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-Isu tiri Nyanzvi PaWebhu Yekushandisa Assessments
-Isu Tiri Nyanzvi Pamusoro peVashandi 'Interactive Training
-Isu tiri Nyanzvi Pamusoro peKunze Vulnerability Ongororo
-Tiri Nyanzvi Pakuongorora Kwekusagadzikana Kwemukati
-Isu Tiri Nyanzvi Pakudzivirira Ransomware Uye Maitiro Akanaka
-Isu tiri Nyanzvi Mukutsvaga Wireless Access Point Mis-Configurations
Nei Zvichikosha Kuongorora Mashandisirwo Ako Wewebhu?
Hackers vanogona kupinza macode akashata mukati mako Website kana sevha yewebhusaiti ichimhanyisa software yechinyakare pane sevha kana plugins inoda kuvandudzwa. Apa ndipo patingabatsira kuziva kusagona uku.
Nei Zvichikosha Kuongorora Nzvimbo Yako Yekuwana?
Matsotsi emunharaunda anogona kubira system yako nyore uye nekuishandisa nezvinangwa zvakaipa kana vakakwanisa kuongorora uye kutsvaga nzvimbo yako yekupinda zvisizvo. Ivo vanogona kupinda nyore pane yako sisitimu nekukanganisa pane yako yekuwana nzvimbo mukati megumi maminetsi.
Nei Isu Tiri Nyanzvi MuCyber Security Online Interactive Training?
Yedu cyber awareness kudzidziswa kunofanirwa kuenda zvakanyanya kupfuura kutumira vashandi vakateedzera phishing emails. Vanofanira kunzwisisa zvavari kudzivirira uye basa ravari kuita mukuchengetedza sangano ravo. Vanofanira kunzwisisa, vari kubatana nesangano rako. Rega dzidziso yedu yekuziva nezve cyber ibatsire vashandi vako kunzwisisa mamiriro ehutsotsi uye huinjiniya hwemagariro hunoshandiswa nematsotsi kuti vakwanise kuchengetedza zvinhu zvako.
Sei Isu Tiri Nyanzvi PaKunze Uye Mukati Mungozi Yekuongorora?
Isu tinoshandisa akawanda maturusi ekuona kuongororwa kwekusagadzikana neakaderera enhema positives. Isu tinozopa vatengi vedu rondedzero yakadzama inovabatsira kuona yakakosha kune yakaderera kusagadzikana. Zvichienderana nekusagadzikana kwakawanikwa, tinoshanda nevatengi vedu kugadzira nzira dzakanakisa dzekudzikisa njodzi dzese dzakawanikwa.
Sei Isu Tiri Nyanzvi Pakushandisa Ransomware Kuderedza Maitiro?
Heano mamwe ehurongwa hweransomware isu tichakubatsira iwe kuita.
-Ita ongororo yenguva dzose yekusagadzikana kuona uye kugadzirisa kusagadzikana, kunyanya iwo ari painternet-akatarisana nemidziyo, kudzikamisa nzvimbo yekurwisa.
-Gadzira, chengetedza, uye shandisa chirongwa chekupindura chiitiko che cyber uye hurongwa hwekutaurirana hunosanganisira mhinduro uye zviziviso zvechiitiko cherudzikinuro.
-Iva nechokwadi chekuti zvishandiso zvakagadzirirwa zvakanaka uye kuti maficha anogoneswa. Semuyenzaniso, dzima zviteshi nemaprotocol asiri kushandiswa kuita bhizinesi.
Bata Isu Nhasi Uye Rega Tikubatsire Iwe Kuchengetedza Sangano Rako!
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Vana vechikoro vakawanda munyika vadzoserwa kumba musi wekuvhurwa kwezvikoro sezvo vange vasina kubhadhara mari dzechikoro idzo dzave kusiwa muzvikoro zvakawanda dziri mumadhora ekuAmerica pachimwe chidimbu. Vakuru vezvikoro vanoti havangabhadharise nedhora rekunyika sezvo riri kuramba richishaya simba.
Vabereki vakaita saVaOscar Makova vane vana vari pazvikoro zvakaita sepa Gokomere High, Pamushana, Mutendi nezvimwe vanoti vana vavo havana kutodarikapagedhi rechikoro sezvo vabva vangodzoserwa kumba.
Zvimwe zvikoro zvine mabhodha zviri kuda mari inosvika mazana maviri ekuAmerica kana kuti US$200. Pamusoro pezvo zvikoro zviri kuda rimwe zana nemakumi mashanu remadhora richibhadharwa nemari yemunyika asi nemutengo wedhora pamusika wemubhanga kana kuti bank rate.
Zvimwe zvikoro zvakazvimirira kana kuti maPrivate schools zvinopinda vana veshoroma zvakaita sana Kyle College, Junior School pamwe nana Riverton zviri kubhadharisa nemadhora ekuAmerica chete dzimwe nguva mari yacho ichidarika churu chemadhora kana kuti 1000 US Dollars pakotoro.
Vamwe vabereki vakaita saAmai Violet Mutigwini vanoti kubhadhariswa mari yekunze kutyora mutemo sezvo hurumende isingazvitenderi.
Mutauriri webazi redzidzo yepasi munyika VaTaungana Ndoro, vati zvikoro zviri kumanikidza vabereki kubhadhara mari yekunze zviri kutyora mutemo wenyika.
Mashoko aVaNdoro anoouya mushure mekunge munyori webazi rezvemari munyika VaGeorge Guvamatanga svondo rapera, vanyorera mapazi ose ehurumende pamwe nemakanzuru tsamba vachivazivisa kuti kubhadharisa vanhu mari yekunze pamabasa akasiyana siyana kutyora mutemo wenyika.
Asi hurumende inonzi iri kubhadharisawo zvimwe zvinhu zvakaita semagwaro ekufambisa uye mafuta ekufambisa dzimotokari nemadhora ekuAmerica.
VaNdoro vaenderera mberi vachiti mutemo wenyika haubvumidzi kuti vana vadzingirwe chikoro nyaya yekukundikana kubhadhara mari yechikoro.
Apo vabereki vari kuchema chema nenyaya dzemari dzezvikoro, vamwe vadzidzisi vanoti vakundikana kuenda kumabasa nhasi nekushaiwa mari dzekufambisa sezvo mari yavanotambira iri shoma.
Mutungamiriri wesangano rinomirira vadzidzisi vekumaruwa, reAlamgamated Rural Teachers Union of Zimbabwe(ARTUZ)VaObert Msaraure vati vadzidzisi vakawanda havana kuenda kubasa nhasi.
Asi hurumende yati vadzidzisi vakawanda vaenda kumabasa ichiti vamwe vatosvika nekudzidzisa vana sezvo kotoro ino isina kuratidzira kwavhiringa kuvhurwa kwezvikoro. Gurukota rezvemari Muzvinafundo Mthuli Ncube vakavimbisawo kuwedzera ari vashandi vehurumende kutanga mwedzi uno.
VaMasaraure vakurudzira hurumende kuti idzose mihoro yevadzidzisi kumari yekuAmerica yavaitambira muna 2018 kuti vasakundikane kuenda kubasa.

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Ruvara rwendarama rwakanangisa dice yakaiswa
Chigadzirwa Chigadzirwa
Chigadzirwa Mateki
Izvo zvinhu iine resin, uye iyo yakapinza micheto iwo maitiro eanopinza dice. Nekuti kuchengetedza hunhu hwediki inopinza, pamusoro pevacheche vamwe pachave nemakwenzi mashoma, asi hazvizokanganisa mwenje unopenya.
Chimiro chakanyatsogadzirwa chakapinza chiyeuchidzo chemazuva ano emitambo uye sarudzo yekutanga yevatambi vadiki.
Iyo yakagadzirirwa neakajeka epurasitiki bhokisi kuratidza ayo epamusoro-magumo maitiro uye inokodzera kuve neyedu.
Nhamba yedhaisi inodiwa:
Kana iwe usingazive chaizvo, ndokumbira utipe fungidziro, tinofanirwa kuziva iyo vector, nekuti pane musiyano wakakura wemutengo pakati pemakumi mashanu seti nema 2000 seti.
Kana iwe usati wakagadzirira kutaura nezve iyo odha, asi iwe uchida imwe color scheme, unogona kuichengeta nemaziso, uye ipapo ingobaya iyo "kurodha" bhatani kuti ugadzire.
Ndokumbirawo muyeuke kuti iyo dhizaini inoratidzwa pane iyo visualization inongori yekufananidzira. Ruvara rwekupihwa uye mifananidzo inoonekwa pachiratidziri chako inogona kutsamira pahunhu hwechiratidziro chako, marongero ega echishandiso nezvimwe zvinhu. Ruvara rwechigadzirwa chekupedzisira runogona kusiyana neizvo iwe zvaunoona pachiratidziko zvakati siyanei zvishoma, tarisa iwo iwo mavara aripo pazasi, kana iwe uchifarira, taura nesu kuti uwane rumwe ruzivo.
Iwo maratidziro echigadzirwa ndiD4, D6, D8, D10, D10%, D12, D20, mazhinji acho anoshandiswa mumutambo webhodhi Makomba nemaDragoni. Maitiro ekugadzira ndeaya anotevera: kutanga chakuvhuvhu, kwobva kwaita kujekesa kwemavara, kwozotevera kupora, Wobva wanyora pane yakasara pamusoro, uye pakupedzisira kara nemhepo yakaoma. Iyi ndiyo nzira yese yekugadzira.
Tine mukana mukugadzira dice nemakona akapinza. Isu tinoshandisa kupurinda manyore kuita kuti micheto iwedzere uye ive yakasarudzika.
Catherine Tauscher, mutengi muUnited States, anoda iyi dice zvakanyanya. Yekutanga odha yave inopfuura makumi mashanu seti. Mushure mekugamuchira izvo zvinhu, ivo zvakare vakasiya iyo 5-nyeredzi chiyero. Hunhu hwedhiza hwakanaka kwazvo, nezvimwewo, izvo zvinoratidza kuti vatengi vanotifarira kwazvo.
Iyo yaunofarira yeiyi yegoridhe yakavarairwa yakanongedzwa dice. Uye mutengi weAustralia Will Spooner-Adey anofarira kwazvo yedu nyowani yegoridhe yakashongedzwa dhayeti.
Mushure mekubvunzurudza pfupi, isu takabva tangoisa odhiyo makumi mana emaseki, uye ndokuzoapakira mune yakasarudzika-yakajeka bhokisi. Fungisisa iyo mhando yedhaisi uye sevhisi yakanaka kwazvo.
MIBVUNZO:
Dhaice yako yakaitwa nemaoko here?
Mhinduro: Hongu, dhayi redu rakakwenenzverwa manyore kuti uve nechokwadi chekuti micheto yakapinza uye kuumbwa kwedhiza kwakanaka kwazvo.
Unogona here kugadzirisa iyo dice?
Mhinduro: Ehe, isu tinokwanisa kugadzirisa dhizaini, uye tinogona kunyora kana kupurinda tsika marogo padhishi. Tsika dice inogona kuitwa.


text:
Chishuwo chako here kushandisa nguva yako yemahara uchitamba mutambo wakasarudzika uye unopindwa muropa? Kana zvirizvo, saka tinogona kukupa iwe mutambo wakanakisa wawakambotamba. Tinokupa zano kuti uedze Vimbai Dash Infinito Mobile Apk pafoni yako yeAroid kuti unakirwe nekunakidzwa kusingagumi uye kunakidzwa.
Hapana mubvunzo kuti kushandisa nguva yako yemahara pane yako mbozhanhare ndiyo imwe yedzakanakisa uye dzakajairika nzira dzekunakidzwa iwe pachako. Nekudaro, kuwana yakanakisa app uye mutambo wekutamba kunogona kuve kwakaoma. Ndosaka tiripo kuti tikubatsire nekukupa mitambo yese yaunoda.
Chii chinonzi Block Dash Infinito Mobile Apk?
Infinito Block Dash Mobile Apk ndeye Android mutambo wemitambo application inopa vatambi vane mutambo unonakidza uye unonakidza unowanikwa. Nechishandiso ichi, unogona kunakidzwa nenguva yako yemahara uine rhythm-based mutambo uchinakidzwa nekusingaperi pane yako Android nhare kana piritsi..
Kune mizhinji yemitambo iripo inopa akawanda gameplay ine vatongi vakasiyana. Izvi zvinoreva kuti mutambo uyu uchanetsa kuti chero munhu atambe mitambo iyi, ndosaka vanhu vazhinji vasingade kutamba mitambo yakadai. Tiri pano neimwe sarudzo yako.
Iyo Block Dash Infinito Mobile Game inopa yakanakisa uye yakapusa mutambo wemutambo, usiri nyore kutamba asi unopinda muropa kune chero mutambi. Saka, kana iwe uchida kuongorora ese aripo masevhisi eiyo 2D Mutambo, saka unongoda kugara nesu kwekanguva uye kufara.
Gameplay
Yakawanda yemutambo wemitambo yakatarisana nekutonga kwechivharo, chaunofanirwa kutama kubva pane imwe nzvimbo kuenda kune imwe. Mune mamwe mazwi, iwe unofanirwa kudzivirira akawanda zvipingamupinyi uye kudhumhana panguva yemutambo. Kana iwe uine chero mhando yekudyidzana nechipingamupinyi, saka iwe unogona kurasikirwa kana kuhwina.
Nekuda kweizvozvo, iwe unozofanirwa kutanga mepu kubva kutanga, ndosaka uchizofanira kuchengetedza mabhuraki kuti utange kutamba. Pachave nezvakawanda zvakasiyana maficha aripo ekuti vatambi vaongorore, uye iwe unonakidzwa nekushandisa nguva yako uchivaongorora.
Mepu
Iwe uchawana pano akasiyana siyana emamepu, anowanikwa kuti iwe utambe. Mepu yega yega yaunogona kutamba pano yakaoma zvakanyanya kune chero munhu, asi unogona kunakidzwa nekutamba pano uye kunakidzwa. Saka, ongorora mazinga asingaperi nemamishoni akasiyana uye uve neanoshamisa mutambo wemitambo!
Iwe unogona kuwana mamwe emhando yepamusoro yekuunganidza masevhisi kuburikidza nepuratifomu, iyo iwe yaunogona kuongorora uye kunakidzwa nekushandisa yako mhando nguva nayo. Tsvaga mamwe akanakisa akaunganidzwa emamepu pachikuva, ayo chero munhu anogona kuwana zviri nyore uye kunakidzwa nekushandisa nguva yake nawo.
Customization
Kufarira kugadzirisa yako block uye kuita kuti inake? Kana hongu, saka pano iwe unogona kuwana akati wandei ekugadzirisa maturusi ayo anozogonesa iwe kuti uite izvozvo chaizvo. Nekushandisa maturusi aya, unogona kugadzirisa zviri nyore chimiro cheblock, ruvara, dhizaini, uye dzimwe dzakawanda sarudzo dzebhuroko rako.
Yave nguva yekuti iwe uise maoko ako paBlock Dash Infinito Mobile Dhawunirodha nhasi, kuti unakirwe nekunakidzwa kusingaperi. Pano iwe unowana mamwe eakanakisa uye ari nyore-kushandisa kudzora, ayo chero munhu anogona kushandisa. Saka, kana iwe uchitsvaga kunakidzwa kusingaperi, saka mutambo uyu ndewako.
Ini ndangokuratidza mashoma ezvimiro zvemutambo, asi pane zvimwe zvakawanda zvaunogona kuwana kana wangodhawunirodha mutambo uye wotanga kushandisa ese masevhisi anowanikwa kwauri. Saka, kana iwe uchida kuwana ese aya maficha, saka iwe unofanirwa kudhawunirodha mutambo wacho uye wotanga kuutamba.
Kune mimwe mitambo yakafanana inowanikwa pawebhusaiti yedu kwamuri mose. Saka, kana iwe uchida kuwana mamwe maapuro akafanana, saka unogona kuedza Tiger Arcade uye GDPS Editor. Ose ari maviri aya akanyanya kufarirwa mitambo iripo, yaunogona kutamba.
App Details
Screenshots yeApp
Nzira yekudhawunirodha Block Dash Infinito Mobile Android?
Kuti uve nekunakidzwa kusingagumi uye kunakidzwa nekushandisa nguva yako, ipapo unogona kudhawunirodha iyo Apk faira uye unakirwe. Iyo yemahara uye ine zvakawanda zvezvinhu zvaunogona kuwana nekushandisa zviri nyore. Saka, zvinokurudzirwa zvakanyanya kuti iwe utore iyo Apk kana uchida kunakidzwa nayo.
Kuwana iyo Apk kubva peji ino hakufanire kuunza chero matambudziko. Ingotsvaga bhatani rekurodha, iro rinopihwa kumusoro uye kuzasi kwepeji. Ita imwe tepi pairi uye mirira masekondi mashoma, uye maitiro ekurodha anotanga otomatiki.
Zvinhu Zvikuru
- Mahara kurodha pasi nekutamba
- Akanakisa Arcade Game
- Misangano Isingaperi
- Smooth uye Simple Controllers
- Kojima Productions GDC Latest Version
- Mutambo Mutsva Une Zvimiro Zvekutanga
- Hapana Third Party Ads
- Kiinura Multiple Levels
- Tsvaga Vamwe Vatambi
- Jump uye Dash
- Gadzira Zvibodzwa Zvitsva zvepamusoro
- Browser
- Mushandisi-ane hushamwari Interface
- Inokwezva uye Yekugadzira Graphics
- Zvakareruka uye Nyore Kutamba
- Mazhinji Akawanda
FAQs
Tinogona Kutamba Block Dash Infinito Mobile Apk Panhare?
Ehe, unogona kuwana mutambo Apk.
Tinogona Kudhawunirodha Block Dash Infinito Apk Faira Kubva kuGoogle Play Store?
Kwete, iyo infinito edition haisi kuwanikwa mu Play Store, asi unogona kuwana yakananga yekurodha link pane ino peji.
Maitiro ekuisa Yechitatu-Bato Apk Mafaira paMafoni eAroid?
Yekugadzika maitiro, unogonesa 'Unknown Sources' Kubva kuAroid Settings Chengetedzo uye isa iyo yakatorwa Apk.
Final Words
Nekuda kweBlock Dash Infinito Mobile Apk inowanikwa pane yako Android kifaa, iwe unokwanisa kuwana akati wandei maficha, ayo iwe aunokwanisa kunakidzwa nekuongorora zviri nyore. Saka, kana iwe uchida kunakidzwa, wobva warodha iyo Apk faira kubva pakurodha link yakapihwa pazasi.


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5 Akanakisa echisikigo echisikigo eEurope
(Last Updated On: 15/01/2022)
Maitiro eEurope uye nzvimbo dzepasirese dzakafemesa ngano. Iyo yakakura nyika ine musha kune zvinoshamisa Hiking mudungwe munzira izvo zvinotungamira kune zvimwe zvinoshamisa zvinoshamisa zvepasirese. Mapako anoshamisa muHungary, Grand Canyon ine turquoise mvura muFrance, echando-dzimbahwe muAustria, uye gomo rakafanana nepiramidhi muItari, vari 5 yezvakanakisa zvisikwa zveEurope.
Izvi zvinoshamisa zvezvisikwa zvinotora kufema kwako, uye nekupa zvinoshamisa nzvimbo dzezororo rakanakira muEurope. Kunyangwe iwe uchikarira kufamba munzira kana kutora mota yemuchina, izvi 5 zvishamiso ingori inofanirwa-kushanya pane chero rwendo kuEurope, zvisingapfuure kamwe muhupenyu.
- Rail senga ndiyo zvakatipoteredza ushamwari nzira yokufamba. Nyaya iyi yakanyorwa kudzidzisa pamusoro Train Travel uye chakaitwa Chengetedza Chitima, The CHEAPEST Train Tickets Website In The World.
1. Akanakisa echisikigo echisikigo eEurope: hofori ice nyika, Ositiriya
Iwe unogona kuyeuka Salzburg kubva kuIzwi reMimhanzi uye vana veVon Trapp vanoimba kumakomo. asi, pasi pemakomo eHochkogel, anovanza bako hombe muEurope. Eisriesnwelt ice bako muAustria ndechimwe chezvishamiso zvinoshamisa zvepanyama zveEurope. Pamusoro pazvose, chinonyanya kukosha mune ino 3000o sq metres imba yechando, ice palace.
Ichi chiitiko chechisikirwo ndicho chikuru chando ice pango, uye yakasikwa nekuumbwa kwechando pasi pemabota kana matombo pasi pevhu.
Ndingasvika sei kuEisriesnwelt ice bako?
Zvinofadza kuti iri 40km bako iri rwendo rwechitima kubva kuSalzburg, uye zvitima zvinosiya awa imwe neimwe. Mukuwedzera kubva kuWerfen, pane 15 maminetsi 'minibus kukwira kubako. Uyezve, vashanyi vazhinji kuenda kuGermany, hauna kuwana chinoshamisa ichi, saka iwe unogona kunge uri mumwe wevanotsvaga zvakakosha. Iwe unogona kuita iyo-maawa-mana kukwira kumusoro kana 3 maawa 'kudzikisira kushanya nekwakatakura ngoro yemotokari.
Munich kuSalzburg Chitima Mitengo
Vienna kuenda kuSalzburg Chitima Mitengo
Graz kuSalzburg Chitima Mitengo
Linz kuSalzburg Chitima Mitengo
2. Akanakisa echisikigo echisikigo eEurope: Verdon Gorge, Furanzi
Grand Canyon yeFrance inotambanukira kunharaunda yekumaodzanyemba kweProvence. Mawere akadzika uye limestone, gadzira nzvimbo inoshamisa yemvura yakanaka kwazvo inoshamisa. saka, ichi chishamiso chakasarudzika zita rakasarudzika "Gorges du Verdon" rinoreva maGorges eblue, muchiFrench.
Iri dziva rinoshamisa muProvence rakanakira kushambira kwezhizha uye kutonhora, pamwe neparadhiso inofamba netsoka. Pane 1500 nzira dzavanokwidza vanokwira vanofarira kuyemura ichi chinoshamisa cheEuropean kubva kumusoro. saka, unosarudza kana iwe kungoda kugeza nezuva uri muigwa, kana kutsvaga netsoka.
Ndingaite Sei Kuti Ndisvike Kune Gorges Du Verdon?
Iro taundi riri padyo neMoustiers-Sainte-Marie, uye unogona kusvika ikoko nechitima kubva kuParis. Wobva unanga kumusuwo pabhiriji Pont du Galeta, kupinda ichi kushamisika.
Paris kuMarseilles Chitima Mitengo
Marseilles kuParis Chitima Mitengo
London kuParis Chitima Mitengo
Marseilles kuClermont Ferrand Chitima Mitengo
3. Akanakisa echisikigo echisikigo eEurope: Matterhorn, Itari
Monte Cervino kuNorth Italy ndizvo 4,478 metres pamusoro pegungwa. Pamusoro pe, Matterhorn ine mukurumbira nekuda kweinogona kukwana piramidhi chimiro. Matterhorn yakasikwa nenzira yechisikirwo apo nyika dzeAfrica neEurope dzakangotsvedza mukati meumwe. Nekuda kwekufamba kwenyika iyi, iro dombo guru rakawana nzira kusvika kumusoro.
Kana iwe uri kutsvaga chiitiko chisingakanganwiki muMatterhorn, wozogara mumusha weigloo pazasi pegomo. Chando nechando igloo inogarisa vafambi kwehusiku husingakanganwike. Kana uchitya kutonhora, chinwiwa nebar chinoita kuti ugare uchidziya paunenge uchiyemura gomo rakanaka pane nyeredzi husiku.
Ndingaite Sei Kuti Ndisvike Kune Matterhorn?
Ichi chishamiso chechisikigo choga ndechekutangira parwendo rwako runoshamisa. Unogona kuenda kuMatterhorn glacier ne chitima kufamba kubva Zermatt. Muchiteshi chepamusoro chechitima muEurope, unogona kuyemura iyo 360º panoramic yeItari, Siwizarendi, uye France. Izvi zvinoreva kuti iwe unogona kuwana iwo mufananidzo wakakwana kubva kune chero kona muChirimo, chirimo, kana chando-chakafukidzwa munguva yechando.
Basel kune Interlaken Chitima Mitengo
Geneva kuZermatt Chitima Mitengo
Bern kuZermatt Chitima Mitengo
Lucerne kuenda kuZermatt Chitima Mitengo
4. Aggtelek Mapango, Hangari
Aggtelek mapako zvinoshamisa zvakasikwa zvakasikwa muEurope. Zita risina kujairika rinoreva 'kudonhedza mvura' iyo yakatanga kubva kune yakasikwa nzira yekudonha kwemvura kuburikidza nedombo. Naizvozvo, sosi yezvimiro zvakanaka mumapako akaisvonaka muAggtelek national Park.
Bararara Domica Cave ndeye makumi maviri neshanu-yakareba-nzira yekudonha guva system pakati peHungary neSlovakia. Saka zvakare iri a UNESCO World Heritage nzvimbo.
Ndingaite Sei Kuti Ndisvike Kune Baradla Domica Mapako?
Aggtelek mapako ndeye 4-maawa chitima rwendo kubva kuBudapest nekuchinja. saka, kana uri kuronga rwendo rwezuva kubva kuBudapest, inogona kuomarara.
Vienna kuenda kuBudapest Chitima Mitengo
Prague kuenda kuBudapest Chitima Mitengo
Munich kuBudapest Chitima Mitengo
Graz kuenda kuBudapest Chitima Mitengo
5. Akanakisa echisikigo echisikigo eEurope: The Black Forest, Jerimani
Yakakurumbira yemiti yayo isinganzwisisike uye yakaoma, ari Dondo Dema kuGerman chishamiso chinoshamisa chemuEurope. Iri rinoyevedza gomo renzvimbo muBaden-Wurttemberg rakafemera ngano zhinji, kunge ngano dzaGrimm. Apa ndipo paunobuda kunze kweBaden-Baden spa town, uye musango rakashongedzwa rengano uye cuckoos.
Kana iwe uri kufarira chinhambwe, Triberg Falls, vakamirira sango vachifamba munzira. Imwe nzira huru yekuongorora ichi chinoshamisa chishamiso muGermany kufamba negwara nekuti chinhu chekupedzisira chaunoda kurasika munzvimbo dzine miti mikuru..
Mukupedzisa, izvi 5 zvishamiso zvepanyama zveEurope zvese zvakavanzika zvepasirese. saka, unogona zvechokwadi kuongorora Europe sevashanyi uye kuita yakakurumbira nzira yekuona nzvimbo, kana iwe unogona kuwana uye kuzvionera iwe nzvimbo dzakanaka kwazvo uye dzinotyisa nzvimbo dzeEurope. Zvizhinji, zvakakosha, zvishamiso zvese izvi zvakasikwa zvinowanikwa nechitima uye dzimwe nzira dzekutakura, kubva kumaguta epakati muEurope.
Offenburg kuenda kuFreiburg Chitima Mitengo
Stuttgart ku Freiburg Chitima Mitengo
Leipzig kuenda kuFreiburg Chitima Mitengo
Nuremberg kuenda kuFreiburg Chitima Mitengo
pano pa Chengetedza Chitima, isu tichafara kukubatsira iwe kuwana nzira yekuenda nechitima kune chero cheizvi zvishamiso zvakasikwa.
Iwe unoda kupinza yedu blog positi "5 Akanakisa echisikigo echisikigo eEurope" pane yako saiti? kana Unogona kutora mapikicha edu uye rugwaro uye kutipa chikwereti ine kubatana iyi Blog romukova. Kana tinya pano: https://iframely.com/embed/https://www.saveatrain.com/blog/best-natural-wonders-europe/?lang=sn - (Mupumburu pasi zvishoma kuona Embed Code)
- Kana uchida kuva nomutsa vanoshandisa dzenyu, unogona kuvatungamirira zvakananga kunyika yedu mapeji kutsvaka. In batanidzo ichi, iwe unowana edu anozivikanwa nzira dzechitima - https://www.saveatrain.com/routes_sitemap.xml. Inside uine Links edu Chirungu kumhara mapeji, asi isuwo tine https://www.saveatrain.com/ja_routes_sitemap.xml, uye iwe unogona kushandura / ja kuti / ja kana / of uye mimwe mitauro.


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Munguva pfupi yadarika, matatu emishonga ekurapa majini akabvumidzwa kushambadzira, anoti: (1) Musi waChikunguru 21, 2022, PTC Therapeutics, Inc. (NASDAQ: PTCT) yakazivisa kuti AAV gene therapy Upstaza™ yakabvumidzwa neEuropean Commission Ndiyo yakatanga kutengeswa jena therapy yakanangidzirwa muuropi (ona zvinyorwa zvakapfuura: Chimwe Chikuru muGene Therapy | Mushonga wekutanga weAAV wepasi rose wakapinzwa muuropi unotenderwa kushambadzira).(2) Musi waNyamavhuvhu 17, 2022, iyo US Food and Drug Administration (FDA) yakabvumidza Bluebird Bio's gene therapy Zynteglo (betibeglogene autotemcel, beti-cel) kurapa beta thalassemia.Kubvumirwa kwekurapa muUnited States pasina mubvunzo "rubatsiro muchando" yeBluebird Bio, iyo iri mumatambudziko emari.(3) Musi wa24 Nyamavhuvhu 2022, BioMarin Pharmaceutical (BioMarin) yakazivisa kuti European Commission yakabvumidza kushambadzira kweROCTAVIAN ™ (valoctocogene roxaparvovec), gene therapy yehemophilia A, yekurapa varwere vasina nhoroondo yeFVIII factor inhibitors. neAAV5 masoja ekudzivirira chirwere akanyanya varwere vane hemophilia A yakanyanya (ona chinyorwa chapfuura: Heavy! BioMarin's hemophilia A Gene therapy inobvumidzwa kutengeswa).Parizvino, 41 gene therapy mishonga yakabvumidzwa kushambadzira pasi rese.
Gene ndiyo yakakosha genetic unit inodzora hunhu.Kunze kwemajini emamwe mavhairasi, ayo anoumbwa neRNA, majini ezvipenyu zvakawanda anoumbwa neDNA.Zvirwere zvakawanda zvechipenyu zvinokonzerwa nekudyidzana pakati pemajini uye zvakatipoteredza, uye zvirwere zvakawanda zvinogona kurapwa kana kuderedzwa mukukosha kuburikidza nejene therapy.Gene therapy inoonekwa seshanduko mumunda wemishonga uye pharmacy.Iyo yakafara gene therapy mishonga inosanganisira zvinodhaka zvinoenderana neDNA-modified DNA mishonga (senge viral vector-based in vivo gene therapy drugs, in vitro gene therapy drugs, vasina kupfeka plasmid drugs, etc.) nemishonga yeRNA (senge antisense oligonucleotide zvinodhaka, siRNA mishonga, uye mRNA gene therapy, nezvimwewo);zvakanyatsotsanangurwa Gene therapy mishonga inonyanya kusanganisira plasmid DNA mishonga, gene therapy mishonga yakavakirwa pamavhairasi mavhairasi, gene therapy mishonga yakavakirwa pamabhakitiriya mavheji, masisitimu ekugadzirisa majini uye sero therapy mishonga inogadziriswa in vitro.Mushure memakore ekukura kwakashata, gene therapy mishonga yakawana zvinokurudzira zvekiriniki.(tisingasanganisire majekiseni eDNA uye mRNA vaccines), 41 gene therapy mishonga yakabvumidzwa kutengeswa munyika.Nekutangwa kwezvigadzirwa uye nekukasira kusimukira kweiyo gene therapy tekinoroji, gene therapy yave kuda kuunza nguva yekukurumidza kukura.
Kukamurwa kwejene kurapwa (Mufananidzo sosi: Biological Jingwei)
Ichi chinyorwa chinonyora 41 gene marapirwo akatenderwa kushambadzira (tisingasanganisire DNA vaccine uye mRNA vaccines).
1. In vitro gene therapy
(1) Strimvelis
Kambani: Yakagadzirwa neGlaxoSmithKline (GSK).
Nguva yemusika: Yakatenderwa neEuropean Union muna Chivabvu 2016.
Zvinoratidza: Pakurapa kwakanyanya kusanganisa immunodeficiency (SCID).
Tsanangudzo: Iyo nzira yekurapa iyi ndeyekutanga kuwana murwere ega masero ehematopoietic stem masero, kuwedzera uye kugadzira iwo mu vitro, uyezve kushandisa retrovirus kuunza kopi inoshanda inoshanda ADA (adenosine deaminase) gene mumasero avo ehematopoietic stem, uye pakupedzisira fambisa iyo yakagadziriswa hematopoietic stem masero.Hematopoietic stem masero anodzoserwa zvakare mumuviri.Mibairo yemakiriniki yakaratidza kuti chiyero chemakore matatu chekurarama kwevarwere veADA-SCID vakarapwa neStrimvelis chaive zana%.
(2) Zalmoxis
Kambani: Yakagadzirwa neMolMed, Italy.
Nguva yemusika: Yakawana EU inomisikidzwa yekushambadzira mvumo muna 2016.
Zvinoratidza: Inoshandiswa kune adjuvant kurapa kwea immune system yevarwere mushure meiyo hematopoietic stem cell transplantation.
Mashoko: Zalmoxis is allogeneic T cell suicide gene immunotherapy yakagadziridzwa neretroviral vector.Iyo 1NGFR uye HSV-TK Mut2 kuzviuraya majini inobvumira vanhu kushandisa ganciclovir chero nguva kuuraya masero eT anokonzera mhinduro dzakaipa dzekudzivirira, kudzivirira kuwedzera kuderera kweGVHD kunogona kuitika, uye kudzorera kushanda kwemuviri kune varwere vane haploidentical HSCT mushure mekuvhiyiwa Escort.
(3) Invossa-K
Kambani: Yakagadzirwa neTissueGene (KolonTissueGene) kambani.
Nguva yemusika: Yakatenderwa kunyorwa muSouth Korea muna Chikunguru 2017.
Zviratidzo: Kurapa kwekuparara kwemabvi arthritis.
Mashoko: Invossa-K inonzi allogeneic cell gene therapy inosanganisira chondrocytes yevanhu.Masero eAllogeneic ane genetically modified in vitro, uye masero akashandurwa anogona kuratidza uye kuvhara kushandura kushandura kukura chinhu B1 (TGF-B1) mushure mejojo ye intra-articular.B1), nokudaro achivandudza zviratidzo zveosteoarthritis.Migumisiro yemakiriniki inoratidza kuti Invossa-K inogona kuvandudza zvakanyanya arthritis yemabvi.Rezinesi rakabviswa neSouth Korea's drug regulator muna 2019 nekuti mugadziri wacho akanyora zvisizvo izvo zvinoshandiswa.
(4) Zynteglo
Kambani: Yakagadzirwa neAmerican bluebird bio (bluebird bio) kambani.
Nguva yemusika: Yakatenderwa neEuropean Union muna 2019, uye yakatenderwa neFDA muna Nyamavhuvhu 2022.
Zvinoratidza: Zvekurapa kwekuisira ropa-inotsamira B-thalassemia.
Tsanangudzo: Zynteglo inonzi lentiviral in vitro gene therapy, iyo inoshandisa lentiviral vector kuti ibudise kopi inoshanda yegeneti ye B-globin gene (BA-T87Q-globin gene) mumasero ehematopoietic stem akabviswa kubva kuvarwere., uye wozopinza aya masero ane genetically modified autologous hematopoietic stem cells kudzokera kumurwere.Kana murwere angove neakajairika BA-T87Q-globin gene, anogona kugadzira yakajairika HbAT87Q protein, inogona kunyatso kudzikisa kana kubvisa kudiwa kwekuwedzerwa ropa.Inguva imwe chete yekurapa yakagadzirirwa kutsiva kuwedzerwa ropa kwehupenyu hwese uye mishonga yeupenyu hwese kune varwere vane makore gumi nemaviri zvichikwira.
(5) Skysona
Kambani: Yakagadzirwa neAmerican bluebird bio (bluebird bio) kambani.
Nguva yemusika: Yakatenderwa neEU kushambadzira muna Chikunguru 2021.
Zviratidzo: Pakurapa kwekutanga cerebral adrenoleukodystrophy (CALD).
Remarks: Skysona gene therapy ndiyo yega-nguva imwe chete gene therapy inotenderwa kurapwa kwekutanga cerebral adrenoleukodystrophy (CALD).Skysona (elivaldogene autotemcel, Lenti-D) is hematopoietic stem cell lentiviral in vitro gene therapy Lenti-D.Maitiro ekurapa ndeaya anotevera: autologous hematopoietic stem masero anotorwa kubva kumurwere, akagadziridzwa in vitro ne lentivirus inotakura yemunhu ABCD1 gene, yozodzoserwa kumashure kumurwere.Nekurapwa kwevarwere vari pasi pemakore gumi nemasere neABCD1 gene mutation uye CALD.
(6) Kymriah
Kambani: Yakagadzirwa naNovartis.
Nguva yemusika: Yakatenderwa neFDA muna Nyamavhuvhu 2017.
Zviratidzo: Kurapa kwe precursor B-cell acute lymphoblastic leukemia (ALL) uye yakadzoka zvakare uye inoramba DLBCL.
Mashoko: Kymriah mushonga welentiviral in vitro gene therapy, mushonga wekutanga kubvumidzwa pasi rose weCAR-T, wakananga kuCD19 uye uchishandisa co-stimulatory factor 4-1BB.Mitengo i$475,000 muUS uye $313,000 muJapan.
(7) Yescarta
Kambani: Yakagadzirwa naKite Pharma, inotsigira yeGiriyedhi.
Nguva yemusika: Yakatenderwa neFDA muna Gumiguru 2017.
Zviratidzo: Pakurapa kwekudzokazve kana kuti refractory hombe B-cell lymphoma.
Remarks: Yescarta iretroviral in vitro gene therapy.Ndiyo yechipiri CAR-T therapy inobvumidzwa munyika.Inonangana neCD19 uye inoshandisa costimulatory factor yeCD28.Mutengo muUS $373,000.
(8) Tecartus
Kambani: Yakagadzirwa neGiriyedhi (GILD).
Nguva yemusika: Yakatenderwa neFDA muna Chikunguru 2020.
Zviratidzo: Zvekudzokazve kana refractory mantle cell lymphoma.
Mashoko: Tecartus ndeye autologous CAR-T cell therapy yakanangana neCD19, uye ndiyo yechitatu CAR-T kurapwa yakabvumidzwa kushambadzira munyika.
(9) Breyanzi
Kambani: Yakagadzirwa neBristol-Myers Squibb (BMS).
Nguva yemusika: Yakatenderwa neFDA muna Kukadzi 2021.
Zviratidzo: Yakadzoka zvakare kana kuti refractory (R / R) yakakura B-cell lymphoma (LBCL).
Remarks: Breyanzi in vitro gene therapy yakavakirwa pa lentivirus, uye yechina CAR-T therapy inotenderwa kushambadzira munyika, yakanangana neCD19.Kubvumidzwa kwaBreyanzi chiitiko chakakosha cheBristol-Myers squibb mumunda we cellular immunotherapy, iyo Bristol-Myers yakawana payakawana Celgene yemabhiriyoni makumi manomwe nemana emadhora muna 2019.
(10) Abecma
Kambani: Co-yakagadziridzwa naBristol-Myers Squibb (BMS) uye bluebird bio.
Nguva yemusika: Yakatenderwa neFDA munaKurume 2021.
Zviratidzo: Yakadzokazve kana kuti refractory multiple myeloma.
Mashoko: Abecma ndeye lentivirus-yakavakirwa in vitro gene therapy, yekutanga pasi rose CAR-T cell therapy yakanangana neBCMA, uye yechishanu CAR-T kurapwa yakatenderwa neFDA.Mushonga wemushonga ndeyekutaura chimeric BCMA receptor pane murwere autologous T masero kuburikidza lentivirus-mediated genetic modification in vitro.Pamberi pekuiswa kwesero gene mushonga, murwere akagamuchira maviri emakemikari e cyclophosphamide uye fludarabine kuti atange kurapwa.Kurapa kubvisa masero eT asina kugadziriswa kubva kumurwere, uyezve kupinza masero eT akagadziridzwa zvakare mumuviri wemurwere kutsvaga nekuuraya BCMA-inoratidza cancer maseru.
(11) Libmeldy
Kambani: Yakagadzirwa neOrchard Therapeutics.
Nguva yemusika: Yakatenderwa neEuropean Union kuti inyore muna Zvita 2020.
Zvinoratidza: Pakurapa metachromatic leukodystrophy (MLD).
Remarks: Libmeldy mushonga wegene wakavakirwa palentiviral in vitro gene gadziriso ye autologous CD34 + masero.Data yekiriniki inoratidza kuti imwe intravenous infusion yeLibmeldy inoshanda mukugadzirisa nzira yekutanga-yekutanga MLD uye yakanyanya mota uye kukanganiswa kwekuziva muvarwere vasina kurapwa vezera rimwe chete.
(12) Benoda
Kambani: Yakagadzirwa naWuXi Junuo.
Nguva yemusika: Zvakatenderwa zviri pamutemo neNMPA munaGunyana 2021.
Zviratidzo: Kurapa kwekudzokazve kana kuti refractory yakakura B-cell lymphoma (r / r LBCL) muvarwere vakuru mushure mechipiri-mutsara kana kupfuura systemic therapy.
Remarks: Benoda is anti-CD19 CAR-T gene therapy, uye zvakare iri musimboti chigadzirwa cheWuXi Junuo.Ndiyo yechipiri CAR-T chigadzirwa chakatenderwa muChina, kunze kwekudzokororwa/refractory hombe B-cell lymphoma.Pamusoro pezvo, WuXi Junuo anorongawo kugadzira jekiseni reRuiki Orenza rekurapwa kwezvimwe zviratidzo zvakasiyana, zvinosanganisira follicular lymphoma (FL), mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), mutsara wechipiri diffuse hombe B-cell lymphoma. (DLBCL) uye acute lymphoblastic leukemia (ALL).
(13) CARVYKTI
Kambani: Legend Bio yekutanga yakabvumidzwa chigadzirwa.
Nguva yemusika: Yakatenderwa neFDA muna Kukadzi 2022.
Zviratidzo: Kurapa kwekudzokazve kana kuti refractory multiple myeloma (R / R MM).
Tsanangudzo: CARVYKTI (ciltacabtagene autoleucel, inonzi Cilta-cel) inonzi CAR-T cell immune gene therapy ine masoja maviri e-single-domain anonangana neB cell maturation antigen (BCMA).Iyo data inoratidza kuti CARVYKTI yakaratidza huwandu hwekupindura kusvika ku98% muvarwere vane myeloma yakadzokororwa kana kuti refractory vanga vagamuchira mana kana anopfuura ekurapa kwepamberi, kusanganisira proteasome inhibitors, immunomodulators, uye anti-CD38 monoclonal antibodies.
2. In vivo gene therapy inobva pahutachiona hwehutachiona
(1) Gendicine/kuzvarwa patsva
Kambani: Yakagadzirwa neShenzhen Saibainuo Kambani.
Nguva yemusika: Yakatenderwa kunyorwa muChina muna 2003.
Zviratidzo: Kurapa kwe squamous cell carcinoma yemusoro nemutsipa.
Mashoko: Recombinant human p53 adenovirus jekiseni Gendicine/Jinshengsheng mushonga weadenovirus vector gene therapy une kodzero dzakazvimirira dzepfuma yekambani yeShenzhen Saibainuo.Mushonga unoumbwa neakajairika bundu remunhu suppressor gene p53 uye artificially modified recombinant replication-deficient Human adenovirus type 5 inoumbwa neadenovirus yemunhu rudzi 5. Iyo yekutanga ndiyo huru chimiro chemushonga kuita anti-bundu mhedzisiro, uye yekupedzisira kunyanya. inoshanda semutakuri.Iyo adenovirus vector inotakura therapeutic gene p53 kupinda musero rinonangwa, uye rinoratidza bundu suppressor gene p53 musero rinotarisirwa.Chigadzirwa chacho chinogona kusimudza-kudzora akasiyana-siyana anopesana negomarara majini uye pasi-kudzora zviitiko zveakasiyana oncogenes, nekudaro kuwedzera anti-tumor mhedzisiro yemuviri uye kuzadzisa chinangwa chekuuraya mamota.
(2) Rigvir
Kambani: Yakagadzirwa nekambani yeLatvia Latima.
Nguva yemusika: Yakatenderwa muLatvia muna 2004.
Zviratidzo: Pakurapa melanoma.
Remarks: Rigvir mushonga wegene wakavakirwa pane gene-modified ECHO-7 enterovirus vector, iyo yakashandiswa muLatvia, Estonia, Poland, Armenia, Belarus nedzimwe nzvimbo, uye zvakare iri kunyoreswa neEMA yeEuropean Union..Mhosva dzekiriniki mumakore gumi apfuura dzakaratidza kuti hutachiona hweRigvir oncolytic hwakachengeteka uye hunoshanda, uye hunogona kuvandudza huwandu hwekupona kwevarwere vemelanoma ka4-6.Pamusoro pezvo, kurapwa kwacho kwakakodzerawo kune akasiyana mamwe magomarara, kusanganisira colorectal cancer, pancreatic cancer, dundira.kenza, kenza yeitsvo, kenza yeprostate, kenza yemapapu, kenza yechibereko, lymphosarcoma, nezvimwe.
(3) Oncorine/Ankerui
Kambani: Yakagadzirwa neShanghai Sunway Biotechnology Co., Ltd.
Nguva yemusika: Yakatenderwa kunyorwa muChina muna 2005.
Zviratidzo: Kurapa kwemusoro nemutsipa bundu, kenza yechiropa, kenza yepancreatic, kenza yechibereko uye mamwe magomarara.
Manzwiro: Oncorine ndeye oncolytic hutachiona gene therapy chigadzirwa uchishandisa adenovirus sevector.Iyo yakawanikwa oncolytic adenovirus inogona kudzokorora zvakananga mumamota anoshaikwa kana abnormal p53 gene, zvichikonzera tumor cell lysis, nekudaro kuuraya bundu maseru.pasina kukuvadza masero akajairika.Mhedzisiro yekiriniki inoratidza kuti Anke Rui ane chengetedzo yakanaka uye inoshanda kune akasiyana siyana emamota akaipa.
(4) Glybera
Kambani: Yakagadziriswa neUniQure.
Nguva yemusika: Yakatenderwa muEurope muna 2012.
Zviratidzo: Kurapa kwe lipoprotein lipase kushomeka (LPLD) neyakaomarara kana inodzokororwa episodhi yepancreatitis kunyangwe yakanyatso kurambidzwa kudya kwemafuta.
Tsanangudzo: Glybera (alipogene tiparvovec) mushonga wegene therapy wakavakirwa paAAV sevheji.Mushonga uyu unoshandisa AAV sevheji kuendesa jini rekurapa LPL mumasero etsandanyama, kuitira kuti masero anoenderana anogona kuburitsa imwe huwandu hwelipoprotein lipase, Inoita basa mukubvisa chirwere, uye kurapa uku kunoshanda kwenguva yakareba mushure meimwe. kutonga (mhedzisiro inogona kugara kwemakore mazhinji).Mushonga uyu wakabviswa muna 2017, uye zvikonzero zvekubviswa kwayo zvinogona kunge zvine chekuita nezvinhu zviviri: mitengo yakawandisa uye kushomeka kwemusika.Mari yeavhareji yekurapwa kumwe chete kwemushonga yakakwira kusvika miriyoni imwe chete yemadhora ekuAmerica, uye murwere mumwe chete ndiye akatenga nekuishandisa kusvika pari zvino.Kunyange zvazvo kambani yeinishuwarenzi yezvokurapa yakaidzorera 900,000 US madhora, zvakare mutoro mukuru kukambani yeinishuwarenzi.Mukuwedzera, chiratidzo chemushonga hachiwanzoitiki, nehuwandu hwechiitiko che 1 mu 1 mamiriyoni uye nehuwandu hwekusaziva.
(5) Imlygic
Kambani: Yakagadzirwa neAmgen.
Nguva yemusika: Muna 2015, yakatenderwa kunyorwa muUnited States neEuropean Union.
Zvinoratidza: Kurapwa kwemaronda e melanoma asingagoni kubviswa zvachose nokuvhiyiwa.
Remarks: Imlygic is a genetically modified (kubvisa ICP34.5 uye ICP47 gene fragments, nekuisa munhu granulocyte-macrophage colony-stimulating factor GM-CSF gene muhutachiona) attenuated herpes simplex virus type 1 (HSV-1) oncolytic virus. , yekutanga FDA-yakatenderwa oncolytic virus gene therapy.Nzira yehutungamiri ndeye intralesional injection.Jekiseni rakananga mumaronda e-melanoma rinogona kukonzera kuputika kwemasero emudumbu uye kuburitsa maantigen anokonzerwa nebundu uye GM-CSF kukurudzira mhinduro dzekurwisa-tumor immune immune.
(6) Luxturna
Kambani: Yakagadziridzwa neSpark Therapeutics, inotsigira Roche.
Nguva yemusika: Yakatenderwa neFDA muna 2017, uyezve yakabvumidzwa kushambadzira muEurope muna 2018.
Zviratidzo: Kurapa kwevana nevakuru vane kurasikirwa kwekuona nekuda kwekushanduka kwekaviri kopi yeRPE65 gene asi nenhamba yakakwana yemasero eretinal anoshanda.
Matauriro: Luxturna ndeye AAV-yakavakirwa gene therapy iyo inotungamirwa ne subretinal jekiseni.The gene therapy inoshandisa AAV2 semutakuri kuunza kopi inoshanda yeyakajairika RPE65 gene mumasero eretinal emurwere, kuitira kuti masero anowirirana aratidze yakajairika RPE65 protein kubhadharira kuremara kwemurwere RPE65 protein, nekudaro kuvandudza chiono chemurwere.
(7) Zolgensma
Kambani: Yakagadziridzwa neAveXis, inotsigira yeNovartis.
Nguva yemusika: Yakatenderwa neFDA muna Chivabvu 2019.
Zviratidzo: Kurapa kwepinal muscular atrophy (Spinal Muscular Atrophy, SMA) varwere vari pasi pemakore maviri.
Mazwi: Zolgensma ijena rekurapa rakavakirwa paAAV vector.Mushonga uyu ndiwo wega-nguva imwe chete chirongwa chekurapa chespinal muscular atrophy chakabvumidzwa kushambadzira munyika.peji, kufambira mberi kukuru.Iyi gene therapy inoshandisa scAAV9 vector kuunza yakajairika SMN1 gene muvarwere kuburikidza ne intravenous infusion, ichigadzira yakajairika SMN1 protein, nekudaro inovandudza basa reakakanganisika maseru akadai semotor neurons.Kusiyana neizvi, mishonga yeSMA Spinraza neEvrysdi inoda kudzokororwa kudzokororwa kwenguva yakareba, neSpinraza inoshandiswa sejekiseni remusana mwedzi mina yega yega, uye Evrysdi, mushonga wezuva nezuva wemukanwa.
(8) Delytact
Kambani: Yakagadzirwa neDaiichi Sankyo Company Limited (TYO: 4568).
Nguva yemusika: Mvumo ine mamiriro kubva kuJapan Ministry of Health, Labor and Welfare (MHLW) muna Chikumi 2021.
Zvinoratidza: Zvekurapa malignant glioma.
Matauriro: Delytact ndiyo yechina oncolytic hutachiona gene therapy chigadzirwa chakabvumidzwa pasi rose uye yekutanga oncolytic hutachiona chigadzirwa chakabvumidzwa kurapwa kwemalignant glioma.Delytact is a genetically engineered herpes simplex virus type 1 (HSV-1) oncolytic virus yakagadzirwa naDr. Todo nevamwe vaaishanda navo.Delytact inounza imwezve yekudzima mutation muG207 genome yechipiri-chizvarwa HSV-1, ichiwedzera yakasarudzika kudzokororwa mumaseru egomarara uye kuiswa kweanopesana netumor immune mhinduro, uku ichichengetedza yakakwirira chengetedzo chimiro.Delytact ndiyo yekutanga chizvarwa chechitatu oncolytic HSV-1 parizvino mukuongororwa kwekiriniki.Mvumo yeDelytact muJapan yaive yakavakirwa pane imwe-ruoko Phase 2 yekiriniki yekuyedza.Mune varwere vane inodzokororwa glioblastoma, Delytact yakasangana nemagumo ekupedzisira ekupona kwegore rimwe, uye mhedzisiro yakaratidza kuti Delytact yakaita zvirinani pane G207.Kudzokorora kwakasimba uye yakakwirira antitumor chiitiko.Izvi zvinoshanda mumhando dzakasimba dzebundu dzinosanganisira zamu, prostate, schwannoma, nasopharyngeal, hepatocellular, colorectal, malignant peripheral nerve sheath tumors uye gomarara rethyroid.
(9) Upstaza
Kambani: Yakagadzirwa nePTC Therapeutics, Inc. (NASDAQ: PTCT).
Nguva yemusika: Yakatenderwa neEU muna Chikunguru 2022.
Chiratidzo: Kushomeka kweL-amino acid decarboxylase (AADC) inonhuhwirira, yakatenderwa kurapwa kwevarwere vane mwedzi gumi nemisere zvichikwira.
Remarks: Upstaza™ (eladocagene exuparvovec) iri in vivo gene therapy uchishandisa adeno-associated virus type 2 (AAV2) sevheta.Murwere ari kurwara nekuda kwekushanduka kwejini encoding iyo AADC enzyme.AAV2 inotakura gene ine hutano inokodha iyo AADC enzyme.Therapeutic effect inowanikwa nenzira ye genetic compensation.Mukutaura, imwe dhesi inoshanda kwenguva yakareba.Ndiyo yekutanga kutengeswa kwejene therapy yakananga muuropi.Mvumo yekushambadzira inoshanda kune ese makumi maviri nenomwe enhengo dzeEU, pamwe neIceland, Norway neLiechtenstein.
(9) Roctavian
Kambani: Yakagadzirwa neBioMarin Pharmaceutical (BioMarin).
Nguva yemusika: Yakatenderwa neEU muna Nyamavhuvhu 2022.
Zviratidzo: Kurapa kwevarwere vakuru vane hemophilia yakaoma A vasina nhoroondo yeFVIII factor inhibition uye AAV5 antibody negative.
Mashoko: Roctavian (valoctocogene roxaparvovec) inoshandisa AAV5 sevheta uye inoshandisa chiropa chemunhu chakananga HLP kufambisa kutaura kwemunhu coagulation factor sere (FVIII) neB domain yakabviswa.Sarudzo yeEuropean Commission yekubvumidza kutengeswa kwevaloctocogene roxaparvovec yakavakirwa pane yakazara data yechirongwa chekiriniki yekuvandudza mushonga.Pakati pavo, chikamu chechitatu chekliniki yekuedza GENEr8-1 yakaratidza kuti kana ichienzaniswa nedheta regore risati ranyoreswa, mushure mekuiswa kamwe chete kwevaloctocogene roxaparvovec, Zvidzidzo zvaive nehuwandu hwekubuda ropa kwegore negore (ABR), kushandiswa kusingawanzoitiki kwechimwe chinhu chechipiri VIII. (F8) mapuroteni ekugadzirira, kana kuwedzera kukuru kwekuita kweF8 muropa remuviri.Mushure memavhiki e4 ekurapwa, zvidzidzo zvegore negore zveF8 kushandiswa uye ABR inoda kurapwa yakaderedzwa ne99% uye 84%, maererano, mutsauko wakakosha (p <0.001).Nhoroondo yekuchengetedza yakanga yakanaka, pasina zvidzidzo zvinosangana neF8 factor inhibition, kuipa, kana thrombotic side effects, uye hapana zviitiko zvakakomba zvine chokuita nekurapa (SAEs) zvakataurwa.
3. Small nucleic acid mishonga
(1) Vitravene
Kambani: Yakabatanidzwa neIonis Pharma (yaimbova Isis Pharma) uye Novartis.
Nguva yemusika: Yakatenderwa neFDA neEU EMA muna 1998 na1999.
Zviratidzo: Kurapa kwe cytomegalovirus retinitis muvarwere vane HIV.
Tsanangudzo: Vitravene is an antisense oligonucleotide drug uye yekutanga oligonucleotide mushonga unobvumirwa kushambadzira munyika.Pakutanga kwemusika, kudiwa kwemusika kwemishonga inorwisa-cytomegalovirus yakanga yakakurumidza zvikuru;zvino nekuda kwekuvandudzwa kweanoshanda zvakanyanya antiretroviral therapy, nhamba ye cytomegalovirus kesi yakaderera zvakanyanya.Nekuda kwekushomeka kwemusika, mushonga wakabudiswa muna 2002 uye 2006 Kubviswa munyika dzeEU uye US.
(2) Macugen
Kambani: Co-yakagadziridzwa naPfizer uye Eyetech.
Nguva yemusika: Yakatenderwa kunyorwa muUnited States muna 2004.
Zviratidzo: Pakurapa neovascular age-related macular degeneration.
Mashoko: Macugen is pegylated modified oligonucleotide drug inogona kutarisa uye kusunga kune vascular endothelial growth factor (VEGF165 isoform), uye inotungamirirwa nejekiseni ye intravitreal.
(3) Defitelio
Kambani: Yakagadzirwa neJazz.
Nguva yemusika: Yakatenderwa neEuropean Union muna 2013, uye yakabvumidzwa neFDA munaKurume 2016.
Zviratidzo: Kurapa kwehepatic venule occlusive chirwere chakabatana nerenal kana pulmonary dysfunction mushure mekuita hematopoietic stem cell transplantation.
Tsanangudzo: Defitelio is oligonucleotide drug, musanganiswa we oligonucleotides ane plasmin properties.Yakabviswa muna 2009 nekuda kwezvikonzero zvekutengesa.
(4) Kynamro
Kambani: Co-yakagadziridzwa naIonis Pharma naKastle.
Nguva yemusika: Yakatenderwa muUnited States semushonga wenherera muna 2013.
Zvinoratidza: Zvekurapa adjuvant ye homozygous mhuri hypercholesterolemia.
Tsanangudzo: Kynamro is an antisense oligonucleotide drug, an antisense oligonucleotide inotarisa munhu apo B-100 mRNA.Kynamro inoshandiswa se 200 mg subcutaneously kamwe pavhiki.
(5) Spinraza
Kambani: Yakagadziriswa neIonis Pharmaceuticals.
Nguva yemusika: Yakatenderwa neFDA muna Zvita 2016.
Zviratidzo: Kurapa kwespinal muscular atrophy (SMA).
Tsanangudzo: Spinraza (nusinersen) is antisense oligonucleotide drug.Spinraza inogona kushandura iyo RNA splicing yeSMN2 gene nekusunga kune splicing saiti yeSMN2 exon 7, nekudaro ichiwedzera kugadzirwa kweanoshanda zvizere SMN protein.Muna Nyamavhuvhu 2016, BIOGEN Corporation yakashandisa sarudzo yayo kuwana kodzero dzepasi rose dzeSpinraza.Spinraza yakatanga kuyerwa kwekiriniki yekutanga muvanhu muna 2011. Mumakore mashanu chete, yakabvumidzwa neFDA muna 2016, zvichiratidza kucherechedzwa kweFDA kuzere kwekuita kwayo.Mushonga uyu wakatenderwa kushambadzira muChina muna Kubvumbi 2019. Kutenderera kwese kwemvumo kweSpinraza muChina kuri pasi pemwedzi mitanhatu.Pave nemakore maviri nemwedzi miviri kubva Spinraza yakatanga kubvumidzwa muUnited States.Chirwere chakadaro che blockbuster chekune dzimwe nyika chisingawanzo mushonga chiri muKumhanya kwekunyora muChina kwatove nekukurumidza.Izvi zvinokonzerwawo ne "Chiziviso Chekuburitswa Kwekutanga Rondedzero YeOverseas Mishonga Itsva Inodiwa Nekukurumidza Kutsvagisa Kliniki" yakapihwa neCentre for Drug Evaluation munaNovember 1, 2018, iyo yakaverengerwa muchikamu chekutanga chemakumi mana akakosha ekunze matsva. mishonga yekukurumidza kuongorora, uye Spinraza yakaiswa mukati.
(6) Eksodho 51
Kambani: Yakagadzirwa neAVI BioPharma (yakazonzi Sarepta Therapeutics).
Nguva yemusika: Yakatenderwa neFDA munaGunyana 2016.
Zviratidzo: Kurapa kweDuchenne muscular dystrophy (DMD) neDMD gene mutation mu exon 51 skipping gene.
Mashoko: Exondys 51 is an antisense oligonucleotide drug.Iyo antisense oligonucleotide inogona kusunga kune exon 51 nzvimbo yepre-mRNA yeDMD gene, zvichiita kuti pave nekuumbwa kwemRNA yakakura.Kubvisa, nokudaro kururamisa chikamu chekuverenga mRNA, kunobatsira murwere kugadzira mamwe maitiro anoshanda edystrophin ari mapfupi pane akajairika mapuroteni, nekudaro achivandudza zviratidzo zvemurwere.
(7) Tegsedi
Kambani: Yakagadziriswa neIonis Pharmaceuticals.
Nguva yemusika: Yakatenderwa neEuropean Union yekushambadzira muna Chikunguru 2018.
Zviratidzo: Pakurapa kwenhaka transthyretin amyloidosis (hATTR).
Tsanangudzo: Tegsedi inonzi antisense oligonucleotide drug inotarisa transthyretin mRNA.Ndiwo mushonga wekutanga kubvumidzwa pasi rose wekurapa hATTR.Nzira yehutungamiri ndeye subcutaneous injection.Mushonga unoderedza kugadzirwa kweATTR protein nekutarisa mRNA ye transthyretin (ATTR), uye ine mukana wakanaka wekubatsira-ngozi mukurapa kweATTR.Hapana danho rechirwere kana kuvepo kwecardiomyopathy yaive yakakosha.
(8) Onpattro
Kambani: Co-yakagadziridzwa neAlnylam naSanofi.
Nguva yemusika: Yakatenderwa kunyorwa muUnited States muna 2018.
Zviratidzo: Pakurapa kwenhaka transthyretin amyloidosis (hATTR).
Tsanangudzo: Onpattro is a siRNA drug inotarisa transthyretin mRNA, iyo inoderedza kugadzirwa kweATTR protein muchiropa uye kuunganidzwa kweamyloid deposits mu peripheral nerve nekutarisa mRNA ye transthyretin (ATTR)., nokudaro kuvandudza uye kubvisa zviratidzo zvechirwere.
(9) Givlaari
Kambani: Yakagadzirwa neAlnylam Corporation.
Nguva yemusika: Yakatenderwa neFDA munaNovember 2019.
Zviratidzo: Kurapa kweacute hepatic porphyria (AHP) muvakuru.
Mashoko: Givlaari mushonga we siRNA, wechipiri siRNA mushonga unobvumidzwa kushambadzira mushure meOnpattro.Mushonga unopihwa pasi uye unonangana nemRNA yekushatisa ALAS1 protein.Mwedzi wega wega Givlaari kurapwa kunogona zvakanyanya uye nekuramba kudzikisa mwero weALAS1 muchiropa, nekudaro kuderedza mazinga eurotoxic ALA nePBG kusvika kune yakajairika, nekudaro Rerutsira zviratidzo zvechirwere chemurwere.Iyo data yakaratidza kuti varwere vanobatwa neGivlaari vaive ne74% kuderedzwa kwenhamba yezvirwere zvinopisa zvichienzaniswa neboka re placebo.
(10) Vyondys53
Kambani: Yakagadzirwa neSarepta Therapeutics.
Nguva yemusika: Yakatenderwa neFDA muna Zvita 2019.
Chiratidzo: Kurapwa kwevarwere veDMD vane dystrophin gene exon 53 splice mutation.
Mashoko: Vyondys 53 is an antisense oligonucleotide drug.Mushonga we oligonucleotide unonangana neiyo splicing process ye dystrophin mRNA precursor.Mune nzira isina kunanga yedystrophin mRNA precursor, iyo yekunze Exon 53 yakanga yakamurwa zvishoma, kureva kuti haipo pane yakakura mRNA, uye yakagadzirirwa kuburitsa truncated asi ichiri inoshanda dystrophin protein, nekudaro ichivandudza kurovedza muviri muvarwere.
(11) Waylivra
Kambani: Yakagadziridzwa neIonis Pharmaceuticals uye inotsigira Akcea Therapeutics.
Nguva yemusika: Yakatenderwa neEuropean Medicines Agency (EMA) muna Chivabvu 2019.
Chiratidzo: Sechirongwa chekuwedzera kune chikafu chinodzorwa muvarwere vakuru vane mhuri chylomicronemia syndrome (FCS).
Tsanangudzo: Waylivra is an antisense oligonucleotide drug, inova mushonga wekutanga unobvumidzwa kurapwa kweFCS munyika.
(12) Leqvio
Kambani: Yakagadzirwa naNovartis.
Nguva yemusika: Yakabvumidzwa neEU muna Zvita 2020.
Zviratidzo: Pakurapa kwevakuru vekutanga hypercholesterolemia (heterozygous yemhuri uye isiri yemhuri) kana yakasanganiswa dyslipidemia.
Mashoko: Leqvio mushonga we siRNA wakanangana nePCSK9 mRNA.Ndiyo yekutanga pasi rose cholesterol-kudzikisa (LDL-C) siRNA therapy.Nzira yehutungamiri ndeye subcutaneous injection.Mushonga unoshanda neRNA kupindira kudzikisa PCSK9 mapuroteni mazinga, ayo anozodzikisa mazinga eLDL-C.Data yekiriniki inoratidza kuti Leqvio inogona kuderedza LDL-C neinosvika makumi mashanu muzana muvarwere vane mazinga eLDL-C asingagone kudzikiswa kusvika panhanho dzakanangwa kunyangwe akaremerwa madosi emastatins.
(13) Oslumo
Kambani: Yakagadzirwa neAlnylam Pharmaceuticals.
Nguva yemusika: Yakabvumidzwa neEU munaNovember 2020.
Zviratidzo: Pakurapa kwekutanga hyperoxaluria mhando 1 (PH1).
Tsanangudzo: Oxlumo is a siRNA drug inotarisa hydroxy acid oxidase 1 (HAO1) mRNA, iyo inotungamirirwa pasi pecutaneously.Mushonga uyu wakagadzirwa uchishandisa Alnylam's ichangoburwa yakagadziridzwa kemikari ESC-GalNAc conjugation tekinoroji, iyo inogonesa inodzorwa pasiRNAs nekushingirira kukuru uye kushanda nesimba.Mushonga wacho unotarisa kuora kana kuvharidzirwa kwehydroxy acid oxidase 1 (HAO1) mRNA, inoderedza chiyero che glycolate oxidase muchiropa, uye inopedza substrate inodiwa pakugadzirwa kweoxalate uye inoderedza kugadzirwa kweoxalate kudzora kufambira mberi kwechirwere nekuvandudza. zviratidzo zvechirwere muvarwere.
(14) Viltepso
Kambani: Yakagadzirwa neNS Pharma, inotsigira yeNippon Shinyaku.
Nguva yemusika: Yakatenderwa neFDA muna Nyamavhuvhu 2020.
Zviratidzo: Kurapa kweDuchenne muscular dystrophy (DMD) neDMD gene mutation mu exon 53 skipping gene.
Mashoko: Viltepso is phosphorodiamide morpholino oligonucleotide mushonga.Uyu oligonucleotide mushonga unogona kusunga kune exon 53 nzvimbo yepre-mRNA yeDMD gene, zvichiita kuti pave nekuumbwa kwemRNA yakakura.Iyo exon inobviswa zvishoma, nekudaro ichigadzirisa chikamu chemRNA yekuverenga furemu, ichibatsira murwere kugadzira mamwe maitiro anoshanda edystrophin ari mapfupi pane akajairika mapuroteni, nekudaro achivandudza zviratidzo zvemurwere.
(15) Amvuttra (vutrisiran)
Kambani: Yakagadzirwa neAlnylam Pharmaceuticals.
Nguva yemusika: Yakatenderwa neFDA muna Chikumi 2022.
Zviratidzo: Kurapa kwevakuru venhaka transthyretin amyloidosis ine polyneuropathy (hATTR-PN).
Tsanangudzo: Amvuttra (Vutrisiran) mushonga we siRNA wakanangana ne transthyretin (ATTR) mRNA, inotungamirwa neiyo subcutaneous jekiseni.Vutrisiran yakagadzirwa zvichibva paAlnylam's Enhanced Stabilization Chemistry (ESC) -GalNAc conjugated delivery platform ine kuwedzera potency uye metabolic kugadzikana.Kubvumidzwa kwekurapa kunobva padatha yemwedzi we9 kubva kuChikamu chechitatu chekiriniki yekudzidza (HELIOS-A), ine mibairo yese inoratidza kuti kurapwa kwakavandudza zviratidzo zvehATTR-PN, nevanopfuura 50% yevarwere vanodzosera kana kumisa kufambira mberi.
4. Mamwe magene therapy mishonga
(1) Rexin-G
Kambani: Yakagadzirwa neEpeius Biotech.
Nguva yemusika: Yakatenderwa nePhilippine Food and Drug Administration (BFAD) muna 2005.
Zviratidzo: Kurapwa kwekenza yepamusoro inopesana nechemotherapy.
Mazwi: Rexin-G ijene-rakatakura nanoparticle jekiseni.Inosuma iyo cyclin G1 mutant gene mumaseru anotangwa kuburikidza neretroviral vector kuti iuraye chaizvo mabundu akasimba.Nzira yekutonga ndeye intravenous infusion.Semushonga wakanangana nebundu uyo unoshingairira kutsvaga nekuparadza maseru egomarara remetastatic, zvine zvimwe zvinokonzeresa kune varwere vasingashande kurwisa mamwe mishonga yegomarara, kusanganisira yakanangwa biologics.
(2) Neovasculgen
Kambani: Yakagadzirwa neHuman stem cell Institute.
Nguva yekunyora: Yakatenderwa kuti inyore muRussia musi waZvita 7, 2011, uyezve yakanyorwa muUkraine muna 2013.
Zvinoratidza: Kurapa kweperipheral arterial disease, kusanganisira yakaoma nhengo ischemia.
Tsanangudzo: Neovasculgen iDNA plasmid-based gene therapy umo vascular endothelial growth factor (VEGF) 165 gene inovakwa pamusana weplasmid uye inopinzwa muvarwere.
(3) Collategene
Kambani: Co-yakagadziridzwa neOsaka University uye venture capital mafemu.
Nguva yekunyora: Yakatenderwa neJapan Ministry of Health, Labor and Welfare kuti inyore muna Nyamavhuvhu 2019.
Zviratidzo: Kurapa kweyakanyanya kuderera kwekupedzisira ischemia.
Mashoko: Collategene iplasmid-based gene therapy, yekutanga yeJapan gene therapy mushonga unogadzirwa neAnGes.Chinhu chikuru chemushonga uyu iplasmid isina kupfeka ine gene sequence ye human hepatocyte growth factor (HGF).Kana mushonga wacho wakaiswa mumisumbu yemakumbo ezasi, iyo HGF inoratidzwa ichakurudzira kuumbwa kwetsinga itsva dzeropa dzakatenderedza tsinga dzeropa dzakavharika.Miedzo yemakiriniki yakasimbisa kushanda kwayo mukuvandudza maronda.
END
Nguva yekutumira: Nov-10-2022


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Naizvozvo varume musatange nekushandira kuti nhengo ngaikure. Chekutanga ndechekushandira kuti igone kumira kwenguva refu uye yakati twii.
Nhamo yenyu ndeyekuona ma porno too much pa internet. Hamuzivi kuti mablue movies its business, uye most of the content yeipapo its artificial, and hazvisizvo zvinotarisirwa nemadzimai mumba. Zvinhu zvepama porno films hazvina yatinoti "emotional attachment".
Sviro yechihure haimbofa yakanaka kudarika sviro yevanodanana. Panerudo pane emotional attachment, and kunakirana kwacho hakuna basa nesize yenhengo yemurume. Basa remudzimai pabonde rakapfava chaizvo kudarika varume. Nhamo yemurume ndeyekuti kana yake isina kumira hapana kufadza mudzimai. Asi munhukadzi anogona kuita basa rake, uye kufadza murume pese pese.
Chake kudzidzira chikapa, mastaira nezvimwe zvima spices zvinodiwa pabonde. Kukura kana huduku hwenhengo handiko kufadza mukadzi.
Kana muchida kunyatsoona kuti size yenhengo haina basa, onai vakadzi vanoita bonyora vaye, anoita bonyora achifunga munhu waanonyatsoda chaizvo, waakamboita emotional sex naye, ipapo unonzwa mukadzi achiputika kutunga achizvikwiza kahibhinzi nekachigunwe chete. Sakai kana mukadzi achitundiswa nekamunwe kemunongedzo kuzoti iwe nenhengo yako ungazvitadza sei?
Ngatisanganeyi Muchikamu Chinotevera.
Read Previous Article Here - Zvidzidzo Zvebonde Series - Kukura Kwenhengo Yemurume Kune Zvakunobatsira Here Kana Kutadzisa Pabonde? (Part 1)


text:
Zvakashatira Kupfimba Mubhazi
From Gokwe to Glory cross-written story
Gore raive 2018 ini hangu Shaddy mwana wa Vheronika ndaive ndakaronga rwendo rwangu rwekuenda Gweru ku university ndichibva Gokwe. Taikwira mabhazi na 2am saka waitorara pa bust stop imwe so yainzi Pamuraravaroyi nenyaya yekuti hakuna aibatwa nehope kana ari normal since paityisa zvisingaite.
Rimwe gore pane mfes akamboenda pachitsiga chaive near that bus stop achida ku lighter mudzanga ndobva chitsiga chiya chati “Nhai Shamwari zvaukundi baya baya ndambokudenhawo here?” anyways musi iwowo bus rakakurumidza kuuya ndobva ndatokwira hangu paya.
Ndaive pa seat riya rogarwa nevanhu 2. Takubhadhara ma tickets ndakabva ndangoona rimwe bhebhi raive rakagara nevamwe mother soo. Haaaa babe iroro rarakanaka boys. Ndakatarisa ndichivhundukira sooo ndobva rango smiler paya.
Ma lights emu bhazi akabva adzimwa ndobva rima ratoti zviii kuzara. Ndakati plan ndeipi manje, ndakabva ndato tora ka bhepa ne pen ndikabva ndanyora number dzangu pa phone and the text: HIE I'M SHADDY, TEXT ME. ndakabva ndapa moms yairi pa side pe bby riya since ndandisiri kusvikira kwaaive. Hana yakabva yatanga kupisa se song iya inonzi Kujata jata, mudumbu ukatanga kurira. Moms iya yakabva yatotaurira mudenga kuti munhu wese anzwe, “Iwe Lydia, pane chimukomana chakunyorera chitsamba hameno chineyi tora chitsamba chacho” vakomana kaaaaaaaa ndakanzwa bus rese richiti bvuuuuu kusekaa.
Kamwe kamudhara kaive kumasure kwebhazi kakabva katopindira nyaya yacho, “Haaa vana vamazuva ano hamuna matyira, mukatonyengana mubhazi shuwa.” nekuonererwa Ka bby kaya kakabva kasunga face ndobva katirisa back kwandaive, “bhudhi imi mundikwanire, hamunyarewo kundinyadzisa Pana Tete vangu shuwa” ndakamboda kuti ndipe bepa re number dzangu asi zvakaramba. Ndakanzwa mate achipera mumuromo ndikatanga kunzwa sendinotsva ndobva ndatonyebedzera kurara.
Kwachena kwave kuzvi 6 uko ndaingoona bhazi rese richinditarisa vachida kuona face yangu haaa day iroro ndakanyara vakomana. Bhazi rakasvika pa Kudzanai bus terminus mu Gweru kuma 9am. Vanhu vese vakati dzvamu kuburuka asi ini ndakaramba ndakagara hangu. Vanhu vese vapera kuburuka ndakabva ndaenda pasi pe seat paive pakagara musikana uya ndichitsvaga number dzangu.
Ndakadzishaya, ndakabva ndatanga kufamba seat by seat ndichitsvaga. Ndashaya ndakabva ndatogara hangu mu bhazi ndakasuwa suwa. After some time ndakabva ndanzwa text message ichipinda: HIE SHADDY, ITS LYDIA. WAUCHIDEI. Haaaa ndakabva ndafara vakomana partly because number dzadzisina kutorwa nemunhu asiri iye. The rest is history, you can read that history pa From Gokwe To Glory 1.


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MotioCI proactively vhezheni zvese zvinogadziriswa munzvimbo yeCognos. Izvi zvinosanganisira shanduko dzakaitwa mune yekunyora studio uye mameseji ekutonga.
Nhasi tichafamba kuburikidza nedzimwe pfungwa dzekutanga dze MotioCI shanduro control nekuita shanduko shoma kumuyenzaniso Mharidzo Chekutanga, ngationgororei nhoroondo yeiyo Chaiyo Vs. MotioCIIyo Revision Nhoroondo skrini. Iyi skrini inotipa nhoroondo yakazara yechinhu, ichitiratidza nguva imwe neimwe yachagadziriswa, naani, uye ichititendera kuti tione shanduko dzakashandiswa.
Tinogona kuona kubva pane skrini iripamusoro, kuti kune 7 kudzokororwa kweiyo chaiyo vs. Target Sales Report. Nguva imwe neimwe mushandisi paanoshandura chinhu ichi muRepota Studio, dzokororo nyowani ichaonekwa mu MotioCI.
Heino tsananguro yeimwe neimwe yemakoramu ari pamusoro:
mhando - mhando yekudzokorora, semuenzaniso yakagadziriswa, yakawedzerwa, yakadzimwa kana kudzoserwa
Rev - nhamba yekudzokorora
Mutengi Ver. - yevatengi inogadziriswa vhezheni nhamba
Major - mureza wekutevera "makuru" maringe ne "madiki" kudzokorora
Zuva - iro chairo zuva uye nguva kudzokorora kwakaitika
Munyori - ndiani akaita shanduko
Mhinduro - ruzivo nezve zvakachinja mukudzokorora
Mavara - inoratidza kuti kudzoreredza ndeiko
Zviito - zviito zviripo zvekudzokorora (dzosera, kusimudzira, kuona, kumhanya, nezvimwewo)
Zvino zvatave kufukidza izvo zvekutanga nhoroondo yekudzokorora, ngatitarisei kuti sei MotioCI proactively vhezheni inoshanduka kumuenzaniso wedu Rondedzera mune idzi ina dzakajairika zviitiko:
1. A Kuchinja kwemidziyo (semuenzaniso zita, screentip, nezvimwewo)
2. A Mvumo inoshanduka
3. A deletion
4. Ku pepeta muChita Studio
Zvinhu zvinochinja
Shanduko yezvivakwa inoreva kuchinjisa chirevo cheCognos zvivakwa senge, mutauro, muridzi, chipikicha, nezvimwe. Dzvanya pane icon yezvivakwa kuunza peji rinotevera:
Ngatitii mumuenzaniso uyu, Adam anoshandura iyo Screen tip chivakwa chemuenzaniso Wedu Mushumo:
Pangosvika Adam kudzvanya "OK" iyo shanduko yezvivakwa ichachengetedzwa kuCognos. MotioCI anobva angoona chiitiko ichi, uye achagadzira idzokororo idzva kuti atore shanduko. MotioCI inoongorora mutsauko uripakati pekudzokororwa kwekare uye kudzokororwa kutsva, uye otomatiki anowedzera chirevo che "Zvakachinjwa Zvivakwa". Inobatawo chokwadi chekuti Adam akakonzera shanduko iyi.
Kugadzirisa mvumo yechinhu chimwe chiitiko chakajairika muCognos Analytics. Mune imwechete yezvivakwa peji peji kubva kune yedu yapfuura muenzaniso, Adam izvozvi anodzvanya pane Mvumo tebhu.
Adam anoenderera mberi nekuita shanduko kumvumo yemuenzaniso wedu wekuenzanisira.
Zvekare, panongodzvanya Adam "OK" mvumo yake shanduko inochengetwa kuCognos. MotioCI pakarepo anoona shanduko kune mvumo uye inogadzira kudzokorora. Mashoko e "Changed Properties" anongowedzerwa uye Adam anotsanangurwa semunyori akaita shanduko.
kushandisa MotioCI's "diff" chiito chekuenzanisa kudzokorodza gumi nekudzokorora 10 kuchapa kuenzanisa kwakadzama kwemvumo "pamberi" uye "mushure".
Zvemukati Kubvisa
Imwe yakakosha vhezheni yekudzora mamiriro ekutora chiitiko chekubvisa zvemukati. Mukuenderana nemuenzaniso wedu wekare, ngatiti Adhama anotarisa bhokisi rekutarisa Rechokwadi vs. Target Kutengesa, obva abaya bhatani bhatani (kumusoro kurudyi).
Kazhinji, paunodzima chinhu chinoenda zvachose.
ne MotioCI'Active Activeing iwe unonyaradzwa nekuziva kuti nekuda kwekuti chirevo chakabviswa hazvireve kuti chakarasika zvachose. Kungofanana chero kumwe kuchinjirwa kuchinhu, kubviswa kunoitiswa ne MotioCI.
Cherekedza kuti kumwe kumwe kudzokororwa kweichi chirevo cheCognos kuchiri kuwanika. Kana iwe uchida kusunungura iyo yekubvisa mashandiro iwe unogona kungo tarisa yapfuura kudzokorora uye tinya iyo "dzosera" bhatani (izvi zvinodzosera kudzokorora kudzoka kuCognos).
Kugadziriswa muRepota Studio
Zvichida mamiriro akajairika ekugadzirisa Nhoroondo zvinhu zvinobva mukati meRepoti Studio. Nezve ruzivo rwekuti sei MotioCI versions Studio edits, ndapota ona yedu yapfuura yekupinda pa Shanduro Kudzora muCognos Report Studio.
pfupiso
Sezvaunogona kuona, MotioCI inopa 360 degree kufukidza kana zvasvika mukushandura zvemukati zveConnos. Mumuenzaniso wanhasi, takaongorora zviitiko zvina zvakajairika zvekugadzirisa Ripoti. MotioCI'Active Activeing inopa nzira iri nyore uye inoshanda yekutevera shanduko dzese dzinoitika munharaunda yeCognos. With MotioCI kuongorora ako maCognos nharaunda, iwe unogara uchiziva ani akaita shanduko, apo vakazvigadzira uye chii vakachinja.


text:
Chimwe chizvarwa cheZimbabwe chinogara kuMinnesota muAmerica Reverend Rebecca Makayi vanoti ivo nemhuri yavo vachange vachipembere zuva reThanksgivig nhasi nekudya zvinonaka nekubatana semhuri.
Vanoti zuva iri rakakosha sezvo riri zuva rekutenda Mwari nezvaanenge akaitira mhuri. Vanoti mhuri yavo yave kukoshesa zuva iri zvikuru nekuti ndiro zuva ravanotura mafemu vachiyanana nekutenda Mwari.
Zororo reThanksgiving muAmerica rinonzi rakatanga muna 1620 apo vachena vakazopamba nyika iyi vakatanga kugara vachidya nevaive varidzi venyika verudzi rweWampanong Indians. Mutungamiri wenyika yeAmerica wekutanga George Washington akazoita zororo zuva reThanksgiving muna 1789.
"Tiri kufara kuti tichange tiri pamwechete semhuri tichiyanana pazuva iri. Zuva iri rakakosha nyanya kunevatendi zvakare sezvo vachitora nguva yekupa kutenda kunaIshe pazuva iri," Reverend Makayi vaudza Studio7.


text:
Nhau DzeBonde
Ndakaridza kamhere apa ichinyura yese zvisina tsitsi
Pandaikura ndaingovafarira semurume watete. Mari ndaipiwa kudarika vamwe vese ko murume weduka. I kept myself ndiri kavirgin not for him but my mother advised us of only kusvirwa after marriage. Ndakapedza a teaching course ndakawana basa at a remote place kumusha chaiko. Ndakaenda kunotaurira tete ndichikumbira babamukuru vandiperekedze all the way kubva Harare kuyenda somewhere close to Vic falls. Ndakawana tete vasipo vachinzi vaenda ku all night prayer kuchurch kwavo. Babamukuru vaive vega sezvo vana vavo vese vainge varoorwa. Vanga vasina mwana mukomana.
Vakati wava kutoshanda usati wandipa makumbo akatsvuka kunge fanta akadai ndikati makambokumbira here mukanyimwa. Takaseka tese nekuti ndiwo mutambiro wacho wataiyita mazuva ose. Vakauya vakagara pedyo neni zvikanzi nhasi ndinokukwira chete ndikati mari yenyu chete. Chiramu change choenda kure apa sekuru vainge vasingatambe.
Vakatanga kundidhonza mazamu ndichibva ndatiza ndoenda kukitchen kutsvaga drink mufridge. Iwe masasi baba vakateverawo vachindibata magaro nekugumisa mboro yavo pandiri. Aika imi babamukuru nyarai mhani. Zvikanzi mboro inonyara here. Ndipe makumbo chete.
Ndakavharirwa mucorner kwava kubatwa batwa kunge tabvumirana apa ndainge ndofemera pamusoro ko ndaigoitawo sei ndiri munhu, zemo rinotobatawo. Pfungwa dzangu dzakandirambira kubviswa humhandara nedhara risina kumbondipfimba. Imi baba mukuru this is not good. Vakaramba vakanyarara ndokupinza mawoko muskirt ndokutanga kupuruzira beche rangu vachibva vabvisa pant rangu apa muviri wese wainge wapera simba. Vakatanga kudhonza matinji angu apa kiss iri tii pamuromo. Ko ndaizodiniwo.
Ndakadhonzerwa musitting room apa ruoko rwavo rwuchitambisa beche inini ndatotesa kare. Mboro nyoro ndiye pamuromo pebeche. Ndakaridza kamhere apa beche richitsemukira mboro yavo ichinyura zvisina tsitsi. Mudhara akasvira pacarpet zvisina tsitsi. Mboro yavo yaisvika pamoyo chaipo. Ndakambofenta kwekanguva ndikamuka vachingokwesha chete. Imi mboro inonaka zvikuru hombe ine anogona kuishandisa. Ndakanzwa kupindwa netumvura tunopisa apo yanga yorutsa zvayo. I lost my mind there. Vakati kubvira nhasi ndichakuitira twese twaunoda uchindipawo mhata.
Haaa imi ndokukwirwa first time kupiwa nhumbu nokuitwa small house na baba mukuru. Mazuva ano vanongouya vachisvira ndakabatirira. Ndongadii ivo vachigona kusvira kwacho. Tete havazivi kuti mwana mukomana wavaida ndiye wavari kuchengeta ndewa baba mukuru. Mudhara andichepesa nemboro kani.
Ndakasvirwa nemurume wemunhu ndikaita kunge beche richabvaruka
Ndakaiswa nayo ndikanzwa makumbo akudedera nekunakirwa!
Kusvirwa kwandakaitwa nyoro muharare neshamwari yangu!
Mainini vakafongora ndokuisa bhurungwa paside ndichibva ndaibairira nyoro pashebeen!
Ndakarohwa nenyere ndikasvirwa nyoro nalandlord!
Ndakaiswa ndakanyatsovhura makumbo apa achiyamwa matits angu!
Ndakaramba ndakatarisa zvidya zvake yakabva yaita kutepuka ichimira!
Ndakawona beche rakaitwa kuyanikwa apa rakanunira mukati
Kuzasi kwangu kwaigara kwakanyorova, zvandakazoitwa nemwana wechikoro mucombi!
Kusvirwa neMurume weShamwari yangu paParty Kumba Kwavo
Ndoita Sei nhai kuti ndinakirwe nemurume wangu?
Confessions of a House Maid Part 1, teasing the Boss while Madam is in the shower
Mainini vakafongora ndokuisa bhurungwa paside ndichibva ndaibairira nyoro pashebeen!
Mboro yemurume wangu haigone kunditundisa!
Nyoro paToll Gate Part 2 – Married Woman Cheats Again
Nyoro paToll Gate – Married woman explains how she CHEATED in South Africa
KuSeducer Brother Yangu kusvika andisvira nyoro
Kurohwa nyoro naBabamunini Bofu
Kusvirwa neMurume weShamwari yangu paParty Kumba Kwavo
I think my neighbour’s wife arikutsvaga kuiswa neni – Please Help
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Nhau DzeBonde4 years ago
Ndakasvirwa nemurume wemunhu ndikaita kunge beche richabvaruka
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Nhau DzeBonde4 years ago
Ndakaiswa nayo ndikanzwa makumbo akudedera nekunakirwa!
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Nhau DzeBonde4 years ago
Kusvirwa kwandakaitwa nyoro muharare neshamwari yangu!
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Nhau DzeBonde3 years ago
Mainini vakafongora ndokuisa bhurungwa paside ndichibva ndaibairira nyoro pashebeen!
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Nhau DzeBonde4 years ago
Ndakarohwa nenyere ndikasvirwa nyoro nalandlord!
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Nhau DzeBonde4 years ago
Ndakaiswa ndakanyatsovhura makumbo apa achiyamwa matits angu!
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Nhau DzeBonde4 years ago
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Ndakawona beche rakaitwa kuyanikwa apa rakanunira mukati


text:
Isu takatotaura nezveLinux uye kuvapo kwayo mune mamwe masisitimu uye maseva anoshandiswa muFomula 1. Zvese zviri zvemagetsi control unit yeavo-zvigaro-zvigaro uye kushandiswa kunoitwa panguva yekuvandudzwa kwemakomputa makuru eCFD. Nekudaro, iwe unogona kunge uchinetseka kana Tux akaita mamaketi mashoma mubhangi oval ye Indianapolis mazana mashanu muIndyCar.
Uye chokwadi ndechekuti hongu, Linux yanga iriko muIndyCar, mumotokari ine nhamba makumi manomwe nenomwe, panguva ino muyedzo motorsport bvunzo. Uye zvakare iri mune mamwe masisitimu ayo anoshandiswa mukuvandudza kweaya Dallara chassis, nezvimwe zvinhu, uye kwete kwete chete semubatsiri.
Pasina mubvunzo chokwadi chinonakidza, kuti iyo IndyCar yakave yakananga kushambadzira kweLinux. Kuisa mucherechedzo parudzi urwu rwemota kunodhura chaizvo, uye hausi iwo maratidziro enheyo dzakawanda uye nharaunda dzekusimudzira. Asi izvi zvakaitwa kuvonga kuna bob moore, ndiani akaisa mari inodiwa.
Imotokari yebhuruu inonzi Linux Car, uye iyo Chastain Motorsport timu. Akamhanyisa muchikamu che91 che Indianapolis 500. Nehurombo, ndiyo yaive mota yekutanga kuita tsaona paRace Svondo, yaive kurova kwakanyanya kune vateveri vegeek vakatevera chiitiko ichi. Uye mazhinji aive majee geeks, ayo akaita mota kunge BSoD yeWindows, nezvimwe.
Tichamuona zvakare? Ichokwadi ndechekuti pane kutove kushambadza kwemaitiro anoshandisa Linux sehwaro, senge AWS, Azure, nezvimwewo, asi zvichave zvakaoma kuona kutsigirwa kwakananga kweiyo yakavhurwa sosi purojekiti, kubvira kutora logo kana iyo mhando ivo vanowanzo kubhadharwa kubva ku € 10.000 kusvika ku € 500.000 kana kupfuura, zvinoenderana nesaizi nekuonekwa. Mari yakawandisa kune vakawanda vanogadzira kana nharaunda idzo dzisingade kuziviswa uku ...


text: Yanger mutungamiriri wetambo dzemugungwa uye mugadziri, Mugadziri wepasirese uye mutengesi.Yanger inopa mhuri yakakura yetambo dzengarava uye mapuratifomu ekumahombekombe ari kuvakwa kutenderera pasirese.kugadzirwa kwakawanda uye zvivakwa zvekutsvagisa, Yanger iri kuenderera mberi nekuvandudza uye kugadzira zvigadzirwa zvitsva nemasevhisi, ichiita kuti tambo dzive nyore kuisa uye kuchinjika, kuve nechokwadi chekuti dziri kushanda uye dzakachengetedzeka kwezvakatipoteredza, kuvandudza kushanda kwemoto uye kurarama uye kugadzira mabasa matsva evatengi.


text:
Kutsvaga heti yakakodzera yechimiro chechiso chako kunogona kuita sekuyedza pamabhuruku ... anogona kunge aine masaizi akafanana pama tag, asi haakwane nenzira imwechete.Mushure mezvose, ngowani imwechete inogona kutaridzika zvakanaka pamunhu mumwechete asi kwete kunyatso taura pfungwa imwechete yehunhu pane inotevera.Uye izvo zvakanaka, nekuti kune heti yakakwana yeese chimiro chechiso uye hunhu.
Usati wabvunza kuti ungawana sei heti chaiyo, unofanira kutanga wazvibvunza kuti "Chii chechimiro chechiso chandiri kushanda nacho?""ndeipi hat color yandinokodzera".Pano pacharatidza mamwe mazano anobatsira ekusarudza heti yakakodzera.
Sarudza ngowani dze "oval face"
Inzwa wakasununguka kuedza marudzi ese eheti!Iwe wakakomborerwa nekutarisa kwakasiyana-siyana!Tora chero chinokodzera manzwiro ako, chero bedzi heti ichienderana nechipfeko chako.Vakadzi vane zviso zveoval vanogona kukwira kumusoro chero ipi zvayo.
Sarudza ngowani dze "round face"
Wedzera imwe asymmetry kune chitarisiko chako.Unogona kubata fedora, ngowani yenhau, kana baseball cap.Ichi chiso chekuenzanisa chinochemera kona nyowani: asymmetry.Ramba wakajeka korona dzakatenderera, dzinogona kusimbisa kutenderera kwechiso chako.
Sarudza ngowani dze "oblong face"
Kana uine chiso chakaomarara edza ngowani ine brim inopenya uye nekorona yakaderera, senge sunhat, cloche, kana fedora ine brim yakakura.Mupendero wakakura wezuva unogona kureba kureba kwechiso chakareba.Dzivisa chero ngowani dzine korona refu, iyo inongorebesa chiso chako zvakanyanya.Chivharo chinopfekwa pazasi patsiye dzako chinogona kubatsira kuvanza huma yako yakakwirira, uye, sehuroyi, kugadzira ratidziro yechiso chakapfupikiswa.
Nguva yekutumira: Sep-22-2022


text:
Makomputa akaumbiridzwa naLILLIPUT akagadzirirwa kushamisika & humbowo hwekudengenyeka, anoshanda pamusoro penzvimbo yakakura yekushisa kubva -20 ° C kusvika + 65 ° C, uye kugadzirisa hunyoro hwakawanda kutarisana nemamiriro ekunze akashata, uye tsaona senge kudonha kana kunyudzwa mumvura. mumvura. Nekudaro, ivo ndivo sarudzo yakasarudzika yekushandisa michini michina.
LILLIPUT ane kusimba kushanduka kugadzirisa zvigadzirwa kuti anyatsoita zvinodiwa nevatengi Tinogona kupa Android, Windows CE kana Linux akawanda mapuratifomu uye huwandu hwakawanda hweI / O madoko kusangana nezvako zvigadzirwa zvigadzirwa. Iyo refu-inogara bhatiri dhizaini inogona kusangana nezvinodiwa zvekushandisa nhare munzvimbo dzakaomarara, kuve nechokwadi chekuti basa rako rekunze rinenge risingamire. Uye zvakare, edu akadzika makomputa anotsigira CAN bhazi uye akasiyana waya masystem senge WLAN / WAP, UMTS, GPRS, GSM, HSDPA kana LTE, kuti ugone kuunganidza nekugadzirisa dhata kubva kumidziyo yemumunda munguva chaiyo. Pfupisa kuendesa kutenderera;
Deredza iyo yese yekushandisa mitengo Realize real-time alerts Save fuel and maintenance cost GPS positioning service;
Reduce machinery downtime Improve life-cycle management Electronic fence system; Anti-collision system;
Server communication system; Wheel detection system; Vehicle monitoring system; Remote control system;
Complete report of field activities.


text:
Haisi chakavanzika chatingaite chero chinhu neRaspberry Pi. Kunyangwe isiri iyo yega, bhodhi iri diki rinotibvumidza isu kuva nekombuta yedesktop komputa, yevhidhiyo mutambo emulator, seti-yepamusoro bhokisi kana kuita ese marudzi emapurojekiti. Pakati peanoshanda masisitimu atinogona kuisa tinayo Chrome OS, yatinofanira kushandisa Etcher software iyo inotibatsirawo ku gadza Android TV mundiro imwe chete.
Muchikamu chino isu tichatsanangura maitiro ekushandura yedu Raspberry Pi pane Android TV, asi isu tiri kuzopa maonero edu pazviri. Zvakakosha? Sei? Uye isu tinofanirwa kutora zvese kufunga, tichitanga nemutengo uye, wadii?, Kupedzisa dhizaini. Nekuti isu zvakare tinofanirwa kuyeuka kuti iyo RP4 ine simba kupfuura mavhezheni apfuura, asi zvakare inopisa kupfuura hanzvadzi dzayo. Uye, kutaura nezve yazvino vhezheni yebhodhi, rutsigiro haruna chokwadi.
Zvakakosha?
La mhinduro yekukurumidza ingave yekuti kwete. Icho chikonzero ndiwo mutengo: kuisa Android TV muRaspberry Pi isu tinofanirwa kutenga bhodhi, magetsi, tambo yekuibatanidza kune iyo yekutarisa uye kadhi re MicroSD. Izvo ndezve padiki nepadiki, nekuti isu tinogona zvakare kukutengera iwe kesi, kuwedzera kune yekupisa inonyura. Kune mapakeji ayo anosanganisira fan. Tichifunga nezvekuti chinangwa chedu ndechekuganhurira mashandisiro ayo kuApple TV uye kuti pane zvishandiso zvinozvisanganisira nekutadza pamutengo wakaderera, hazvina basa.
Asi hongu inogona kuikodzera mune imwe yezviitiko izvi:
- Isu tatova neimwe uye hatizive zvekuita nayo. Kana isu tiine Raspberry Pi yakamira padyo nezvose zvinodiwa kuti iite kuti ishande uye isu hatizive zvekuita nayo, isu tatozviita. Kuichinjira kuita set-yepamusoro bhokisi ne Android TV ingori imwezve sarudzo.
- Tichaishandisa nguva nenguva. Ini ndinotaura izvi nekuti kuchinja kubva pakushandisa chimwe kuenda pane chimwe kunogona kuve nyore sekutora kadhi rimwe uye kuisa imwe. Zviripachena kuti kana tikazviita kakawanda pazuva, pakupedzisira kadhi rinogona kutyoka, asi zano ringave rekuisa mune microSD ine Android TV uye toshandisa iro kadhi patinenge tichida kushandisa Raspberry yedu seApple TV.
- Zviite nekuda kwekuti tinogona.
Maitiro ekuisa Android TV pane yako Raspberry Pi
Isu tatove tatsanangura tichitaura nezvemutengo iyo Rasbperry Pi ndiro, hapanazve, uye kuti tiite chero chinhu chatinofanira wedzera zvinhu mairi. Ini handikurudzire kutenga Raspberry Pi kuti ushandise neApple TV, asi zvinofanirwa kutaurwa kuti zvirinani tinoda ndiro, magetsi, tambo yeHDMI kuti ibatanidze kune yekutarisa uye chimwe chinhu chinoshanda sekuraira, icho chinogona uve mbeva kana mutongi weBluetooth. Kana isu tiine zvese, maitiro ekuisa Android TV pane Raspberry Pi angave anotevera:
- Takaburitsa vhezheni yeLineageOS yeedu Raspberry Pi kubva Iyi link. Sezvauri kuona, inoti "Raspberry Pi 3", zvinoreva kuti rutsigiro runongovimbiswa neiyo vhezheni yebhodhi.
- Isu tinoisa iyo inoshanda sisitimu ne Whale Etcher:
- Tinoisa kadhi muverengi.
- Takatanga Balena Etcher.
- Isu tinosarudza iwo mufananidzo watakatora pasi padanho rekutanga.
- Isu tinosarudza chinhu chakanangwa (kadhi redu).
- Uye tinodzvanya pa «Flash».
- Tinomirira kusvikira maitiro apera.
- Tevere, isu tinoisa iyo kadhi mune yedu Raspberry Pi. Zvatichaona mushure mekutanga LineageOS yakati siyanei zvishoma pane izvo zvinopihwa neakatanga Android TV.
- Nhanho inotevera kurodha pasi Open GApps. Isu tichazviita kubva kuRaspberry Pi nekuwana Iyi link, tichisarudza chikuva chedu (ARM mune iyo RP3), iyo vhezheni yeApple yatiri kushandisa uye, pakupedzisira, iyo Open GApps package yatiri kuda. Chinhu chakakurudzirwa ndeye tvstock.
- Kuisa iyo Open GApps isu tinofanirwa kuenda kune yekuvandudza sarudzo (kana Mushambadzi, zvinoenderana nemutauro urinoratidzwa) Zvirongwa / ruzivo rwefoni / Vaka nhamba / gadziriso yesarudzo. Tinovamutsa.
- Iye zvino tinoenda kuMidzi Yekushandisa uye kumisikidza iyo Apps uye ADB sarudzo.
- Mune inotevera nhanho, isu tinovhura iyo yekushandisa system terminal uye yekutanga mhando "su" uyezve "rpi3-recovery.sh", ese asina makotesheni, kuti apinde kugadzirisa mamiriro.
- Isu tinotangazve kuti script imhanye.
- Kana pakanga pasina matambudziko, iyo Recovery Console (TWR) ichaonekwa. Tinofanira kusarudza "Isa".
- Tevere, isu tinotsvaga iyo nzira yatakatora pasi iyo ZIP yeOpen GApps uye isu tinosarudza iyo. Haufanire kuisunungura, asi sarudza sarudzo "Tangazve mushure mekuisa" uye sarudza sarudzo "Isa ZIP".
- Mushure mekutanga kwekutanga, izvo zvatinozoona ichave yave Android TV vhezheni yeLineageOS ine Open GApps, saka isu tinofanirwa kungonakidzwa nayo.
Wakashandura yako Raspberry Pi kuita Android TV? Nekuda kwekuda kuziva: nei wafunga kuzviita iwe?


text:
Yakareruka kuisa, inodhura izere HD 1080P mota Dvr kamera, 4.3-inch yakakwira-tsananguro mota yekutyaira rekodhi mbiri-lens mota kamera, DVR 4.3-inch yakakwira-tsananguro yehusiku chiratidzo mota yekutyaira rekodhi ine maviri masitayera erima negoridhe furemu yako sarudzo. Dhizaini yakagadzirirwa vanhu, zvese zvese ndezvekuchengetedza kwako chete. * Saizi yeLCD saizi: 4.3 inches 16: 9âVerenga ZvakawandaTumira Kubvunza
Yakakwirira-yekupedzisira uye yemuchadenga HD DVR yekutyaira rekodhi ine simbi goko, 5.18-inch yekuona kumashure girazi HD mota kamera, ye-Ultra-yakatetepa yekubata skrini HD 1080P yekutyaira rekodhi ine kumberi uye kumashure maviri malenzi uye isina mvura yekumashure kamera. (Hombodo yeplastiki inosarudzika) Mhando mbiri dzezvinhu zvaunosarudza.Verenga ZvakawandaTumira Kubvunza
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text:
NYAYA IRI PAKAVHA | MAONERO ANOITA MWARI KUSVUTA
Dambudziko Renyika Yose
Fodya muurayi asinganeti.
Yakauraya vanhu 100 000 000 mumakore ekuma1900.
Inouraya vanhu vanenge 6 000 000 pagore.
Paavhareji, inouraya munhu mumwe chete pamasekonzi 6 oga oga.
Uye hapana chinoratidza kuti zvichachinja.
Zviremera zvinofungidzira kuti kana zviri kuitika izvi zvikaramba zvakadaro, nhamba yevanhu vanofa pagore pamusana pekusvuta ichatopfuura 8 000 000 panozosvika 2030. Uye vanoti pachazosvika 2100, vanhu 1 000 000 000 vachange vafa pamusana pekusvuta.
Fodya haingokuvadzi vanoisvuta chete. Mhuri inenge yasiyiwa inorwadziwa uye inorasikirwa nemari, uyewo pane vanhu 600 000 vasingasvuti vanofa gore rimwe nerimwe pamusana pekufema utsi hunobudiswa nevanosvuta. Dambudziko racho rinova remunhu wese pakuti kurapwa kunenge kwava kudhura.
Dambudziko iri rakasiyana nezvirwere zvinopararira nokukurumidza zvinoita kuti vanachiremba vamhanye-mhanye kutsvaga mushonga pakuti rinorapika; uye mushonga wacho unonyatsozivikanwa. Mutungamiriri wesangano reWorld Health Organization anonzi Dr. Margaret Chan akataura kuti: “Dambudziko refodya idambudziko rinokonzerwa nevanhu pachavo, uye rinogona kugadziriswa kana vanhu vakashanda nesimba pamwe chete nehurumende.”
Zviri kuitwa nenyika dzakawanda pakugadzirisa dambudziko iri reutano hazvisati zvamboitwa kubvira kare. Kubva muna August 2012, nyika dzinenge 175 dzakabvumirana kutora matanho ekuderedza kushandiswa kwefodya. * Zvisinei, pane zvimwe zvinoita kuti dambudziko racho rirambe richitowedzera. Gore negore, indasitiri yefodya inopedzera mabhiriyoni emadhora pakushambadzira kuitira kukwezva vamwe vatsva, kunyanya vakadzi uye vechidiki vari munyika dzichiri kusimukira. Kupinda muropa kunoita fodya kunoitawo kuti vanhu vanourayiwa nayo varambe vakawanda pavanhu vanosvika bhiriyoni vakatopindwa muropa nayo. Kana vari kusvuta iye zvino vakasarega, nhamba yevanhu vanourayiwa nayo ichakwira zvakaipa mumakore 40 ari kutevera.
Kushambadzira uye kupindwa muropa kunoita kuti vakawanda varambe vaine tsika yavanoshuva kurega. Izvi ndizvo zvakaitika kuna Naoko. Akatanga kusvuta achiri mumakore okuyaruka. Kutevedzera maitiro aaiona mune zvinobudisa nhau kwaiita kuti azvione semunhu anoziva zvaanoita. Pasinei nokuona vabereki vake vachifa nekenza yemapapu, akangoramba achisvuta, kunyange paairera vanasikana vake vaviri. Anobvuma kuti, “Ndaitya kubatwa nekenza yemapapu uye ndainetseka nezveutano hwevana vangu, asi ndaisakwanisa kurega. Ndaifunga kuti ndaisazombofa ndakakwanisa kurega kusvuta.”
Asi Naoko akazorega. Chinhu chakamubatsira kukunda tsika yokusvuta ndicho chakabatsirawo mamiriyoni evanhu kuti vasatombotanga kusvuta fodya. Chii ichocho? Tapota ramba uchiverenga.
^ ndima 11 Matanho aya anosanganisira kudzidzisa vanhu nezvengozi dzekusvuta, kuita kuti fodya isanyanyotengeswa, kukwidza mitero yefodya, uye kuita zvirongwa zvekubatsira vanhu kurega kusvuta.


text:
In 2018, Darrell worked with Dr. Paul Thistle at Karanda Mission Hospital to produce “Important Information About Women’s Health,” an eight-page brochure for women in the community in both Shona and English. Dr. Thistle worked with Akanksha Kulshreshtha, a Zimbabwean medical student at the University of Toronto, to produce the Shona version, presented here.
Bhuku iri haritsanangudze zvose maererano neutano hwevanhukadzi.
Ruzivo pamusoro pe HIV/AIDS ne zvimwe zvirwere zvepabonde rinokwanisa kuwanikwa mune mamwe mabhuku
Bhuku rino rakagadzirwa nerutsigiro kubva kuBetter Healthcare for Africa Inc. na Family Child Healthcare Providers Karanda Mission Hospital
Vanyori: Akanksha Kulshreshtha na Dr. Paul Thistle
KURONGA MHURI
Kwakakosherei?
- Kuronga mhuri isarudzo inoitwa nevaviri kana mumwe arikuchengeta mhuri.
- Munhu wese ane kodzero yekusarudza kuti anoda kuita vana vangani
- Kusarudza kuregera kuita mwana kunoderedza mukana wekutapudzira utachiona hwe HIV kumwana
- Kuita pamuviri kanodarika kashanu pamwechete nekuita nguva pfupi pakati pekuzvitakura kwega kwega, zvinhu zvinogona kukanganisa utano hwemwana naamai
- Kuronga mhuzi kunobatsira kusimbisa utano hwemwana naamai
Ndedzipi nzira dzingashandiswe kuronga mhuri
- Nzira dzinoshanda kwenguva diki
- Mapiritsi ekunwa
- Makondomu
- Kubaiwa majekiseni
- Nzira dzinoshanda Kwenguva Refu
- Mushonga wemuganda – Jadelle & Implanon
- Simbi dzemuchibereko
- Nzira dzinoshanda kweupenyu hwese
- *Nzira dzokudzivirira pamuviri kweupenyu hwese dzinokurudzirwa kwazvo kumadzimai ane vana vashanu zvichikwira*
- Dzevakadzi- Kusungwa machubu echibereko
- Dzevarume- Kusungwa machubu anofamba nembeu
GOMARARA REMUROMO WECHIBEREKO
(CERVICAL CANCER)
Chii?
- Gomarara rinoitika pamuromo wechibereko
- Rinokonzerwa ne nutachiona unonzi Human Papilloma Virus (HPV), hunowanzotapuriranwa nenzira yepabonde
Ungaridzivirira sei?
- Kushandisa makondomu nguva dzose pabonde
- Kudzvirira kuita shamwari dzakawanda dzepabonde
- Kudzvirira kutanga zvepabonde kune vasati vabva zera
Rinoonekwa sei pachirine nguva yekubastirika?
- Nekutariswa Muromo wechibereko:
- Visual Inspection with Acetic Acid and Cervicography (VIAC) or Pap Test.
Kuonekwa zvichena paVIAC hakurevi kuti mune gomarara remuromo wechibereko nguva dzose. Dzimwe nguva zvinogona kureva kuti mune zvimwewo zvirwere.
Ndiani anofanira kuongororwa?
- Munhukadzi wese anoenda pabonde.
Munofanira kuongororwa kangani?
- Kamwe chete pamakore matatu kana usina utachiona hweHIV
- Kamwe chete pagore kana uine utachiona hweHIV
Zvinokwanisa kuratidza kuti ungava uine gomarara remuromo wechibereko.
- Kuburitsa zvinonhuwa kuzasi
- Kubuda ropa rakawandisisa pamazuva ako ekutevera kana kutanga kubuda ropa mushure mekunge waguma kutevera.
GOMARARA REZAMU (BREAST CANCER)
Chii?
- Bundu kana mapundu anokura mumazamu
- Haasi ese mapundu anobuda mumazamu anoita gomarara, zvikuru sei kumadzimai echidiki nevanoyamwisa
Chii chinowedzera mukana wekuita gomarara rezamu?
- Makore ekuberekwa anopfuura makumi mana
- Kana mumwe wemumhuri akamboita gomarara rezamu
- Kuputa fodya ne kunwa doro
- Kudya kune mafuta emhuka/enyama akawanda kana zvekudya zvakatsetseka zvisina matsengwa
Zvii zvinogona kuratidza gomarara rezamu?
- Bundu kana kuomarara muzamu kana pedyo ne zamu kwenguva inodarika mwedzi mumwechete
- Bundu muhapwa kwenguva inodarika mwedzi mumwechete
- Mvura ine ropa kana yakachena inobuda pa zamu
- Kushanduka kweganda pakutarisa kana pakubata zamu
- Kusiyana kwemazamu kana minyatso yemazamu
Ungazvidzivirira sei?
- Kuzviongorora kwema zamu
- Itai izvi pakati pemazuva matatu kusvika mashanu mushure mekunge matevera (kuenda kumwedzi) nekuti panguva iyi mazamu anenge asina kuzvimba uye anenge asingarwadzi
- Ongororai nekubata mazamu pamberi pechioneso muchitsvaga zvinhu zvinogona kuratidza gomarara rezamu zvataurwa pamusoro. (kuti muzive zvizere munokwanisa kubvunza vezveutano kuzvipatara zviripedyo nemi)
- Kubatwa kwegomarara rezamu pachine nguva zvinobatsira pakurapika kwechirwere ichi.
KUGUMA KUTEVERA/ KUGEZA/KUENDA
Chii?
- Izvi zvinoitika kuvanhukadzi vose kazhinji kune vane makore makumi mashanu zvichikwira
- Kuguma kutevera hachisi chirwere
- Chiratidzo chekuti munhukadzi aguma kubereka vana
- Pane zvakawanda zvinoshanduka mumuviri panguva lyi
- Kunyangwe hazvo munhukadzi aguma mbereko hazvireve kuti haachakwanise kusangana nemunhurume pabonde
Unoziva sei kuti wasvika pakuguma kutevera
- Kana mazuva ekutevera asisauye nenguva kuvakadzi vanemakore aripakati pemakumi mana nemakumi mashanu.
Ndezvipi zvinoratidza kuti nguva yekuguma mbereko yasvika
- Kuwedzera pahuremu hwemuviri
- Kunzwa kupiswa zvakanyanya kana kudikitira zvakanyanya pakurara
- Kushaikwa kwehunyoro kana kuti kuoma kwenhengo yechikadzi
- Kutadza kubatwa nehope
- Kunzwa marwadzo mumuviri wese
- Kuomarara kweganda
- Kunzwa marwadzo mumabhonzo
(Kana muchinzwa izvi monokwanisa kuenda kunachiremba kunoongororwa kana kuri kuguma kwembereko.)
Mungazvibatsire sei panguva iyi?
- Munogona kubatsirika nekudya chikafu chinovaka, kusimbisa muviri kuburikidza nekubata basa kana kumhanya (exercise) uye kusafunganya
- Kana muchipiswa uye kudikitira zvakanyanya munogona kunwa mvura yakawanda
- Kuderedza kunwa zvinwiwa zvine caffeine zvakaita se coffee, putugadzike (tea) kana coca cola
- Matambudziko edundiro akafanana nekuita weti pese pese kusanganisa pakukosora kana kuseka endai munoonekwa nachiremba
- Kuramba muchienda pabonde kunogona kubatsira pane zvamunenge muchinzwa
- Kunwa mukaka wakawanda kunosimbisa mabhonzo
ZVIRWERE ZVEHUPENYU HWESE
Zvirwere izvi zvinosanganisira chirwere chinokanganisa kufema zvakanaka (asthma), chirwere chemoyo (heart failure), chirwere chemabhonzo (arthritis) pamwe nezvirwere zvichataurwa pasi.
CHIRWERE CHESHUGA
Zvii zvinogona kuwedzera mukana wekuita chirwere ichi?
- Kana vamwe vemumhuri vanechirwere cheshuga
- Kusabata mabasa zvinogona kukonzera huremu hwemuviri hwakanyanyisa.
- Kuputa fodya nekunwa doro
Ndezvipi zvinoratidza kuti munogona kunge muine chirwere ichi?
- Kudzikira pahuremu hwemuviri
- Kunyanya kunzwa nyota
- Kuita weti kakawanda kunyanya pakati peusiku
- Kunzwa kunyanya kuneta
- Kunzwa nzara padiki padiki
Munokwanisa kuzvibatsira sei mukabatwa nechirwere ichi?
- Kuderedza kudya zvikafu zvine shuga ne mafuta
- Kuwedzera zvikafu zvakaita se muriwo nemichero
- Kuchengetedza utano hwakanaka kuburikidza nekubata mabasa kana kumhanya (exercise)
- Mishonga yekunwa kana yekuzvibaya inoderedza shuga muropa yamunogona kupihwa neveutano kuchipatara mushure mekunge mabatwa shuga.
- Kuzviongorora huwandu hweshuga muropa pachezvenyu kuburikidza nekushandisa muchini wekumba. Izvi zvinogona kuitwa kuchipatara chiri pedyo nemi kana musingakwanise kuwana muchini uyu.
Chii chinoitika kana chirwere cheshuga chikasarapwa?
- Zvirwere zvemoyo, zvirwere zveitsvo, zvirwere zvemaziso, kuoma rutivi, zvirwere zvemutsinga
Munokwanisa kutaura nachiremba wenyu kuti muwane ruzivo rwezvinoratidza kuti shuga yemuropa yenyu yakawandisa kana kuti yakaderera kunyanya vaya vanozvibaya mishonga yekuderedza shuga muropa
CHIRWERE CHEKUKWIRA KWEBP
Munokwanisa kuzvibatsira sei mukabatwa nechirwere ichi
- Kuderedza kudya zvikafu zvine mafuta akawanda.
- Kudya michero nemiriwo yakawanda
- Kuderedza munyu muchikafu.
- Kuchengetedza utano hwakanaka kuburikidza nekubata mabasa kana kumhanya (exercise)
- Mishonga yekunwa inoderedza BP yamunogona kupihwa neveutano kuchipatara mushure mekunge mabatwa nechirwere ichi
- Kumira kuputa fodya kana kunwa doro
Zvii zvinogona kuwedzera mukana wekuita chirwere ichi?
- Kana vamwe vemumhuri vanechirwere chekukwira kweBP
- Kusabata mabasa zvinogona kukonzera huremu hwemuviri hwakanyanyisa.
- Kuputa fodya nekunwa doro
Chii chinogona kuitika kana chirwere chekukwira kweBP chikasarapwa?
- Zvirwere zvemoyo, zvirwere zveitsvo, zvirwere zvemaziso, kuoma rutivi (stroke)
MIBVUNZO NEMHINDURO PAMUSORO PEVIAC KUDZIVIRIRA GOMARARA REMUROMO WECHIBEREKO
Chii chinonzi VIAC?
VIAC inzira inoshandiswa kuchipatara kuongorora shanduko pamuromo wechibereko. VIAC inosanganisira kuongorora shanduko pamuromo wechibereko pachishandiswa vinegar. Umbowo hwegomarara remuromo wechibereko unoonekwa nekuchena. Kubvisa zvichena izvi zvinobatsira kudzivirira gomarara rechibereko pamakore anotevera
Zvino revei kana ongororo yeVIAC ine umbowo?
Kana ongororo yeVIAC ine umbowo hwegomarara remuromo wechibereko. Zvinoda kuti murapwe kuburikidza nerubatsiro kubva kune vezveutano. Umbowo hwegomarara hazvirevi kuti matova negomarara. (Kana VIAC isina kuonesa umbowo zvinoreva kuti muromo wechibereko unoratidzika zvakanaka hapana kurapwa kunodiwa).
Kurapwa kuburikidza neVIAC zvingadzivirira gomarara zvachose here?
Kana mudzimai aneumbowo hwegomarara arapwa zvinotarisirwa kuti dambudziko iri rinopera zvachose. Mushure mekurapwa pane mukana mudiki wekuti dambudziko iri ringadzoke zvakare panguva inotevera. Zvinokurudzirwa kuti munoongororwa nevehutano.
Mudzimai anogona kutapukirwa neutachiona hweHIV kubva pazvinhu zvinoshandiswa kuita VIAC?
Kwete. Midziyo inoshandiswa kuita VIAC insukwa nekuchengetedzwa zvakachena nenzira dzemuchipatara, uye midziyo iyi inoshandiswa kamwe chete pamudzimai mumwe.
Ongororo yeVIAC inogona kuona zvirwere zvepabonde here? Ongororo yeVIAC inobatsira kuona shanduko pamuromo wechibereko zvinogona kuzokonzera gomarara, asi ongororo yeVIAC inosanganisira kutarisa nhengo yemudzimai nemuromo wechibereko. Kutariswa uku kunobatsira kuzoonawo mamwe matambudziko akaita semhopo, zvinobuda kuzasi/kusikarudzi nezvimwewo.


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Kuchinja Zvikumbiro Kwaramba
Mubvunzo: Ndeipi shanduko yakakumbirwa yakarambwa pane imwe nguva?
tsananguro
Zvikumbiro zvekuchinja zvinotsanangurwa sezviri mukati Chinja Zvikumbiro. Zvikumbiro zvakarambwa zvekuchinja ndezviya zvinozovharwa pasina kubatanidzwa munheyo yekodhi yepurojekiti.
Semuyenzaniso, muGitHub kana chikumbiro chekudhonza chakavharwa pasina kusanganisa, uye kuzvipira kunoratidzwa mairi hakugone kuwanikwa mugit repository, inogona kunzi yakarambwa (asi ona yakadzama nhaurirano pazasi). Zvimwe chete zvinogona kutaurwa nezve GitLab yekubatanidza zvikumbiro. Panyaya yeGerrit, ongororo yekodhi inogona "kusiyiwa" zviri pamutemo, inova nzira yekuona zvakaramba zvikumbiro zvekuchinja mune ino system.
zvinangwa
- Kuwanda kwebasa rekodhi. Zvikumbiro zvakarambwa zveshanduko imiriri yechiitiko chiri muprojekiti. Nekuverenga zvikumbiro zvekuchinja zvakarambwa museti yezvinyorwa zvinoenderana nepurojekiti, unogona kuve neruzivo rwezvese chiitiko chekodha muchirongwa icho chisina kutungamira kune shanduko chaidzo. Ehe, iyi metric handiyo yega inofanirwa kushandiswa kuteedzera huwandu hwekuita coding.
Kutevedzera
Iko kushandiswa uye kuparadzirwa kwehutano metrics kunogona kukonzera kukanganisa kwekuvanzika. Masangano anogona kusangana nenjodzi. Njodzi idzi dzinogona kubva mukutevedzera GDPR muEU, nemutemo wenyika muUS, kana nemumwe mutemo. Panogona zvakare kuve nenjodzi dzekondirakiti dzinoyerera kubva kumatemu ebasa kune vanopa data vakaita seGitHub neGitLab. Iko kushandiswa kwema metrics kunofanirwa kuongororwa kune njodzi uye zvinogona kuitika dambudziko re data. Ndapota onai CHAOSS Data Ethics gwaro kune rimwe gwara.
Aggregators:
- Count. Huwandu hwezvikumbiro zvekuchinja zvakarambwa panguva iyi.
- Ratio. Reshiyo yezvikumbiro zvekuchinja zvakarambwa pamusoro pehuwandu hwezvikumbiro zvekuchinja panguva iyoyo.
Parameters:
- Nguva yenguva. Kutanga uye kupedza zuva renguva iyo yakaramba zvikumbiro zvekuchinja zvinotariswa. Default: zvachose.
- Maitiro ekwakabva kodhi. Algorithm. Default: mafaera ese ari source code. Kana isu tikatarisa pane kodhi kodhi, isu tinoda mucherechedzo wekusarudza kuti faira ndeyako kodhi here kana kwete.
filters
- Nevatambi (anotumira, muongorori, kubatanidza). Inoda kubatanidza mazita anoenderana nemutambi mumwe chete.
- Nemapoka evatambi (mushandi, murume kana mukadzi... kune mumwe nemumwe wevatambi). Inoda kuungana kwevatambi, uye pamwe, kubatanidza mutambi.
Visualizations
- Verenga panhambo nekufamba kwenguva
- Ratio panhambo nekufamba kwenguva
Izvi zvinogona kuiswa mumapoka (pamutambi werudzi, kana neboka revatambi) nekushandisa mafirita, uye anogona kumiririrwa semabhawa machati, nenguva ichimhanya mu X axis. Bhawa rega rega raimiririra zvikumbiro zvekuchinja zvakarambwa pane imwe nguva (semuenzaniso, mwedzi).
Data Kuunganidza Strategies
Tsanangudzo chaiyo: GitHub
Panyaya yeGitHub, zvikumbiro zvakarambwa zvekuchinja zvinotsanangurwa se "kudhonza zvikumbiro zvakavharwa nekuchinja kwavo kusaverengerwa mugit repository", chero bedzi ichikurudzira shanduko kune source code mafaera.
Ona nhaurirano mune yakananga tsananguro yeGitHub mukati Chinja Zvikumbiro Zvinogamuchirwa, sezvo zvichishanda pano zvakare.
Inosungirwa paramita (yeGitHub):
- Heuristic yekuona yakaramba zvikumbiro zvekuchinja, ichitaurira patsanura idzo nyaya uko chikumbiro cheshanduko chakavharwa, asi shanduko dzakaverengerwa mugit repository nemaoko. Default: Hapana.
Tsanangudzo chaiyo: GitLab
Panyaya yeGitLab, ongororo dzakarambwa dzinotsanangurwa se "kubatanidza zvikumbiro zvakavharwa neshanduko dzadzo dzisiri kuverengerwa mugit repository", chero ichikurudzira shanduko kumafaira ekodhi.
Inosungirwa paramita (yeGitLab):
- Heuristic yekuona yakaramba zvikumbiro zvekuchinja, kuudza patsanura idzo nyaya apo chikumbiro chekubatanidza chakavharwa, asi shanduko dzakaverengerwa mugit repository. Default: Hapana.
Tsanangudzo chaiyo: Gerrit
Panyaya yaGerrit, zvikumbiro zvekuchinja zvakarambwa zvinotsanangurwa se "shanduko dzakasiiwa", chero bedzi vachikurudzira shanduko kumafaira ekodhi.
Mandatory parameters (yeGerrit): Hapana.


text:
About Luxo Tende
Sichuan Aixiang Technology Co., Ltd. ndiye nyanzvi chiedza-uremu mapurani chivako muna China, pamwe pezvitsiga maviri, Aixiang Agriculture uye Luxo Tende pasi payo kuti zita.
The kambani iri riri Chengdu, musoro aruminiyamu tende mugadziri uye rokutengesa kwemajoini boka iri Western China.
Tiri mubasa kugadzira & zvibereko mumwe-vanorega chirongwa nyaya basa, uye redu zvinogadzirwa uye pashure-basa anozivikanwa kwose mhiri kwamakungwa & mumhuri vatengi. Isu 'RE vakazvitsaurira kupa kwazvo munhu zvichienderana mazano uye customized glamping tende, umbozha uyai tende, uye hotera tende nokuda yevedza gwapa, tourism Real Estate, zvipenyu nezvakazvipoteredza yokufaranuka Eenhede emakambani, kwezvakatipoteredza magadzirirwo kuronga uye dzimwe akakodzera dzakabatana.
Isu tine yakasarudzika yakasarudzika yematende anotaridzika, inopisa matende dhijitari yesarudzo yako.
Kune vatengi vari kutsvaga yakawedzera mutsva dhizaini yekugadzira, tinogona kupa yakakwirira-kumagumo yakagadzirirwa masevhisi.
Isu tinopa huwandu hwakazara masevhisi kubva kumagadzirirwo epfungwa kuenda kumisasa yeprojekiti yekuitwa.
Dzokai-chinokosha Solution nokuda Light-Weight Architectural Structure
The kambani ano kugadzirwa zvokushandisa, simba tsvakurudzo & kukura simba uye kuvakwa, nyanzvi chikwata pamwe pamwe nemakore unyanzvi ruzivo. Tinopa design, zvibereko, kugadzwa, uye kugadzira basa mhando dzose aruminiyamu chiwanikwa uye chiedza-uremu simbi pepuranga zvivako.
The Engineering and Technology Department zvino ane Makontakta maviri prc they vaipupurirwa kirasi yokutanga, vatatu Makontakta prc they vaipupurirwa kirasi yechipiri, nomwe mukuru vagadziri nezvitanhatu Sales, vari panguva yavo mabasa anopfuura 5 makore uye rinogona nyanzvi chigadzirwa magadzirirwo uye chirongwa dambudziko vatengi nokukurumidza uye zvakanaka
Tsika Kambani
Tsika dzedu: nokuvonga, akatendeseka, nyanzvi, vaneshungu, co-kushanda
Luxo Tende anobata basa uzivi kuti kuvimbika sezvo mudzi, unhu pokutanga, kuzvipira zvaanoda utsanzi nemaitiro matsva kuti fananidza zvose kushanda, ichipa mari-inoshanda chigadzirwa uye basa kuti vatengi kumba uye kunze nemaitiro edu matsva.
Isu kwete chete kupa pamwero basa kuti chinoita vatengi yedu sokuti youmambo. Nguva dzose noushamwari chirimwa kwatinoita basa-nzvimbo kuferefeta kugamuchira kuvaka bhizimisi-mudiwa ukama nesu.