwaye isebe ngalinye linakho ukuvelisa izibonelelo ezininzi.
● Iimpawu ze-Antioxidant
Esona sibonelelo siphambili sokuba neepropathi zokulwa ne-antioxidant kuncitshisiwe koxinzelelo lwe-oxidative emzimbeni. Uxinzelelo lwe-oxidative lubhekisa kuxinzelelo kwiiseli nakwizicubu zomzimba njengesiphumo sokudibana kwemichiza evelisa iikhompawundi ezingazinzanga, ezikwabizwa ngokuba ziiradicals simahla. Ezi radicals zasimahla zinokubanakho ukuthatha inxaxheba ekuphenduleni kweekhemikhali emzimbeni, imveliso ezonakalisa iiseli kunye nezicubu.
IiUrolithins ziyaluthintela uxinzelelo lwe-oxidative, olukhokelela kuthintelo lokonzakala kweseli kunye nokwandisa amathuba okusinda kweseli. Ezi ziphumo zenziwe ukuba zincitshiswe ekuvelisweni kwe-Intracellular Reactive Oxygen Species (iROS), eluhlobo lweeradicals zasimahla. Ngaphaya koko, iipropathi ze-antioxidant ze-Urolithin A kunye ne-Urolithin B nazo ziyavela ngokuncitshiswa kwe-NADPH oxidase subunit expression, ebaluleke kakhulu ekuphenduleni kwemichiza ekhokelela kuxinzelelo lwe-oxidative.
Ukuvelisa iipropathi zokulwa ne-antioxidant, ii-Urolithins zikwonyusa ukubonakaliswa kwe-antioxidant heme oxygenase-1 nge-Nrf2 / ARE ebonisa indlela. Oku kunceda ekunciphiseni kuphela iikhompawundi eziyingozi kodwa kukonyusa ii-enzymes ezilungileyo ezikhuthaza iipropathi zokulwa ne-antioxidant.
Ii-Urolithins, xa zinikwa iimpuku ezinomonakalo we-LPS owenziwe ngengqondo, zithintele ukusebenza kwe-microglial, okanye ngendlela elula, ukubola kunye nokudumba okungonyusa umngcipheko wokonakaliswa kwengqondo okusisigxina. Esi siphumo se-urolithins kukholelwa ukuba ngumxube weempawu ze-antioxidant kunye neempawu ezichasayo.
● Iipropathi ezichasene nokuvuvukala
Iipropathi ezichasayo zokuthintela ukudumba ze-Urolithins sesinye sezona zizathu ziphambili zodumo lwayo olukhulayo kwihlabathi elongezelelayo. Indlela ezisebenzisa ngayo ezi khompawundi, ngakumbi i-Urolithin A, i-Urolithin B, kunye nefom yeglucuronides, yahluke kakhulu kwaye ivelisa iziphumo ezahlukeneyo ngokulinganayo.
Isiphumo sokuchasana nokudumba kwe-Urolithin A kunye ne-Urolithin B sinendlela efanayo ne-Non-Steroidal Anti-inflammatory Drugs okanye i-NSAID ezinje nge-Ibuprofen kunye ne-Aspirin. Ii-Urolithins zaziwa ngokuba nefuthe kuthintelo kwimveliso ye-PGE2 kunye nembonakalo ye-COX-2. Njengoko ii-NSAID zithintela ukubonakaliswa kwe-COX 1 kunye ne-COX 2, kunokugqitywa ekubeni ii-Urolithins zineziphumo ezichaseneyo zokuchasana.
Iimpawu ezichasayo zokuthintela ukudumba ze-Urolithins zingqinisisiwe ukuba azilwi nje kuphela nokudumba emzimbeni kodwa ziyakwazi ukuguqula umonakalo owenziwe kumalungu ngenxa yokuvuvukala kwexesha elide okukhokelele ekusileleni komzimba. Kuphononongo lwakutsha nje olwenziwe kwiimodeli zezilwanyana, kwafunyaniswa ukuba ukusetyenziswa kwe-urolithin kunakho ukunciphisa i-nephrotoxicity ebangelwa sisiyobisi ngokuthintela ukufa kweeseli kunye nokudumba.
Kwafunyaniswa ukuba i-urolithin A powder, enikwe ngomlomo, yayinefuthe kuthintelo kwindlela yokuvuvukala kunye ne-proapoptotic cascade, yiyo loo nto, ikhusela ukusebenza kwe-renal. Ezi ndawo ze-Urolithin A kunye namanye amanqaku e-urolithins aya kwikamva apho ezi zinto zinokusetyenziselwa amayeza kunye nokusetyenziswa kwazo njengangoku njengezongezelelo.
● Iimpawu zeAnti-Carcinogenic
Ii-Urolithins zikholelwa ekubeni zichasene ne-carcinogenic ngenxa yokukwazi kwabo ukuba neziphumo ezinje ngokubanjwa komjikelo weseli, ukuthintela i-aromatase, ukwenziwa kwe-apoptosis, uxinzelelo lwethumba, ukukhuthazwa kwe-autophagy, kunye ne-senescence, umgaqo okhutshelweyo wokubhalwa kwe-oncogenes, kunye ne-factor factor ukukhula. Ezi ziphumo, ukuba azikho, zinokubangela ukukhula okungalunganga kweeseli zomhlaza. Iimpawu zokuthintela ii-Urolithins zibonakalisiwe, ngakumbi umhlaza webala kunye nomhlaza wekolon, kunye nabaphandi abaninzi bahlanganisela ukusetyenziswa kweeUrolithins njengamayeza anokuthintela umhlaza webala.
Isifundo esenziwe ngo-2018 sifunde iziphumo ze-Urolithin kwindlela ye-MTOR ngenjongo yokufumana unyango kunyango lomhlaza wepancreatic. Umhlaza wepancreatic unxulunyaniswa namazinga aphezulu okusweleka, kodwa uphando lwakutsha nje lubonisa ukuba iUrolithin ayinakho ukunyusa kuphela izinga lokusinda kodwa inqanda ukudityaniswa kweeseli zethumba kwamanye amalungu omzimba, okukhokelela kwimastastasis. I-Urolithin A yafundwa ngokukodwa kwaye iziphumo zazithelekiswa neziphumo eziveliswe yirejimeni yonyango esemgangathweni. Kwagqitywa kwelokuba i-Urolithin A ivelise iziphumo ezingcono xa isetyenziselwa ukulawula umhlaza wepancreatic, kuzo zombini iimeko; xa isetyenziswa yodwa okanye isicwangciso sonyango esiqhelekileyo.
Ngophando oluthe kratya, izibonelelo ze-Urothilins zinokuqulatha unyango lomhlaza wepancreatic ngokunjalo.
● Iimpawu zeAntibacterial
Ii-Urolithins ziyaziwa ngeempawu zazo zokulwa ne-antibacterial kwaye zinesiphumo ngokuthintela amajelo onxibelelwano ezinto ezincinci, zingazivumeli ukuba zihambe okanye zisulele iiseli. Kukwakholelwa ukuba baneempawu zokungunda, nangona indlela eyiyo ingekacaci.
Zimbini izifo ezithi ii-Urolithin zibe nefuthe elinamandla ngakumbi, zikhokelela kukhuseleko lomzimba womntu. Ezi zintsholongwane ziintsholongwane ze-malaria kunye neYersinia enterocolitica, zombini zibangela usulelo olomeleleyo ebantwini. Indlela apho iiUrolithin zineempawu zokulwa neentsholongwane ngaphandle kwento ephilayo iyafana.
● Iipropathi ze-Anti Estrogenic kunye ne-Estrogenic
I-Estrogen yihomoni ebalulekileyo emzimbeni wabasetyhini, kwaye ukwehla kwamanqanaba ayo kunxulunyaniswa neempawu ezinjengokugungxula, ukubanomlilo oshushu, kunye nokuncipha kwethambo. Ngenxa yokubaluleka kwehomoni, iyavakala into yokuba umntu obambeleyo uyakhangelwa. Nangona kunjalo, iihomoni zangaphandle zineziphumo ebezingalindelekanga ezithile ezenza ukusetyenziswa kwazo kungathandeki.
Nangona kunjalo, i-Urolithin A kunye ne-Urolithin B zinesakhiwo esifanayo ne-endo native estrogen kunye nokudibana kwe-estrogen receptors emzimbeni. I-Urolithin A inobumbano obomeleleyo, ngakumbi i-alpha receptor xa kuthelekiswa ne-beta receptor. Nangona zombini ezi zinto zinokufana nokwakheka kwe-estrogen, ii-urolithins zineempawu ze-estrogenic kunye ne-anti-estrogenic, ngokungafaniyo ne-estrogen engapheliyo.
Ubume besiphumo se-Urolithins bubenza ukuba babe lukhetho olunokubakho kunyango lweengxaki ezithile ezivela xa kunikwa i-estrogen engaphandle ukunyanga iimpawu zokusilela kwe-estrogen.
● Ukuthintelwa kweProteni Glycation
Iprotein glycation yinkqubo apho imolekyuli yeswekile ibotshelelwe kwiproteni. Le nkqubo ibonwa ngexesha lokuguga okanye njengenxalenye yeengxaki ezithile. Ii-Urolithins zithintela ukongezwa kweswekile, yiyo loo nto kubangela ukuba kungabikho glycation. Ngapha koko, zithintela ukwakheka kokugqibela kwe-glycation endproducts, ekuqokeleleni inyathelo elibalulekileyo kuphuhliso lwesifo seswekile.
Izibonelelo zeUrolithinsIiUrolithins zineendlela ezahlukeneyo zokwenza imveliso ukukhusela izibonelelo ezahlukeneyo emzimbeni womntu. I-Urolithin A powder kunye ne-Urolithin B powder inceda ukuvelisa izongezo ezidumileyo ngenxa yezibonelelo zezithako eziphambili. Zonke izibonelelo zezi zinto zemichiza zixhaswa bubungqina besayensi, kwaye kusenziwa uphando oluthe kratya ukuxhasa ukongezwa kwee-Urolithins kwizikhokelo zonyango lweengxaki ezahlukeneyo.
Izibonelelo zezi khompawundi, ngokusekwe kwiinkqubo ezichazwe apha ngasentla, zibandakanya:
● Iimpawu ze-Antioxidant
IiUrolithins zitsalwe kukutya okunee-ellagitannins ezininzi ezaziwa njengezityebi kwii-antioxidants. Umthombo wokutya oqhelekileyo we-ellagitannins kunye ne-ellagic acid ziirharnate, kwaye zikwangumthombo omkhulu wee-antioxidants. Nangona kunjalo, kubalulekile ukwahlula ukuba iipropathi ye-antioxidant yomthombo wokutya kunye nee-urolithins ziyafana okanye ukuba umntu unamandla aphezulu kunenye.
Izifundo zokuqala ze-Urolithin A kunye ne-Urolithin B zibonise ukuba iziphumo zokulwa ne-antioxidant kwezi zazingamaxesha angama-42 ngaphantsi kwesiqhamo ngokwaso, yiyo loo nto oku kuthetha ukuba ezi khompawundi zazingazenzi izithako ezifanelekileyo zokuncedisa.
Nangona kunjalo, uphononongo lwamva nje olunendlela eyahlukileyo yohlalutyo lubonisa ukuba i-Urolithin A kunye ne-B zombini ziyasebenza kwaye zinamandla okulwa ne-antioxidant eziza kulwa nefuthe loxinzelelo lwe-oxidative. Xa kwa indlela efanayo yohlalutyo yayisetyenziselwa ukufunda zonke ii-urolithin ukubona ukuba yeyiphi eyona inamandla, i-Urolithin A yema ngaphandle. Iziphumo zaphinda zaphinda zaveliswa kwisifundo esifanayo kunye no-Urolithin A okhokelayo kwi-potency, kwakhona.
Ngapha koko, olunye lwezifundo lujolise ekuvavanyeni iipropathi zokulwa nezixhobo zemichiza ngokuvavanya amandla abo okulwa noxinzelelo lwe-oxidative. Ukulungiselela olu phononongo, abaphandi bonyanzelisa uxinzelelo kwiiseli ze-neuronal kwaye xa bevezwa kwii-Urolithins, ngakumbi i-Urolithin B, baqaphela ukwehla okuphawulekayo koxinzelelo kunye nokunyuka kokuphila kweeseli ze-neuronal.
● Iipropathi ezichasene nokuvuvukala
Iimpawu ezichasayo zokudumba ze-Urolithins zivelisa izibonelelo ezininzi, zonke ezo zibonakaliswe ngokwenzululwazi.
Isiphumo soku-1
Unyango olwenziwe ekhaya lonyango lwe-malaria olusetyenziswa kakhulu kwiindawo ezithile zasemaphandleni kubandakanya ukusetyenziswa kwePomegranate. Abaphandi bazamile ukuqonda isiphumo esilungileyo sesi sixhobo kunyango lwe-malaria ngokudibanisa iziphumo kunye nee-Urolithins ezixutywe emathunjini ukusuka kwirharnate.
Uphononongo lwenziwe ukujonga isiphumo se-Urolithins ekunyangeni isifo seengcongconi ngokuveza iiseli ze-monocytic ezosulelekileyo kwii-Urolithins. Olu phononongo lufumanise ukuba iikhompawundi zemichiza zithintela ukukhutshwa kwe-MMP-9, nto leyo ebalulekileyo kwimetalloproteinase kuphuhliso nakwintsholongwane egazini yemalariya. Ukuthintela ikhompawundi kuthintela imalariya ekubeni yintsholongwane emzimbeni, yiyo loo nto kukholelwa ukuba inefuthe lokulwa nemalariya.
Iziphumo zophononongo zikwabonakalisile ukuba ii-Urolithins zithintele ukubonakaliswa kwe-mRNA yezifo ezibangelwa yi-malaria, okukhokelela ekuthinteleni ngakumbi ukubanakho kweentsholongwane. Iziphumo zolu phononongo zibonisa ukuba iziphumo eziluncedo zamayeza enziwe ekhaya kubandakanya neerharnate zibangelwa ziziphumo ze-urolithin.
2. Iziphumo kwiiseli ze-Endothelial
I-atherosclerosis yimeko eqhelekileyo ekhokelela kwizithuko zentliziyo kunye ne-infyoction ye-myocardial. Izinto ezimbini eziqhelekileyo ezibangela ukukhula kwe-atherosclerosis kukungasebenzi kakuhle kunye nokudumba. Izifundo zamva nje zizamile ukungqina ukuba iipropathi ezichasene nokudumba kwe-Urolithin zinokuthintela ukungasebenzi kakuhle kwe-endothelial, yiyo loo nto kulawulwa ukwakheka kwe-atherosclerosis kunye nophuhliso.
I-Urolithin A yafunyanwa ngabaphandi ukuba babe nelona nyathelo liphezulu lokulwa nokudumba phakathi kwazo zonke ii-urolithins. Uphononongo lwamva nje lujolise kwiiseli ze-endothelial zabantu ezazifakwe i-LDL ene-oxidized, eyimfuneko yokwakheka kwe-atherosclerosis, kunye ne-Urolithin A. ukunciphisa ukuvuvukala kunye nokuhla kwamandla eeseli, ngakumbi ii-monocytes ukubambelela kwiiseli ze-endothelial, ngokwahlukeneyo. Ukuncitshiswa kokubambelela kwi-monocytic kunciphisa ukungasebenzi kakuhle kwe-endothelial.
Ngaphaya koko, i-Urolithin A yafunyanwa ukunciphisa ukubonakaliswa kwe-tumor necrosis factor a, i-interleukin 6, kunye ne-endothelin 1; Zonke ii-cytokines ezichasayo.
3. Iziphumo kwiifibroblast kwiColon
IColon ibonakalisiwe kwizifo ezingaqhelekanga kunye nezinto zokutya ezenza ukuba sesichengeni sokudumba, ekuhambeni kwexesha kungakhokelela kwimicimbi yezempilo eliqela. Njengoko i-Urolithin A kunye ne-Urolithin B ziveliswa ziintyatyambo zamathumbu, kubalulekile ukuba wazi iziphumo zazo kwindawo yokuqala emzimbeni ezakhiwe ngayo.
Ukufunda iziphumo ze-Urolithins kwiiseli zekholoni kunye ne-fibroblasts, abaphandi benza uvavanyo apho i-fibroblast yavezwa kwii-cytokines ezinokutsha kunye ne-Urolithins. Njengoko kukhankanyiwe apha ngasentla, kwafunyaniswa ukuba iiUrolithins zithintela ukubambelela kwi-monocyte kunye nokufuduka kwe-fibroblast ukuthintela ukudumba kwikholoni.
Ngaphaya koko, kwafunyaniswa ukuba ii-Urolithins zithintele ukwenziwa kwento ye-NF-kB, ebalulekileyo kulawulo lokudumba. Ngapha koko, abaphandi bakholelwa ukuba le yeyona nto iphambili ekuchaseni ii-urolithins.
● Iimpawu zeAnti-Carcinogenic
IiUrolithin zinxulunyaniswa neepropathi ezichasene nomhlaza, kwaye indlela yezi zinto zichazwe ngasentla. Nangona kunjalo, izibonelelo zezi zinto zichazwe apha ngezantsi:
1. Ukukhuselwa kwiCancer Prostate
Ukuchongwa kwe-Urolithins emzimbeni kuhlala kwenziwa kusetyenziswa igazi okanye umchamo; Nangona kunjalo, banokufunyanwa kwikholoni yamadoda nabasetyhini kunye neprostate gland yamadoda.
Ngenxa yoku kufumanisa, abaphandi bazamile ukuvavanya ukuba izibonelelo zeekhemikhali ziyabonakala kwi-Prostate gland njengakwikholoni. Yiyo loo nto uphononongo luyilelwe, iziphumo ezingqina ukuba ii-Urolithin zinefuthe lokukhusela kwi-prostate gland.
Kwafunyaniswa ukuba i-Urolithin A kunye ne-Urolithin B, kunye ne-Urolithin C kunye ne-Urolithin D yathintela i-enzyme ye-CYP1B1 kwi-prostate gland. Le enzyme ijolise kwichemotherapy kwaye yayithintelwe ngamandla yi-Urolithin A, xa kuthelekiswa nezinye ii-urolithins. Baye bathintela i-CYP1A1, nangona kunjalo, uxinzelelo oluphezulu lwee-urolithins kwakufuneka ukuba zivelise loo nto.
Olunye uphononongo lwenziwe kufundo lweprotrate ye-Urolithins. Kwafunyaniswa ukuba i-Urolithin A inefuthe elichasene nomhlaza kumhlaza wesibeletho kuzo zombini, i-p53 exhomekeke kuyo kunye ne-p53 ngendlela ezimeleyo.
2.I-Topoisomerase 2 kunye ne-CK 2 inhibition
IiUrolithins zineempawu ezichasene nomhlaza ngokuthintela iindlela ezininzi zeemolekyuli ngokuthe ngqo okanye ngokungathanga ngqo ezikhokelela kuthintelo lokukhula komhlaza. I-enzyme ye-CK2 yi-enzyme ebalulekileyo ethatha inxaxheba kwiindlela ezinje ngeemolekyuli, eyona nto iphambili kuyo kukukhuthaza ukudumba kunye nomhlaza.
Ii-Urolithins zithintela iindlela ezahlukeneyo ukufikelela kwi-enzyme ekuyo yonke indawo, i-CK2 ekugqibeleni inqanda ukusebenza kwayo, njengepropathi yokukhuthaza umhlaza. I-Urolithin A ibonakalisiwe ukuba inamandla CK2 inhibitor, kwi-silico.
Ngokufanayo, iTopoisomerase 2 inhibition kukholelwa ukuba ineziphumo ezichasene nomhlaza. Ngapha koko, lo matshini usetyenziswa ziiarhente ezithile zekhemotherapy ezinje ngeDoxorubicin. Kuphononongo lwakutsha nje, kwafunyaniswa ukuba iUrolithin A inamandla ngaphezu kweDoxorubicin ekuthinteleni iTopoisomerase 2, yiyo loo nto, ifuna ukongezwa kwayo kwizikhokelo ezikhoyo ngoku zokunyanga eminye imihlaza.
● Iimpawu zeAntibacterial
Iimpawu ze-Urolithins ezichasene ne-antibacterial zixhomekeke kwi-Quorum Sensing Inhibition esusa amandla e-microorganism ukunxibelelana, ukuhamba, kunye nokwenza izinto ezinobungozi. Yindlela ebalulekileyo yokusinda kwentsholongwane, kunye nokuthintela iUrolithins kuyabulala amagciwane.
Eyona nto iphambili kwi-antibacterial ye-Urolithin sisakhono sayo sokukhusela amathumbu kwindawo engaphezulu kweYersinia enterocolitica. Ngapha koko, ii-Urolithins zinxulunyaniswa nokumodareyitha kweentyatyambo zamanzi esiswini, izityalo ezifanayo ezijongene nemveliso yazo kwasekuqaleni. Oku kubaluleke ngakumbi kuba zizinto ezithile eziphilayo ezinokunyusa imveliso yeUrolithins.
● Iipropathi ze-Anti Estrogenic kunye ne-Estrogenic
IiUrolithins zibopha ii-Estrogen receptors kwaye zivelise zombini, iipropathi ze-estrogenic kunye ne-anti-estrogenic. Oku kuyenza ukuba ibe ngumgqatswa omkhulu kwi-Selective Estrogen Receptor Modulators okanye ii-SERMs, ezona ndlela ziphambili zokuba nefuthe elihle kwindawo enye yomzimba kunye nefuthe lothintelo kwenye indawo yomzimba.
Kwesinye sophando olwenziwe kwiziphumo ze-urolithins kwii-estrogen receptors, kwafunyaniswa ukuba, ngakumbi i-urolithin A, inqanda ukubonakaliswa kofuzo lweeseli zomhlaza ze-end-endometrium, okukhokelela kuxinzelelo lomhlaza we-endometrium. I-Endometrial hypertrophy sisiphumo esibi secala elichazayo le-estogenus engaphandle kwi-neoplasia yeposi njengabafazi abathatha unyango lwe-hormone, kwaye ukusetyenziswa kwe-urolithins kukholelwa ekubeni kunefuthe elikhuselayo kwi-endometrium. Nangona kunjalo, olunye uphando kufuneka lwenziwe ngaphambi kokuba ii-Urolithins zibe ngamayeza e-SERM alandelayo.
● Ukuthintelwa kweProteni Glycation
Ubukho beemveliso zokuphela kwexesha le-glycation luphawu lwe-hyperglycemia oluchaphazela abantu kwisifo seswekile esimalunga nesifo sentliziyo okanye isifo se-Alzheimer's. I-Urolithin A kunye ne-Urolithin B ibonakalisiwe ukuba inefuthe lokuchasana ne-glycation ethintela ukuthukwa kwentliziyo kunye nokunciphisa umngcipheko we-neurodegeneration kakhulu.
Yiyo loo nto ukuthintelwa kweprotein glycation yi-Urolithins kukholelwa ukuba ineziphumo ze-cardioprotective kunye ne-neuroprotective.
Izibonelelo ze-Urolithin A zikhankanywe apha ngezantsi:● Yandisa ixesha lokuphila
Ukwaluphala, uxinzelelo kunye nokuphazamiseka okuthile kunokonakalisa i-mitochondria, ebaluleke kakhulu kwimveliso yamandla yesiqhelo kunye nokusetyenziswa komzimba. Ngaphaya koko, i-mitochondria ihlala ibizwa ngokuba 'yindawo yamandla eseli', oko kuthetha ukubaluleka kokusebenza kweseli. Ngenxa yoko, nawuphi na umonakalo kweli gunya lombane unokuchaphazela kakubi iseli kunye nokunciphisa ixesha lokuphila.
Ii-Urolithins zenza into ethile eyaziwa ngokuba yi-mitophagy evumela umzimba ukuba ususe i-mitochondria eyonakeleyo, ngaphandle kwesizathu somonakalo, kwaye wandise ixesha lokuphila. Ngokusekwe kubungakanani bomonakalo, i-mitochondria inokuphinda isetyenziswe kwakhona kwizondlo kunye nemveliso yamandla.
● Ukunyanga i-Neuroprotective
Njengoko sele kukhankanyiwe apha ngasentla, ii-urolithin zineempawu ezichaseneyo nokudumba kwaye zezi zinto zikhuthaza ukwakheka kweeseli ze-neuronal kwingqondo, enefuthe elihle kulwazi kunye nokugcinwa kwememori. Ngaphaya koko, i-Urolithin A ikhusela ngokuchasene ne-neurodegeneration ebonwa sisifo se-Alzheimer, yiyo loo nto ke sisiphumo se-neuroprotective.
● Thintela umhlaza wedlala lobudoda
I-Urolithin A inezinto ezichasene nomhlaza kodwa zibonakala ngakumbi kwimeko yomhlaza wedlala lobudoda, kunye nezifundo ezininzi ezikhuthaza ukusetyenziswa kwepomegranate kunye neminye imithombo yeUrolithins kunyango lomhlaza wesibeletho.
● Nyanga Ukutyeba Ngokugqithiseleyo
I-Urolithin A ineempembelelo ezichasene nokutyeba kakhulu njengoko ingathinteli nje kuphela ukuqokelelana kweeseli ezinamanqatha emzimbeni kodwa ikwathintela nabamakishi abanoxanduva lwe-adipogenesis. Kwisifundo esenziwe kwiimodeli zezilwanyana, kwafunyaniswa ukuba i-Urolithin A inefuthe eliphezulu kwi-T3 hormone ye-thyroid, ekhokelela kwinkcitho yamandla kwiimpuku. Oku kunciphisa i-thermogenesis kwaye kubangele amanqatha emdaka anyibilike, ngelixa amafutha amhlophe enyanzelwa ukuba abe mnyama.
Kwakweso sifundo sinye, kwafunyaniswa ukuba i-URolithin A inefuthe lokuthintela ukutyeba nkqu nakwiimpuku ezondliwe ukutya okunamafutha aphezulu. Oku kubonisa isithembiso esikhulu malunga nokutyeba kakhulu kwaye abaphandi bacele ukusetyenziswa kwabantu kwezi zinto zifunyanisiweyo ukuze bakwazi ukusebenzisa eli qela ukulwa umbandela wokutyeba kakhulu.
Izibonelelo ze-Urolithin B zezi zilandelayo:● Thintela ukuphulukana nezihlunu
Urolithin B wabelana ngezibonelelo ezithile ze-Urolithin A kodwa unesibonelelo esithile, esahlukileyo kuye yedwa. I-Urolithin B yaziwa ngokuthintela ukulahleka kwemisipha kuwo omabini amanqanaba omzimba kunye nophendlo lwezifo. Ngapha koko, ikhuthaza ukukhula kwamathambo ngokunyusa iiprotein synthesis kwiimisipha.
Ikwanayo nefuthe lothintelo kwi-atrophy yemisipha njengoko kubonisiwe kuphononongo olwenziwe kwiimpuku ezazisuswe intsholongwane. Oku ngekukhokelele kwi-atrophy yemisipha kodwa iimpuku zafakwa iimpompo ezincinci ze-osmotic eziqhubeka ukubanika u-Urolithin B. Kwafunyaniswa ukuba ezi mpuku zinendlela yabo ye-ubiquitin-proteasome ecinezelweyo, ekhokelele ekusweleni okucacileyo kwe-atrophy yemisipha ngaphandle kwesahlulo se-sciatic nerve .
Ubungakanani be-UrolithinsIi-Urolithins zithathwe kwimixube yendalo kwaye izongezo zazo zithathwa njengezinyamezeleka kungekho ntatheli. Nangona kunjalo, kubalulekile ukugcina engqondweni ukuba ezi zinto zisephantsi kophando kwaye zinemida yethamo ekufuneka ilandelwe ngokungqongqo.
● Urolithin A
Emva kophando olunzulu ngezibonelelo ze-Urolithin A, bekukho uphando oluninzi olwenziwe ukuvavanya idosi elungileyo yale khompawundi. Ukufunxwa, ukugaywa, ukuColwa kweMetabolism, kunye nesifundo sokupheliswa kwenzelwa ukuhlalutya amanqaku ekhompawundi.
Uphononongo lwahlulwe kubini, kuxhomekeke kwinani leentsuku, kwaye kwafunyaniswa ukuba isifundo seentsuku ezingama-28 sine-0, 0.175, 1.75, kunye ne-5.0% ye-Urolithin A exutywe ekudleni nakwisifundo seentsuku ezingama-90 kunye no-0, 1.25, I-2.5, kunye ne-5.0% i-Urolithin A exutywe ekutyeni ayibonisanga lutshintsho kwiiparameter zeklinikhi, ikhemistri yegazi, okanye ihematology, kwaye ayikhange ichaze naziphi na iindlela ezinobungozi. Zombini ezi zifundo zazineyona dosi iphezulu yavavanywa kwi-5% ye-UA ngokobunzima bokutya okukhokelele kwezi dosi zilandelayo; I-3451 mg / kg BW / ngosuku emadodeni kunye ne-3826 mg / kg BW / ngosuku kubantu ababhinqileyo kwisifundo se-90 seentsuku zomlomo.
● Urolithin B
Ifana ne-Urolithin A, Urolithin B yafundwa ngokubanzi ukuvavanya idosi efanelekileyo. Nangona kubalulekile ukuba uqaphele ukuba izifundo zijolise kwidosi ekhuselekileyo ukufezekisa ukonyuka kwemisipha ngokufanelekileyo. Le dosi ifunyenwe iyi-15uM, kubo bobabini abesilisa nabasetyhini, ngaphandle kobunzima.
● Urolithin A 8-Methyl Ether
Le khompawundi isetyenziswa ngokunjalo, ikakhulu kuba iphakathi ngexesha lokuveliswa kwe-Urolithin A. Nangona kunjalo, akukho phando lwaneleyo lwenziweyo kumthamo ofanelekileyo omiselweyo kule Urolithin.
Imithombo yokutya yeeUrolithinsIi-Urolithins azifumaneki ngokwendalo kuwo nawuphi na umthombo wokutya, nangona kunjalo zifunyanwa njenge-ellagitannins. Ezi tanins zihlahlela zibe yi-ellagic acid, ethi iphinde iqhubekeke ibe yi-Urolithin A 8-Methyl ether, emva koko iye kwi-Urolithin A, kwaye ekugqibeleni, Urolithin B. Ukutya okunotyebileyo kwii-Urolithins zezi:
Njengoko kubonisiwe kwitafile, ii-Cloudberries ziziqhamo ezine-Ellagitannins ephezulu kunye ne-Ellagic acid, enePomegranate njengesibini esisondeleyo. Ipomegranate Juice, nangona kunjalo, ingumthombo onamandla ngakumbi, phantse amaxesha amathathu anamandla njenge-Cloudberries.
Kubalulekile ukuba uqaphele ukuba umxholo we-asidi ye-ellagic kwimithombo yokutya ayilingani nomlinganiselo ofanayo we-urolithin emzimbeni. Ukufumaneka kwe-URolithins kuxhomekeke kakhulu kwi-gut microbiota yomntu ngamnye.
Kutheni ufanele uthenge kwiFektri yoMvelisi wethu?I-Urolithin Powder A kunye ne-Urolithin Powder B ziyafumaneka ngobuninzi, kumzi-mveliso wethu wokudibanisa odibanisa imveliso, uphando, uphuhliso kunye nentengiso yezi zongezo. Iimveliso zethu zenziwe kusetyenziswa ubuchwephesha obugqithisileyo ukulandela zonke izikhokelo zokhuseleko, eziqinisekisa umgangatho ophezulu kunye nokhuseleko lwemveliso yokugqibela. Zonke iimveliso ziphandiwe ngaphambi kokwenza kwaye zivavanywa ngocoselelo ngexesha nasemva kwemveliso ukufezekisa imigangatho yakho esemgangathweni.
Emva kwemveliso, iimveliso ziyavavanywa kwiilebhu zethu elinye ixesha lokujonga umgangatho, amandla kunye nokhuseleko lwe-Urolithin powders kunye nezinye iimveliso. Xa sele zilungele ukuhanjiswa, iimveliso ziyapakishwa kwaye zigcinwe kumaziko afanelekileyo, kubushushu obufanelekileyo ngelixa ulandela zonke izikhokelo zokuqinisekisa ukuba imveliso ekumgangatho ophezulu ifikelela kuwe. I-Urolithin powders ayivelwanga kukukhanya kwelanga ngexesha lokuhambisa, ukupakisha, okanye ukugcinwa njengoko kunokonakalisa imveliso yokugqibela.
Ukuthenga i-Urolithin A powder kunye ne-Urolithin B powder evela kumzi-mveliso wethu oqinisekisa imveliso ekumgangatho ophezulu ngamaxabiso afikelelekayo.
Imbekiselo:
- UTotiger TM, uSrinivasan S, uJala VR, et al. I-Urolithin A, iNoveli yeNdalo yeNdalo kwiithagethi ze-PI3K / AKT / mTOR kwiPancreatic Cancer. Umhlaza Cancer Ther. 2019; 18 (2): 301-311. ikhonkco: 10.1158 / 1535-7163.MCT-18-0464.
- UGuada M, uGanugula R, uVadhanam M, uRavi Kumar MNV. I-Urolithin A iyanciphisa i-Cisplatin-ye-Nephrotoxicity ekhutshiweyo ngokuthintela ukuvuvukala kweRenal kunye ne-Apoptosis kwiModeli yoVavanyo lweeRat. J Pharmacol Exp Ther. Ngo-2017; 363 (1): 58-65. ikhonkco: 10.1124 / jpet.117.242420.
- UJuan Carlos Espín, Mar Larrosa, María Teresa García-Conesa, uFrancisco Tomás-Barberán, "Ukubaluleka kwe-Biological ye-Urolithins, i-Gut Microbial Ellagic Acid-Derives Metabolites: Ubungqina ngoku" Ngo-2013, iNqaku le-ID 270418, iphepha eli-15, 2013. https://doi.org/10.1155/2013/270418.
- U-Lee G, iPark JS, uLee EJ, uAhn JH, uKim HS. Iinkqubo ezichasene nokuvuvukala kunye ne-antioxidant ye-urolithin B kwi-microglia esebenzayo. Unyango lwezonyango. 2019; 55: 50-57. ikhonkco: 10.1016 / j.phymed.2018.06.032.
- I-Han QA, i-Yan C, i-Wang L, i-Li G, i-Xu Y, i-Xia X. I-Urolithin A ifumana ukungasebenzi kakuhle kwe-ox-LDL-incothelial endodhelial inxenye ngokumodareyitha indlela ye-microRNA-27 kunye ne-ERK / PPAR-Y. Ukutya Res kweMon Nutr. Ngo-2016; 60 (9): 1933-1943. ikhonkco: 10.1002 / mnfr.201500827.


text:
Umbhobho weAluminiyam luhlobo lombhobho wesinyithi ongenantsimbi, owenziwe ngealuminium ecocekileyo okanye ialuminiyam kwaye ikhutshelwe kwimingxunya yentsimbi engenanto kunye nobude bayo obude.
Ngokwendlela ye-extrusion, yahlulahlulwe ngombhobho we-aluminium ongenamthungo kunye nombhobho oqhelekileyo okhutshiweyo
Ngokuchaneka: iityhubhu zealuminium eziqhelekileyo kunye neetyhubhu ezichanekileyo zealuminium, phakathi kwazo iityhubhu zealuminium ezichanekileyo ngokubanzi kufuneka ziphinde zenziwe emva kokukhutshwa, njengokuzoba kubandayo, ukuzoba kakuhle kunye nokuqengqeleka.
Yahlulwe ngokobukhulu: umbhobho oqhelekileyo wealuminiyam kunye nombhobho wealuminium obhityileyo
Ukusebenza: ukumelana nokubola, ubunzima bokukhanya.


text:
OTURN OOMATSHINI yindawo yentengiso yaphesheya kunye nendawo yokuthengisa esekwe ziifektri zeqela lethu. Yikuphi ukugxila kwi-R & D kunye nokuveliswa komgangatho ophezulu, oomatshini abasebenza ngokugqibeleleyo kunye nenjongo ekhethekileyo kumthengi, sikwayila isisombululo semigca yokuvelisa kubathengi ukusuka kwi-0 ukuya kwi-100. Khetha okwangoku eyona ndlela isebenzayo yokwenza abathengi, kwaye ugcine ngokufanelekileyo Iindleko zotyalo-mali lwezixhobo kunye nokufumana kwakhona iindleko zangaphambili.
Amashishini aphambili abandakanyekayo koomatshini kunye nakwimigca yokuvelisa iivenkile ezahlukeneyo zeshishini, ukufakela umbhobho, iflange, oomatshini bokwakha amandla, ukuhambisa, ukungunda kunye namanye amashishini. Uyilo lweqela lobuchwephesha kuMveliso weMveliso yeValve, ekwakheni umgca wokudibanisa ukuya kwiindidi zokwenza imveliso yevalve, ukuvavanywa kwevalve kunye ne-welding, sonke sinamava entengiso kunye namatyala.
Iimveliso zoomatshini eziveliswa liQela lethu njengezantsi
I-Valve Production Production Line ikwayimveliso yethu edumileyo neyaziwayo eyilelwe liqela lethu lobuchwephesha, ekwakheni umgca wokuphosa iindibano kwiindidi ze-machining ze-valve, ukuvavanywa kwevalve kunye ne-welding, sonke sinamava entengiso kunye namatyala.
Izisombululo zomngundo zeZithuthi kunye neziXhobo zeKhaya ziyafumaneka ngokweQela lethu.
Iseke ubudlelwane bexesha elide kunye ne-FAW-Volkswagen, i-SAIC-Volkswagen, iMercedes-Benz kunye neToyota, iFoton kunye ne-Denso air-conditioning.
Ukubonelela abathengi bethu ngokuthenga izixhobo zokuma kunye, ngelixa bethembisa ukubonelela ngamaxabiso amahle kunye nokuthengisa kwangaphambili kunye nokuthengisa emva kweenkonzo.Ngoko ke umthengi uhlala esinika ingxelo elungileyo ngokuchacha okuphezulu.
Impumelelo yeshishini isekwe kwimigangatho ephezulu, amashumi eminyaka yamava kunye nezisombululo ezigqwesileyo ngenkonzo ebalaseleyo, sisoloko sinesisombululo esikhethekileyo nesinokuthenjwa ngeendlela ezahlukeneyo zabathengi.
Ukuza kuthi ga ngoku sithumele kumazwe angaphezulu kwama-50, afana ne-United States, Canada, Mexico, Germany, Italy, Sweden, Russia, Saudi Arabia, Turkey, Iran, India, South Korea, Morocco, South Africa, Thailand njalo njalo.
Ukuba inkampani yakho ifuna ukuphucula ukusebenza kwemveliso kunye nokunciphisa iindleko, zidibanise nathi, isisombululo sethu siya kuba sesona silungileyo.


text:
Amagosa
ezempilo athe sa iinzwane ekhangela abantu abebedibe noBen Motshwari. Oku
kudizwe liqela lakhe, i-Orlando Pirates, emva kokuba kufunyenwe ichaphaza
lekhorona. UMotshwari ngumdlali wokuqala odlala kwiPremier Soccer League
ofunyenwe enekhorona. IPirates ikhuphe ingxelo ebhaliweyo ethi umdlali wayo uza
kuhlala yedwa iiveki ezimbini. “Siliqela sifuna ukungqina okokuba ngokwenene
uBen Motshwari unechaphaza lekhorona. UBen uye wabanjwa ngumkhuhlane oye
waneempawu ezikrokrisayo kwiveki ephelileyo. Uye wenziwa uvavanyo, iziphumo
zibuye zisithi ngokwenene unekhovithi-19. Umdlali uza kugcinwa endaweni
ekhethekileyo ade aphile. Ngoku iqela likhangela bonke abantu ebekhe wadibana
nabo kwaye liyalele umdlali axelele ugqirha bonke abantu acinga ukuba
ebesondelelene nabo,” itshilo ingxelo ekutshwe yi-Orlando Pirates.
UMotshwari ngomnye
wabadlali abathembekileyo kwiPirates – kodwa ukubhaqwa kwakhe kwangoko kuza
kumnika ithuba lokuphila ngoku isamisiweyo imidlalo. Zimbini iinyanga imidlalo
ye-Absa Premiership ingasadlalwa ngenxa yekhovithi-19 eyaqhambuka eChina
ekupheleni kuka-2019. EMzantsi Afrika, basukela amawaka alithoba abantu
abanekhorona, kanti kwihlabathi basukela izigidi ezine. Ugqirha Mahlane Phalane
uthi imeko kaMotshwari ngeke ichaphazele izicwangciso zePSL egushuzela
ukugqibezela imidlalo eshiyekileyo. “Okwenzekileyo ngeke kuchazele iinzame
zePSL zokudlalisa amaqela kwakhona. Sithe mabavavanywe bonke abadlali. Ngalo
ndlela sakukwazi ukuvumela bonke abangenayo ikhorona babuyele emaqeleni wabo. Akhona
amaqela aphaya kwisithandathu esele senze iimvamvanyo kuwo,” utshilo ugqirha
Phalane osebenzela iPSL.
Nangona ikhovithi-19
isagqugqisa emazweni ehlabathi – kodwa amanye amazwe aseYurophu alungiselela
ukuvumela imidlalo kwakhona. Yonke imidlalo eyakuthi idlalwe okwangoku kukho
ikhorona, iya kudlalwa bengekho abalandeli bebhola emabaleni kuba kungafunwa
kosuleleke abantu abaninzi. Urhulumente akayimelanga imidlalo kwisigaba sesine
sokuvalwa kweentshukumo zoluntu. Nangona kunjalo, uMphathiswa uNathi Mthethwa,
uthe ufuna iSafa nePSL inike urhulumente umkhombandlela. Intlanganiso yePSL
yayizolo ibingekakhuphi nto ecacileyo.


text:
The chill house ห้องพักไสตล์รีสอร์ท
Igumbi lakho lokulala e i-resort sinombuki zindwendwe onguAu
Iindwendwe eziyi-2, Istudiyo, Ibhedi eyi-1, Igumbi lokuhlambela eli-1
I-Wifi
Iindwendwe ziyathanda ukukhangela le nto inokusetyenziswa ithandwayo
Izinto enazo le ndawo
I-Wifi
Indawo yokupaka ngaphakathi esimahala
I-TV
Isixhobo sokomisa iinwele
Ifriji
Abantu abaza kuhlala ixesha elide bavumelekile
Ayikho: Ialam yomsi otyhefayo
Ayikho: Ialam yomsi
Akukho zimvo (okwangoku)
Silapha ukuze senze uhambo lwakho luhambe kakuhle. Zonke iindawo ezibhukishwayo zikhuselwe Sisiqinisekiso Sokubuyiselwa Okulahlekileyo sakwa-Airbnb.
Apho uza kuba khona
Tambon Wang Sala, Chang Wat Kanchanaburi, Thailand
- Isazisi siqinisekisiwe
Ukuze ukhusele ukubhatala kwakho, ungaze uthumele imali okanye uthethe nabantu ungasebenzisi iwebhsayithi okanye i-app yakwa-Airbnb.
Izinto ofanele uzazi
Imithetho yekhaya
Ixesha lokubhalisa xa ufika: Emva ko 14:00
Ixesha lokuphuma lingo:11:00
Akutshaywa
Azivumelekanga izilwanyana zasekhaya
Ezempilo nokhuseleko
Kusebenza izikhokelo zika-Airbnb zokungasondeli ebantwini nezinye ezinento yokwenza neCOVID-19
Akukho alam elumkisa ngomoya otyhefayo echaziweyo Bonisa okungakumbi
Akukho alam elumkisa ngomsi echaziweyo Bonisa okungakumbi
Imithetho engokurhoxa
Hlola ezinye iindawo onokukhetha kuzo e- Tambon Wang Sala
Iindawo ezingakumbi onokuhlala kuzo e Tambon Wang Sala:


text:
Imibongo yokwenza umfazi onzima athande "Ndingathanda ukukuxelela zonke izinto ezintle endiziva ...
Imifanekiso
Imibongo yothando Ndithande. Ikhoboka lam! Ndikunye nawe ukutshona kwelanga ...
Enkosi ngawo onke amaxesha esabelana ngawo ixesha elizele ziimvakalelo kunye neengcinga, amaphupha kunye ...
Mhla ndadibana nawe yayiyinto entle.Ngalo mzuzu ndaqonda ukuba uzakuba ...
Imibongo yothando lomgama kumfana endithandana naye- "Ndikugcina ndikho kwiingcinga zam kuyo yonke into ...
Imibongo yokuthandana nomhlobo owileyo kuwe Ndimamela iingxaki zakho, ndiyakusula iinyembezi. Ndiyakuthanda…
Imibongo kubahlobo abafutshane Umhlobo wam, iqabane lam leentsuku ezibuhlungu, ubusuku bam obude, umcebisi ku ...
Imibongo emide yobuhlobo Ubuhlobo lelinye lawona magama amnandi kunye nelona ...
Imibongo yokuthandana noSuku lweValentine Yonke inzolo yakho, lonke uncumo olunika ilanga, konke ukumbombozela ...
IPunto y Coma - Mónica Laví Ndilukuhle ngeekoma zakho, kunye neendawo zakho zokubambana, ukuphefumla kwakho ...
Imibongo kubahlobo abakhethekileyo Kuthatha umzuzu kuphela ukuba uqaphele umntu, iyure ...
Oko ndikwazile, ndifuna ukubhiyozela uSuku lweValentine iintsuku ezingama-365 ngonyaka. Uthando endiziva ...
Ndikubhalela ezi ndinyana ngesizathu esibalulekileyo, ndiyathemba ukuba uyifunda ngononophelo nokuba iyavakala into egqithisileyo ...
Amandla ahlala esomelela, ethintela usizi, xa kukho into ehamba gwenxa. Kwaye ingumthombo ...
Imibongo emifutshane yothando Ndifuna wazi ukuba ulilizwe lam, ubomi bam bonke, sithandwa sam, ...


text:
Iintlobo zomhlaza
Khetha uhlobo lomhlaza ukuze ufunde ngonyango, oonobangela kunye nokuthintela, ukuhlolwa, kunye nophando lwamva nje.
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
A
Ileukemia eqhelekileyo yeLymphoblastic (BONKE)
I-Myeloid Leukemia (AML) efanelekileyo
Abafikisayo, uMhlaza ngaphakathi
- Ubuntwana beAdrenocortical Carcinoma- jonga iiCancer ezingaqhelekanga zoBuntwana
Umhlaza onxulumene noGawulayo
- IKaposi Sarcoma (iTissue Tissue Sarcoma)
- ILymphoma enxulumene noGawulayo (iLymphoma)
- IPrayimari ye-CNS yeLymphoma (iLymphoma)
Isihlomelo somhlaza - jonga i- Gastrointestinal Carcinoid Tumors
I-Astrocytomas, Ubuntwana (Umhlaza weBongo)
I-Atypical Teratoid / Rhabdoid Tumor, Ubuntwana, iNkqubo eNkulu yeNervous (Umhlaza weBongo)
B
I-Basal Cell Carcinoma yolusu - jonga uMhlaza wolusu
- Umhlaza weSinyi somhlaza-bona imihlaza engaqhelekanga yobuntwana
Umhlaza wamathambo (kubandakanya i-Ewing Sarcoma kunye ne-Osteosarcoma kunye neMalignant Fibrous Histiocytoma)
Amathumba eBronchial (Umhlaza wemiphunga)
IBurkitt Lymphoma - jonga i- Non-Hodgkin Lymphoma
C
- Ubuntwana beCarcinoid Tumors-jonga iiCancer ezingaqhelekanga zoBuntwana
ICarcinoma yePrayimari engaziwayo
- Ubuntwana beCarcinoma yePrayimari engaziwayo-bona imihlaza engaqhelekanga yobuntwana
Intliziyo (Intliziyo) amaThumba, uBuntwana
Inkqubo eNkulu yeNervous
- I-Atypical Teratoid / Rhabdoid Tumor, Ubuntwana (Umhlaza weBongo)
- IMedulloblastoma kunye nezinye i-CNS Embryonal Tumors, Ubuntwana (Umhlaza weBongo)
- I-Germ Cell Tumor, Ubuntwana (Umhlaza weBongo)
- Umhlaza womlomo wesibeleko sabantwana-bona imihlaza engaqhelekanga yobuntwana
Umhlaza wobuntwana, ongaqhelekanga
I-Cholangiocarcinoma-jonga umhlaza weBile Duct
Chordoma, Ubuntwana- jonga iiCancer ezingaqhelekanga zoBuntwana
Ileukemia enganyangekiyo yeLymphocytic (CLL)
Isifo seeleukemia esingapheliyo (CML)
Neoplasms engapheliyo ye-Myeloproliferative
- Umhlaza weColorectal Cancer- jonga iiCancer ezingaqhelekanga zoBuntwana
Craniopharyngioma, Ubuntwana (Umhlaza weBongo)
I-T-Cell Lymphoma ye-Cutaneous - jonga iLymphoma (iMycosis Fungoides kunye neSézary Syndrome)
D
IDuctal Carcinoma In Situ (DCIS) - jonga umhlaza webele
E
Izilonda embryonal, iMedulloblastoma kunye neNkqubo eNtsha yeNervous, Ubuntwana (Umhlaza weBongo)
Umhlaza we-Endometrial (Umhlaza wesibeleko)
I-Ependymoma, Ubuntwana (Umhlaza weBongo)
I-Esthesioneuroblastoma (Intloko kunye neCancer Neck)
I-Ewing Sarcoma (Umhlaza wamathambo)
I-Extracranial Germ Cell Tumor, Ubuntwana
I-Extragonadal Germ Cell Tumor
Umhlaza wamehlo
- Ubuntwana be-Intraocular Melanoma-jonga iiCancer ezingaqhelekanga zoBuntwana
F
I-Fibrous Histiocytoma ye-Bone, Malignant, kunye ne-Osteosarcoma
UG
- Isisu somntwana (isisu) somhlaza - jonga umhlaza ongaqhelekanga wobuntwana
Amathumba eStromal Stromal Tumors (GIST) (iTissue Tissue Sarcoma)
- Amathumbu eSisu eSisu eStromal Tumors-jonga iiCancer ezingaqhelekanga zoBuntwana
- Ukudumba Kweseli Yentsholongwane
- Inkqubo yaBantwana ePhakamileyo yeNervous Germ Germ Tumors (Umhlaza weBongo)
H
Umhlaza wentloko kunye nentamo
Ukudumba kwentliziyo, ubuntwana
Umhlaza weHepatocellular (Isibindi)
I-Histiocytosis, iseli yaseLangerhans
Umhlaza wehypopharyngeal (iNtloko kunye nomhlaza womqala )
Mna
Ubuntwana be-Intraocular Melanoma-jonga iiCancer ezingaqhelekanga zoBuntwana
Islet Cell Tumors, Pancreatic Neuroendocrine Tumors
U-K
IKaposi Sarcoma (iTissue Tissue Sarcoma)
Izintso (i-Renal Cell) Umhlaza
U-L
ILangerhans Cell Histiocytosis
Umhlaza welaryngeal (iNtloko kunye nomhlaza womqala)
Umhlaza womlomo kunye nomlomo womlomo (iNtloko kunye neCancer Neck)
Umhlaza wemiphunga (Iseli engeyiyo encinci, Iseli encinci, iPleuropulmonary Blastoma, kunye neTracheobronchial Tumor)
M
Imbali ebulalayo yeFibrous Histiocytoma yeBone kunye neOsteosarcoma
- Ubuntwana beMelanoma-bona imihlaza engaqhelekanga yobuntwana
I-Melanoma, Intraocular (Iliso)
- Ubuntwana be-Intraocular Melanoma-jonga iiCancer ezingaqhelekanga zoBuntwana
IMerkel Cell Carcinoma (Umhlaza wolusu)
Umhlaza weMatastatic Squamous Neck kunye nePrayimari yokuSebenza (iNtloko kunye neCancer Neck)
I-Midline Tract Carcinoma eneenguqu ze-NUT Gene
Umhlaza woMlomo (iNtloko kunye noMhlaza womqala)
I-Endocrine Neoplasia Syndromes ezininzi-jonga iiCancer ezingaqhelekanga zoBuntwana
I-Myeloma / i-Plasma Cell Neoplasms ezininzi
IMycosis Fungoides ( iLymphoma )
I-Myelodysplastic Syndromes, iMyelodysplastic / iMyeloproliferative Neoplasms
Ileukemia enganyangekiyo, engapheliyo (i-CML)
I-Myeloid Leukemia, Acute (AML)
I-Myeloproliferative Neoplasms, engapheliyo
U-N
Impumlo yeNasal kunye neParanasal Sinus Cancer (Intloko kunye neCancer Neck)
Umhlaza weNasopharyngeal (Intloko kunye neCancer Neck)
Umhlaza wemiphunga ongekho mncinci
O
Umhlaza womlomo, Umlomo kunye noMlomo womlomo womlomo kunye noMhlaza weOrtharyngeal ( Umhlaza weNtloko kunye neNtamo yomhlaza)
I-Osteosarcoma kunye ne-Malignant Fibrous Histiocytoma ye-Bone
- Umhlaza we-Ovarian Cancer- jonga iiCancer ezingaqhelekanga zoBuntwana
Iphe
Umhlaza wePancreatic Cancer- jonga iiCancer ezingaqhelekanga zoBuntwana
IPancreatic Neuroendocrine Tumors (Islet Cell Tumors)
IPapillomatosis (iLaryngeal yoBuntwana)
Ubuntwana beParaganglioma-jonga iiCancer ezingaqhelekanga zoBuntwana
I-Paranasal Sinus kunye ne-Nasal Cavity Cancer (iNtloko kunye neCancer Cancer)
Umhlaza wePharyngeal (Intloko kunye nomhlaza womqala)
Ubuntwana bePheochromocytoma-jonga iiCancer ezingaqhelekanga zoBuntwana
IPlasma Cell Neoplasm / iMyeloma ezininzi
I-Pleuropulmonary Blastoma (Umhlaza wemiphunga)
Ukukhulelwa kunye noMhlaza webele
Inkqubo yasePrayimari yeNervous System (CNS) yeLymphoma
Umhlaza wasePrayimari wePeritoneal
R
Iseli seNtsholongwane (izintso) Umhlaza
IRhabdomyosarcoma, Ubuntwana (iTissue Tissue Sarcoma)
S
Umhlaza wedlala yesalivary (Intloko kunye nomhlaza womqala)
ISarcoma
- I-Rhabdomyosarcoma yobuntwana (iTissue Tissue Sarcoma)
- Izilonda zeVascular Tumors ( Isoft Soft Tissue Sarcoma)
- I-Ewing Sarcoma (Umhlaza wamathambo)
- IKaposi Sarcoma (iTissue Tissue Sarcoma)
- I-Osteosarcoma (Umhlaza wamathambo)
ISezary Syndrome (iLymphoma)
- Umhlaza wolusu lomntwana - jonga umhlaza engaqhelekanga wobuntwana
Umhlaza wesifo semiphunga omncinci
I-squamous Cell Carcinoma yolusu - jonga uMhlaza wolusu
Umhlaza wentamo weSquamous ngePrayimari yokuSebenza, iMetastatic (iNtloko kunye neCancer yeNeck)
- Isisu sabantwana (isisu) somhlaza- jonga umhlaza ongaqhelekanga wobuntwana
T
I-T-Cell Lymphoma, i-Cutaneous- jonga iLymphoma (iMycosis Fungoides kunye neSèzary Syndrome)
- Umhlaza wamatyhalarha obuntwana - jonga iiCancer ezingaqhelekanga zoBuntwana
Umhlaza womqala (iNtloko kunye neCancer Neck)
I-Thymoma kunye ne-Thymic Carcinoma
Izilonda zetracheobronchial (umhlaza wemiphunga)
Utshintsho lweCancer Cancer yeRenal Pelvis kunye neUreter ( yeZintso (i-Renal Cell) Cancer)
U
IPrayimari engaziwayo, iCarcinoma
- Umhlaza woMntwana kwiPrayimari engaziwayo-bona imihlaza engaqhelekanga yobuntwana
Imihlaza engaqhelekanga yobuntwana
Ureter kunye no-Renal Pelvis, uMhlaza weSifo seTshintsho seNtlungu (izintso (i-Renal Cell) Umhlaza
Umhlaza wesibeleko, i-Endometrial
V
- Umhlaza woMhlaza welungu lobufazi-jonga iiCancer ezingaqhelekanga zoBuntwana
Izilonda zeVascular (iTissue Tissue Sarcoma)
UW
I-Wilms Tumor kunye nezinye iZintso zeZintso zaBantwana
Y
Abantu abadala abancinci, umhlaza ngaphakathi


text:
Intshayelelo yeMveliso
• Yongeza inkqubo yokuCwangciswa kweLogic Controller (i-PLC) kwisiseko somatshini oqhelekileyo owenza umatshini, owamkela izixhobo zombane eziphambili kunye ne-pneumatic, kunye nokusebenza kunokutshintshwa ngokuzenzekelayo nangokuzenzekelayo. Sisiqalo esiphakathi kwaye sinokutshintsha iindlela zokufudumeza ngokweefom zemveliso.
• Ihlisa iimfuno zobugcisa kubaqhubi kwaye yonke imisebenzi inokulawulwa yi-PLC.
• Ukondla ngaxeshanye iindawo zokutyisa ezininzi konga kakhulu ixesha lokondla.
• Ixesha lomjikelo wonke wokondla izinto, ukufudumeza, ukupholisa kunye nokonakalisa luchanekile kwaye luzinzile. Igcina ixesha, inciphisa iindleko, iphucula izibonelelo zoqoqosho kunye nokuphucula umgangatho wemveliso.
Kukwanciphisa ukusebenza kunye nokusebenza ukuze umntu omnye akwazi ukusebenzisa oomatshini abaliqela.
Ipharamitha yobuGcisa
I-EPS Shape Molding Machine isetyenziselwa ukuvelisa ibhokisi yokupakisha i-EPS, ibhloko ye-ICF, ibhloko yekhonkrithi, ibhloko engenanto, i-hourdis, ukulahleka kwe-foam, i-cornice yokuhlobisa, ibhodi yesilivere, ikholomu, isigcina-ntloko, njl.
Umatshini unokwenza imveliso eyahlukeneyo yeeps, ibhokisi, ipakethe, itreyi, njl. Sele sithengisa umatshini kumazwe angaphezu kwe-100, sinodumo oluhle. Bonke abathengi bathanda uyilo kunye nomgangatho ozinzileyo.
Inkampani yethu ineminyaka engaphezu kwama-30 yembali kule ntsimi, uphawu lwethu yi-CHX, sikwiNdawo yoMntla, iNanlv Industrial Zone, iXinji City, kwiphondo lase-Hebei, China. Ngaphezulu kwe-3000m2 workshop, abasebenzi abangaphezulu kwama-200, iinjineli ezingama-20. I-10 ekhethekileyo yokuyila kunye nokuphucula oomatshini abatsha. Ndonwabile ngokwenene ukuba ungandwendwela umzi-mveliso wethu xa ukhululekile. Ithemba kufuneka ngentsebenziswano elide kunye nenkampani yakho.


text:
Igalari yobugcisa yeRoyi yeyona venkile yokuma yabathandi bezobugcisa ekhangela umzobo ogqibeleleyo okanye eminye imisebenzi yobugcisa ngamaxabiso afikelelekayo.
Ngobugcisa beRoyi, uthenga ngokuthe ngqo kwisitudiyo, abadali, abaqulunqi kunye namagcisa. Sidibene amawaka eoyile entle epeyinti yehlabathi, ukusukela kubugcisa bezinto zakudala zaseYurophu ukuya kubugcisa beli xesha.
Ioyile yokwenene, iibhulashi zeNene, iiArhente zoBugcisa, ubuGcisa bokwenyani.
U-Alizee, ongumthandi wobugcisa bokwenyani ngokwakhe, uphethe iintloko zorhwebo zaseRoyi Art phesheya. Kule minyaka ilishumi idlulileyo, uAlizee usebenze ngokusondeleyo nabaqulunqi bengaphakathi, abaqulunqi, abanini begalari, abaqokeleli bobugcisa, njl njl. Sivakalelwa kukuba xa sisebenza kunye nabo, ngcono ukuba sikwazi ukufezekisa iimfuno zabo kwaye sizalisekise iminqweno yabo. Umntu ngamnye wegcisa lethu unetalente yakhe ekhethekileyo kwizifundo ezithile okanye kubuchwephesha. Njengoko sisenza okanye siphinda senze kwakhona i-odolo ekhethekileyo, sipeyinta iqhezu ngalinye lobugcisa ngokuthe chu kwaye ngononophelo. Sakhe ishishini lethu kwisithunzi sethu sokwanelisa iimfuno zomthengi ngamnye.


text:
Sotto le Vigne, relax o smartworking nel Canavese
I-townhouse yonke sinombuki zindwendwe onguLorella
Iindwendwe eziyi-3, Amagumbi okulala ayi-2, Iibhedi eziyi-2, Amagumbi okuhlambela ayi-2
Indawo yonke
Iza kusetyenziswa nguwe yonke le indlu yasedolophini.
Ukucoca Okuphuculiweyo
Lo mbuki zindwendwe uzibophelele kwinkqubo yokucoca ephuculiweyo enamanyathelo ayi-5 yakwa-Airbnb.
I-Wifi
Iindwendwe ziyathanda ukukhangela le nto inokusetyenziswa ithandwayo
Indawo oza kulala kuyo
Igumbi lokulala 1
1 ibhedi elala abantu ababini
Igumbi lokulala 2
ibhedi elala umntu omnye eyi-1
Izinto enazo le ndawo
Ikhitshi
I-Wifi
Indawo yokupaka ngaphakathi esimahala
I-TV
Umatshini wokuhlamba impahla
Umatshini okhupha umoya obandayo okanye oshushu
Ibhafu
Iindawo zokuhlala phandle
Ayikho: Ialam yomsi otyhefayo
Ayikho: Ialam yomsi
Izimvo eziyi-2
- Izimvo eziyi-9
- Isazisi siqinisekisiwe
Credo che le persone si debbano sentire a casa loro nel mondo, e così vorrei che si sentissero a casa mia.
Ngexesha lokuhlala kwakho
I'll be your host for check in and check out.
In caso di necessità potete contattarmi via mail o cellulare.
Carmen sarà sempre disponibile se avrete necessità durante il soggiorno.
In caso di necessità potete contattarmi via mail o cellulare.
Carmen sarà sempre disponibile se avrete necessità durante il soggiorno.
- Ulwimi: English
- Izinga lokuphendula: 100%
- Ixesha lokuphendula: lungaphelanga usuku
Ukuze ukhusele ukubhatala kwakho, ungaze uthumele imali okanye uthethe nabantu ungasebenzisi iwebhsayithi okanye i-app yakwa-Airbnb.
Izinto ofanele uzazi
Imithetho yekhaya
Ixesha lokubhalisa xa ufika: Emva ko 15:00
Akutshaywa
Azivumelekanga izilwanyana zasekhaya
Ayivumelekanga imisitho okanye amatheko
Ezempilo nokhuseleko
Uzibophelele kwinkqubo yokucoca ephuculiweyo yakwa-Airbnb. Bonisa okungakumbi
Kusebenza izikhokelo zika-Airbnb zokungasondeli ebantwini nezinye ezinento yokwenza neCOVID-19
Ayikho ialam yomsi
Isixhobo sokuva umoya otyhefayo asidingeki Bonisa okungakumbi
Idiphozithi Yokhuseleko - ukuba wenza umonakalo kwikhaya, usenokubhataliswa ukuya kutsho kwi-$116
Imithetho engokurhoxa
Hlola ezinye iindawo onokukhetha kuzo e- Strambino
Iindawo ezingakumbi onokuhlala kuzo e Strambino:


text:
“Ukusebenza kwiNkundla yoMgaqosiseko kwabuguqula ubomi bam,” lawo ngamazwi kaYanela Ntloko welali yaseNgcingwane, eDutywa, emva kokuqeshwa yeyona nkundla inkulu eMzantsi Afrika. UYanela, 30, usebenza kwi-Ofisi yeJaji eyintloko eMzantsi Afrika, uMnu Mogoeng Mongoen. Ngonyaka wokugqibela esenza izifundo zakhe zomthetho (LLB Degree) e-Unisa, kwathi gqi ithuba lokusebenza neJaji eyiNtloko eza kuthatha umhlalaphantsi kungekudala. Oko yaba kukuzalisekiswa kwephupha lakhe uYanela ngoba ukuba ligqwetha yinto asuka nayo kwaGrade 7 emva kwesiganeko esibi esenzekayo esengumfundi eQumrha. “Amapolisa amhlophe asibuza ukuba sifuna ntoni edolophini, atsho esibamba singabafundi eQumrha. Emva koko, uMnu. Koki wasifundisa ngamalungelo oluntu esikolweni. Wonke umntu wayenowakhe umqulu. Owam wawugxile kumalungelo wabantwana. Ndaphuma esikolweni ndifuna ukuba ligqwetha,” utshilo uYanela.
Nangona wayeqinisekile ngokwenza izifundo zomthetho, uNtloko waphazanyiswa kakubi kukusweleka komntu obalulekileyo kuye, umakazi wakhe. Kodwa waya e-Unisa – apho afunde khona izifundo ezomthetho. Ithuba lokusebenza kwiNkundla yoMgaqosiseko lithe gqi xa egqibezela ngo-2015. Ethetha ngokubizwa kwakhe, uYanela uthe: “Ndandothukile emva kokuqeshwa kwam kanti kukufezekiswa kwephupha lam. Yinkundla ebaluleke kakhulu leya ngoba izigqibo zayo ziguqula ubomi babantu belizwe,” utshilo uYanela, owanexhala phambi kokuqala kwakhe. “Okwenzekayo kwaguqula ubomi bam. Ayekhona amagingxigingxi – kodwa ukusebenza neJaji eyintloko, kwandibonisa ukuba akukho nto engenokwenzeka xa ungathandabuzi,” utshilo uYanela.
“Unyaka endiqeshwe ngawo (2016) ibe sisiqalo sobomi bam kwezomthetho. Indlela endiwubona ngawo umthetho yaguquka ndafunda nendlela umthetho obanceda ngayo abantu,” utshilo uYanela, obalule ubuntu obenziwa nguJaji Mogoeng kwa ngomhla wokuqala wabo emsebenzini. Uthi uJaji Mogoeng wabamkela njengomzali wabo. “Bantwana bam, ndiyacela nilisebenzise kakuhle ithuba elinifumeneyo. Andifuni kuva kusithiwa kukho omnye wenu olambayo. Wazazisa kuthi ukuba ungubani watsho esithi ukuba kukho umntu odinga uncedo, angonqeni ukuthetha. Lawo mazwi afumana indawo yokuhlala entliziyweni yam. Xa uJaji Mogoeng efumene ithuba lokuthetha nabantu, usoloko ebanika amazwi wenkuthazo nobulumko,” utshilo uYanela, othwaliswe isidanga yiCampbridge University kwizifundo zomthetho (LLB Master) ngeli thuba leKhorona.
“2019 ndagqiba kwelokuba ndifunde kwakhona. Iphupha lam lakudala yayikukufunda e-Oxford University okanye eCampbridge University. Ngethamsanqa ndamkelwa yiCampbridge phambi kokufika kweKhorona. Ndasifumana isidinga kwezomthetho ndingumntana waseDutywa ebunzimeni. Le nto ithetha ukuthi nam indifanele into endiyifumeneyo nokuba ndiphuma phi. Endikufundileyo kukuba kufuneka uqine xa ufuna into nokuba kunzima kangakanani na. Yinto enkulu kakhulu kum le ngoba zininzi izinto endizifundileyo eCampbridge. Ayikangeni ncam into yokuba uYanela waseQelane ufunde eNgilane – kodwa umakhulu wam wayedla ngokuthi ubowaleqa amaphupha wakho nokuba awuwabamba onke. Oku ibe kukuzalisekiswa kwephupha lam,” utshilo uYanela.


text:
Ngaba ufuna imoto erentisayo? Emva koko ufikelele kwiphepha obukade ulikhangela. Sebenzisa eyethu umntu oqeshisa imoto kwaye ufumane enye ngexabiso elifanelekileyo kunye nazo zonke iziqinisekiso ezinokwenzeka.
Injini yokukhangela imoto yokuqeshisa
Ngaphezulu kwale migca uya kufumana i-injini yethu yokukhangela enamandla eya kukunceda ufumane Elona xabiso libalaseleyo liqinisekisiwe. Ukuyisebenzisa kulula kakhulu, ngenisa ngokulula indawo yokuqokelela, phawula imihla yokuqokelela kunye nokubuya kwaye kuya kufuneka ukhangele kwaye uya kuba nayo eyona nto uyiqeshayo kwimoto yakho.
Index
- 1 Injini yokukhangela imoto yokuqeshisa
- 2 Qasha imoto
- 3 Izinto eziluncedo ngokuqasha imoto
- 4 Qasha imoto kwi-Intanethi
- 5 I-injini yokukhangela ye-intanethi isebenza njani
- 6 Ndingayiqasha imoto ngaphandle kwekhadi letyala?
- 7 Isebenza njani imoto phakathi kwabantu?
Qasha imoto
Enye yezona nkxalabo zihlala zivela xa sicwangcisa uhambo lwethu, ngakumbi ukuba zikwinqanaba elikhulu, yinto emasiyenze xa sinesidingo kufuneka wenze iindlela zobunzima obuthile okanye uhambo oluya kwezinye iidolophu.
Uninzi lubalekela ukusetyenziswa kwezithuthi zikawonkewonke, nokuba kungenxa yokungabikho kwentuthuzelo kunye nenkululeko ngokweeshedyuli, njl. oku kuthetha ukuba, okanye kungenxa yokonyuka abakuvelisayo kwiindleko zizonke okanye kuhlahlo-lwabiwo mali. Nangona kunjalo, ukuhamba nesithuthi sethu akusoloko kusenzeka, kulapho umbono we iimoto eziqeshisayo.
Kusenokwenzeka ukuba ekuqaleni, ukuqasha imoto ngumsebenzi onzima, kodwa akukho nto inyanisekileyo. Emva koko, sichaza kwaye sikuncede ukuba wenze njani. Kwaye ukuba ufuna ukufumana elona xabiso lincinci kufuneka ucofe apha.
Izinto eziluncedo ngokuqasha imoto
Ukuthatha isigqibo sokucela imoto eqeshisayo kuhambo lwakho kunokuba neenzuzo ezinkulu:
- Inkululeko Iishedyuli zokuhamba nokuhamba.
- Mkhulu intuthuzelo.
- Cwangcisa iindlela kuxhomekeke kwiimfuno zakho.
- UkulondolozaKuba ukuqesha imoto, ukuba ayisiyiyo imoto ephezulu, inokuba nexabiso eliphakathi kwe- € 5 kunye ne- € 15 ngosuku. Nangona kunjalo, ukuba sikhethe izithuthi zikawonkewonke, le mali ingangaphezulu kakhulu.
- Ukubanakho ukuphatha i isixa esikhulu semithwalo.
Qasha imoto kwi-Intanethi
Okwangoku, kwinethiwekhi sifumana uluhlu olubanzi lweenkampani ezinikezelwe ekuqeshweni kwezithuthi ezisinika ithuba lokucela iinkonzo zazo ngokupheleleyo online. Kodwa le nto ayipheleli apha, kodwa sinenye inketho enje ngamaphepha ewebhu ahlukeneyo asinika iinjini zokukhangela ezilandelela phakathi kwee-franchise ezahlukileyo ezinikezelwe kweli candelo ukuze zisibonise Amaxabiso aphezulu.
Phakathi kwezona zibalaseleyo, sinokuthi:
Iimoto eziqeshisayo
IiRentalCars liqonga elikuvumela ukuba uthelekise bonke ababoneleli beenkonzo zokuqeshisa iimoto ukufumana elona xabiso liphantsi. Ukuyisebenzisa kulula kakhulu, nje kufuneka ucofe apha, Gcwalisa yonke idatha kwaye ngoku unokugcina imoto eqeshisayo ngexabiso elifanelekileyo.
ibhajethi
Uhlahlo-lwabiwo mali lusekwe eCalifornia, ngakumbi kwisixeko saseLos Angeles, ngo-1958. Yaqala njengeshishini losapho oluncinci elinemoto ezili-10 kuphela eziqeshisayo.
Namhlanje, inoluhlu olubanzi lweemoto, iilori kunye neeveni, ukongeza kwisimbuku se Iiofisi ezingama-3.400 ezikumazwe ali-128.
Europcar
Inkampani ekhethekileyo ukuqesha imoto eYurophu Ngaphezulu kweminyaka engama-60 yamava kwaye uthenjwe ngabathengi abangaphezu kwezigidi ezithandathu ngo-2014. Unokulufumana unikezelo lwabo ngokungena kule khonkco.
Zintsi
I-Six.es yinkonzo ekwi-Intanethi enikezela ngokuqeshisa iimoto kulo lonke elaseSpain nakwamanye amazwe angaphezu kwe-105 kwihlabathi liphela. Kwaye ngoku Ungabhukisha ngesaphulelo se-10% Enkosi kwi- AbsolutViajes ucofa apha. Ngaba uza kuliphosa ithuba?
KAYAK
Kule mihla, apho iiapps ziye zaba sisixhobo esibalulekileyo sokwenza ubomi bethu "bube lula", kuvela iKAYAK, injongo yayo kukusinika isandla xa sicwangcisa uhambo lwethu olufanelekileyo. ngokuthelekisa amaxabiso aphezulu phakathi kwamaphepha ewebhu ahlukeneyo. Kwaye, ewe, ikwasinika nethuba lokufumana imoto eqeshisayo efanele iimfuno zethu.
umbono
Umntu ngamnye unezinto azithandayo, yiyo loo nto i-Avis isinika i- izithuthi ezininzi Zonke iintlobo: ukusuka kwiimoto ezilula ukuya kwezinamandla kunye nobunewunewu. Ikwasinika rhoqo izaphulelo ezahlukeneyo rhoqo. Inketho yokuhlala uyikhumbula, nayo Ngoku unesibonelelo seentsuku ezi-3 ngexabiso le-2 ngokunqakraza apha.
I-injini yokukhangela ye-intanethi isebenza njani
Nokuba sijonge kwinjini yokukhangela ethelekisa amaxabiso phakathi kweenkampani ezahlukeneyo zokuqeshisa imoto okanye ukuba iyinjini yokukhangela kwinkampani ethile, ukusebenza kuhlala kufana.
Kuzo sikho Siza kubonisa isikrini esineebhokisi ezahlukeneyo kunye nokhetho ekufuneka silugcwalisile. Okokuqala, kufuneka sibonise indawo apho sinomdla wokuthatha khona isithuthi. Emva kwexesha, siza kubonisa imihla yokuqokelelwa kunye nokuhanjiswa okufanayo. Okokugqibela, kufuneka sichaze udidi kunye neempawu zesithuthi.
Kufuneka kuqatshelwe ukuba, ngokuxhomekeke kwinjini yokukhangela esetyenzisiweyo, sinyanzelekile ukuba sinikeze ezinye iintlobo zolwazi. Nangona kunjalo, ezi mfuno zikhankanywe apha ngasentla zezo zibonakala njengomthetho ngokubanzi kwiifom zokukhangela, kwaye amandla esiqhelo ahlala njengoko kuchaziwe.
Ndingayiqasha imoto ngaphandle kwekhadi letyala?
Uninzi lweenkampani ziyathandabuza ukuvumela ukuqeshiswa kwesithuthi ngokusebenzisa intlawulo yemali, kodwa funa kwikhadi le khredithi ngayo. Ke ngoko kunokuba yinto engenakwenzeka ukufumana imoto yokuqasha ngaphandle kolu hlobo lomsebenzi.
Isizathu sokwala imali esesandleni silula kakhulu. Iimoto ziyabiza, kunzima ukuzigcina kwaye, ngakumbi, zinokulungiswa kwezinye iimeko kunokuba kubiza kakhulu. Yiyo loo nto iinkampani kufuneka ziqinisekise ukuba iimoto azizukufumana monakalo kubangelwa ngabathengi, kwaye ukuba oku akuzalisekiswa, kufuneka bazame ukuzinciphisa azizukuvelisa ilahleko kwezoqoqosho. Ngale ndlela, bayila inshorensi eqhotyoshelweyo kwirente yezithuthi.
Ezi inshurensi zigcinwa kwidiphozithi ngohlobo lwemali oluya kubonelelwa kuphela ngumthengi kwimeko apho kufuneka khona (ukonakala koomatshini, ukwaphuka, ukubethwa, njl. Njl.). Ngamakhadi etyala kulula ukwenza olu hlobo lwedipozithi, "ukuvimba" isixa esithile semali esele ikhona eya kuthi "ikhutshwe" xa kuziswa imoto.
Nangona, njengoko yonke into ikhula kobu bomi, le meko ibingazukuba ncinane. Sele kwizixeko ezikhulu kukho iinkampani ezikulungeleyo ukurenta izithuthi zazo kuthi ngentlawulo yemali. Ukuhamba nge-intanethi kunzima ngakumbi, kodwa sele kukho iimeko ezithile ezinje nge-AutoEurope.
Isebenza njani imoto phakathi kwabantu?
Kumaxesha akutshanje, ukuqeshisa imoto kuye kwakho inguquko. Ngakumbi nangakumbi ziinkampani ezinganikeli ngezithuthi zazo, kodwa zisebenza ngabantu. Oko kukuthi, ngabantu abanomdla wokwenza ishishini okanye ukwenza inzuzo ethile ngubani banikela ngeemoto zabo ukuzenza zifumaneke kubasebenzisi.
Abanini bakhetha ixabiso kunye nokufumaneka, kwaye emva kokufumana isicelo sokurenta, bakhetha leyo babona ilunge kakhulu ngokusekwe kwimidla yabo. Emva kwexesha bayakuqinisekisa kwaye bathumele idilesi kunye nemiyalelo yokuthatha isithuthi kumqeshi.
Imoto ihlala kufuneka ibuyiswe ne itanki igcwele ngokupheleleyo ngamafutha (njengokuba yayinjalo ngexesha lonikezelo), kwaye bekunye, umnini kunye nomqeshi, jonga imeko yesithuthi ukuqinisekisa ukuba akukho monakalo ufumanekayo.
Inyathelo elidityaniswa ngabantu abaninzi nangakumbi abafuna ukufumana imali eyongezelelweyo.
Ukuthatha isigqibo sokuqasha imoto okanye naluphi na uhlobo lwesithuthi ngexesha lohambo lwethu kunokhetho olunzulu lokuba sisigqibo esingasayi kuzisola ngaso.
Ekuqaleni, sakuba sigqibile ukuyenza, sinokuba nemibuzo eliwaka kunye nokuthandabuza okuthile ezingqondweni zethu. Nangona kunjalo, xa sele sifunde konke oku kungentla, sinethemba lokuba yonke le mibuzo iphendulwe kwaye namathandabuzo aphelisiwe.


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ISouthern Kings neCheetahs ngamaqela amabini aseMzantsi Afrika adendwayo kwitumente yeSuper Rugby ekupheleni konyaka ka2017 emva kokuba ISANZAR ikhale ngokwehla kwezinga lale tumente.
Kwanyanzeleka ukuba iSaru ibe manxadanxada ikhangele itumente eza kugcina amaqela adlala kumgangatho ophezulu.
La maqela afunyanelwa indawo kwiPRO 14 equka amaqela akwilizwekazi laseYurophu.
Yenze kakuhle iCheetahs kule tumente, ilwe yoyiswa kumdlalo wokulwela indawo owandulela owamagqibela kankqoyi.
ICheetahs ibethwe ziintshatsheli ezikhuselayo iScarlets – kodwa bekunzima kakhulu kwiSouthern Kings.
IKings iphumelele umdlalo omnye kwimidlalo engamashumi amabini ananye eyidlalileyo.
Umdlali weKings, uNtabeni Dukisa, ukholelwa ukuba ukungaqheli ukudlala kwimvula nengqele yaseYurophu kube negalelo kwindlela abaqhube ngayo kwiPRO 14.
“Uninzi lwethu besingaqhelanga ukudlala kwimozulu enjeya yaye ndikholelwa ukuba isibethile kakhulu lo nto kwimidlalo emininzi,” utshilo uDukisa.
Noxa lingenzanga kakuhle iqela laseMpuma Koloni, le ndedeba ithi kuninzi abakufundileyo kwisizini yabo yokuqala kwiPRO 14.
“Ewe, asenzanga kakuhle kule tumente, kodwa kuninzi esikufundileyo. Amava esiwazuze kule sizini aza kusinceda ukubheka phambili,” utshilo uDukisa.
“Ukungadlali rhoqo ngenxa yokonzakala yenye yezinto ezindivise kabuhlungu kule sizini.”
Le ndedeba iyibulele inkxaso abayifumene kubalandeli bombhoxo baseMpuma Koloni.
“Okokuqala siyaxolisa ngokungenzi kakuhle. Siyabulela inkxaso nothando lwabo abasibonise lona,” utshilo uDukisa.
Kwezinye iindaba, iiBorder Bulldogs ziza kungquzulana ne-Eastern Province Elephants kumdlalo weSupersport Challenge.
Omabini la maqela awazihambeli kakuhle izinto kule tumente. IBulldogs ibethwe kuyo yomithathu, ngelixa zona iElephants ziphulukene nayo yobimibini eyazo imidlalo.
Eli dabi lamaqela aseMpuma Koloni liza kubaseBuffalo City Stadium ngentsimbi yezixhenxe malanga umhla weshumi elinanye kwekaCanzibe.


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ILILLIPUT igxile kuyilo, kuphuhliso nakwimveliso yezisombululo zesiko kwiimarike ezahlukeneyo. Iqela lobunjineli likaLILLIPUT liza kubonelela ngoyilo olunengqiqo kunye neenkonzo zobunjineli ezibandakanya:
Umsebenzi osebenzayo, uvavanyo lwebhedi yovavanyo lweHardware, uyilo loyilo lweSchematic, iimfuno zeBrand.
Indlu yesiqhelo
Ulwakhiwo sokubumbela uyilo kunye nokuqinisekisa, isampulu yokuqinisekisa isampulu
Indlu yesiqhelo
Uyilo lwePCB, ukuphuculwa koyilo lwebhodi yePcb, ukuyila kwenkqubo yeBhodi kunye nokulungisa ingxaki.
Indlu yesiqhelo
Inkqubo yokusebenza kwesoftware yesicelo, i-OS yokwenza ngokwezifiso kunye nokuhamba, inkqubo yomqhubi, uvavanyo lweSoftware kunye notshintsho, uvavanyo lweNkqubo.
Indlu yesiqhelo
Incwadana yokusebenza, uyilo lwePakeji.


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Zithe
xibilili izibilini zabalandeli beChippa United emva kokuba idlale ntanganye
neStellenbosch ngegowuli elinye macala (1-1) emdlalweni we-Absa Premiership
obubanjelwe eTuks Stadium ngorhatya lwanamhlanje. Igowuli elifakwe nguThokozani
Sekotlong ngomzuzu wokugqibela lilo elikhulule iChippa United ebihamba emva
kwiStellenbosch ehambe phambili ngegowuli elifakwe nguWaseem Isaacs kwangoko
kwisiqingatha sokuqala. Idemesha eyenziwe nguWaseem yenzeke emva kokuba
abadlali beChippa bengakwazanga ukuchitha ibhola ngaphakathi emhlabeni
kanozinti. UVeli Mothwa ngoyena nozinti obexakekile kwakwisigaba sokuqala
somdlalo ngoba iStellenbosch ibilelona qela ebelihlasela futhi lidala amathuba
acacileyo emdlalweni. Kuyiwe kwixesha lokuphumla iqela likaSteve Barker
linethuba lokuwuthathela kuwo umdlalo ngokupheleleyo.
Nangona
iChippa iye yawunyusa umdlalo wayo emva kwegowuli likaWaseem Isaacs – kodwa idlale
kakhulu kwisigaba sesibini somdlalo. UPhetso Maphanga noFrederic Nsabiyumva
benze umsebenzi oncomekayo emva ngoba iifolosi zeStellenbosch bezifuna igowuli
lesibini. Phambili, u-Andile Mbenyane no-Augustin Kwem bazamile ukuxhokonxa –
kodwa ukungena kukaKurt Lentjies noLehlohonolo Masalesa kukona kuye kwaguqula
izinto emdlalweni. Abadlali beChippa baquqe bebuyelela emhlabeni
weStellenbosch, uLee Langeveldt obevale mba ude wavuma ngomzuzu wokugqibela
sele kuncanyiwe. Iza kuhlala kwindawo yeshumi elinesibini iChippa, kanti yona
iStellenbosch ibambe indawo yesibhozo. Izolo, iMamelodi Sundowns ibethe iKaizer
Chiefs ngo’1-0. Yona iBloemfontein Celtic ibambene neBidvest Wits ngo’1-1. NgoLwesibini,
iSuperSport United ibethe iBlack Leopards ngo’1-0.