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Udidi lweziyobisi: Isizukulwana sesithathu se-cephalosporins
By Uhlaziyo lweMedia; Ukuhlaziywa ngu-Varixcare.cz. Igqityelwe ukuhlaziywa ngoFebruwari 19, 2021.
Kweli Phepha
- Inkcazo
- Ikhemesti yezonyango
- Iimpawu kunye nokusetyenziswa
- Ukungqinelana
- Izilumkiso
- Ukulumkela
- Ulwazi ngeNgcebiso ngezigulana
- Ukusebenzisana kweziyobisi
- Iziphumo ezingalunganga / Iziphumo ebezingalindelekanga
- Ukugqithisa
- Isisombululo kunye noLawulo
- Unikezo / ugcino kunye nokusingathwa
- Izalathiso
Iipilisi zeCefditoren Pivoxil 200 mg kunye ne-400 mg
Ukunciphisa ukukhula kweebhaktiriya ezinganyangekiyo ngamachiza kunye nokugcina ukusebenza kweepilisi zeCefditoren Pivoxil kunye nezinye iziyobisi ezichasene ne-antibacterial, iCefditoren Pivoxil kufuneka isetyenziselwe kuphela ukunyanga izifo ezithi zingqine okanye zikrokrelwe ngamandla ukuba zibangelwa ziintsholongwane.
Inkcazo yeCefditoren Pivoxil
Iipilisi zeCefditoren Pivoxil ziqulathe i-Cefditoren Pivoxil, i-semi-synthetic cephalosporin antibiotic yolawulo lomlomo. Yiprodrug ene-hydrolyzed by esterases ngexesha lokufakwa, kwaye ichiza lihanjiswa kwigazi elijikelezayo njenge-cefditoren esebenzayo.
Ngokwamachiza, iCefditoren Pivoxil ngu (-) - (6R, 7R) -2,2-dimethylpropionyloxymethyl 7 - [(Z) -2- (2-aminothiazol-4-yl) -2-methoxy-iminoacetamido] -3 - [(( Z) -2- (4-methylthiazol-5-yl) ethenyl] -8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylate. Ifomula yobungqina nguC25H28U-N6OKANYE7S3kunye nobunzima beemolekyuli ngu-620.73. Ifomula yolwakhiwo lweCefditoren Pivoxil iboniswe ngezantsi:
ICefditoren Pivoxil
Uhlobo lwe-amorphous lweCefditoren Pivoxil eyenzelwe ukusetyenziswa kweklinikhi ngumgubo otyheli omthubi. Isinyibilika ngokukhululekileyo ekunciphiseni ihydrochloric acid kwaye inyibilike kumanqanaba alingana no-6.06 mg / mL kwi-ethanol kunye<0.1 mg/mL in water.
Iipilisi zeCefditoren Pivoxil ziqulathe i-200 mg okanye i-400 mg ye-cefditoren njenge-Cefditoren Pivoxil kunye nezinye izinto ezingasebenziyo: i-croscarmellose sodium, i-mannitol, i-magnesium stearate, i-sodium caseinate (iprotein yobisi), kunye ne-sodium tripolyphosphate. Ipeyinti yecwecwe iqulethe i-carnauba wax, i-hypromellose, i-polyethylene glycol kunye ne-titanium dioxide. Amacwecwe aprintwe nge-inki equkethe i-opacode eluhlaza okwesibhakabhaka S-1-10533.
ICefditoren Pivoxil - Ikhemesti yezonyango
PharmacokineticsUkufunxa
Ukufumaneka komlomo ngomlomo
Ukulandela ukulawulwa ngomlomo, i-Cefditoren Pivoxil ifunxwe ukusuka kwithumbu lesisu kunye ne-hydrolyzed ukuya kwi-cefditoren ngama-esterases. Ubuninzi beeplasma (Cubuninziye-cefditoren phantsi kweemeko zokuzila umndilili we-1.8 ± 0.6 µg / mL kulandela idosi enye ye-200 mg kwaye yenzeka i-1.5 ukuya kwiiyure ezi-3 emva kedosi.
Ngaphantsi kokonyuka ngokulinganayo kwethamo kwiCubuninzikunye nendawo ephantsi kwekhefu lexesha lokuxinana (AUC) zajongwa kumthamo we-400 mg nangaphezulu. ICefditoren ayiqokeleli kwiplasma kulandela ukulawulwa kabini kwemihla ngemihla kwizifundo ezinomsebenzi oqhelekileyo we-renal. Ngaphantsi kweemeko zokuzila, uqikelelo lokufumaneka ngokupheleleyo kweCefditoren Pivoxil lumalunga ne-14%. Ukufumaneka ngokupheleleyo kweCefditoren Pivoxil kulawulwa ngesidlo esinamafutha asezantsi (i-693 cal, 14 g fat, 122 g carb, 23 g protein) yi-16.1 ± 3.0%.
Iziphumo zokutya
Ulawulo lweCefditoren Pivoxil kulandela ukutya okunamafutha aphezulu (i-858 cal, 64 g fat, 43 g carb, 31 g protein) kukhokelele kwi-70% yokunyuka kwe-AUC kunye ne-50% yokunyuka kwe-C.ubuninzixa kuthelekiswa nolawulo lweCefditoren Pivoxil kwimeko yokuzila. Emva kwesidlo esinamafutha aphezulu, uCubuninziI-avareji ye-3.1 ± 1.0 µg / mL ilandela idosi enye ye-200 mg yeCefditoren Pivoxil kunye no-4.4 ± 0.9 µg / mL kulandela idosi eyi-400 mg. ICefditoren AUC kunye noCubuninziIxabiso elivela kwizifundo ezenziwa ngesidlo esinamafutha asezantsi (i-648 cal, 27 g fat, 73 g carb, 29 g protein) ziyafana nezo zifunyenwe kulandela ukutya okunamafutha aphezulu.Ukuhanjiswa
Umthamo wentetho yokuhanjiswa kwimeko ezinzileyo (VssI-cefditoren yi-9.3 ± 1.6 L. Ukubopha kwe-cefditoren kwiiproteni zeplasma zi-avareji ye-88% ukusukai-In vitroUkuchongwa, kwaye ukuzimelela koxinaniso kwi-cefditoren concentrations ukusuka kwi-0.05 ukuya kwi-10 µg / mL. ICefditoren ikakhulu ibotshelelwe kwi-albhamu ye-serum yomntu kwaye ukubopha kwayo kuyancipha xa i-serum albumin concentrations incitshisiwe. Ukubopha kwi-a-1-acid glycoprotein isusela kwi-3.3 ukuya kwi-8.1%. Ukungena kwiiseli ezibomvu zegazi akunantsingiselo.
Ulusu blister fluid
Ubuninzi be-cefditoren kwi-blister fluid eyenziweyo ifunyenwe i-4 ukuya kwiiyure ze-6 emva kolawulo lwedosi ye-400 mg yeCefditoren Pivoxil enentsingiselo ye-1.1 ± 0.42 µg / mL. Kuthetha ukuba amaxabiso e-blister fluid AX amaxabiso ayengama-56 ± 15% yeeplasma ezixineneyo.
Iitoni
Kwizigulana ezikhawulezileyo ezenza i-tonsillectomy ekhethiweyo, uxinzelelo lwe-cefditoren kwithishu yeethoni 2 ukuya kwiiyure ze-4 emva kolawulo lwedosi ye-200 mg yeCefditoren Pivoxil yayiyi-0.18 ± 0.07 µg / g. Kuthetha ukuba iithoni zoxinaniso lwe-cefditoren yayiyi-12 ± 3% yezingqinisiso ze-serum ezihambelanayo.
Ulwelo lweCerebrospinal (CSF)
Idatha yokungena kwe-cefditoren kulwelo lwe-cerebrospinal fluid ayifumaneki.Imetabolism kunye nokuNgena
I-Cefditoren isuswe kwi-plasma, inesiphelo sokuphelisa ukuphela kobomi (t1/2I-1.6 ± 0.4 yeeyure kubantu abadala abasempilweni. ICefditoren ayixatyiswanga kakuhle. Emva kokufakwa, i-cefditoren isuswa ikakhulu kukukhutshwa komchamo, ngokususwa kwezintso malunga ne-4-5 L / h. Izifundo ezenziwa nge-arhente yokuthintela i-tubular ye-arhente yokuthintela i-probenecid ibonisa ukuba ukhuseleko lwe-tubular, kunye ne-glomerular filtration iyabandakanyeka ekususeni i-cefditoren. Ukususwa kwezintso kwi-Cefditoren kuncitshisiwe kwizigulana ezinokungoneliseki kwezintso. (Jonga abantu abakhethekileyo,Ukungoneliseki kweNtsokwayeUhlalutyo lweHemodialysis.)
I-Hydrolysis yeCefditoren Pivoxil kwicandelo layo elisebenzayo, i-cefditoren, ikhokelela ekwenziweni kwepivalate. Ukulandela idosi ezininzi zeCefditoren Pivoxil, ngaphezulu kwe-70% ye-pivalate ifunxwe. I-pivalate ikakhulu ishenxiswa (> 99%) ngokukhutshwa kwezintso, phantse ngokukodwa njenge-pivaloylcarnitine. Ukulandela irejimeni ye-200 mg ye-BID yeentsuku ezili-10, intsingiselo yokwehla kweeplasma ye-carnitine iyonke yayiyi-18.1 ± 7.2 nmole / mL, emele ukwehla kwe-39% kwi-plasma carnitine concentrations. Ukulandela irejimeni ye-400 mg ye-BID yeentsuku ezili-14, ukwehla kokuthetha koxinaniso lweplasma ye-carnitine yayiyi-33.3 ± 9.7 nmole / mL, emele ukwehla ngama-63% kwi-plasma carnitine concentrations. Ukugxilwa kwePlasma ye-carnitine kubuyile kuluhlu oluqhelekileyo lokulawula ngaphakathi kwe-7 ukuya kwiintsuku ezili-10 emva kokupheliswa kweCefditoren Pivoxil. (JongaUKULUMKELA,ngokubanzikwayeULAWULO.)Abemi abakhethekileyo
Geriatric
Iziphumo zobudala kwi-pharmacokinetics ye-cefditoren yavavanywa kwizifundo ezingama-48 zamadoda nabasetyhini abaneminyaka engama-25 ukuya kwengama-75 banikwa i-400 mg Cefditoren Pivoxil BID yeentsuku ezisi-7. Utshintsho lomzimba olunxulumene nokwanda kweminyaka lukonyusa ubungakanani bokuvezwa kwe-cefditoren kwi-plasma, njengoko kungqinwa yi-26% ephezulu Cubuninzikunye ne-33% ephezulu ye-AUC kwizifundo ezineminyaka engama- years iminyaka engama-65 xa kuthelekiswa nezifundo ezincinci. Inqanaba lokususwa kwe-cefditoren kwi-plasma yayisezantsi kwizifundo ezineminyaka eyi-years engama-65, nge-t1/2Ixabiso le-16-26% ixesha elide kunezifundo ezincinane. Ukucinywa kwe-renal kwe-cefditoren kwizifundo ezineminyaka eyi-65 iminyaka yayiyi-20-24% isezantsi kunezona zifundo zincinci. Olu tshintsho lunokubalelwa kwiinguqu ezinxulumene nobudala kugqitho lwe-creatinine. Akukho luhlengahlengiso lwedosi luyimfuneko kwizigulana ezindala ezinesiqhelo (kubudala bazo) umsebenzi we-renal.
Isini
Iziphumo zesini kwi-pharmacokinetics ye-cefditoren yavavanywa kwizifundo ezingama-24 zamadoda kunye nezi-24 zabasetyhini ezinikwe i-400 mg Cefditoren Pivoxil BID yeentsuku ezisi-7. Ubungakanani bokuvezwa kwiplasma kwakukukhulu kubantu basetyhini kunakwamadoda, njengoko kungqinwa yi-14% ephezulu yeCubuninzikunye ne-16% ephezulu ye-AUC yamabhinqa xa kuthelekiswa neyamadoda. Ukucoca i-renal kwe-cefditoren kwabasetyhini yayiyi-13% isezantsi kunamadoda. Lo mahluko unokubangelwa kukungafani okunxulumene nesini kubunzima bomzimba. Akukho luhlengahlengiso lwethamo luyimfuneko kwisini.
Ukungoneliseki kweNtso
ICefditoren pharmacokinetics iphandwe kwizifundo zabantu abadala ezingama-24 ezinamanqanaba ohlukeneyo omsebenzi wokurhola emva kolawulo lweCefditoren Pivoxil 400 mg BID yeentsuku ezisi-7. Ukuncipha kwemvume yokudala (CLcr) yayanyaniswa nokonyuka kwesiqwengana se-cefditoren engafakwanga kwiplasma kunye nokwehla kwenqanaba lokususa i-cefditoren, kukhokelela ekuvezweni okungaphezulu kwenkqubo kwizifundo ezinokukhubazeka kwezintso. C ongasikelwanga mdaubuninzikwaye i-AUC yayifana kwizifundo ezinobuthathaka obuthathaka bezintso (CLcr: 50-80 mL / min / 1.73 m2) xa kuthelekiswa nezifundo ezinomsebenzi oqhelekileyo wezintso (CLcr:> 80 mL / min / 1.73 m2). Iphakathi (CLcr: 30-49 ml / min / 1.73 m2okanye ezinzima (CLcr:<30 mL/min/1.73 m2) Ukukhubazeka kwezintso kwonyuse ubungakanani bokuvezwa kwiplasma, njengoko kungqinwa kukungagungqi kweCubuninziamaxabiso angama-90% kunye no-114% ngaphezulu kunye ne-AUC ama-232% nama-324% ngaphezulu kunaleyo yezifundo ezinomsebenzi oqhelekileyo wezintso. Ireyithi yokupheliswa kweplasma yayisezantsi kwizifundo ezinokungahambi kakuhle okanye ukukhubazeka okukhulu kwezintso, kunye nentsingiselo efanelekileyo t1/2Ixabiso le-2.7 kunye neeyure ezingama-4.7. Akukho lungelelwaniso lwethamo luyimfuneko kwizigulana ezinokukhubazeka okuncinci kwezintso (CLcr: 50-80 mL / min / 1.73 m2). Kuyacetyiswa ukuba kungabikho ngaphezulu kwe-200 mg ye-BID enikezelwa kwizigulana ezinokuthothisa kwezintso ngokulinganayo (CLcr: 30-49 ml / min / 1.73 m2) kunye ne-200 mg QD inokwenziwa kwizigulana ezinokukhubazeka okukhulu kwezintso (CLcr:<30 mL/min/1.73 m2). (JongaIDOSI NOLAWULO.)
Uhlalutyo lweHemodialysis
ICefditoren pharmacokinetics iphandwe kwizifundo zabantu abadala ezithandathu ezinesifo se-renal sokugqibela (ESRD) esenza i-hemodialysis enikwe idosi enye ye-400 mg yeCefditoren Pivoxil yahluka kakhulu. Intsingiselo t1/2yayiziiyure ezingama-4.7 zaza zaqala kwiiyure eziyi-1.5 ukuya kwezili-15. IHemodialysis (ixesha leeyure ezi-4) isuswe malunga neepesenti ezingama-30 ze-cefditoren ukusuka ekujikelezeni kwenkqubo kodwa ayitshintshanga ukuphela kokupheliswa kwesiqingatha sobomi. Idosi efanelekileyo yezigulana ze-ESRD ayichongwanga. (JongaIDOSI NOLAWULO.)
Isifo sesibindi
I-Cefditoren pharmacokinetics yavavanywa kwizifundo zabantu abadala ezithandathu ezinokuthothisa okungathethekiyo kwe-hepatic (Umntwana-uPugh Class A) kunye nesithandathu esinokukhubazeka okuphakathi kwe-hepatic (Umntwana-Pugh Class B). Ukulandela ukulawulwa kweCefditoren Pivoxil 400 mg BID yeentsuku ezisi-7 kwezi zifundo, kuthetha ukuba uCubuninzikwaye amaxabiso e-AUC ayemancinci (<15%) greater than those observed in normal subjects. No dose adjustments are necessary for patients with mild or moderate hepatic impairment (Child-Pugh Class A or B). The pharmacokinetics of cefditoren in subjects with severe hepatic impairment (Child-Pugh Class C) have not been studied.
Microbiology
I-Cefditoren yi-cephalosporin enomsebenzi we-antibacterial ngokuchasene ne-gram-positive kunye ne-gram-negative pathogen. Umsebenzi we-bactericidal we-cefditoren uvela kuthintelo lwe-synthesis yodonga lweseli ngokudibana kweeproteni ezibopha ipenicillin (PBPs).
I-Cefditoren izinzile xa kukho iintlobo ze-lact-lactamases, kubandakanya iipenicillinase kunye nezinye ze-cephalosporinases. ICefditoren ibonakalisiwe ukuba iyasebenza ngokuchasene neentlobo ezininzi zebacteria zilandelayo, zombinii-In vitronakusulelo lweklinikhi, njengoko kuchaziwe kwiIZALATHISO NOSETYENZISOicandelo.
I-Aerobic Gram-Positive Microorganisms
IStaphylococcus aureus(Iintlobo ze-methicillin-ezichaphazelekayo, kubandakanya i-ß-lactamase-Production strains)
Qaphela: ICefditoren ayisebenzi ngokuchasene nemethicillin-resistantIStaphylococcus aureus
IStreptococcus pneumoniae(Iintlobo zeepenicillin ezinokubakho kuphela)
IStreptococcus pyogenes
I-Aerobic Gram-Negative Microorganisms
Haemophilus influenzae(kubandakanya iintlobo ze-ß-lactamase ezivelisa)
Haemophilus parainfluenzae(kubandakanya iintlobo ze-ß-lactamase ezivelisa)
UMoraxella catarrhalis(kubandakanya iintlobo ze-ß-lactamase ezivelisa)
Ezilandelayoi-In vitroidatha iyafumaneka,kodwa ukubaluleka kwazo kwezonyango akwaziwa. Imiboniso yeCefditoreni-In vitroUbuncinci be-inhibitory concentrations (MICs) ye-≦ 0.125 µg / mL ngokuchasene uninzi (≧ 90%) iintlobo zezi bhakteriya zilandelayo; Nangona kunjalo, ukhuseleko kunye nokusebenza kwe-cefditoren kunyango losulelo lweklinikhi ngenxa yezi ntsholongwane khange kumiselwe kwizilingo ezaneleyo nezilawulwa kakuhle.
I-Aerobic Gram-Positive Microorganisms
IStreptococcus agalactiae
IStreptococcusAmaqela C no-G
IStreptococcus, iqela le-viridans (iintlobo zeepenicillin ezinokuthi zithinteke kwaye ziphakathi)
Uvavanyo lokuqonda
Iindlela zokuCoca
Iindlela zobungakanani ezisetyenziselwa ukumisela ii-MICs zibonelela ngoqikelelo olunokuphinda lubekho kwiintsholongwane. Ii-MICs kufuneka zimiselwe kusetyenziswa inkqubo emiselweyo. Iinkqubo ezimiselweyo zisekwe kwiindlela zokunyibilikisa1(umhluzi) okanye ulingana nokuxinana kwe-inoculum esemgangathweni kunye nokugxininiswa okumiselweyo komgubo we-cefditoren. Amaxabiso eMIC afunyenweyo kufuneka atolikwe ngokwezi khrayitheriya zilandelayo:
UkuvavanyaHaemophilusspp.ukuyakwayeIStreptococcusspp. kubandakanyaS. pneumoniaeb:
ukuyaLo mgangatho wokutolika usebenza kuphela kuvavanyo lokuchaphazeleka kwengqondo yomhluzi ngeHaemophilusspp. usebenzisaHaemophilusUvavanyo oluPhakathi (HTM).1
bLe migangatho yokutolika isebenza kuphela kwiimvavanyo zokuchaphazeleka komhluzi nge-microdilutionIStreptococcusspp. usebenzisa umhluzi ohlengahlengisiweyo we-Mueller-Hinton broth ene-2-5% yegazi lehashe eligreyidiweyo.1
Iikhrayitheriya zovavanyo lokuqonda ukungabinakho ukusekwaS. aureus
Ingxelo ye-Susceptible ibonisa ukuba i-pathogen inokuthi ithintelwe ukuba i-antimicrobial compound egazini ifikelela kuxinzelelo oluqhele ukufezekiseka. Ingxelo yesiGaba esiPhakathi ibonisa ukuba iziphumo kufuneka zithathelwe ingqalelo ngokulinganayo, kwaye, ukuba i-microorganism ayinabungozi ngokupheleleyo kwezinye iindlela, amayeza afanelekileyo eklinikhi, uvavanyo kufuneka luphindwe. Eli nqanaba lithetha ukuba kunokwenzeka kokusebenza kweeklinikhi kwiindawo zomzimba apho iyeza ligxile emzimbeni okanye kwiimeko apho kunokusetyenziswa idosi ephezulu. Eli nqanaba likwabonelela ngendawo yokuthintela ethintela izinto ezincinci, ezingalawulwayo kubuchwephesha ekubangeleni ukungangqinelani okukhulu kutoliko. Ingxelo ye-Resistant ibonisa ukuba i-pathogen ayinakuthintelwa ukuba i-antimicrobial compound egazini ifikelela ekugxininiseni ngokuqhelekileyo inokufezekiswa kwaye olunye unyango kufuneka lukhethwe.
Iinkqubo zovavanyo lokuchaphazeleka ngokusemgangathweni zifuna ukusetyenziswa kolawulo lweelebhu zentsholongwane ukulawula imiba yezobuchwephesha yeenkqubo zaselebhu. I-cefditoren powder esemgangathweni kufuneka ibonelele ngezi zinto zilandelayo ze-MIC kwezi ntlobo zolawulo lomgangatho:
ukuyaOlu luhlu lolawulo lomgangatho lusebenza kuphelaS. pneumoniaeI-ATCC 49619 ivavanywe yinkqubo ye-microdilution isebenzisa i-cation-adjusted Mueller-Hinton broth ene-2-5% yegazi eligaziweyo.1
bOlu luhlu lolawulo lomgangatho lusebenza kuphelaH. influenzaeI-ATCC 49247 kunye ne-ATCC 49766 kuvavanywa inkqubo ye-microdilution kusetyenziswa i-HTM.1
Iimpawu kunye nokusetyenziswa kweCefditoren Pivoxil
I-Cefditoren Pivoxil ibonakalisiwe kunyango losulelo olungephi ukuya kolulinganiselweyo kubantu abadala nakwishumi elivisayo (abaneminyaka eli-12 ubudala okanye ngaphezulu) ezibangelwa ziintsholongwane ezinokuchaphazeleka kwizifo ezichongiweyo kwezi meko zidweliswe ngezantsi.
Ukwanda kweBacterial Exacerbation ye-Bronchitis engapheliyoyenziwe nguHaemophilus influenzae(kubandakanya iintlobo ze-ß-lactamase ezivelisa),Haemophilus parainfluenzae(kubandakanya i-ß-lactamase yokuvelisa iintlobo),IStreptococcus pneumoniae(penicillin susceptible strains), okanyeUMoraxella catarrhalis(kubandakanya iintlobo ze-ß-lactamase ezivelisa).
I-Pneumonia eFunyenwe nguLuntuyenziwe nguHaemophilus influenzae(kubandakanya iintlobo ze-ß-lactamase ezivelisa),Haemophilus parainfluenzae(kubandakanya iintlobo ze-ß-lactamase ezivelisa),IStreptococcus pneumoniae(iintlobo ezinobungozi beepenicillin kuphela), okanyeUMoraxella catarrhalis(kubandakanya i-ß-lactamase yokuvelisa iintlobo).
iziphumo ebezingalindelekanga ze-meloxicam kunye notywala
Pharyngitis / tonsilsyenziwe nguIStreptococcus pyogenes. QAPHELA: I-Cefditoren Pivoxil iyasebenza ekupheliseni iIStreptococcus pyogenesukusuka kwi-oropharynx. Amacwecwe e-Cefditoren Pivoxil khange afundwe kuthintelo lwe-rheumatic fever elandelayoIStreptococcus pyogenespharyngitis / tonsillitis. Kuphela yi-penicillin ye-intramuscular ebonakalisiweyo ukuba iyasebenza ekuthinteleni i-rheumatic fever.
Ulusu oluntsonkothileyo kunye noSulelo loLwakhiwo lolusuyenziwe nguIStaphylococcus aureus(kubandakanya iintlobo ezivelisa lact-lactamase) okanyeIStreptococcus pyogenes.
Ukunciphisa ukukhula kweebhaktiriya ezinganyangekiyo ngamachiza kunye nokugcina ukusebenza kweCefditoren Pivoxil kunye nezinye iziyobisi ezichasene ne-antibacterial, iCefditoren Pivoxil kufuneka isetyenziselwe kuphela ukunyanga izifo ezithi zingqine okanye zikrokrelwe ngamandla ukuba zibangelwa ziintsholongwane. Xa inkcubeko kunye nolwazi lokuchaphazeleka lufumaneka, kufuneka ziqwalaselwe xa kukhethwa okanye kuguqulwa unyango lwe-antibacterial. Ukungabikho kwedatha enjalo, i-epidemiology yendawo kunye neepateni zokuchaphazeleka kunokuba negalelo kukhetho lonyango olunamandla.
Ukungqinelana
I-Cefditoren Pivoxil iyaphikiswa kwizigulana ezinokwaliwa kwiklasi ye-cephalosporin ye-antibiotics okanye naliphi na icandelo layo.
I-Cefditoren Pivoxil iyaphikiswa kwizigulana ezinesiphene se-carnitine okanye iimpazamo ezizelwe kwimetabolism ezinokubangela ukunqongophala kwe-carnitine eklinikhi, kuba ukusetyenziswa kweCefditoren Pivoxil kubangela ukuphuma kwezintso kwe-carnitine. (JongaAMANYATHELO, Ngokubanzi.)
Iipilisi zeCefditoren Pivoxil ziqukethe i-sodium caseinate, iprotheni yobisi. Izigulana ezinobisi lweeprotein hypersensitivity (hayi ukunganyamezelani kwe-lactose) akufuneki zinikezwe iCefditoren Pivoxil.
Izilumkiso
NGAPHAMBI KOKUNYANGISWA KUNYE NE-Cefditoren Pivoxil ISETYENZISIWE, KUFUNEKA KWENZIWE UKUBA KUFUNYANWE UKUBA UMGAQO UTHETHE NJANI UKUGQIBELA KWI-CYPERSENSITIVITY TO Cefditoren Pivoxil, EZINYE I-ORPHALOSPORINS, UKUBA i-Cefditoren Pivoxil iza kunikwa abaguli be-PENICILLIN-SENSITIVE PATIENTS, ISILUMKISO KUFUNEKA SISETYENZISWE NGOKUBA UMNQOPHISO WE-CROSS-HYPERSENSITIVITY PHAKATHI KWI-LACTAM ANTIBIOTICS KUQHELEKILE NGOKUQHELEKILEYO UKUGQIBELA I-AITI I-ITI IYA KUKUQHUBA I-AYI NGOKUQHELEKILEYO. UKUBA UKUSETYENZISWA KWE-ALERGIC KWI-Cefditoren Pivoxil KUYENZEKA, IZIYOBISI AZIYEKI. IZINTO EZINOKWENZEKA ZINOKUFUNA UNYANGO NGE-EPINEPHRINE KUNYE NEZINYE IIMILINGANISO ZOKUNGXAMISEKA, KUFUNEKA I-OXYGEN, I-FLUIDS EZITHANDEKAYO, I-ANTIHISTAMINES EZITHANDEKAYO, I-CORTICOSTERO INCOSAZI, I-AYISIMAZI YOKUFUNDA.
I-Pseudomembranous colitis iye yaxelwa phantse kuzo zonke iiarhente zokulwa neentsholongwane, kubandakanya iCefditoren Pivoxil, kwaye inokuthi iqale ngobukrakra ukusuka kubumnene ukuya kusongela ubomi. Ke ngoko, kubalulekile ukuba uqwalasele oku kufunyanwa kwizigulana ezinikezela kurhudo emva kolawulo lweearhente zokulwa neentsholongwane.
Unyango kunye neearhente zokulwa neentsholongwane lutshintsha iintyatyambo eziqhelekileyo zekolon kwaye lunokuvumela ukwanda kwe-clostridia. Izifundo zibonisa ukuba ityhefu eveliswe yiIClostridium difficile (C. difficile)ngoyena nobangela uphambili wesifo sokudumba okuchasene namayeza.
Emva kokuba kufunyaniswe isifo sepseudomembranous colitis, kufanelekile amanyathelo onyango. Amatyala amancinci e-pseudomembranous colitis ahlala ephendula ekuyekisweni kweziyobisi kuphela. Kwimeko ezimodareyithi ukuya kwezinzima, kufuneka kuthathelwe ingqalelo kulawulo olunamanzi kunye neelectrolyte, isongezelelo seprotein, kunye nonyango lwechiza lokulwa neentsholongwane.Kunzimaukudumba.
Ukulumkela
ngokubanzi
Ukumisela i-Cefditoren Pivoxil ngokungabikho kosulelo lwebhaktiriya oluqinisekisiweyo okanye olurhanelwa okanye isibonakaliso seprophylactic akunakulindeleka ukuba sibonelele kwisigulana kwaye sonyusa umngcipheko wophuhliso lweebhaktheriya ezinganyangekiyo ngamachiza.
I-Cefditoren Pivoxil ayikhuthazwa xa unyango olude lwe-antibiotic luyimfuneko, kuba ezinye iikhompawundi eziqulethe izoyikiso zibangele ukubonakaliswa kweklinikhi yokunqongophala kwe-carnitine xa isetyenziswe kwisithuba seenyanga. Akukho ziphumo zeklinikhi yokuncipha kwe-carnitine enxulumene nonyango lwexesha elifutshane. Iziphumo ekugxininiseni kwe-carnitine yeekharityhulamu zexesha elifutshane eziphindaphindiweyo zeCefditoren Pivoxil aziwa.
Kwizigulana zenyumoniya ezifumaneke eluntwini (N = 192, iminyaka engama-50.3 ± 17.2 yeminyaka) inikwe irejimeni ye-200 mg ye-BID kangangeentsuku ezili-14, ukwehla kokuthetha koxinzelelo lwe-serum ye-carnitine iyonke ngelixa kunyango yayiyi-13.8 ± 10.8 nmole / mL, emele I-30% yehle kwi-serum carnitine concentrations. Kwizigulana zenyumoniya ezifunyenwe luluntu (N = 192, iminyaka engama-51.3 ± 17.8 yeminyaka) inikwe irejimeni ye-BID engama-400 mg kangangeentsuku ezili-14, ukwehla kokuthetha koxinzelelo lwe-serum ye-carnitine iyonke ngelixa kunyango yayiyi-21.5 ± 13.1 mole / mL, emele Ukuhla kwe-46% kwi-serum carnitine concentrations. Ukugxilwa kwePlasma ye-carnitine kubuyile kuluhlu oluqhelekileyo lokulawula ngaphakathi kweentsuku ezisi-7 emva kokupheliswa kweCefditoren Pivoxil. Ukwehla kokuthelekiswa kwe-carnitine kwabonwa kumavolontiya asempilweni (iminyaka yobudala engama-33.6 ± 7.4 iminyaka) kulandela irejimeni ye-200 mg okanye ye-400 mg ye-BID. (JongaIKHEMIKHALI YEKHAYAUvavanyo lwenyumoniya olufunyenwe eluntwini alubonisanga ziganeko zichaphazela ukwehla koxinzelelo lwe-serum carnitine.
Nangona kunjalo, abanye abantu abaphantsi (umz. Ngapha koko, idosi efanelekileyo kwizigulana ezinesifo se-renal sokugqibela asichongwanga. (JongaIdosi NOLAWULO, abaguli abanesifo sokungasebenzi kakuhle).
Njengakwamanye amayeza okubulala iintsholongwane, unyango olude lungakhokelela ekuveleni nasekukhuleni kwezinto ezinganyangekiyo. Ukuqwalaselwa ngononophelo kwesigulana kubalulekile. Ukuba ukosuleleka kakhulu kwenzeka ngexesha lonyango, kufuneka kwenziwe olunye unyango olufanelekileyo.
I-Cephalosporins inokunxulunyaniswa nokuwa komsebenzi weprothrombin. Abo basemngciphekweni babandakanya abaguli abane-renal okanye i-hepatic impair, okanye imeko yokungondleki, kunye nezigulana ezifumana ikhosi yexesha elide yonyango lwe-antimicrobial, kunye nezigulana ebezizinziswe ngaphambili kunyango lwe-anticoagulant. Ixesha leprothrombin kufuneka libekwe esweni kwizigulana ezisemngciphekweni kunye nevithamini K engaphandle elawulwa njengoko kubonisiwe. Kwezilingo zeklinikhi, kwakungekho mahluko phakathi kwe-cefditoren kunye ne-cephalosporins yokuthelekisa kwimeko yexesha elandayo leprothrombin.
Ulwazi kubaguli
Izigulana kufuneka zicetyiswe ukuba iziyobisi ezichasene ne-antibacterial kubandakanya ne-Cefditoren Pivoxil kufuneka zisetyenziselwe kuphela ukunyanga izifo ezosulelayo. Abalunyangi usulelo lwentsholongwane (umzekelo, ingqele eqhelekileyo). Xa iCefditoren Pivoxil imiselwe ukunyanga usulelo lwebacteria, izigulana kufuneka zixelelwe ukuba nangona kuqhelekile ukuba uzive ungcono kwikhosi yonyango, amayeza kufuneka athathwe kanye njengoko kuyalelwe. Ukutsiba iidosi okanye ukungaligqibi ikhosi epheleleyo yonyango kunoku (1) kunciphise ukusebenza konyango olukhawulezileyo kwaye (2) kwandise amathuba okuba iintsholongwane zikhule zichasane kwaye azizukunyangwa nguCefditoren Pivoxil okanye ezinye iziyobisi ezichasayo kwixa elizayo.
I-Cefditoren Pivoxil kufuneka ithathwe kunye nokutya ukuphucula ukufunxeka.
I-Cefditoren Pivoxil inokuthi ithathwe ngokudibeneyo kunye nezicwangcisi zomlomo.
Akukhuthazwa ukuba iCefditoren Pivoxil ithathwe ngokukhawuleza kunye ne-antacids okanye ezinye iziyobisi ezithathwa ukunciphisa isisu. (JongaAMANYATHELO, Unxibelelwano lweziyobisi.)
Iipilisi zeCefditoren Pivoxil ziqukethe i-sodium caseinate, iprotheni yobisi. Izigulana ezinobisi lweeprotein hypersensitivity (hayi ukunganyamezelani kwe-lactose) akufuneki zinikezwe iCefditoren Pivoxil.
Ukusebenzisana kweziyobisiIzinto zokucwangcisa zomlomo
Iidosi ezininzi zeCefditoren Pivoxil zazingenampembelelo kwi-pharmacokinetics ye-ethinyl estradiol, icandelo le-estrogenic kuninzi lokucwangcisa ngomlomo.IiAntacids
Ukulawulwa ngokudibeneyo kwethamo elinye le-antacid equle zombini i-magnesium (800 mg) kunye ne-aluminium (900 mg) i-hydroxides inciphise ukufakwa ngomlomo kwethamo elinye le-400 mg yeCefditoren Pivoxil elawulwa emva kwesidlo, njengoko kungqinwa ukwehla kwe-14% Kuthetha ukuba nguCubuninzikunye nokwehla nge-11% kwi-AUC. Nangona ukubaluleka kweklinikhi kungaziwa, ayikhuthazwa into yokuba iCefditoren Pivoxil ithathwe ngokudibeneyo ne-antacids.H2-Izichasi ezichasene nomamkeli
Ukulawulwa ngokudibeneyo kwethamo elinye le-famotidine (20 mg) efakwe ngaphakathi ngaphakathi yanciphisa ukufakwa ngomlomo kwethamo elinye le-400 mg yeCefditoren Pivoxil elawulwa emva kwesidlo, njengoko kungqinwa ukwehla kwe-27% kwentsingiselo Cubuninzikunye ne-22% yokwehla kwe-AUC. Nangona ukubaluleka kweklinikhi kungaziwa, ayikhuthazwa into yokuba iCefditoren Pivoxil ithathwe ngokudibeneyo ne-H2abachasi be-receptor.Iiprobene
Njengakwezinye i-ß-lactam antibiotics, ukusebenzisana ngokubambisana kwe-probenecid kunye neCefditoren Pivoxil kukhokelele ekwandeni kokuvezwa kweplasma ye-cefditoren, nge-49% yokunyuka kwe-Cubuninzi, i-122% inyuka kwi-AUC, kunye ne-53% inyuke ngo-t1/2.
Ukudibana kovavanyo lweziyobisi / elebhu
I-Cephalosporins yaziwa ukuba ngamanye amaxesha ifaka uvavanyo oluchanekileyo lwe-Coombs. Impendulo engeyonyani yeglucose kumchamo inokwenzeka ngovavanyo lokunciphisa ubhedu (isisombululo sikaBenedict okanye sikaFehling okanye iipilisi zeCLINITEST®), kodwa hayi ngovavanyo lwe-enzyme lwe-glycosuria (umzekelo, CLINISTIX®, TES-TAPE®). Njengokuba iziphumo ebezingalunganga zinokuvela kuvavanyo lwe-ferricyanide, kuyacetyiswa ukuba kungasetyenziswa indlela ye-glucose oxidase okanye ye-hexokinase ukumisela amanqanaba egazi / iplasma yeswekile kwizigulana ezifumana iCefditoren Pivoxil.
ICarcinogenesis, iMutagenesis, ukungasebenzi kakuhle kokuchuma
Akukho zifundo ze-carcinogenicity zexesha elide ezenziweyo kunye neCefditoren Pivoxil. I-Cefditoren Pivoxil yayingeyiyo i-mutagenic kwi-Ames ye-bacterial reverse mutation assay, okanye kwi-mouse lymphoma mutation assay kwi-hypoxanthineguanine phosphoribosyltransferase locus. Kwiiseli zamaphaphu zaseTshayina ze-hamster lung, i-chromosomal aberrations yaveliswa nguCefditoren Pivoxil, kodwa hayi nge-cefditoren. Izifundo ezilandelayo zibonise ukuba i-chromosome aberrations ibangelwa kukukhutshwa kwe-formaldehyde kwi-pivoxil ester moietyi-In vitroInkqubo ye-assay. Nokuba i-cefditoren okanye i-Cefditoren Pivoxil ayivelisanga i-chromosomal aberrations xa ivavanywai-In vitrowolingo lwe-lymphocyte yegazi lomntu, okanye kwikwi vivoimouse micronucleus kulingwa. I-Cefditoren Pivoxil ayikhange ibangele i-DNA engacwangciswanga xa ivavanywa. Kwiigundane, ukuchuma kunye nokuzala kwakhona akuchaphazelekanga yiCefditoren Pivoxil kumthamo womlomo ukuya kuthi ga kwi-1000 mg / kg / ngosuku, malunga namaxesha angama-24 idosi yomntu ye-200 mg BID esekwe kumg / m2/usuku.
Iziphumo zokukhulelwa-TeratogenicUdidi lokukhulelwa B
ICefditoren Pivoxil yayingeyiyo iteratogenic ukuya kuthi ga kwiidosi eziphezulu ezivavanyiweyo kwiigundane kunye nemivundla. Kwiigundane, le dose yayiyi-1000 mg / kg / ngosuku, ephantse ibe ngama-24 edosi yomntu eyi-200 mg BID esekwe kumg / m2/usuku. Kwimivundla, elona dose liphezulu lavavanywa yayiyi-90 mg / kg / ngosuku, ephantse iphindaphindwe kane idosi yomntu ye-200 mg BID esekwe kumg / m2/usuku. Le dosi ivelise ubutyhefu obukhulu bomama kwaye ikhokelele kwityhefu yomntwana kunye nokuqhomfa.
Kwisifundo sophuhliso lwasemva kokubeleka kwiigundane, i-Cefditoren Pivoxil ayivelisanga ziphumo zingalunganga kubomi basemva kokubeleka, ukukhula ngokwasemzimbeni kunye nokuziphatha, amandla okufunda, kunye namandla okuzala ekukhuleni ngokwesondo xa kuvavanywa idosi ukuya kuthi ga kwi-750 mg / kg / ngosuku, elona dose liphezulu kuvavanywayo . Oku kuphantse kube li-18 idosi yomntu ye-200 mg BID esekwe kumg / m2/usuku.
Akukho zifundo zaneleyo nezilawulwa kakuhle kwabasetyhini abakhulelweyo. Kuba izifundo zokuzala kwezilwanyana azisoloko ziqikelela ukuphendula kwabantu, eli chiza kufuneka lisetyenziswe ngexesha lokukhulelwa kuphela xa kufuneka ngokucacileyo.
Ezabasebenzi kunye nokuhanjiswa
I-Cefditoren Pivoxil ayifundanga ukuba isetyenziswe ngexesha lomsebenzi kunye nokuhanjiswa.
Oomama Abongikazi
ICefditoren yafunyanwa kubisi lwebele lweempuku ezincancisayo. Ngenxa yokuba amachiza amaninzi akhutshiwe kubisi lomntu lwebele, isilumkiso kufuneka senziwe xa iCefditoren Pivoxil yenziwa kubafazi abangabongikazi.
Ukusetyenziswa kwabantwana
Ukusetyenziswa kweCefditoren Pivoxil akukhuthazwa kwizigulana ezingaphantsi kweminyaka eli-12 ubudala. Ukhuseleko kunye nokusebenza kweetafile zeCefditoren Pivoxil kolu luhlu lwabantu, kubandakanya naziphi na iimpembelelo zoxinzelelo lwe-carnitine, azikenziwa. (JongaAMANYATHELO, Ngokubanzi.)
Ukusetyenziswa kweGeriatric
Kwizigulana ezingama-2675 kwizifundo zeklinikhi ezifumene iCefditoren Pivoxil 200 mg BID, 308 (12%) zazineminyaka engama-65 ubudala. Kwizigulana ezingama-2159 kwizifundo zeklinikhi ezifumene iCefditoren Pivoxil 400 mg BID, 307 (14%) zazineminyaka engama-65 ubudala. Akukho mahluko ubalulekileyo eklinikhi ekusebenzeni okanye kukhuseleko waqwalaselwa phakathi kwezigulana ezindala kunye nezincinci. Akukho luhlengahlengiso lwedosi luyimfuneko kwizigulana ezinesifo esiqhelekileyo (sobudala bazo) umsebenzi we-renal. Eli chiza liyaziwa ukuba liphume kakhulu zizintso, kwaye umngcipheko wokuphendula okunetyhefu kweli chiza unokuba mkhulu kwizigulana ezinomsebenzi wokungasebenzi kakuhle kwezintso. Ngenxa yokuba abaguli abalupheleyo kunokwenzeka ukuba banciphise ukusebenza kwezintso, ukhathalelo kufuneka lwenziwe ekukhetheni idosi, kwaye kunokuba luncedo ukubeka esweni umsebenzi we-renal. (JongaIsikali NO ULAWULO.)
IZIGANEKO EZIBALASELEYO
Uvavanyo lweklinikhi- Iipilisi zeCivditoren zePivoxil (zaBadala kunye neziGulana eziFikisa iminyaka eli-12 ubudala)
Kwizilingo zeklinikhi, abaguli abadala abangama-4834 kunye nabakwishumi elivisayo baye banyangwa ngeedosi ezinconyelwayo zeepilisi zeCefditoren Pivoxil (200 mg okanye 400 mg BID). Uninzi lweziganeko ezigwenxa zazinobulali kunye nokuzimela. Akukho kufa okanye ukukhubazeka ngokusisigxina okuye kwabangelwa yi-cefditoren.
Iziganeko ezimbi ezilandelayo zazicingelwa ngabaphandi ukuba kunokwenzeka, mhlawumbi, okanye ngokuqinisekileyo zinxulumene neepilisi ze-cefditoren kwizilingo zedosi ezininzi:
ukuyaibandakanya i-amoxicillin / clavulanate, cefadroxil monohydrate, cefuroxime axetil, cefpodoxime proxetil, clarithromycin, kunye ne-penicillin
b1428 ababhinqileyo
cI-1135 yabasetyhini
ipilisi l544 icala elinye
d1461 ababhinqileyo
Iziganeko zizonke zeziganeko ezigwenxa, kwaye ngakumbi isifo sorhudo, sonyuke ngeqondo eliphakanyisiweyo eliphezulu leCefditoren Pivoxil.
Unyango olunxulumene neziganeko ezigwenxa ezanyangezelwa yi-0.1% yezigulana ezafumana i-200 mg okanye i-400 mg ye-BID yeCefditoren Pivoxil yayingamaphupha angaqhelekanga, i-allergies reaction, i-anorexia, i-asthenia, isifuba, ixesha lokujiya lenyukile, ukuqhina, isiyezi, umlomo owomileyo, ulwaziso, ukudumba kobuso, umkhuhlane, ukuqumba, usulelo lomngundo, isifo sesisu, isifo sokuqaqanjelwa sisisu, ukonyuka kokutya, ukuqaqanjelwa sisisu, leukopenia, leukorrhea, uvavanyo lwesibindi ukusebenza ngokungaqhelekanga, i-myalgia, uvalo, i-moniliasis yomlomo, iintlungu, i-peripheral edema, i-pharyngitis, i-pseudomembranous colitis, irhashalala, irhashalala, irhashalala , somnolence, stomatitis, ukubila, ukungcamla okugqwethekileyo, ukunxanwa, i-thrombocythemia, i-urticaria kunye ne-vaginitis. Iimpawu ze-Pseudomembranous colitis zingaqala ngexesha okanye emva konyango lwezifo. (JongaIZILUMKISO.)
Amashumi amathandathu ananye angama-2675 (2%) abaguli abafumene i-200 mg ye-BID kunye ne-69 ye-2159 (3%) yezigulana ezafumana i-400 mg ye-BID yeCefditoren Pivoxil iyekile amayeza ngenxa yezehlo ezimbi ebekucingelwa ngabaphandi, mhlawumbi, okanye ngokuqinisekileyo enxulumene nonyango lwe-cefditoren. Ukupheliswa ikakhulu bekuphazamiseka esiswini, kuhlala kurhudo okanye isicaphucaphu. Urhudo yayisisizathu sokupheliswa kwi-19 yama-2675 (0.7%) yezigulana ezafumana i-200 mg ye-BID kunye ne-31 ye-2159 (1.4%) yezigulana ezafumana i-400 mg BID yeCefditoren Pivoxil.
Utshintsho kwiiparameter zelebhu zokubaluleka kweklinikhi okunokwenzeka, ngaphandle kokujonga ubudlelwane beziyobisi kwaye ezenzeka kwi-1% yezigulana ezifumene iCefditoren Pivoxil 200 mg okanye i-400 mg BID, yayiyi-hematuria (3.0% kunye ne-3.1%), yonyusa umchamo iiseli ezimhlophe zegazi ( I-2.3% kunye ne-2.3%), ukunciphisa i-hematocrit (2.1% kunye ne-2.2%), kunye nokunyusa iswekile (1.8% kunye ne-1.1%). Ezo ziganeko zenzeke kwi-0.1% yezigulana zibandakanya oku kulandelayo: ukwanda / ukunciphisa iiseli ezimhlophe zegazi, ukwanda kwe-eosinophils, ukwehla kwe-neutrophils, ukwanda kwe-lymphocyte, ukwanda kwenani leplatelet, ukwehla kwe-hemoglobin, ukwehla kwesodium, ukonyuka kwe-potassium, ukunciphisa i-chloride, ukunciphisa i-phosphorus engaphiliyo, ukunciphisa i-calcium, inyusa i-SGPT / ALT, inyusa i-SGOT / AST, yonyusa i-cholesterol, yehla i-albhamuin, proteinuria, kunye nokunyusa i-BUN. Ayaziwa ukuba oku kungahambi kakuhle kubangelwe sisiyobisi okanye imeko ephantsi iyanyangwa.
I-Cephalosporin Class yeempendulo eziGwenxa
Ukongeza kwiziphumo ezibi ezichazwe apha ngasentla eziye zabonwa kwizigulana ezanyangwa ngeCefditoren Pivoxil, ezi ziphumo zilandelayo zichaseneyo kunye neziphumo zovavanyo zelabhoratri eziguqulweyo ziye zaxelwa i-cephalosporin class antibiotics:
Ukuphendula okungalunganga: Ukuphendula ngokuchaseneyo, i-anaphylaxis, umkhuhlane weziyobisi, iStevens-Johnson syndrome, i-serum-like reaction, i-erythema multiforme, i-epidermal necrolysis, i-colitis, ukungasebenzi kakuhle kwezintso, i-nephropathy enetyhefu, i-hyperactivity eguqukayo, i-hypertonia, ukungasebenzi kakuhle kwe-hepatic kubandakanya i-cholestasis, i-aplastic anemia, i-hemolytic anemia, ukopha, kunye ne-superinfection.
Uvavanyo lweLabhoratri eguqulweyo: Ixesha elide leprothrombin, uvavanyo oluchanekileyo lweCombombs, uvavanyo lobuxoki lwe-glucose yomchamo, i-alkaline phosphatase ephezulu, i-bilirubin ephezulu, i-LDH, i-creatinine, i-pancytopenia, i-neutropenia, kunye ne-agranulocytosis.
Ii-cephalosporins ezininzi ziye zanyanzeliswa ekubangeleni ukubanjwa, ngakumbi kwizigulana ezinokukhubazeka kwezintso xa idosi ingancitshiswanga. (JongaIDOSI NOLAWULOUkuba ukubanjwa kunxulunyaniswa nonyango lweziyobisi, ichiza kufuneka liyekwe. Unyango lwe-Anticonvulsant lunokunikwa ukuba kubonisiwe eklinikhi.
Amava entengiso
La mava mabi alandelayo, ngaphandle kolwalamano lwabo noCefditoren Pivoxil, axeliwe ngexesha lokuthengisa emva kokuthengisa, ukuqala ngokuvunywa eJapan ngo-1994: inyumoniya, i-eosinophilic pneumonia acute, ukusilela kwezintso, i-arthralgia, thrombocytopenia, erythema multiforme, uStevens-Johnson I-Syndrome, i-epidermal necrolysis enetyhefu kunye neempendulo ze-anaphylactoid ezinokuthi zikhatshwe yi-hypotension.
Ukugqithisa
Ulwazi malunga ne-Cefditoren Pivoxil overdosage ebantwini alufumaneki. Nangona kunjalo, ngamanye antibiotics-lactam amayeza okubulala iintsholongwane, iziphumo ezibi kulandela ukugcwala komzimba zibandakanya isicaphucaphu, ukugabha, uxinzelelo lwe-epigastric, isifo sorhudo kunye nokuxhuzula. IHemodialysis inokunceda ekususweni kwe-cefditoren emzimbeni, ngakumbi ukuba umsebenzi we-renal uphazamisekile (i-30% yokuncitshiswa kweeplasma emva kweeyure ezi-4 ze-hemodialysis). Phatha i-ogqithdosting ngokweempawu kwaye wenze amanyathelo okuxhasa njengoko kufuneka.
Kwizifundo ezinobungozi bezilwanyana ezinobuthi, i-Cefditoren Pivoxil xa ivavanywa kumyinge womlomo we-5100 mg / kg kwiigundane ukuya kuthi ga kwi-2000 mg / kg kwizinja azibonisanga ziphumo zempilo zixhalabisayo. Iziphumo ezithile, ezinje ngesifo sorhudo kunye nesitulo esithambileyo esihlala iintsuku ezimbalwa ziye zabonwa kwezinye izilwanyana njengoko kulindelwe uninzi lwee-antibiotics zomlomo ngenxa yokuthintela i-microflora yamathumbu.
I-Cefditoren Pivoxil Isikali kunye noLawulo
(JongaIZALATHISO NOSETYENZISOyezifo ezibonakalisiweyo.)
* Kufuneka kuthathwe kunye nokutya
Izigulana ezinokungoneliseki kweNtso
Akukho lungelelwaniso lwethamo luyimfuneko kwizigulana ezinokukhubazeka okuncinci kwezintso (CLcr: 50-80 mL / min / 1.73 m2). Kuyacetyiswa ukuba kungabikho ngaphezulu kwe-200 mg ye-BID enikezelwa kwizigulana ezinokuthothisa kwezintso ngokulinganayo (CLcr: 30-49 ml / min / 1.73 m2) kunye ne-200 mg QD inokwenziwa kwizigulana ezinokukhubazeka okukhulu kwezintso (CLcr:<30 mL/min/1.73 m2). Idosi efanelekileyo kwizigulana ezinesifo se-renal sokugqibela ayichongwanga.
Izigulana ezineZifo zeHepatic
Akukho luhlengahlengiso lwedosi luyimfuneko kwizigulana ezinokuthamba okanye ukumodareyitha kokuphazamiseka kwesibindi (Umntwana-Pugh Class A okanye B). I-pharmacokinetics ye-cefditoren khange ifundwe kwizigulana ezinokukhubazeka okunesibindi (i-Child-Pugh Class C).
Ibonelelwa njani ngeCefditoren Pivoxil
Amacwecwe e-Cefditoren Pivoxil aqukethe i-Cefditoren Pivoxil elingana ne-200 mg okanye i-400 mg ye-cefditoren iyafumaneka njengemhlophe, i-elliptical, iipilisi ezifakwe ifilimu ezibhalwe nge-CBP 200 okanye i-CBP 400 ngombala oluhlaza okwesibhakabhaka. Ezi pilisi ziyafumaneka kwiiphakheji zeblister, ngolu hlobo lulandelayo:
- I-NDC 24486-802-20: 400 mg 20 count blister. Amacwecwe e-Cefditoren Pivoxil aqukethe i-Cefditoren Pivoxil elingana ne-400 mg ye-cefditoren ayafumaneka emhlophe, elliptical, amacwecwe agutyungelwe ifilimu abhalwe i-CBP 400 ngombala oluhlaza okwesibhakabhaka.
- I-NDC 24486-802-28: 400 mg 28 yokubala iblister. Amacwecwe e-Cefditoren Pivoxil aqukethe i-Cefditoren Pivoxil elingana ne-400 mg ye-cefditoren ayafumaneka emhlophe, elliptical, amacwecwe agutyungelwe ifilimu abhalwe i-CBP 400 ngombala oluhlaza okwesibhakabhaka.
- I-NDC 24486-801-20:Inani lamabala angama-20. Amacwecwe e-Cefditoren Pivoxil aqukethe i-Cefditoren Pivoxil elingana ne-200 mg ye-cefditoren ayafumaneka emhlophe, elliptical, amacwecwe agutyungelwe ifilimu abhalwe i-CBP 200 ngombala oluhlaza okwesibhakabhaka.
UKUGCINWA
Gcina kuma-25 ° C (77 ° F); iihambo ezivunyelweyo ukuya kwi-15 ° -30 ° C (59 ° -86 ° F). [Jonga ubushushu begumbi elilawulwayo le-USP.] Khusela ekukhanyeni nasekufuma. Ukuhambisa kwisitya esomeleleyo, esinganyangekiyo.
Abaqeqeshi bezempilo banokutsalela umnxeba iAristos Pharmaceuticals Information Line (1-866-280-5755) ngolwazi ngale mveliso.
IZALATHISO
1. IKomiti yeSizwe yeMigangatho yeLebhu yeLabhoratri.Iindlela zoLusu lokuLumkisa iiAntimicrobial Susceptibility Uvavanyo lweeBacteria ezikhula ngokwasemoyeni- uHlelo lwesihlanu; Umgangatho ovunyiweyo, uXwebhu lwe-NCCLS M7-A5, Vol. 20, No. 2, NCCLS, Wayne, PA, Januwari 2000.
Rx kuphela
Yenziwe ngu:
I-Tedec-Meiji Farma, S.A.
IMadrid, eSpain
Ihanjiswe ngu:
Imbuyekezo Aristos Pharmaceuticals, Inc.
CaryI-NC 27518
I-CTS-002-1211-00-SPL
A233140-201111 / 01
Iipilisi zeCivditoren Pivoxil
ICefditoren Pivoxil 200 mg


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Nanini na xa siphuma ngaphandle, sihlaselwa zizinto ezahlukeneyo ezinjengemibala, imifanekiso okanye ...
Iifonti ezivuyayo zikhona, kwaye kungengenxa yokuba zinoncumo, kodwa ngenxa yokuba imilo yazo isinika imvakalelo evuyayo. NONE
Ukuba ujonga inkcazo yoyilo kunye noyilo, uya kufumana phakathi kwazo zonke iinkcazo, igama "InDesign". Funda inqaku kakuhle ...
Ubugcisa beConcept, i-Concept Art okanye i-Concept Art yinto enye. Banokubizwa ngokuba luphuhliso olubonakalayo ...
Nangona namhlanje idijithali ibonakala iyinto kuphela ebalulekileyo, amakhadi oshishino aqhubeka nokuba luncedo kakhulu ...
Ukubala ubungakanani bomfanekiso wedijithali akunzima. Nangona kunjalo, kukho imigaqo emininzi enxulumene nemifanekiso yedijithali ...
Ipowusta yeyona ndlela ilungileyo yokwazisa ngalo naluphi na uhlobo lomsitho, iprojekthi okanye inyathelo. Uyilo lwayo luyinto ...
Ufunda phi kwiAdobe Illustrator kwi-Intanethi Ukuba unomdla kuyilo lwegraphic kwaye ungathanda ukufunda okungakumbi malunga nomzobo wevektha, unga…
Ukuba ujonga ikhosi ye-Photoshop ekwi-Intanethi ehambelana neemfuno zakho, awungekhe uphuthelwe yile post. NONE
Ukusuka eDomestika silifumene eli nyathelo apho siza kukwazi ukudibana nabaculi bezinto ...
IiMacs ezine-M1 chip entsha ngoku zinokuthembela kwiAdobe Photoshop emva kokubhengezwa ngaphambili ...

robotstxt: allowed

filter: keep


text:
Dlulela kumxholo Siyaxolisa, ezinye iindawo zewebhusayithi ye-Airbnb azisebenzi kakuhle xa ungayivumelanga i-JavaScript. Iindawo zeholide eziqeshisayo eYoron, Oshima District
Fumana uze ubhukishe iindawo zokuhlala ezikhethekileyo kuAirbnb
Ezona zindlu eziqeshisayo zeholide ezithandwayo eYoron, Oshima District
Iindwendwe ziyavuma: ezi ndawo zokuhlala ziconywa kakhulu ngendawo ezikuyo, ucoceko nokunye.
Inqugwala · Iindwendwe eziyi-4 · Iibhedi eziyi-2 · 1.5 igumbi lokuhlambela Northernmost Okinawa old house with a free car !The home is an old style Okinawa home with upgrades. Create a fusion of traditional house and mod cons. Located in Hedo, about 5 mintues from Hedo Point, in a quiet area that backs up to the park and easy trail with children.
Special offer for pick up from Naha airport / Naha city with RV or drive a free convertible by yourself.
Easy and free to explore the island with RV / free car.
Option for Surfing, Snorkeling or BBQ.
Please contact me for your requests. Iflethi okanye indlu ekwi-complex (icondo) yonke · Iindwendwe eziyi-4 · Iibhedi eziyi-4 · Igumbi lokuhlambela eli-1 ⭐Welcome to Yoron Island⭐ヨロン島で滞在するのにとても便利な立地.
お部屋は,ゆったりとした落ち着いたスペースに,セミダブルベッド1台,シングルベッド1台の他に敷布団をご用意してます.また,ソファー,テーブル,TV,Wi-Fi,キッチン,冷蔵庫,お風呂,トイレ,洗濯機等もございますので,まるで与論島にある「我が家のような感覚」で旅を楽しめます.
周辺には,スーパーやお食事処,また,同建物1階は漁師の店「あぐん茶」があり,長期滞在はもちろん,初めての与論観光の方にもオススメです.
1人旅の方はもちろん,カップル,ファミリー等幅広い方に安心してお泊り頂けます.
ご希望があれば,姉妹施設Tandy Marineの「百合が浜ツアー」や「レンタカー」のご紹介等もいたします. Igumbi lakho lokulala · Iindwendwe eziyi-2 · Iibhedi eziyi-2 · igumbi lokuhlambela labucala eliyi-1 (1Fベッド個室)絶景!くじらカフェFamilyがおもてなしするプライベートゲストハウス1日2組限定こんにちは!KUJIRA HOSTELのYukiです☆
自然あふれる場所で子育てしたくて東京から7年前に完全移住し,
「くじらカフェ&商店」をゆるゆる営んでいます.
2021年は,週3日で営業.
昨年から宿業も主人からバトンタッチして,トライしてみることに致しました.
当HOSTELは,ホテルのような宿ではありません.
ゲストハウスのようなラフでカジュアルな交流もしつつ,プライベートTimeも充実させたい.
ホームステイ感覚で,それでいてプライバシーもある程度欲しい.
そんな方にオススメの1日2組&長期滞在限定.
敷地内に暮らす私たちと,玄関から独立した各客室が2つしかいないので,
贅沢にのんびりゆったり過ごしていただくことができます.
リモートワークしながら,空いた時間に目の前の海に飛び込んだり,家族との時間を過ごしたり・・・・.
ハンモックで本を読んで,そのあとはたっぷりお昼寝して,夜は一緒に語りあったり・・・・.
忘れかけていた「自分らしさ」を取り戻せるような,素敵な島時間を味わっていただけますように... Iindawo eziqeshisayo zeholide zazo zonke iintlobo
Fumana indawo ekulingeneyo.
Amakhaya
Iindawo ezintofontofo ezinayo yonke into eyimfuneko
Iihotele
Indawo yokuhlala nezinto onokuzisebenzisa
Iindawo zokuhlala ezikhethekileyo
Iindawo ezingaphaya kwendawo nje yokulala
Izinto ezinokusetyenziswa ezithandwayo kwiindawo eziqeshisayo zeholide eYoron, Oshima District Indawo yokupaka ngaphakathi esimahala Umatshini okhupha umoya obandayo okanye oshushu Ezinye iindawo zeholide eziqeshisayo eYoron, Oshima District Indlu enendawo yokuphola yonke · Yoron, Oshima District 与論島 プール&ビーチ付きプライベートヴィラ 満点の星空 家族や仲間と一緒にBBQ・花火OK $414 / usuku Yi$414 ngosuku Indlu engasemva yonke · 大島郡与論町 Shima Hotel ☆Ocean front☆ 1mins to the beach! $738 / usuku Yi$738 ngosuku Igumbi lakho lokulala · Yoron, Oshima District Hoshizunaso/JPN room 6 tatami mats/NonSmoke/NoMeal Indlu ekumhlaba osikelwe izindlu yonke · Yoron, Ōshima-gun 与論島 百合ヶ浜すぐ近く 最高のロケーションの一棟貸ヴィラ あぐんちゃヴィラ与論島 $303 / usuku Yi$303 ngosuku Iflethi okanye indlu ekwi-complex (icondo) yonke · Yoron, Ōshima-gun Stay in Yoron Condominium ⭐Tandy House⭐ $121 / usuku Yi$121 ngosuku Igumbi lakho lokulala · Yoron, Ōshima-gun 百合ヶ浜ビーチハウス(101号室) $142 / usuku Yi$142 ngosuku Indlu enendawo yokuphola yonke · Yoron, Oshima District (冬限定プラン)1日1組限定・プール付貸別荘・素泊まり★団体様★家族★恋人同士★お子様添い寝無料 $387 / usuku Yi$387 ngosuku Iindawo onokuya kuzo ezikufutshane © 2021 Airbnb, Inc. All rights reserved


text:
Namhlanje sineenkwenkwezi ze-CBB uLisa Appleton ohamba egxuma elunxwemeni. Ke ngaphandle kokuphosa iKentucky ihamba ze sikhumbula uPiggy ehamba engenanto. Ngokucacileyo wayezama ukuzenza umntu, kwaye uthatha ukuwa njengoKate Upton elunxwemeni eWales, kodwa wasilela ngexesha elikhulu kuloo mzamo. Ke oku kuyakuba luvuyo lokwenene kuni nonke oqolileyo ...Funda Ngaphezulu >
Ukugqibela kwam ukubonisa u-Lisa Appleton, wayelele echibini elingcolileyo njengengulube evule umlomo kwaye ii-boobs zibhabha zijikeleza! Ngeli xesha akazobangcono! Kuyanetha kwakhona kwaye ihenyukazi elidala uLisa akanasinxibo kwakhona! Ukunxila njengoFuck Appleton wayebonisa ii-boobs zakhe ezinkulu zendalo kunye ne-esile elisicaba elijikelezileyo ...Funda Ngaphezulu >
Jonga ihagu enyanyekayo uLisa Appleton kwiiklasi zakhe ze-yoga ezingagqitywanga eSpain! Le MILF ityebile, imbi kwaye yenza yonke into ukufumana ingqwalaselo, ke sukucinga ukuba oku bekungekho ngenjongo! Wabona umfana wepaparazzi, ke waqala ukubeka i-ice cream kwi-boobs yakhe enkulu ehamba ze ngelixa i-ayiskhrim yayivuza kuye ...Funda Ngaphezulu >
I-piggy etyebileyo uLisa Appleton uyisilo sasendle kakhulu kunangaphambili! Wabonisa iinwele zakhe ezintsha eSpain kwaye enye into yabaneka ngebhikini yakhe! Ngokuqinisekileyo oku akuzange kwenzeke ngengozi! I-Big Brother Star yaziwa kakhulu ngobuyatha bayo, njengoko sowusazi kwigalari yokugqibela ngaye, apho uLisa wayebeka i-ayiskhrim kwizitokhwe zakhe kwaye ebeka ...Funda Ngaphezulu >
Kukho amanqatha amadala kaLisa Appleton phantse ahamba ze, ambonisa into yakhe ecekisekayo engenanto, ethe tyaba njengentsimbi kwaye iphaphathekile kakhulu! Utyebile kwaye umbi, kwaye konke akwenzayo kukuqhwanyaza amabele akhe amakhulu neempundu, asinike into yokuhleka nokuthetha ngayo! Le nto ayisiyokuxhuzula, ngaphandle kokuba uthanda oonongogo abafana noLisa! Lisa ...Funda Ngaphezulu >
Oo ndoda, ihagu etyebileyo enezothe uLisa Appleton ehamba ze wangana nomthi kwindawo ethile ehlathini kwaye sabelana naye ngeefoto zakhe ze! Kutheni le MILF ifuna ukuba lodumo? Ndiyabazi ngokwenene abantu abaliqela abaxhwitha yonke imihla ngokubukela ama-boobs amakhulu ka-Appleton, kodwa ndiyathemba ukuba ubukele le nto uyonwabisa nje! Waphinda wambonisa ...Funda Ngaphezulu >


text:
Viaggi in famiglia? I bambini staranno bene qui!
5.0
Iflethi eqeshisayo yonke sinombuki zindwendwe onguAnamaria
Iindwendwe eziyi-4, Igumbi lokulala eliyi-1, Iibhedi eziyi-3, Igumbi lokuhlambela eli-1
Indawo yonke
Iza kusetyenziswa nguwe yonke le iflethi okanye indlu ekwicomplex.
Ukucoca Okuphuculiweyo
Lo mbuki zindwendwe uzibophelele kwinkqubo yokucoca ephuculiweyo enamanyathelo ayi-5 yakwa-Airbnb.
I-Wifi
Iindwendwe ziyathanda ukukhangela le nto inokusetyenziswa ithandwayo
Umbuki zindwendwe onomlinganiselo ophezulu
UAnamaria ufumene umlinganiselo weenkwenkwezi eziyi-5 kwi-100% yeendwendwe zakutshanje.
Izinto enazo le ndawo
Ukubona igadi
Ukubuka amasimi eediliya
Ikhitshi
I-Wifi
Indawo yokupaka ngaphakathi esimahala
I-TV ene-izitishi zeTV eziqhelekileyo
Ukuhlamba iimpahla ngomatshini yi-Isimahla – Useflethini
Ukomisa iimpahla ngomatshini yi-Isimahla – Useflethini
Ayikho: Ialam yomsi otyhefayo
Ayikho: Ialam yomsi
Ukufikeleleka
Igumbi lokulala
Akudingeki unyuke izitepsi ukuze ungene endlini
Ikhitshi elipheleleyo
Akudingeki unyuke izitepsi ukuze ungene endlini
5.0 out of 5 stars from 7 reviews
Ukucoceka
Ukuchana
Unxibelelwano
Indawo
Ukubhalisa xa ufika
Ixabiso
- Izimvo eziyi-7
- Isazisi siqinisekisiwe
- Umxhasi weAirbnb.org
Abito con la mia famiglia a Farra di Soligo, TV, nelle magiche colline del Prosecco. Le nostre passioni sono leggere, camminare in montagna e scoprire paesaggi e luoghi esclusi dal turismo di massa. Abbiamo due splendide e felici bambine che ci stimolano a scoprire il mondo ed ogni forma di conoscenza.
Abito con la mia famiglia a Farra di Soligo, TV, nelle magiche colline del Prosecco. Le nostre passioni sono leggere, camminare in montagna e scoprire paesaggi e luoghi esclusi dal…
- Iilwimi: English, Italiano
- Izinga lokuphendula: 100%
- Ixesha lokuphendula: ingekapheli iyure
Ukuze ukhusele ukubhatala kwakho, ungaze uthumele imali okanye uthethe nabantu ungasebenzisi iwebhsayithi okanye i-app yakwa-Airbnb.
Izinto ofanele uzazi
Imithetho yekhaya
Ixesha lokubhalisa xa ufika: Emva ko 17:00
Ixesha lokuphuma lingo:14:00
Akutshaywa
Azivumelekanga izilwanyana zasekhaya
Ayivumelekanga imisitho okanye amatheko
Ezempilo nokhuseleko
Uzibophelele kwinkqubo yokucoca ephuculiweyo yakwa-Airbnb. Bonisa okungakumbi
Kusebenza izikhokelo zika-Airbnb zokungasondeli ebantwini nezinye ezinento yokwenza neCOVID-19
Akukho alam elumkisa ngomoya otyhefayo echaziweyo Bonisa okungakumbi
Akukho alam elumkisa ngomsi echaziweyo Bonisa okungakumbi
Imithetho engokurhoxa
Hlola ezinye iindawo onokukhetha kuzo e- Farra di Soligo
Iindawo ezingakumbi onokuhlala kuzo e Farra di Soligo:


text:
Isinyithi i-RGB / ukukhanya okuMibala | TC135A-RGB
Ingcaciso:
Inkcazo
Iimbonakalo
Ukucaciswa
Iimpawu zemveliso
I-RGB Pocket Light TC135A-RGB Ikhamera yokuKhanya kweMoto encinci yeVidiyo yokuKhanya kwePaneli Gcwalisa ukuKhanya okupheleleyo kweMveliso yeVidiyo yokuKhanya okuKhanyayo kwe-135pcs yeLampu ubuKhanya ngeScreen seYouTube, Vlog, DSLR, Ngaphandle, ukudubula kweFowuni
• [RGB Umbala oPheleleyo wokuPhuma kweVidiyo yokuKhanya kweVidiyo] I-RGB 0-360 umbala opheleleyo, kunye nohlengahlengiso lokugcwaliswa kombala ngo-1-100, iindlela ezi-9 ezisebenzayo, 3200K-5600K yokulawula ubushushu bombala kwiindawo ezininzi zokudubula, Sebenzisa ubuhlalu besibane se-HD, RA≥96 ukuya bonelela ngokukhanya okungaphaya komthombo wokudubula kwakho.
Ulwakhiwo oluhlala luhleli kunye nobukhulu obuncinci] Isakhiwo somzimba weAluminiyam sikhusela ukukhanya kakuhle kwaye ayisindi. Incinci kune-iPhone, kulula ukuyiphatha ngesandla esinye kwaye kufuneka upakishe into kwibhegi yam yekhamera, incinci kakhulu kodwa ikhupha ukukhanya okufanelekileyo. Umgangatho we-1/4 isikrufu ulungele i-tripod kunye nokuma, kunye nentaba ebandayo yezihlangu yeekhamera okanye i-DSLR njl.
• [Dlala iziphumo zakho zoMbala ngeQhosha nje] Guqula phakathi kweendawo ezi-9 phantsi kweendidi ezintathu kwimo yeMEKO, unokufumana iziphumo ezinje ngokuKhanya kweAmbulensi, ukukhanya kwesibane okanye ukukhanya kwesibane seKhandlela ngonqakrazo olunye, endaweni yenkqubo enzima yekhompyuter. I-360 ° Umbala opheleleyo kunye neendlela ezisebenzayo ziya kwenza ukuba ukufota kwakho kube nemibala ngakumbi.
• [Umboniso weLCD kunye neLi-Polymer Ibhetri] Ibhetri ye-4000mAh ye-Li-Polymer eyakhelweyo ngaphakathi, inokuhlawulwa ngezibuko le-USB (Intambo ye-USB ifakiwe). Uncedo ngakumbi kwaye ulungele umsebenzi ongaphandle, ongaphakathi okanye wasebusuku wokudubula kunye nepaneli ye-HD ye-HD ecacileyo enokufundwa ukuze kukwazise useto oluchanekileyo kwaye wenze usebenze ngokulula.
• [Iimpawu eziPhakamileyo zoMgangatho] Ukukhanya kwevidiyo ye-TC135A-RGB kugqwesile ngokufota ngefowuni, ukurekhoda ividiyo, ukudubula kwemveliso, kunye nefoto enkulu, njl. Ukukhanya okulula kunye nokuphathekayo kunika ukukhanya okuphezulu, ukusebenza okufanelekileyo kunye nokushisa kombala ochanekileyo.
Umzekelo: TC135A-RGB
I-LED: 135pcs
Ukukhanya kweMax: 1200LUX / 0.5m 5600K
Eyakhelwe-ngaphakathi Lithium Ibhetri: 3.7V 4000mAh
Amandla aphezulu: 13W
Uluhlu lwamaqondo oMbane: 3200-5600K
Umbala we-RGB umbala: 0-360 ° umbala opheleleyo (HSL)
Material: Aluminium ingxubevange
Ixesha lokuSebenza: Imizuzu engama-90 (100%, 5600K)
Umbala onikezela ngeRa≥96 +
Imodi yokusebenza kokukhanya: iindlela ezingama-21
Uluhlu lokukhupha: 1-100%
Igalelo: USB-C 5V / 2A
Iziphumo: USB 5V / 2A
Ubunzima bomzimba: 200g
Ubukhulu: 151 * 80 * 11.5mm


text:
Abandwendweli baseJibouti banokuphinda bafumane eyona ndlela indala kurhwebo lweetyuwa ngelixa behamba ...
Udidi-lweeendaba ezizii-Djibouti Breaking News
Iindaba ezaphulayo ezivela eDjibouti -Uhambo noKhenketho, iFashoni, uLonwabo, iNkcubeko, iNkcubeko, imisitho, uKhuseleko, uKhuseleko, iiNdaba kunye neTrends.
Iindaba zokuhamba kunye nezokhenketho zaseJibouti zabahambi kunye neengcali zokuhamba. Iindaba zakutshanje zokuhamba nezokhenketho eDjibouti. Iindaba zamva nje kwezokhuseleko, iihotele, iindawo ekuchithelwa kuzo iiholide, izinto ezinomtsalane, ukhenketho kunye nezothutho eDjibouti. Ulwazi lohambo lweJibouti
Umbutho woLawulo lweZibuko laseMpuma naseMazantsi eAfrika ...
Umbutho woLawulo lweZibuko eMpuma naseMazantsi eAfrika (PMAESA) namalungu akwi-9 ...
Ukubonisa uKhenketho lwe-Djibouti kwiNtengiso yeHlabathi yokuHamba eLondon: A ...
Ilizwe elincinci le-Djibouti libizwa ngokuba lelinye lawona mazwe atyelelweyo kwihlabathi-kodwa ngoku ...


text:
Siyaxolisa, ezinye iindawo zewebhusayithi ye-Airbnb azisebenzi kakuhle xa ungayivumelanga i-JavaScript. Iindawo zeholide eziqeshisayo eKampung Melayu Majidee
Fumana uze ubhukishe iindawo zokuhlala ezikhethekileyo kuAirbnb
Ezona zindlu eziqeshisayo zeholide ezithandwayo eKampung Melayu Majidee
Iindwendwe ziyavuma: ezi ndawo zokuhlala ziconywa kakhulu ngendawo ezikuyo, ucoceko nokunye.
Iflethi okanye indlu ekwi-complex (icondo) yonke · Iindwendwe eziyi-4 · Ibhedi eyi-1 · Igumbi lokuhlambela eli-1 1Tebrau *Netflix *Youtube *Nice View *RelaxingKeep it simple at this peaceful and centrally-located place. Iflethi okanye indlu ekwi-complex (icondo) yonke · Iindwendwe eziyi-4 · Ibhedi eyi-1 · 1.5 igumbi lokuhlambela 1Tebrau Netflix *Modern, Stylish, Luxe*Enjoy a stylish experience at this centrally-located place. Iflethi eqeshisayo yonke · Iindwendwe eziyi-2 · Ibhedi eyi-1 · 1.5 igumbi lokuhlambela JY SWEET HOMESTAY @REGENCYAn affordable yet comfortable studio unit located in a strategic location "Mount Austin" where lots of tasty foods are just steps away from you! Enjoy your unforgettable moments here in JB perfected with a good night's rest with us now! Points of interest near this unit include:
. TOPPEN Mall (3 Mins)
• AEON Tebrau (3 Mins)
• IKEA Tebrau (3 Mins)
• Mount Austin Water Theme Park (3 Mins)
• Downtown (10 Mins)
• KSL City Mall (10 Mins)
• City Square (15 Mins)
• Singapore Immigration (15 Mins) Iindawo eziqeshisayo zeholide zazo zonke iintlobo
Fumana indawo ekulingeneyo.
Amakhaya
Iindawo ezintofontofo ezinayo yonke into eyimfuneko
Iihotele
Indawo yokuhlala nezinto onokuzisebenzisa
Iindawo zokuhlala ezikhethekileyo
Iindawo ezingaphaya kwendawo nje yokulala
Izinto ezinokusetyenziswa ezithandwayo kwiindawo eziqeshisayo zeholide eKampung Melayu Majidee Indawo yokupaka ngaphakathi esimahala Umatshini okhupha umoya obandayo okanye oshushu Ezinye iindawo zeholide eziqeshisayo eKampung Melayu Majidee Iflethi okanye indlu ekwi-complex (icondo) yonke · Johor Bahru S2001 Midvalley Mall (4minsDrive) WIFI Sanitised Iflethi okanye indlu ekwi-complex (icondo) yonke · Johor Bahru S2214 Midvalley Mall(4minDrive) NETFLIX‼ Sanitised Iflethi eqeshisayo yonke · Johor Bahru 1 Tebrau Infinity Pool Iflethi okanye indlu ekwi-complex (icondo) yonke · Johor Bahru N1810 Netflix 🍿Infinity Pool🏊🏻 WIFI Sanitised Iflethi eqeshisayo yonke · Johor Bahru 🌏1Tebrau💫@UHA 1BR 1-3pax Free WiFi ,near KSL,SgCIQ Iflethi okanye indlu ekwi-complex (icondo) yonke · Johor Bahru N1007 NETFLIX‼ Movies Infinity Pool WIFI Sanitised Iflethi eqeshisayo yonke · Johor Bahru ☘ 1Tebrau☘ @UHA 3BR 7pax FreeWiFi near MidValley Indawo ekukho umntu oncedisayo kuyo yonke · Johor Bahru 快樂的小窩 Indlu ekumhlaba osikelwe izindlu yonke · Johor Bahru SemiD,wifi, free park, 5min to Sogo, 12min Toppen Iflethi okanye indlu ekwi-complex (icondo) yonke · Johor Bahru 🌏1 Tebrau💫 @UHA 3BR 6pax WiFi near KSL SgCIQ Iflethi eqeshisayo yonke · Johor Bahru 🌏1Tebrau💫@UHA 3BR 4-5pax Free WiFi,near KSL,SgCIQ Iflethi okanye indlu ekwi-complex (icondo) yonke · Johor Bahru Suite27 at 1Tebrau* Eat, Fun & Pool* © 2021 Airbnb, Inc. All rights reserved


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Kwiintsuku ezimbalwa ezidlulileyo siqhube uhlalutyo olupheleleyo lwefayile ye- UChuwi Hi10 Plus, Elinye lawona macwecwe mabalaseleyo anokufumaneka namhlanje kwimarike, kuthathelwa ingqalelo ixabiso lemali. Ukuba ngelo xesha bekubonakala ngathi kungaphezulu kwesixhobo esichanekileyo, ngoku sifumanisa ukuba inkampani inoxanduva ithathe isigqibo Hlaziya iprosesa yakho, ye-Intel Atom Cherry Trail X5 Z8350.
Le processor intsha ayizukutshintsha ixabiso lesixhobo, nangona iya kuphucula amandla kunye nokusebenza kwethebhulethi ngokubanzi, iyenze ibe nomtsalane ngakumbi nakowuphi na umsebenzisi.
Apha sikubonisa ifayile ye- Ezona zinto ziphambili kwesi sixhobo sithandwa kakhulu;
- Imilinganiselo nje nge-8.8 yeemilimitha ubukhulu
- Ubunzima: 686 gram
- Iscreen: 10.8 intshi ngesisombululo se-1920 × 1280 pixels kunye ne-3: 2 ratio ngokukhanya kwe-450 nits
- Inkqubo: Intel Atom Cherry Trail X5 Z8350
- Imemori ye-RAM: 4GB
- Ukugcinwa kwangaphakathi: 64GB
- Ibhetri: 8.400 mAh
- Inkqubo yokusebenza: Windows 10 kunye ne-Remix OS 2.0 esinokuyisebenzisa njengoko sifuna
Ngenxa yeempawu zayo kunye nokubalulwa, sinokuqonda ukuba sijamelene nesixhobo esinomdla ngakumbi, esinexabiso elingaphantsi kwe-euro ezingama-239, ngokungathandabuzekiyo lelinye inqaku elinomdla. Kwaye kukuba ngexabiso elingengaphezulu kakhulu sinokuba necwecwe elibalaseleyo eliza kusivumela ukuba siqhube phantse nawuphi na umsebenzi.
Ngaba ucinga ukuba i-Chuwi Hi10 Plus iya kuba nakho ukuma kwiitafile ezinkulu ezentengiso?. Sixelele uluvo lwakho kwisithuba esibekelwe amagqabantshintshi kule posi okanye ngayo nayiphi na inethiwekhi yoluntu apho sikhona.


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Ubungqongqo kunye nokwenza izinto elubala.
Umgaqo-nkqubo wethu wokuhlela usekwe kumanqaku e-7 aqinisekisa ukuba yonke imixholo yethu iya kuba ngqongqo, ithembeke, ithembeke kwaye ibonakale.
- Sifuna ukuba kube lula kuwe ukuba uyazi obhala ntoni kwindalo esingqongileyo nakulwazi lwethu Kufuneka uyenze.
- Sifuna uyazi imithombo yethu, siphefumlelwe ngubani kunye neendlela nezixhobo esizisebenzisayo.
- Sisebenza ukwenza konke oku kwenzeke ngokunika abafundi ithuba lokuba basazise ngazo naziphi na iimpazamo abazifumanayo kunye nolunye uphuculo abafuna ukulucebisa.
Kwi-intanethi ene-infoxication sifo, kubaluleke kakhulu ngakumbi ukuba sikwazi ukwahlula phakathi kweendaba ezinokuthenjwa nezingathembekanga.
Sisekela imigaqo-nkqubo yethu yokuhlela kumanqaku ayi-7, esiya kuthi siphuhlise apha ngezantsi:
Index
Ukunyaniseka kolwazi
Lonke ulwazi esilupapashayo iqinisekisiwe ukuqinisekisa ukuba iyinyani. Ukufezekisa le njongo, sizama ukubhala uxwebhu ngemithombo ephambili, ekugxilwe kuyo ezindabeni, kwaye ke siphephe ukungaqondani okanye ukutolikwa okungalunganga kolwazi.
Asinanxaxheba kwezopolitiko okanye kwezorhwebo kwaye sibhala sithathe icala, sizama ukuba njalo ngenjongo ezinokwenzeka xa uhambisa iindaba kunye nokunikezela ngobuchule bethu kuphononongo lweemveliso kunye nothelekiso.
Abahleli abakhethekileyo
Umhleli ngamnye uyazi ngokugqibeleleyo umxholo asebenza kuwo. Sisebenzisana neengcali kwicandelo ngalinye. Abantu ababonisa yonke imihla ukuba banolwazi olukhulu kwisifundo ababhala ngaso. Ukuze ubazi, sishiya ulwazi malunga nabo kunye nokunxibelelana neeprofayili zabo zentlalo kunye ne-biography.
Umxholo wokuqala
Yonke imixholo esiyipapashayo yeyokuqala. Asikhupheli okanye siguqulele kwezinye iindaba. Sinxibelelana nemithombo ehambelanayo ukuba siyisebenzisile, kwaye sikhankanya abanini bemifanekiso, imithombo yeendaba kunye nezixhobo esizisebenzisayo ukunika olona lwazi luchanekileyo, sinika igunya elifanelekileyo.
Hayi kwi-Clickbait
Asizisebenzisi izihloko ezibubuxoki okanye ezithandekayo ukuze sitsalane nomfundi ngaphandle kokuba iindaba zingenzi nto. Singqongqo kwaye sinyanisile, kunjalo izihloko zamanqaku ethu ziyahambelana noko uza kufumana kumxholo wethu. Asivelisi ulindelo malunga nomxholo ongekho emzimbeni weendaba.
Umgangatho kunye nokugqwesa komxholo
Senza amanqaku asemgangathweni kunye nomxholo kwaye sihlala sifuna ukugqwesa kuyo. Ukuzama ukukhathalela zonke iinkcukacha kwaye usondeze umfundi kufutshane nolwazi abalukhangelayo nabaludingayo.
Ukulungiswa kweempazamo
Nanini na xa sifumana impazamo okanye sinxibelelana nathi, siyijonga kwakhona kwaye siyilungise. Sinenkqubo yangaphakathi yolawulo lwempazamo esinceda ukuba sihlale sigqibezela amanqaku ethu, kunye nokuthintela ukuba zingaphinde zenzeke kwixesha elizayo.
Uphuculo oluqhubekayo
Sisoloko siphucula umxholo kwiindawo zethu. Kwelinye icala, ukulungisa iimpazamo kwaye kwelinye icala, ukwandisa ii-tutorials kunye nomxholo ongapheliyo. Enkosi ngalo mkhuba, wonke umxholo wewebhu uguqulwa ube sisalathiso kunye nomxholo oluncedo kubo bonke abafundi, ngalo lonke ixesha ufundwa.
Ukuba unesikhalazo okanye ingcebiso malunga nenqaku okanye umbhali, siyakumema ukuba usebenzise eyethu Unxibelelwano.


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Casa Mariposa: Sombrero Beach Neighborhood
I-Superhost
Igumbi lakho lokulala e igumbi elinomnyango ophumela ngaphandle sinombuki zindwendwe onguRobert/Merlou
Iindwendwe eziyi-2, Igumbi lokulala eliyi-1, Iibhedi eziyi-2, igumbi lokuhlambela labucala eliyi-1
Ukucoca Okuphuculiweyo
Lo mbuki zindwendwe uzibophelele kwinkqubo yokucoca ephuculiweyo enamanyathelo ayi-5 yakwa-Airbnb.
Ukuzibhalisa xa ufika
Zingenele ngokufaka ikhowudi emnyango.
Yindawo entle
100% yeendwendwe zakutshanje zinike indawo izinga leenkwenkwezi eziyi-5.
Izinto enazo le ndawo
Ukubona igadi
I-Wifi
Indawo yokupaka simahla eseyadini – inendawo eyi-1
Isetyenziswa nangabanye phandle amanzi anetyuwa inamanzi ashushu ipuli ende
I-HDTV ene-I-Roku
I-aircon ekwindawo enye esebenza kuwo onke amagumbi
Iindawo zokuhlala phandle
Ngasemva eyadini
Ukothulwa komthwalo kuvumelekile
Isixhobo sokomisa iinwele
4.97 out of 5 stars from 88 reviews
Ukucoceka
Ukuchana
Unxibelelwano
Indawo
Ukubhalisa xa ufika
Ixabiso
- Izimvo eziyi-207
- Isazisi siqinisekisiwe
- I-Superhost
We are a professional couple who enjoy travel, the outdoors, and meeting new people. Our interests include everything from camping in National Parks, to touring overseas, hiking, kayaking, cycling, gardening, and time with family and friends. As guests and hosts, we are quiet, neat and relaxed.
We are a professional couple who enjoy travel, the outdoors, and meeting new people. Our interests include everything from camping in National Parks, to touring overseas, hiking, k…
Ngexesha lokuhlala kwakho
We live in our home full-time, and therefore will be around often. We use our pool and patio, and spend a lot of time in our garden. Hosts are both fully vaccinated against Covid for both your safety and theirs.
URobert/Merlou yi-Superhost
Ii-Superhost zinamava, zikwizinga eliphezulu ibe eyona nto iphambili kuzo, kukuba iindwendwe zihlale kamnandi.
- Izinga lokuphendula: 100%
- Ixesha lokuphendula: ingekapheli iyure
Ukuze ukhusele ukubhatala kwakho, ungaze uthumele imali okanye uthethe nabantu ungasebenzisi iwebhsayithi okanye i-app yakwa-Airbnb.
Izinto ofanele uzazi
Imithetho yekhaya
Ixesha lokubhalisa xa ufika: 16:00 - 22:00
Ixesha lokuphuma lingo:11:00
Ukuzibhalisa xa ufika Indawo esemnyango yokufaka ikhowudi
Ayibafanelanga abantwana neentsana
Akutshaywa
Azivumelekanga izilwanyana zasekhaya
Ayivumelekanga imisitho okanye amatheko
Ezempilo nokhuseleko
Uzibophelele kwinkqubo yokucoca ephuculiweyo yakwa-Airbnb. Bonisa okungakumbi
Kusebenza izikhokelo zika-Airbnb zokungasondeli ebantwini nezinye ezinento yokwenza neCOVID-19
Ichibi, umlambo, nezinye iindawo ezinamanzi ezikufutshane
Ialam yecarbon monoxide
Ialam yomsi
Imithetho engokurhoxa
Hlola ezinye iindawo onokukhetha kuzo e- Marathon
Iindawo ezingakumbi onokuhlala kuzo e Marathon:


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I-Aurora Cannabis iceba ukothula enye yezona zindlu zokugcina izindlu zibiza kakhulu kwaye zibiza kakhulu ezisetyenziselwa ukukhulisa i-cannabis kwimbali, kodwa nawuphi na umthengi onokubakho angaxakeka ekufumaneni inkcitho engakumbi ukuze iprojekthi igqitywe ngempumelelo.
Ngokwezixhobo zentengiso ezifumanekayo esidlangalaleni, i-Aurora ityale imali ezizigidi ezingama-260 zeedola zaseCanada (i-205 yezigidi zeedola zaseMelika) "zonke zibandakanyiwe" kwisigidi seenyawo esikwi-1.7 seMedicine Hat, eAlberta, apho inkampani iya kuba yintloko yeColliers International, ebekwe eToronto, kudweliswe njengomcebisi wezezimali kunye ne-arhente yoluhlu lwezindlu ezizalisiweyo.
Nangona kunjalo, ukuba umthengi ugqibezela ukusetyenziswa kwendlu yendlu eluhlaza ("njengeziko lobugcisa lendawo yokunyanga greenhouse"), inokufuna izigidi zeedola kwinkcitho eyongezelelweyo, kwaye ukuba igqityiwe nge-non-cannabis ukusetyenziswa, kunokufuna inkcitho encinci.
Olu luhlu ngumzekelo wakutshanje wokurhoxa okukhulu komvelisi omkhulu waseCanada kwizindlu zokugcina ii-cannabis ezinkulu kunyaka ophelileyo, kwaye umlimi ugqithise kakhulu kumhlaba olimekayo phakathi konyaka ka-2017 nowama-2019.
Ngokwengxelo ye- "Cannabis Business Daily", uninzi lweeprojekthi zegreenhouse, nokuba zakhiwe ngokudityaniswa kunye nokufunyanwa okanye ukugqitywa ngokudityaniswa kunye nokufunyanwa, ekugqibeleni kubangele abavelisi abanelayisensi baseCanada ukuba bahlupheke ngokuthe ngqo izigidi zeedola kwilahleko yokuthengiswa kwezindlu kunye nezigidi zezigidi zeedola. Uluhlu lokubhala phantsi.
Idilesi kwincwadana yase-Alberta Greenhouse iyahambelana nedilesi esetyenziswe sisakhiwo se-Aurora Sun.
I-MJBizDaily ifunde ukuba i-Aurora iphelise ngokufanelekileyo ukusetyenziswa kwe-Aurora Sun greenhouse kunyaka ophelileyo, kwaye izisa ipropathi kwintengiso ngaphandle kwengxaki "yokufumanisa ixabiso" lokubuza amaxabiso. Oku kuya kunceda ukufumanisa amaxabiso asethi kwiimarike ezinokuguquguquka.
Ngokwencwadana enemifanekiso, "ukugqitywa kwethagethi" kudwelisiwe njengekota yesibini ukuya ekuqaleni kwekota yesithathu yalo nyaka.
Le ntshukumo iza kunyaka omnye emva kokuba u-Aurora amkele isibonelelo sayo kwigreenhouse enkulu e-Exeter, e-Ontario, kwaye ibhidi malunga nesiqingatha se-C $ 17 yezigidi zexabiso lokudweliswa kunye nesinye kwisithathu sexabiso lokuqala lokuthenga.
Kwingxelo ye-imeyile eya kwi-MJBizDaily, isithethi siqaphele ukuba i-Aurora "iyaqhubeka nokujonga kwakhona inethiwekhi yokusebenza yenkampani ukuqinisekisa ukuba ilungele ishishini lethu langoku nelifutshane."
Isiteyitimenti siqhubile: "Ukuphendula kutshintsho lwamva nje kwicandelo kunye neemfuno zethu zobuchule, inkampani ibhengeze ukuba iyakumisa ngokungenammiselo ukusebenza eAurora Sun eMedicine Hat, eAlberta."
"Sikhuthaza ngokukuko ukusetyenziswa kwezinye izibonelelo. Akukho zinkcukacha zithe kratya ngeli xesha kuba le nkqubo isekwinqanaba layo lokuqala."
Uyathengiswa sisakhiwo esingundoqo seenyawo ezizizigidi ezili-1.4 kunye nesakhiwo esincedisayo seenyawo ezingama-285,000.
Ngokwencwadana enemifanekiso, umthengisi (u-Aurora kule meko) uvuleleke kuluhlu olubanzi lwezinto ezinokubakho zentengiselwano kunye neendlela zokuqwalaselwa ukwandisa ixabiso.
"Oku kuyakuquka, kodwa kungaphelelanga apho, ukuthengiswa ngokuthe ngqo kwesakhiwo esinye okanye ezibini ezinkozo okanye ezinye iindlela zokuqwalaselwa; ukuthengiswa kwenxalenye yesahlulelo kwiqabane; okanye ukuqeshiswa kwesakhiwo."
Nangona imali eninzi ityalwe, i-Medicine Hat's greenhouse ayikagqitywa.
"Inkcitho eyongezelelekileyo yemali eyimfuneko iyafuneka ukugqiba indawo, kodwa iindleko ziya kumiselwa kukusetyenziswa komthengi," utshilo umphathi weColliers International uMatt Rachiele uxelele iMJBizDaily nge-imeyile.
"Sifumene isikhokelo sokuqala kakhulu kwiinjineli. Ukuza kuthi ga ngoku, indleko zokugqiba onke amaziko okusetyenziselwa ukungasebenzisi intsangu inokuba ngaphantsi kwe-10% yenkcitho, kodwa ukugqitha kwinjongo ebicetyelwe yona kwasekuqaleni, kufuneka ichithe kakhulu yemali. "
URachiele uthe iindawo ezintandathu kwezingama-37 zesakhiwo esikhulu sele zigqityiwe kwaye ezinye ezintandathu zigqityiwe.
Olu xwebhu lwentengiso luthi: "Nangona ekuqaleni yayijolise ekubeni igqitywe njengeziko lokugcina impilo kwigreyidi yezonyango, isakhiwo kunye nezixhobo ezinxulumene noko zinokusetyenziselwa ngokulula uluhlu olubanzi lokusetyenziswa okunokubakho."
UMat Lamers ungumhleli wamanye amazwe we-Cannabis Business Daily, esekwe kufutshane neToronto. Ungaqhagamshelana naye nge- [Email Protection].
Ndiyathemba ukuba umntu othile uza kuphanda ukuba kutheni ubungakanani bemakethi ye-cannabis yaseCanada igqithisiwe. Ngaba ukukhula ngokungekho mthethweni (okungekho mvume) okanye irhafu egqithileyo inokuchaza ezinye zeengxaki?
Ndingathanda ukubona iCanada ithumela ngaphandle i-cannabis e-Illinois. Izidleleli ezibawayo apho zibiza imali eninzi kwaye zifumana inzuzo kubathengi bazo. Abaswele imigaqo yokuziphatha okanye imigaqo yokuziphatha kwezeshishini. Izidalwa ezinje kufuneka ziboshwe.
Ishishini le-Cannabis mihla le-ngowona mthombo uthembekileyo weendaba zemihla ngemihla, ezibhalwe ngokukodwa ziintatheli ezinobungcali kolu shishino. Funda nzulu
Ixesha lokuposa: Mar-25-2021


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Inkqubo yokuLawula i-1:
Lo matshini udityanisiwe kunye nezinto zokuqala zentsimbi eziphambili ze-elektroniki kunye ne-PLC eQokelelweyo yeLogic Controller (iJamani, i-Siemens) kunye nesiboniso somboniso waseTshayina. Ngeenkqubo ezininzi zokuzikhusela kunye nealam, isebenza ngokulula ukwenza imveliso ezenzekelayo ukusuka ekondleni, kulawulo lobushushu, kwisabelo, koxinzelelo, njl.
Iindlela 2.Work:
Isebenza ngeendlela ezimbini: ukondla okuqhelekileyo kunye noxinzelelo lokondla imathiriyeli, kwaye ezi ndlela zimbini zinokutshintshwa njengesakhiwo kunye nefom yokubumba. Unokukhetha ngokuzenzekelayo kunye nokuzenzekelayo.
Inkqubo yeStam
Lo matshini unento yokulinganisa ivalve ukuqinisekisa umphunga kunye nobushushu obuzinzileyo, kunye nokusetyenziswa kancinci komphunga.
Inkqubo ye4.
Umatshini uqhutywa ngoxinzelelo lwe-hydraulic ngenkqubo ekhawulezayo / ecothayo yokwahlula-hlula ukuqinisekisa ixesha elichanekileyo lokuvulwa komngundo kunye nokuvalwa ngexesha elinoqoqosho kunye nokusebenza okuzinzileyo.
Inkqubo yeVacuum (uyazikhethela)
Umatshini unenkqubo efanelekileyo yokuphucula ukukhawulezisa isantya sokubumba imveliso, mfutshane ixesha lokupholisa kunye nokunciphisa umxholo wamanzi emveliso.
6.Olunye Uncedo:
Umatshini unokwenza ngokuzenzekelayo nangokufanelekileyo ukwenza ukufudumeza, ukupholisa, ukondla kunye nenkqubo yokuqhawula ingot ukuziqhelanisa neemveliso ezahlukeneyo ze-EPS. Iindlela ezahlukeneyo zokufudumeza zinokusetyenziswa ngokuzikhethela kwifom yemveliso ukuqinisekisa umgangatho wemveliso. Umshini kunye nenkqubo yoxinzelelo engalunganga inokuqinisekisa umxholo wamanzi asezantsi, ukubumba ngokukhawuleza, kunye nexesha elifutshane lokumisa (okanye ngaphandle kokumisa).
I-EPS Shape Molding Machine isetyenziselwa ukuvelisa ibhokisi yokupakisha i-EPS, ibhloko ye-ICF, ibhloko yekhonkrithi, ibhloko engenanto, i-hourdis, ukulahleka kwe-foam, i-cornice yokuhlobisa, ibhodi yesilivere, ikholomu, isigcina-ntloko, njl.


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I-OnePlus 6T yenye yeefowuni ekulindeleke ukuba ziwe. Inguqulelo entsha yesiphelo esiphakamileyo esenziwe yibhanti yaseTshayina kwiinyanga ezimbalwa ezidlulileyo iza kufika kungekudala. Kwezi veki sifumana idatha engakumbi nangaphezulu malunga nomnxeba, nangona umhla wokunikezelwa kwayo uhlala uyimfihlakalo. Kodwa oku kubonakala ngathi sele kutshintshile, enkosi kwinkampani.
Ibi Enkosi kwisibhengezo senqaku elitsha elibizwa ngokuba yiScreen Unlock, ukuba sikwazile ukubona ukuba ngowuphi umhla wokuboniswa kwale OnePlus 6T. Kubonakala ngathi asizukuhlala silinde ixesha elide ukubona oku. Ngaphezulu nje kwenyanga.
Ukusukela enkosi kulo mfanekiso ulungisiweyo kwifemu, oko kuthetha ukuba Ngo-Okthobha i-17, i-OnePlus 6T iya kuziswa ngokusemthethweni. Ngokomgaqo, sisikrini esingabalulekanga, kodwa ubukho balo mhla kunye nekhalenda yokukhutshwa kwangaphambili kwenkampani, bacebisa ukuba kubalulekile.
Iimodeli zangaphambili bezisoloko zivezwa iinyanga ezintlanu emva kweyokuqala. I-OnePlus 6 iboniswe ngoMeyi 16, ke inyani yokuba le modeli intsha iboniswe ngo-Okthobha u-17 ayiqhelekanga. Kuba iinyanga ezintlanu sele zidlulile phakathi kwenye nenye.
Kwelinye icala, sele sinedatha yomsebenzi omtsha wale OnePlus 6T. Eyokuqala kukuba isiphelo esiphakamileyo siya kuba nayo isivamvo somnwe esakhelwe kwiscreen sakho, Oko kulandela imeko esiyibonayo kwimarike, ebonakala ngathi isebenzisa lo msebenzi mtsha weScreen Unlock oboniswe namhlanje.
Ngoko ke, Sele sinomhla esinokulindela ukuba i-OnePlus 6T iboniswe ngayo. Kungenzeka ukuba sifumane iinkcukacha ezithe kratya malunga noluhlu kwiiveki ezizayo. Siyathemba ukuba inkampani iyakuqinisekisa ngokusemthethweni lo mhla wokufayilisha.


text:
Willow Tree Farm Entire Guest Suite
5.0I-Superhost
Igumbi elinomnyango ophumela ngaphandle yonke sinombuki zindwendwe onguMalinda
Iindwendwe eziyi-4, Istudiyo, Iibhedi eziyi-2, Igumbi lokuhlambela eli-1
Indawo yonke
Iza kusetyenziswa nguwe yonke le igumbi elinomnyango ophumela ngaphandle.
Ukucoca Okuphuculiweyo
Lo mbuki zindwendwe uzibophelele kwinkqubo yokucoca ephuculiweyo enamanyathelo ayi-5 yakwa-Airbnb.
Ukuzibhalisa xa ufika
Zingenele ngokufaka ikhowudi emnyango.
Kubekuhle ukubhalisela ukungena
100% yeendwendwe zakutshanje zinike indlela yokungena izinga leenkwenkwezi eziyi-5.
Indawo oza kulala kuyo
Egumbini lokulala
\u00A0Ibhedi enkulu eyi-1, isofa ekwayibhedi eyi-1
Izinto enazo le ndawo
Ukwazi ukuya elwandleIsetyenziswa nangabanye
Ikhitshi
I-Wifi
Indawo yokupaka ngaphakathi esimahala
32" HDTV
Isixhobo sokomisa
I-aircon ekwindawo enye esebenza kuwo onke amagumbi
Iveranda okanye ibhalkhoni Yeyabucala
Ngasemva eyadini
Kukho iikhamera kule ndlu
5.0 out of 5 stars from 18 reviews
Ukucoceka
Ukuchana
Unxibelelwano
Indawo
Ukubhalisa xa ufika
Ixabiso
- Izimvo eziyi-19
- Isazisi siqinisekisiwe
- I-Superhost
Ngexesha lokuhlala kwakho
Our family lives in the main home attached to the guest suite so you should be aware you will hear kids often. You will likely see and hear our children enjoying the great outdoors or playing on Bauder Blvd play space. My husband & I are available for questions or if you'd like to schedule a visit with our Great Pyrenees dog, Winnie or have an opportunity to pet some of our friendly chickens.
Our family lives in the main home attached to the guest suite so you should be aware you will hear kids often. You will likely see and hear our children enjoying the great outdoors…
UMalinda yi-Superhost
Ii-Superhost zinamava, zikwizinga eliphezulu ibe eyona nto iphambili kuzo, kukuba iindwendwe zihlale kamnandi.
- Ulwimi: English
- Izinga lokuphendula: 100%
- Ixesha lokuphendula: ingekapheli iyure
Ukuze ukhusele ukubhatala kwakho, ungaze uthumele imali okanye uthethe nabantu ungasebenzisi iwebhsayithi okanye i-app yakwa-Airbnb.
Izinto ofanele uzazi
Imithetho yekhaya
Ixesha lokubhalisa xa ufika: Emva ko 15:00
Ixesha lokuphuma lingo:11:00
Ukuzibhalisa xa ufika Indawo esemnyango yokufaka ikhowudi
Akutshaywa
Azivumelekanga izilwanyana zasekhaya
Ayivumelekanga imisitho okanye amatheko
Ezempilo nokhuseleko
Uzibophelele kwinkqubo yokucoca ephuculiweyo yakwa-Airbnb. Bonisa okungakumbi
Kusebenza izikhokelo zika-Airbnb zokungasondeli ebantwini nezinye ezinento yokwenza neCOVID-19
Ikhamera yokhuseleko/isixhobo sokurekhoda Bonisa okungakumbi
Ichibi, umlambo, nezinye iindawo ezinamanzi ezikufutshane
Indawo ephakamileyo engenayo indawo yokubambelela okanye engakhuselekanga
Imithetho engokurhoxa
Hlola ezinye iindawo onokukhetha kuzo e- Allegan
Iindawo ezingakumbi onokuhlala kuzo e Allegan:


text:
Ukungalingani (ngokwezibalo)
Kwi - mathematics, i-inequality lunxulumano oludibanisa noluqinisa ubudlelwane phakathi kwee-values xa zithe zahlukana zaziintsalu.
- Uphawu olungu-a ≠ b kuthetha ukuthi u-a akalingani no-b.
- Le ntetho ingasentla ayithi enye kwezi zimbini inkulu kunenye, kwaye ayizithelekisi nangobukhulu bazo.
Ukuba kuye kwathi kanti ezi values kuthethwa ngazo zingamalungu engqokolela yamanani ekuthiwa yi-ordered set, efana nee-intergers okanye ii-real numbers, zisenokuthelekiswa ngokobukhulu bazo.
- Uphawu olungu a < b luthetha okokuba u-a ungaphantsi ku-b
- Uphawu olungu a > b luthetha okokuba u-a ungaphezulu okanye mkhulu kuno b
- Kulo naliphi na icala kula mabini, u-a akalingani no-b. Obu budlelwane baziwa ngokuba bubonisa ukungalingani okungqingqwa nokungqalileyo. Umzekelo wobungqingqwa siwubonaxa sisithiu-a < b usengafundekangolu hlobo "u-a ungaphantsi ku-b ngaphandle kwamathandabuzo"
Ukanti ke xa sithelekisa nokungalingani okungqalileyo, kukho iintlobo ezimbini zobudlelwane obungekho ngqingqwa ezibonakalisa ukungalingani.
- Umbhalo othi a ≤ b uthetha okokuba u-a ungaphantsi/mncinane okanye ulingana no-b (okanye uyalingana, akakho ngaphezu kuka-b, or at most b); "not greater than" can also be represented by the symbol for "greater than" bisected by a vertical line, "not." (The unicode for ≤ is "U+ 2264".)
- The notation a ≥ b means that a is greater than or equal to b (or, equivalently, not less than b, or at least b),; "not less than" can also be represented by the symbol for "less than" bisected by a vertical line, "not." (The unicode for ≥ is "U+ 2265".)
Kwinjineli yee-sciences,izinga eliphantsi lokusetyenziswa ngokusesikweni kombhalo kukucacisa okokuba i-quantity enye "inkulu ngakumbi" kunenye, eziqhele ukusetyenziswa zii-orders of magnitude eziliqela.
- Umbhalo ongu-a ≪ b uthetha okokuba u-a mncinane ngakumbi ku-b. (Kodwa ke xa kuthethwa ngethyori yomlinganiselo, nangona kunjalo, lo mbhalo usetyenziselwa ukuqhubela phambili, uhlobo lwesigama olungaqhelekanga nolungenakuthelekiswa nanto).
- Umbhalo ongu-a ≫b uthetha okokubau-a mkhulu ngakumbi kuno-b
Iimpawu[tshintsha | Yenza izilungiso kokubhaliweyo]
Ezi ntlobo zokungalingani zilawulwa zezi mpawu zilandelayo. Zonke ke ezi mpawu ziyakuthi ukuze zivakale okanye zibambeke kuthi kanti endaweni yazo zonke iintlobo zokungalingani okungekho ngqingwqa ezinjengezi (≤ and ≥) kubekwe oogxa bazo abangqingqwa abanjengaba ( )


text:
Nantsi igalari yethu yeengcamango zebhloko yomoya wepatio kubandakanya indlela yokuvimba umoya usebenzisa iindlela ezahlukeneyo zoyilo. Ipatio yangasemva iyindawo efanelekileyo yokuhlala. I-barbecues ehlotyeni, isidlo sasemini kunye nabahlobo ekwindla kunye nekomityi yekofu engafanelekanga ngexesha lekhephu ebusika yenza ipatiyo indawo yokuhlanganisana lonke ixesha.
Ngaphandle kwezo ntsuku zisahleliyo, nakuphi na ukuphazamiseka kwemozulu kuhlala kubangela iimeko zomoya. Umoya ovuthuzayo unokumkeleka, kodwa xa umoya ovuthuzayo usasaza i-tableware, i-napkins, imiqamelo kunye neminye imihombiso yomgangatho, ibhloko yomoya yepatio ngumbono olungileyo.
Abantu abaninzi bakhetha ukungafaki iipatio zabo ukugcina ukuziva kwangaphandle kwaye bonwabele umbono ojikeleze bona. Kwesi sikhokelo, siza kuphonononga izimvo zebhloko yomoya ukuze unqume ukuba loluphi ukhetho olulungele wena.
Isiqulatho
- Ungawuthintela njani umoya kwiPatio
Ungawuthintela njani umoya kwiPatio
Ukuthintela umoya kwipatio okanye ibhalkhoni yegumbi kuvumela abanini khaya nabahlali ithuba lokonwabela umoya omtsha. Nangona kunjalo, imozulu embi inokuzisa umoya ovuthuzayo ophelisa ulonwabo.
Ezinye iindawo zinokuba nomoya kuba zibekwe kwintlambo phakathi kweentaba ezimbini okanye zibekwe kunxweme lolwandle. Ukufumana indlela elula nefanelekileyo yokuthintela umoya kuthetha ixesha elininzi ukonwabela ipatio okanye ibhalkhoni.
Jonga olu cingo lumoya lwepatio apha Amazon [ikhonkco elixhasiweyo]
Apha ngezantsi kukho iindlela ezininzi kunye nemibono onokuyisebenzisa ukukhusela emoyeni. Ngamnye uxhomekeke kuhlobo lwepatio, indawo ejikelezileyo, kunye nokuba ungakanani umoya umninikhaya ofuna ukuwuthintela.
Ucingo lweBlock block
Iibhloko zomoya zocingo zeenkuni ziza njengeepaneli ezenziwe ngomthi ezinokusikwa kwipateni yokulinganisa okanye yobugcisa. Umoya kunye nokukhanya kuyavunyelwa kungene, kodwa umoya onamandla uyagcinwa.
Ucingo olubiyelweyo luya kusebenza njengebhloko yomoya kunye nemfihlo yokubonelela ngokwamkela indawo yepatio yekofu yakusasa. Iingcingo zebloko zomoya zenziwe ngomthi okanye iiplanga zomthi ezihlanganisiweyo, ezivumela imibala emininzi kunye neepateni.
iindlela zokubaleka zothando phakathi kumbindi
Iingcingo eziqinileyo azisebenzi kakuhle njengesixhobo somoya. Umoya uya kuvuthuza ubhekise kumphezulu oqinileyo kwaye uhambe ngaphezulu nangaphezulu ukuze wehle umva uye kwelinye icala. Ukubiyela i-lattice, ucingo oluthandwayo, okanye i-bamboo zonke zenza ukhetho olukhulu lothango lomoya.
IPatio Wind Deflector
I-deflector yomoya wepatiyo akufuneki ukuba iqhotyoshelwe kwipatio. Nje ukuba umninikhaya abone apho uvela khona umoya, i-deflector yomoya inokumiswa ukunqanda umoya ukuba ungafiki kwipatiyo.
Iiphaneli zocingo zinokucwangciswa ngokuzimeleyo kwezinye iingcingo kwaye kude nepatio apho kuvela khona umoya.
Amatyholo anje ngearborvitaes akhula aba ludonga olukhulu lwendalo, kwaye imithi enjenge-oki, i-maple trees, kunye nemithi yepayini isebenza kakuhle. Ngelixa aba baphambukeli bendalo bekhula, abaninimzi banokusebenzisa iipaneli zokuxhoma okwexeshana okanye izikrini ukuthintela umoya.
Iimpawu zangaphandle zokuVimbela umoya
Iimpawu zeepatiyo zenza iibhloko zomoya ezinkulu kwaye zongeze umnxeba wokuhonjiswa kuyilo lwepatio. Ukhetho olwahlukileyo lwendwangu lubandakanya izinto eziqinileyo, ezomeleleyo, okanye ezilukiweyo.
Ukuthintela umoya ngokufuthi kuza nothango lokuthintela ukubabetha emoyeni kwaye babonelele ngesibonelelo esongezelelweyo ngokuthintela imvula elula okanye ikhephu. Bona Okuninzi Iindidi zeepatio ezivalekileyo Apha.
Qengqa uKhuselo loMoya
Imithunzi inokuxhoma kwizixhobo ezilula ezinokuthathwa xa zingasetyenziswanga okanye zifakelwe njengokhuseleko lomoya. Abavelisi banikezela ngee-shades ezenziwe ukuba zifakelwe ipatio engaphandle.
Ukuphakamisa okanye ukwehlisa i-shades kwenziwa ngee-pulleys, okanye iipaneli zinokufakwa kulawulo lombane. Ukuqengqeleka kukhuseleko lomoya kubonelela ngenketho efanelekileyo xa umoya uzolile.
Cacisa iiVinyl Curtains
Mhlawumbi ubonile amakhethini acacileyo e-vinyl asetyenziswa kwiivenkile kunye nemivalo enezihlalo zangaphandle. Ngokufana neetarps ezinkulu ezicacileyo, ezi ndawo ze-vinyl azinamanzi kwaye ziza ngobukhulu obahlukeneyo ngokuxhomekeke kwimfuno yakho.
Cacisa i-vinyl / i-pvc amalengalenga ahlala enganyangeki kwimitha ye-UV kwaye uhlala ephathwa nge-anti-microbial coating. Zihlala zithengiswa nge-20 mil okanye 30 mil ubukhulu. Ikhethini elingqingqwa kucetyiswa ukuba linganyangeki ngenxa yemozulu ebandayo.
Jonga eli likhethini licacileyo lepati Amazon [ikhonkco elixhasiweyo]
Ezi ziza nee-grommets ukuze ubanike kwi-patio yakho okanye kwiveranda usebenzisa iihuku okanye ezinye iintlobo zokubopha. Ukuqinisekisa ukuba abayenzi ingxolo eninzi kwaye bahlala bekhuselekile kufuneka banamathele phezulu nasezantsi.
Iindleko zokuthenga iikhethini ezicacileyo ze-vinyl zibiza ixabiso eliphantsi nge- $ 75 ukuya kwi-100 yeedola nge-8ft ngephaneli ye-8ft.
IPlexiglass kunye neeNqobo zomoya zeGlasi
Ipatio inokujamelana nolwandle kunye nolwandle okanye inikeze umbono omuhle weentaba. Kwimeko enjalo, isenokungabi ngumbono olungileyo ukusebenzisa isitshingitshane somoya esiphazamisa ubuhle bendawo nokuba sisixa esincinci, njengezikrini.
Cacisa iglasi okanye iipaneli ze-plexiglass zibonelela ngesiphene somoya ukuba nje ziphezulu ngokwaneleyo ukugcina umoya ungabuyeli ezantsi kwipatio. Ukuba iglasi okanye iipaneli ze-plexiglass zibaleka ukusuka kumgangatho wepatio ukuya phezulu kuphahla lwomoya, umoya uya kujoliswa ngaphezulu kophahla kwaye kude nepatio.
Ibhloko yoMoya ephathekayo
Ibhloko yomoya ephathekayo lukhetho lwethutyana olwenziwe kwiiphaneli ezigutyungelwe ngezinto ezahlukeneyo.
Ezi paneli zihlala zityhutyha isakhelo sepatio. Izinto ezisebenza kakuhle zibandakanya isikrini, ilaphu elipheleleyo, umqhaphu, i-burlap, okanye ukhuselo kwimozulu embi, njengeplastiki ecacileyo.
Iibhloko zomoya ezizimeleyo ezisebenza ngokuzimeleyo ziyasebenza kwaye zinokucwangciswa ukuvimba umoya ovela kulo naliphi na icala lepatiyo. Abanini bamakhaya bangasebenzisa izixhobo zokuyila ukuxhasa ukuhonjiswa kwepatio.
Idisk Wind Screen
Jonga le bhloko yethala lomoya kwiipatio Amazon [ikhonkco elixhasiweyo]
Isikrini somoya somgangatho sidityaniswa kusetyenziswa amaplanga okhoyo okanye isinyithi isakhelo sesakhelo kwaye sigutyungelwe ngezinto zomnatha ezomeleleyo. Ukuhlolwa kwesikrini kunokuqhutyelwa kwi-patio yonke okanye kumacala aqhelekileyo afumana umoya.
Iingcingo zebloko zomoya ziphinda kabini njengesikrini sabucala ngokuxhomekeka kuhlobo lwescreen esisetyenzisiweyo. Abavelisi banikezela ngeendlela ezikhethiweyo zebhloko zomoya ezibonelela ngokhetho olufana nombala, ubukhulu, izinto eziphathekayo, izinto ezinokumelana ne-UV kunye nesikrini sabucala.
Izikrini zomoya wedesika zezona ntlobo zifikelelekayo kwiibhloko zomoya zeepatio.
ubudlelwane obuhle bomfana wakho
Iibhloko zoMoya zeNdalo
Izityalo kunye nemithi yindlela efanelekileyo yokusebenzisa i-block blocker yendalo. Izihlahla ezityalwe zijikeleze ipatio zenza uthango oluhle.
Zigcine zinciphisiwe malunga ne-3 ukuya kwi-4 yeenyawo ukuphakama, ukuze zingathinteli umbono, kodwa ziyayikhusela ipatio kwimimoya enamandla. IiHedges zibonelela ngenkangeleko yeklasikhi nakwiyadi.
Ingca ende okanye uqalo lungumqobo kwiintsuku ezinomoya kwaye zenza umxholo wetropiki kumakhaya akwiindawo ezifudumeleyo.
Ukuba ipatio ifreyimu, i-trellises kunye nezityalo zemithi yenza ukongeza okuhle kulungiso lomhlaba, kwaye ngokusebenzisa i-trellis, izityalo zingenziwa ukuba zikhule kwiindawo ezivulekileyo zepatio ukunciphisa umoya.
Olunye ukhetho lokuhombisa kukusebenzisa iiplantara ezinkulu ezinezityalo ezinde ezibekwe zijikeleze ipherimitha. Ingca ende kunye nenqanaba elineentyatyambo zezityalo zenza ingxelo emangalisayo kwaye isikwa ngumoya.
Imithi eyinzalelwane yommandla yenza ukongezwa okuhle kuyo nayiphi na iyadi, inceda ukugcina umoya ucocekile, kunye nokucothisa imimoya enamandla. Ukutyala imiqolo yee-conifers ezinje nge-spruce eluhlaza okwesibhakabhaka okanye umthi we-tamarack kudala ukomelela, kwendalo Ipatio evaliweyo udonga olwamkela iindidi zeentaka kunye nezilwanyana zasendle.
Zithini izimvo zakho zebhloko oyithandayo? Sazise apha ngezantsi kwizimvo oza kwabelana ngazo. Funda ngakumbi iintlobo zeepatios kweli phepha.