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Wyndham Mahotera & Resorts nhasi yakazarura zvirongwa zvekuvhura mahotera ayo ekutanga muNepal neBhutan, nepo ichizivisa kuvhurwa kwazvino kweHawthorn Suites naWyndham Dwarka-yekutanga Hawthorn Suites nehotera yeWyndham kuIndia.
Mahotera ese ari matatu chikamu chekuedza kukuru kwaWyndham kuwedzera zvakanyanya tsoka dzayo kuyambukira Indian subcontinent uye zvinowedzeredzwa nezvimwe zvivakwa mudunhu izvo zvichangovhurwa kana zvakatemerwa kuvhura mumwedzi mipfumbamwe inotevera. Wyndham parizvino ndeimwe yemakambani makuru epahotera epasi rose muIndia.
Nikhil Sharma, director director wenzvimbo, Eurasia, Wyndham Hotels & Resorts vakati, "Mumakore mashoma apfuura, Bhutan neNepal vakaona kuwedzera kwakatsiga mukushanya, zvichivaita nzvimbo dzakanaka kuti isu tiwedzere. Zvakare, ivo vanowirirana zvakakwana mukana uye kukwidziridzwa kwemusika wepakati muIndia, watakasimbisa nhasi nekuunzwa kweHawthorn Suites neWyndham brand. Sezvo Indian subcontinent iri kuramba ichiita masaisai muindasitiri yekugamuchira vaeni, Wyndham inoramba iri laser yakanangana nekupinda mumisika yayo mikuru uye kuzadzikisa basa redu rekuita kuti kufamba kwehotera kugoneke kune vese.
Anouya mahwindo ekuvhura anosanganisira:
- Ramada neWyndham Valley Thimpu (Bhutan)
Kuisa mucherechedzo kusvika kwaWyndham muBhutan, iyo Ramada® neWyndham Valley Thimpu ichapa makamuri akapamhama makumi mana neshanu, kusanganisira akawanda ane panoramic maonero eakanaka Himalaya. Yakadzika mumupata weThimpu nerwizi rweRaidāk rwunoyerera, nzvimbo yayo ichapa nyore kuwana zviitiko zvakakosha paTasichho Dzong, chifananidzo chikuru cheBuddha Dordenma, uye nenzvimbo inoyera yeChirangaridzo Chorten. Ihotera iri rinotarisirwa kuvhurwa munaKurume 41.
- Ramada Encore naWyndham Kathmandu Thamel (Nepal)
Kupinda kwekutanga kwaWyndham muumambo hweHimalaya muNepal, iyo Ramada Encore naWyndham Kathmandu Thamel iri mudunhu reThamel muguta guru reKathmandu, rave riri iro nzvimbo yeindasitiri yevashanyi kweanopfuura makumi mana emakore. Ihotera iyi ichapa makumi mapfumbamwe nemakumi mapfumbamwe makamuri akanakisa emakamuri evaenzi ane huwandu hwenzvimbo dzekuita kuti ugare zvakanaka uye padenga remba uine maonero anoyevedza eguta. Ihotera iri rinotarisirwa kuvhurwa muna Nyamavhuvhu 90.
- Ramada naWyndham Mussoorie Mall Road (India)
Ichipararira kune imwe acre yenyika, iyo Ramada naWyndham Mussoorie Mall Road ichapa makamuri makumi mana nemashanu zvese nezvinodiwa zvakakosha kuti vashanyi vafarire nguva yavo. Ihotera iyi ichave iri pane imwe yenzvimbo dzinoyemurika dzemakomo kumaodzanyemba kweIndia, inonziwo Mambokadzi weMakomo, inozivikanwa pakati pezororo pamwe nevashanyi vebhizinesi. Ihotera iri rinotarisirwa kuvhurwa kupera kwemwedzi uno.
Munguva pfupi yapfuura 2020 kuvhura kunosanganisira:
- Hawthorn Suites naWyndham Dwarka (India)
Inoratidza kusvika kweHawthorn Suites neWyndham brand muIndia subcontinent, iyo Hawthorn Suites naWyndham Dwarka inzvimbo yeecko-yemweya inopa 202 makamuri akapararira evashanyi uye iri padyo padyo neDwarkadhish Temple, Dwarka Beach uye Gomti Ghat. Iyo chivakwa, yakavhurwa muna Kubvumbi 2020, inopa yakakura mukana wekunze kuwana nemukana wekutarisa pahutano uye kuongorora zvisikwa.
- Ramada naWyndham Aligarh GT Road (India)
Ihotera nyowani-yekuvaka iri muAligarh, mudunhu rekumadokero kweUttar Pradesh nyika, iyo Ramada naWyndham Aligarh GT Road yakavhurwa muna Ndira 2020 uye inoratidzira makumi matanhatu emakamuri evaenzi emazuva ano, nzvimbo yakakura yehuswa, uye nzvimbo dzakawanda dzezvinhu. Inowanikwa munzvimbo yakanaka ine nyore kuwana kuAligarh Junction Railway Station uye Aligarh Bus Stand, hotera yacho inogadzira imba huru yekufamba munzvimbo yese.
- Ramada Plaza naWyndham Pune Hinejwadi (India)
Yakamiswa padivi pePune Bangalore Highway, ingori awa yekutyaira kubva kune anozivikanwa kupera kwevhiki senge Lonavala, Khandala, uye Lavasa, ndiyo Ramada Plaza naWyndham Pune Hinejwadi. Ihotera, yakavhurwa munaKurume 2020, inogadzira makamuri evashanyi akapamhama zana nemakumi maviri nenomwe uye inopa mukana wekutarisa zvinoshamisira zviri padyo nenzvimbo dzekunze dzakadai seAga Khan Palace.


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Kugadzikana, kupenya, kufema, kutambanudza, kusimba, uye zvimwe ndizvo zvaunowana kubva kusiriki.
Kukurumbira kwaro munyika yefashoni hakusi kubudirira kwazvino. Kana iwe ukashamisika nepo ichidhura kupfuura mamwe machira, chokwadi chakavanzwa munhoroondo yacho.
Shure kumashure apo China yaitonga indasitiri yesirika, yaionekwa sechinhu chepamusoro. Madzimambo chete nevanhu vakapfuma ndivo vaikwanisa. Yakanga yakakosha kwazvo zvekuti yaimboshandiswa senzvimbo yekuchinjana.
Nekudaro, iyo iyo nguva iyo ruvara rwunotanga kupera, inova isina kukodzera kune yakasarudzika zvinangwa zvawakazvitenga kuti ushumire.
Avhareji yaigona kuirasa. Asi iwe haufanire kudaro. Muchikamu chino, iwe unozodzidza maitiro ekugadzirisa marara akapera matambudziko pasilika yako. Ramba uchiverenga!
Tisati tapinda mumatanho, zvingave zvakanaka kuti iwe uzive zvimwe chokwadi nezve sirika.
Chokwadi nezve silika
- Silika inonyanya kugadzirwa neprotein inonzi fibroin. Fibroin is fiber yemuzvarirwo inogadzirwa nezvipembenene zvinosanganisira uchi nyuchi, mahoneti, masvosve anoruka, honye dzesilika, uye nezvinodiwa.
- Kuve jira rinopinza zvakanyanya, ndeimwe yemachira akanakisa ekugadzira majasi ezhizha.
Iye zvino ngatitaurei nezvekupera kwemavara.
Ruvara kupera mu silika
Ruvara kupera runoitika kana iyo pigment iri musirika ikarasikirwa neayo mamorekuru kukwezva nejira. Mukudzoka, izvo zvinhu zvinotanga kurasikirwa nekubwinya kwazvo. Uye pakupedzisira, shanduko yemavara inotanga kuoneka.
Wati wakambozvibvunza here kuti nei silika vara ichipera? Chikonzero chakakurumbira kubhenesa. Dzimwe nguva, nekuda kwekuchinja kwemakemikari. Asi muzviitiko zvakawanda, kupera kunoitika nekuda kwekuramba uchionekwa nechiedza chezuva.
Zvimwe zvikonzero zvinosanganisira - kushandiswa kwemadhayi emhando yepamusoro, matekinoroji asina kukodzera kudhaya, kushandiswa kwemvura inopisa yekuwacha, kupfeka, uye kubvarura, zvichingodaro.
Nzira yakanakisa yekudzivirira ruvara kupera musirika ndeyekuteerera kumirairo yemugadziri. Ngatimhanyei nehumwe hwayo - Usashandise mvura inopisa kupfuura yakakurudzirwa, yekuwachira, dzivisa kugeza nemuchina wekuwachisa, uye shandisa chete sipo dzinokurudzirwa uye mhinduro yekurapa.
Matanho ekugadzirisa silika yakadzima
Kutsva hakusi kwakasiyana nesiriki, rinenge jira rega rinopera kana ratarisana nemamiriro akashata. Haufanire kuyedza yega mhinduro imwe inouya kwauri. Aya anotevera akareruka mishonga yekugadzirira kugadzirisa yakasviba sirika.
Maitiro ekutanga: Wedzera munyu
Kuwedzera munyu pakushambidza kwaunoita ndeimwe yemishonga yekuita yako yakapera sirika zvinhu zvioneke kuva zvitsva zvakare. Iko kushandiswa kweyakajairika midziyo yemumba senge hydrogen peroxide yakasanganiswa nemvura yakaenzana haina kusiiwa kunze, nyorovesa silika kune iyi mhinduro kwenguva yakati wobva washambidza zvakanaka.
Maitiro maviri: Soak nevhiniga
Imwe nzira yekubuda ndeyekudzika nevhiniga usati wageza. Izvo zvinobatsirawo mukubvisa kutarisa kwakadzima.
Maitiro matatu: Shandisa baking soda uye dhayi
Nzira mbiri dzekutanga dzakanyanya kukodzera kana jira rakadzikira semhedzisiro yemavara. Asi kana iwe ukavaedza ivo uye silika yako ichiri yakasviba, unogona kushandisa kubika soda nedhayi.
Maitiro ekugadzirisa iyo yakadzima nhema silika pillowcase
Heano akareruka anokurumidza ekugadzirisa matanho iwe aunotora kuti udzore kupenya kweako kwakadzima sirika pillowcase.
- Nhanho yekutanga
Dururira ¼ mukombe wevhiniga chena mukati mekapu ine mvura inodziya.
- Nhanho mbiri
Simbisa musanganiswa zvakanaka uye nyudza pillowcase mukati memhinduro.
- Nhanho nhatu
Siya pillowcase mumvura kusvika yanyorova kwazvo.
- Nhanho ina
Bvisa pillowcase uye sukurudza zvakanaka. Iwe unofanirwa kuona kuti unosuka mushe kusvikira vhiniga yese uye hwema hwayo hwaenda.
- Nhanho shanu
Svina zvinyoro nyoro ndokuwaridza pachirauro kana tambo isinga zarwe nechiedza chezuva. Sezvandakambotaura, chiedza chezuva chinokurumidzira ruvara kupera mumachira.
Izvo zvaunofanirwa kuita usati watenga machira esilika
Ruvara kupera ndiyo imwe yezvikonzero nei vamwe vagadziri vachirasikirwa nevatengi vavo. Kana chii chaunotarisira kubva kumutengi asina kuwana kukosha kwemari yake? Iko hakuna nzira yaanogona kudzokera kune mumwechete mugadziri kune wechipiri kutenga.
Usati wawana machira esilika, kumbira wako anogadzira kuti akupe iwe bvunzo mushumo we colorfastness yejira re silika. Ndine chokwadi chekuti hauzodi jira resilika rinoshandura ruvara mushure mekuwacha kaviri kana katatu.
Laboratory mishumo ye colorfastness inoratidza kuti yakasimba sei machira zvinhu.
Rega nditsanangure muchidimbu kuti kutsanya kwemavara ndeipi nzira yekuyedza kusimba kwejira, maererano nekukurumidza kwarinogona kuita kumarudzi emhando dzinodzika
Semutengi, kunyangwe mutengi akananga kana mutengesi / wekutengesa, zvakakosha kuti iwe uzive kuti jira resilika rauri kutenga rinoita sei nekuwacha, ironing, uye zuva. Uyezve, colorfastness inoratidzira machira 'mwero wekurwisa ziya.
Unogona kusarudza kukanganwa zvimwe zvechirevo kana iwe uri mutengi akananga. Sveta seSGS bvunzo mushumo . Nekudaro, kuita izvi semutengesi kunogona kumisikidza bhizinesi rako paslip pasi. Iwe neni tinoziva izvi zvinogona kudzinga vatengi kure newe kana micheka ikashata.
Kune vatengi vakanangana, sarudzo yekuti urege kuteerera mamwe anokurumidza mushumo ruzivo zvinoenderana nezvakarongedzerwa zvemucheka.
Heino kubheja kwako kwakanyanya. Usati watumirwa, ita shuwa kuti chii chiri kugadzirwa nemugadziri chinosangana nezvido zvako kana zvinodiwa nevatengi vako zvaungave zvichidaro. Nenzira iyi, haufanire kunetseka nekuchengetwa kwevatengi. Kukosha kwakakwana kukwezva kuvimbika.
Asi kana iyo bvunzo mushumo isipo, unogona kumhanya nekuzviongorora pachako. Kumbira chikamu chemucheka wauri kutenga kubva kumugadziri uye geza nemvura yakasangana nemvura yegungwa. Mushure meizvozvo, chengetedza nesimbi inopisa yekuwachira. Zvese izvi zvaizokupa iwe pfungwa yekuti yakasimba sei iyo sirika zvinhu.
Mhedziso
Sirik zvinhu zvinogara, zvisinei, zvinofanirwa kubatwa zvine hungwaru. Kana imwe yehembe dzako ikadzima, unogona kuiita nyowani nekutevera chero nzira dzambotaurwa.
Post nguva: Sep-04-2021

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Vashanyi vanogamuchirwa zvakare muSamoa, chero bedzi vafambi vanosvika vaine chitupa chekubaira gwirikwiti. Samos akasimudza yavo Measles State yeEmergency.
Samoa.travel inoti: “Tsika yedu inodziya, ine ushamwari uye nzvimbo dzinoyevedza dzinoita kuti Samoa ive nzvimbo yakanaka pachitsuwa chePacific yekushanya.”
Kubuda kwegwirikwiti kweSamoa kwe2019 kwakatanga munaGunyana 2019. Kubva musi wa26 Zvita, pakanga paine vanhu zviuru mazana mashanu nemakumi matanhatu nemakumi matanhatu nezviuru zvegwirikwiti uye kufa kwevanhu makumi masere nemasere, kubva muvagari vemuSamoa vanosvika mazana maviri nemazana masere nemazana masere nemakumi manomwe nenomwe. Vanopfuura zvikamu zviviri muzana zvevanhu vakatapukirwa
Vanachiremba navanamukoti kubva kutenderera pasirese, kubva kuHawaii kuenda kuUK vakasiya Krisimasi neshamwari uye mhuri kuti vabatsire kuponesa hupenyu mukupararira kwegwirikwiti muPacific Island Nation.
Mamiriro ekukurumidzira akaziviswa musi wa17 Mbudzi, achiraira kuvharwa kwezvikoro zvese, kuchengeta vana vari pasi pemakore gumi nemanomwe kure nezviitiko zveruzhinji, uye kuita kuti nhomba yekumanikidza. Musi wa17 Zvita, mamiriro ekukurumidzira akawedzerwa kusvika musi wa14 Zvita. Mumiriri weSamoa anodzivirira nhomba Edwin Tamasese akasungwa akapomedzerwa mhosva yekukurudzira "hurumende."
Musi wa2 Zvita 2019, hurumende yakamisa mutemo wekudzokera kumba uye yakanzura mhemberero dzese dzeKisimusi pamwe nekuungana kwevanhu. Dzese mhuri dzisina kubayiwa majekiseni dzakarairwa kuti dziratidze mureza mutsvuku kana jira pamberi pedzimba dzavo kuti vayambire vamwe nekubatsira nhomba yekudzivirira. Dzimwe mhuri dzakawedzera mameseji anoti "Rubatsiro!" kana "Ndinoda kurarama!".
Musi wa5 na6 Zvita, hurumende yakavhara zvese zvimwe kunze kwezvekushandisa zveruzhinji kuendesa vese vashandi vehurumende kumushandirapamwe wekudzivirira. Iyi nguva yekumiswa yakasimudzwa musi wa7 Zvita apo hurumende yakafungidzira kuti zvikamu makumi mapfumbamwe kubva muzana zvevanhu zvakasvikirwa nechirongwa chekubaisa. Kubva musi wa90 Zvita, inofungidzirwa kuti 22% yevagari vemo vakakodzera vakabayiwa jekiseni.
Inbound Vashanyi kuSamoa unofanirwa kuve nehupo hwekudzivirira gwirikwiti.


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International Air Transport Association (IATA) yakazivisa kuti Transparency in Payments (TIP) yakaitwa mumisika yeFinland, Norway neSweden. ZANO, iro riri kuunzwa pamwe chete neNewGen ISS, chirongwa cheindasitiri chakanangana nekupa nendege nekuwedzera kujekesa uye kutonga mukutora kwezvavanotengesa zvakagadzirwa mukanzuru yesangano rekufamba. Panguva imwecheteyo, zvinoita kuti vafambi vafambe nenzira itsva dzekubhadharira mari yevatengi.
“Mamiriro ezvinhu pari zvino ekubhadhara mabasa achinja zvakanyanya, uye vatambi vatsva uye nzira dzekubhadhara dziri kubuda, zvichipa vafambi mafambiro makuru ekubhadhara mari yevatengi kunhandare dzendege. Nekudaro, kusvika parizvino, nendege dzakatadza kuoneka mune idzi nyowani nzira dzekubhadhara. TIP ichataura nezvenyaya iyi, ichiunza mikana mitsva yendege nevamiriri vekufamba, ”akadaro Aleks Popovich, Mutevedzeri weMutungamiri weIATA, Financial and Distribution Services.
Hapana nzira yekutumira mari inorambidzwa neTIP, asi vamiriri vekufamba vanogona kungoshandisa iwo mafomu ayo ndege yakambopa mvumo. Zvakakosha, kana kambani yendege ikabvuma, ZANO rinobvumidza vamiririri vekufamba kushandisa makadhi avo echikwereti. IATA yakashanda padhuze neakakosha maindasitiri vanobatika kugadzira TIP kuona kuti inopa:
- Kuwedzera kujekesa uye kutonga kwemumwe mutambi
- Sisitimu inoshanda uye maturusi ekugonesa vamiririri nendege kubvumirana pamwe chete mukushandiswa kweimwe nzira yekuchinjisa, senge makadhi echikwereti nenhamba dzenhoroondo dzenhengo (VANs), yekubhadharira ndege dzesangano Billing uye Settlement Plan (BSP) kutengesa
- Iyo resolution resolution iri nani kuchinjiswa kune zvemitemo uye mamiriro emusika.
Pasi peTIP, vanopa dzimwe nzira dzekuchinjisa vanoshuvira kutora chikamu mumitero yakanangana nekutumira ndege kumabhizimusi eBSP vanotengesa vachanyorera neIATA, vopa ruzivo rwakakodzera nezvezvinhu zvavanobhadhara. Vamiririri nendege vachange vachiwana irworwu ruzivo pane inoda-kuziva-hwaro. “Tinotarisira kushanda pamwe nevanopa dzimwe nzira dzekuchinjisa dzakaita seAirPlus International neEdenred Corporate Payment, vanotsigira misimboti iri muTIP. Tinofungidzira kuti vamwe vanopa rubatsiro vanozozvipira kunyoresa zvigadzirwa zvavo mukati megadziriro yeTIP kana nzvimbo yavo yehunyanzvi yagadzirira, kuti vabatsire pakujekesa kwendege neecosystem, "akadaro Popovich.
Pamasvondo anotevera, TIP ichaitwa muIceland neDenmark (9 Chivabvu), Canada (16 Chivabvu), neSingapore (23 Chivabvu), kuburitswa kunotarisirwa kuzadzikiswa mumisika yese yeBSP naQ1 2020.


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Product Description
Delmadinone Acetate powder video
Delmadinone Acetate powder Basic Characters
Delmadinone Acetate powder cycle
Mazita
Kemikari Mazita: Delmadinone Acetate powder
Mazita eBrand: Delmate, Estrex, Tardastren, Tardastrex, Vetadinon, uye Zenadrex, Tardak. Delmadinone acetate (DMA) poda, 13698-49-2
Zvinyananiso: 17- (Acetyloxy) -6-chloropregna-1,4,6-triene-3,20-dione; 17-Acetoxy-6-chloropregna- 1,4,6-triene-3,20-dione; 17A-Acetoxy-6-chloropregna-1,4,6-triene-3,20-dione; 6-Chloro-17-hydroxypregna-1,4,6-triene-3,20-dione Acetate; Delminal; Estrex; RS 1301; Tardastrex; Tarden; Zenadrex; A1-Chlormadinone Acetate;
Delmadinone Acetate powder Usage
Delmadinone Acetate powder (CAS 13698-49-2) inokonzera kudzvinyirira kudzvinyirira kubva mukudziviswa kwekusunungurwa kweAACTH kubva pane gland pituitary. Imbwa dzinobatwa dzingave dziri pangozi yekudzidzira zviratidzo zvekushaya glucocorticoid kana ichitarisana nezviitiko zvinokonzera panguva kana mushure mekurapa. Kusawirirana kweglucose kana hypersomatotropism inoratidzika kunge imbwa dzevarume dzakapiwa Delmadinone Acetate powder pamwero wakakurudzirwa weuzhinji, asi kukwanisa kwekuwedzera kukura kwehomoni mune zvakagadziriswa zvinoramba zvisingatauri.
Delmadinone Acetate powder, progesterone ine antiestrogen uye antiandrogen; yakashandiswa kubvisa Estrus nekudzivirira kubata pamuviri nembwa.
Chirwere chemakiriniki chakasiyana-siyana chakashandiswa kuti chienzanise nekurapa kwemaitiro e osaterone acetate neaya eDelmadinone Acetate powder mukurapa kwebenign prostatic hyperplasia muimbwa. I-osaterone yakashandiswa pamuromo pa 0 · 25 mg / kg bodyweight kamwe pazuva kwemazuva manomwe kumbwa 73. Ida delmadinone yaitungamirirwa nechirwere chimwechete chemuviri kana chechikati chemukati pa 3 mg / kg bodyweight kusvika kuIzinja 69. Munguva yekutongwa kwe180-zuva, imbwa dzaiongororwa kaviri nokuda kwechirwere chechirwere uye prostate volume. Iyo mishonga miviri yakanga yakafanana nekugadzirisa zviratidzo zvekliniki uye kukonzera kukwana kwekuregererwa kwekliniki, uye zvose zvakakonzera imwe yakafanana yezviduku, zvishoma nezvishoma zvakashata zvinoguma. Osaterone yakaderedza huwandu hweprostate glands yembwa zvakakurumidza kudarika delmadinone.
Ndeipi inonzi Dedmadinone Acetate powder
Delmadinone Acetate powder is antiandrogen ine simba rinopfuura ra progesterone mukukwanisa kwaro kupinza testosterone kukura nekudzivisa interstitial cell function. Chigumisiro chayo ndechokuderedza hutano hwehutano hwehutano kana libido.
Antiandrogens inotendwa ine maitiro maviri ekuita:
1. inhibit pituitary gonadotrophin kubudiswa uye,
2. zvichiita hutano hwekuita zvepabonde.
Delmadinone (Tardak) migumisiro inozivikanwa kuti inogona kuchinjwa apo mishonga inomiswa.
Kunyangwe isina kupihwa marezenisi emakonzo, iyo Pfizer drug kambani yakaraira kuti inogona kushandiswa pamwero mumwechete wedhiza uye chiratidzo senge imbwa dzechirume nekatsi: - kureva 0.1 mL subcutaneous yeavhareji 500g rat, uye inogona kudzokororwa mazuva gumi mushure mekubayiwa kwekutanga jekiseni kana zvisiri kushanda kana zvichidikanwa - pamwe mushure memasvondo matatu - mana kana zvido zvichipera. (Yekuwedzera veterinarian chirevo chekushandisa kwedosi: 10)
* Cherechedzai:
VETI INOFANIRA KUTEVERA MAZANO ASI PASI DHAHEDHA. Zviratidzo zvepamusoro ndezvimwe nzira dzoutsinye uye kutya mukati mamakonzo. (Chimiro chemakemikari.)
NB Kuchinja mumucheka wenguvo kunogona kuitika saka kana izvi zvingava dambudziko, semuenzaniso mukuratidza mhuka dzimwe nzvimbo dzejojo dzinogona kuonekwa
Iyo Delmadinone Acetate powder inoshanda sei
Delmadinone Acetate powder (INN, USAN, BAN) (mazita ezita rokuti Delmate, Estrex, Tardak, Tardastren, Tardastrex, Vetadinon, Zenadrex), dzimwe nguva akafukidzwa se Delmadinone Acetate powder, uyewo anozivikanwa se1,6-bisdehydro-6-chloro-17a-acetoxyprogesterone , steroidal progestin ne antigonadotropic (uye naizvozvo, antiandrogenic uye antiestrogenic) dzimba dzinoshandiswa kurapa zvirwere zve-androgen zvine chokuita nemishonga yezvokurapa. Inofanira kushandiswa nekuchengetedza sezvo inogona kuita kuti adrenal isakwanira kuburikidza nekudzivisa adrenocorticotropic hormone ( ACTH) kuporesa kubva planduri yepituitary.
Kunyange zvazvo isinganzwisisi zvakakwana, zvinogona kuitwa zveprogesagens kuderedza gonadotropic hormone secretion, nokudaro kudzivirira mavari ovarian cyclicity.
yambiro
Kuchenjerera kunofanira kushandiswa paunobatanidza nemamwe marudzi e-steroid therapy.
Delamadinone Acetate Raw Powder (CAS 13698-49-2)
Min order 10grams.
Inobvunza pamusoro pezvakawanda (mukati 1kg) inogona kutumirwa mumaawa e12 mushure mekubhadhara.
Kuti uwedzere kurongeka kunogona kutumirwa mumazuva ekushanda kwe3 mushure mekubhadhara.
Delmadinone Acetate powder Marketing
Kuti igoverwe mune ramangwana riri mberi.
Dhimadinone Acetate powder Ane Mikana Dzakashata
Rakadhindwa mashoko pamusoro peDelmadinone Acetate powder yakawanda. Zvinonzi migumisiro yemigumisiro inowedzera kuwanda, polydipsia, kugadzirwa kweganda remukati uye huwandu hwehutachiona hwehutachiona. Dhichipatimendi data inoratidza kuti nguva iri pakati pemagumo ekurapa kweDA uye kudzokera kunopisa inogona kuwedzerwa, saka zvichida zvakanakisa kuti isashandise DA pakubereka mhuka. Kune zvose Delmadinone Acetate powder uye chlormadinone acetate, kurapwa kunoratidzika kunge kunoshanda kubudirira kwenguva refu kwenguva refu muimbwanana kana inorowa mwedzi yose ye4, uye dzimwe nguva kuputika kupisa panguva yekurapa kunoratidzwa. Mishonga haisi yakakosha yekugadziriswa kwenguva pfupi kwekufamba kwenguva kana kwekudzora-kuderedza panguva yeproestrus. Ikoko kunotora kurapa kunonzi kunowanzoitika kune vose. Nenguva yakatarwa kubva pakurapa kusvika kune imwe inotevera ndeyemwedzi ye8 ye delmadinone mune nhamba shomanana yembwa, uye inoshanduka kusvika kumakore maviri echlormadinone.
Nzira yekutenga Delmadinone Acetate powder kubva kuAASraw
1.Kutaurirana nesu ne email yedu yekubvunza system, kana online skypeMutariri wevashandi (CSR).
2.Kutipa isu yakabvunzwa nekero.
3.Our CSR ichakupa iyo quotation, nguva yekubhadhara, nhamba yekutsvaga, nzira yekuendesa uye inofungidzirwa zuva rekuuya (ETA).
4.Payment yakaitwa uye zvigadzirwa zvichaendeswa mumaawa e12 (Kurongeka mukati me10kg).
5.Goods inogamuchira uye inopa mhinduro.


text:
Iyo colocation Kubata kana "Colocation Kubata”Muitiro unoita wekubata maseva akazvimiririra uye netiweki michina munzvimbo yechitatu-data. Ndokunge, panzvimbo pekuchengeta iyo mukati maseva mumahofisi kana munzvimbo yakavanzika yedhata, makambani anosarudza "kuisa" michina yavo nekuhaya nzvimbo mukati mekococation Center.
Ndeipi dzimba dzekuisa?
Kusiyana nezvinoitika nevamwe mhando dzewebhu kubata, apo vatengi vanogona kukwereta nzvimbo pane server iyo inowanikwa newebhu inomiririra mupi, ine colocation inomiririra, mutengi atova neyake akati server uye anongorenda nzvimbo yepanyama yavanoda kuitisa mukati me data centre kana data centre.
Ndezvipi zvakanakira kubatanidzwa kwecococation
Iye zvino a colocation inobata mupi Haangoreti nzvimbo munzvimbo yedata uko vatengi vanogona kuisa yavo michina. Inopawo iyo simba, bandwidth, pamwe neIP kero, pamwe nehurongwa hwekutonhora hunodiwa nemutengi kuti vabudirire kumhanyisa server yavo.
Izvo zvakakodzera kutaura kuti ino nzvimbo iri maroja akavakirwa pamatombo uye makabati. Mune ino kesi, furemu inobvumira kuti midziyo ikwirwe, kazhinji yakatwasuka. Mutengo wegadziriro yekuisa unoverengerwa zvichienderana nenhamba yeyuniti inodiwa. Vatengi vanobatsirwa maererano nehupfumi hwechiyero icho chingave chisingawanikwe pamwe neimba-sarudzo.
Mukuwedzera, the Colocation Kubata inobvumira vashandisi kutora mukana weiyo data centre zvivakwa nepo vachichengetedza kutonga pamusoro peiyo server kumisikidza uye kugadzirisa. Iyo mhando yekugara inova inobatsira uye zvakare inosunungura yakakosha nzvimbo hofisi. Colocation inomirira zvakare inochengetedza zvigadzirwa zvekushandisa nekudzivirira kuchengetedza maseva-mumba.


text:
Mukati mekuru runyorwa rwevanyori veSpanish, rimwe remazita ane mavara makuru ekusimbisa, pasina kupokana, ...
Kufa muna Mbudzi ibhuku razvino raGuillermo Galván. Mumusika kubvira 13th, ndiyo ...
Abdulrazak Gurnah munyori weTanzania akahwina mubairo we2021 Nobel muLiterature.Sweden Academy yakaratidza ...
Juan Francisco Ferrándiz ndiye munyori wenyaya yenhoroondo ine mazita akadai seRima Maawa, iwo Murazvo weUchenjeri kana ...
Musi waGumiguru 7 yegore rino, zita remunhu anokunda iro zana nemakumi maviri edition ye ...
Wawa. Vanoti ndiyo mwaka unodakadza kwazvo wegore, kunyangwe chitubu chinotora mukurumbira, ...
Julio Llamazares ndomumwe wevanyori vanozivikanwa muSpain, asi kwete chete kune rake basa semunyori, asi ...
Matilda ndeyemhando yezvinyorwa zvevana zvakanyorwa nemunyori wenhau anozivikanwa Roald Dahl. Yayo yepakutanga vhezheni muAnglo-Saxon ...
Dzimwe Dzakazara Nhau ndiwo musoro webhuku idzva naDomingo Villar, iyo inoratidzwa ne linocuts neshamwari yake ...
Parizvino, anenge wese munhu akaona Mutambo weZigaro nhevedzano anoziva zita raGeorge ...
Emilio Lara akaburitsa gore rino Centinela de los Sueños, yake yazvino nyowani. Iye Jaen munyori ave ...


text:
Lymphatic Detox Kuporesa Ginger Patch
$7.95
Mudura
Mhinduro yakanakisa yemusikirwo yema lymphatic drainage, kuzvimba, nezvimwe!
Ndizvo kuedzwe uye kuratidzwa kurapwa kwemakwenzi kuti inobatsira kudzikamisa lilmph node, nhengo kana maronda emuviri, migraine, uye dumbu kubuda.
Uyezve, aya matamba ari nyore kushandisa. Imi ingo kuinamatira kune chero chikamu chemuviri wako nokuti kusunungurwa nekukurumidza kubva pakurwadziwa kwemuviri. Inopa a kunzwa kunodziya zvinokugonesa zorora mushure mezuva refu, rinonetesa.
KURUMIDZA uye GADZIRA IYO URANGO WAKO ZVEZVO izvozvi, sezvazviri VASHURE AMADZIMAI LEFT nekuda kwe ZVIKURU ZVAKADZIDZA KWEMUTENGESI ZVINODA!
YEDU YEDU
Isu tinoita zvatinokwanisa kuti tigadzire zvigadzirwa zvakasarudzika uye zvitsva zvatinogona kuwana, uye kuve nechokwadi chekuti iwe, mutengi wedu, unogara uine ruzivo rwakanyanya paunotenga nesu.
Kana nekuda kwechimwe chikonzero iwe usina ruzivo rwakanaka nesu, tapota tizivise uye tichaita chero zvatingagona kuona kuti uri 100% kugutsikana nekutenga kwako.
Kutenga online kunogona kutyisa, asi isu tiri pano kuti zvinhu zvive nyore.
Isu tinofara kana imi muchifara!
Pane zvachose ZERO RISK inotenga kubva kuJoopzy Official chitoro - saka titumire email kana iwe uchida chero rubatsiro.
✔ Hapana kushamisika kana mari yakavanzwa.
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text:
Chigadzirwa Zvimiro Kutengesa Points Iyo 1080P mota kamera iyo inogona kuona iyo vhidhiyo mumotokari, 4.0 inches 170 ° yakazara HD 1080P HD 3 lens mota DVR mota yekutyaira rekodhi G sensor 3 lens yekurekodha mota kamera yekutyaira rekodhi panguva imwe chete, zvese zviri chete kuchengeteka kwako.Verenga ZvakawandaTumira Kubvunza
Chigadzirwa chinotengesa poindi mukana Iyo mbiri-lens 4G WIFI yakakwira-tsananguro yehusiku chiratidzo mota kamera, yekurekodha yekurekodha iyo inogona kuona vhidhiyo parunhare mbozha, mota mini kamera ine iri kure yekutarisa basa, uye 2-inch kuratidzaVerenga ZvakawandaTumira Kubvunza
Chigadzirwa chinotengesa poindi mukana, yakavanzika WIFI yekutyaira rekodhi yakabatana nenhare mbozha, WiFi mota nhema bhokisi, mota HD mbiri kamera DVR, yakazara HD DVR mota yakavanzwa WiFi rekodhi, mota yepasirese yakavanzwa DVR. Inogona kuiswa mune ese mamodheru.Verenga ZvakawandaTumira Kubvunza
Yakavanzika USB yepasirese rekodhi iyo inogona kuve yakabatana nemota GPS GPS hombe-screen kufamba. Yakakwira-tsananguro USB mota DVR kamera yekutyaira rekodhi chiono chehusiku chishandiso, yaishandiswa kubatanidza iyo Android yekufambisa inomhanyisa mota DVD GPS yekufambisa, yakanangana plug-in yakabatana neiyo USB interface yeiyo GPS kufamba.Verenga ZvakawandaTumira Kubvunza


text:
Sezvo mamiriro ekunze anotanga kutonhorera munzvimbo zhinji kutenderera pasirese, Sandals Resorts muCaribbean iri kugamuchira kudonha nezvakakosha zvipo. Kwenguva yakati rebei, vashanyi paSandals vanogona kutora chikamu mune yakakosha pikicha kiredhiti munzvimbo dzayo zhinji dzakatanhamara munzvimbo dzinodziya uye dzinodziya dzeCaribbean.
Vashanyi vanowana madhora mazana maviri nemakumi mashanu emadhora kumaficha panzvimbo yakasarudzwa. Kuti ugamuchire iyi kiredhiti inonakidza iyo inotora ndangariro dzezororo reroto, vashanyi vanofanirwa kunyoresa mukati maawa makumi manomwe nemaviri ekubhuka kushanya. Uye ichi chakakosha kudonha chinogona kusanganiswa neazvino kuenderera kwekushambadzira kushambadzira:
- 1 Yemahara Husiku
- Mune mapoka emakamuri akasarudzwa
- $ 1,000 Kubhadharira Kiredhiti
- Kusvikira ku65% Yega Rack Rates
Tarisa uone nzvimbo dzese dzakanakisa kupihwa, senge zvataurwa uye zvimwewo, zvinogona kuwanikwa kubva kuSandals sezvo kudonha kunopinzwa muCaribbean:
- Sandals Emerald Bay muGreat Exuma, Bahamas
- Sandals Grande Antigua muSt. Johns, Antigua neBarbuda
- Sandals Royal Bahamian muNassau, Bahamas
- Shangu dzeBarbados muSt. Lawrence, Barbados
- Shangu Royal Barbados muSt Lawrence Gap, Barbados
- Shangu Grenada muSt. George's, Grenada
- Sandals Montego Bay muMontego Bay, Jamaica
- Shangu Negril muNigril, Jamaica
- Sandals Ochi muOcho Rios, Jamaica
- Sandals Royal Caribbean muMontego Bay, Jamaica
- Sandals Royal Kudyara muOcho Rios, Jamaica
- Shangu dzekumaodzanyemba Coast muWhitehouse, Jamaica
- Sandals Grande St. Lucian muGros-Islet, Saint Lucia
- Shangu Halcyon muCastries, Saint Lucia
- Shangu Regency La Toc muCastries, Saint Lucia
Bhuku rine chivimbo
Sandals ine online yekubhuka injini iyo inozongoerekana yaisa zvese zvinosanganisirwa zvinopihwa kupa vashanyi zvakanakisa mwero wezvaunoda mazuva ekufamba. Muchokwadi, Sandals ichavimbisa kuti kana vashanyi vakawana mutengo wakachipa chero kupi, unozofananidzwa. Kana mukati maawa makumi maviri nemana ekubhuka zororo repamhepo pa www.mumusi.com, mutengo wakaderera wezuva rimwe chete rekuuya unofarira huwandu hwakaenzana hwehusiku nenzvimbo dzekugara, maSandals achadzorera mutsauko.
Hapana chikonzero chekumirira!
Kukodzera kubhuka kuchave nesarudzo yeku "bata iyo kamuri" ye $ 49pp chete. Kana iyo "yekubata" sarudzo ikasarudzwa, kiredhiti kadhi inoshandiswa dhipoziti inozobhadhariswa imwezve $ 302 mumazuva makumi maviri nerimwe. Mari yese yasara yezororo inozobhadhariswa mazuva makumi mashanu nemashanu zuva risati rasvika.
Nezvipo zvakawanda zviripo uye zvinovimbisa kugadzira kwekufamba kuronga mhepo, nguva yacho yakakodzera kuti ubike zororo rekudonha neSandals Resorts.
#rekuvakazve


text:
- Musoro weBalkan Chitsauko cheiyo World Tourism Network (WTN), Aleksandra Gardasevic-Slavuljica yakasimudzirwa
- Aleksandra Gardasevic-Slavuljica parizvino ari zvakare Director-General for Tourism Policies uye Strategies ku Ministry of Economic Development in Montenegro
- Izvi zvinounza kudyidzana pakati peWTN neMontenegro kune nhanho nyowani.
Juergen Steinmetz, sachigaro weWTN akarumbidza achiti: “Tese tiri kuWTN tinokorokotedza Aleksandra pachigaro chake chakakosha. Aleksandra anga ari chikamu chakabatana chesangano redu uye ari kutora basa rake semutambi wepasirese wepasirese kuenda padanho rinotevera. Tinomushuvira zvese zvakanaka uye tiripano kuti tibatsire munzira ipi neipi yatinogona.
"Tiri kutarisira kushanda naAleksandra neMontenegro mukuvakazve kufamba."
Aleksandra Gardasevic-Slavuljica Akati:
“Iri idanho guru rehunyanzvi uye kuzivikanwa kukuru kwandiri. Zvinonzwa zvakanaka kana mumwe munhu akabvuma kuedza kwako uye ruzivo uye kana iri rumbidzo yako huru yebasa racho. Unogona kushamisika nekutaura kwangu, asi ini ndinozvitaura nechikonzero. Ndinovimba kuti Montenegro haisi munzira yekushanya kwayo uye kupora kwecovid asiwo mukugadzira nzanga yemabatiro, uko vanhu vachapihwa zvinoenderana nehunyanzvi hwavo neruzivo.
Tine nzira refu refu yekuenda, asi ndine chokwadi chekuti munguva pfupi Montenegro ichava parera reMediterranean, asi zvechokwadi. Ndinofanira kutaura uye ndinotaura zvinonzwika kuti ini ndinopa chikwereti chikuru kune vamwe vangu kubva kuWorld Tourism Network. Kuva nhengo yechikwata chenyu, ndakadzidza zvakawanda kubva pamuri mese. Ndinonzwa ndakasimba nekuve neWTN semutsigiri wangu uye chipangamazano wangu. ”
Sangano reWorld Tourism Network riri kufambisa nhaurirano yekufambisa nevatungamiri venyika dzekushanya munyika zana nemakumi maviri nenomwe Zvekuva nhengo uye rumwe ruzivo shanya www.wtn.travel


text:
VECHIDUKU VANOBVUNZA KUTI
Tinofanira Kurambana Here? (Chikamu 2)
Unofanira kuudza sei mumwe wako kana mava kuda kurambana? Kutanga, sarudza kuti ndepapi pazvinoita kuti mukurukurirane. Pangava papi?
Uri iwe uri kurambwa waizoda kuti zviitwe sei? (Mateu 7:12) Waizoda kuti zvitaurwe pamberi pevamwe vanhu here? Hawaizoda kuti zvidaro.
Kunze kwokunge zvisingaiti, zvaizova zvakanaka kuti musagumisa kufambidzana kwenyu muchishandisa muchina wokudavira foni, kutumira meseji pafoni kana kuti pakombiyuta. Sarudza nguva nenzvimbo zvichaita kuti mukwanise kukurukura nyaya iyi inokosha.
Unofanira kutaura kuti kudii kana nguva yokuti utaure yasvika? Muapostora Pauro akakurudzira vaKristu kuti ‘vataurirane chokwadi.’—VaEfeso 4:25.
Saka nzira yakanakisisa ndeyokuti uve akangwarira asi usingatsuduguki. Taura zvakajeka nei uchifunga kuti kufambidzana kwenyu hapana kwakunokusvitsai.
Haufaniri hako kutaura ndandanda yezvikanganiso kana kuti kuramba uchingotsoropodza mumwe wako. Chokwadi, pane kuti utaure kuti, “Hauite izvi” kana kuti “Haumbofi wakaita izvo,” zvingava nani kuti utaure mashoko ane chokuita nemanzwiro ako—“Ndinoda munhu aka- . . .” kana kuti “Ndinofunga kuti kufambidzana uku kunofanira kuguma nokuti . . .”
Ino haisi nguva yokuti pamunhondo pamusasa kana kuti yokuchinjwa mafungiro ako nomumwe munhu. Yeuka kuti wasarudza kumuramba pamusana pechikonzero chakanaka. Saka ngwarira kana mumwe wako akaedza kuchinja mafungiro ako achikunyengetedza nemanomano. Mumwe musikana anonzi Lori anoti, “Pashure pokunge ndaramba mukomana wangu, akatanga kugara akasuruvara nguva dzose. Ndinofunga kuti aiita izvozvo kuitira kuti ndimunzwire tsitsi. Ndaimunzwira tsitsi asi handina kumbobvumira zvaaiita kuti zvichinje chisarudzo changu.” Kufanana naLori, ziva zvaunoda. Omerera pane zvaunenge wasarudza. Aiwa wako ngaave aiwa.—Jakobho 5:12.


text:
Tourism ndiko kuyambuka kwemiganhu kune chiitiko. Mitambo Tourism ndechimwe chiitiko chakadai kuunza vakawanda kuyambuka miganhu sezvo vachiverengerwa nhasi seMitambo Yevashanyi Vamiririri.
Iyo 2019 edition yeAfrican Sports Tourism - mutungamiri, Pan-Africa kusangana kwevatori vechikamu kubva kune ese ari maviri emitambo uye enzvimbo dzekushanya, inofamba gore rega kubva kune imwe nyika yeAfrica ichienda kune imwe ichaitirwa Ghana gore rino uye zviitiko zvikuru zviviri zvakarongerwa kuti zvive musoro wevhiki.
Iwo maAfrican Sports Tourism Summit & Olimpiki Roundtable uye African Sports Kuenda Makomborero. Musangano uyu uchaona kuungana kwemasangano emitambo / makomisheni / makanzuru, makomiti eOlimpiki, makomiti ekuronga emuno, mabhodhi ezvekushanya, vanoita zvekushanya nevamwe vanobatanidzwa kubva kune ese ari maviri emitambo uye ezvekushanya. Vachave vachiyambuka-mazano uye vachichinjana ruoko rwekuyanana, vakananga Africa iyo mitambo inoonekwa uye inosvikirwa sekushanya. Ichabata ku Oak Plaza Mahotera muAccra Ghana, musi wa19 - 20 Nyamavhuvhu, 2019.
Pane runyorwa rwevatauri ndiJuliet Bauwah, Dev Govindjee, Geoff Wilson, Tafadzwa Mapanzure, Abi Ijasanmi naSeyi Akinwunmi.
Juliet Bawuah izita remukadzi rechikadzi mumitambo muAfrica yose. Iye anogara panhanho inosarudza CAF African Nhabvu yeGore. Muvambi weAfrican Women Sports Summit ishamwari yeRadio Netherlands Training Center. Iye parizvino mutambi wenhabvu wemu Africa paTRT, kambani inotungamira yeEuropean terevhizheni muTurkey.
Seyi Akinwunmi gweta rakakwana iro munguva yakapfuura rakamisa hunyanzvi nevatambi veindasitiri yekushanya. Anoshanda sa1 Mutevedzeri Wemutungamiriri weNigeria Nhabvu Federation uye sachigaro weLagos FA.
Dev Govindjee inyanzvi yemutambo wekiriketi wekuSouth Africa uyo akatamba mumitambo makumi mana nemashanu yekirasi yekutanga kuEastern Province pakati pa45 na1971. Akashanda neInternational Cricket Council kweanopfuura makore gumi. Parizvino mutambi wepasi rese wemutambo.
Nhengo yebhodhi ku Tourism Northern Ireland - Geoff Wilson anomhanyisa bhizinesi rake rekushambadzira nekutaurirana, achitarisa zvakanyanya pamitambo. Pakutanga Musoro weKushambadzira uye Kutaurirana (Irish FA), aive nebasa rehukama neruzhinji, zvirongwa zvebhizimusi, kusimudzira mhando uye kutaurirana kune vateveri.
Geoff anoshanda nezvinodiwa zveFIFA, UEFA, AFC, FIBA nemamwe masangano emitambo epasirese munzvimbo dzakasiyana siyana kubva pakuronga zvine hungwaru, kushambadza nekutaurirana, digitaalinen, vateveri kuita, zviitiko zveveruzhinji uye kugovana ruzivo / zvirongwa zvekuchinjana. Uye zvakare, Geoff anobvunzana nemakambani akati wandei emitambo muCRM, eSports, inopfeka uye nevefeni nzvimbo yekubatira. Geoff ari mudzidzisi wenguva pfupi mukushambadzira paQueen's University Belfast uye ari Sachigaro weNetball Northern Ireland.
Tafadzwa Mapanzure chipangamazano muindasitiri yemitambo ane makore ekuziva mukushambadzira kwemitambo mudunhu reSouthern Africa.
Abi Ijasanmi aive mumwe wevamiririri vechikadzi kutanga kutaurirana mihoro, zvibvumirano uye midhiya madhiri evatambi veUS Basketball muEurope, Asia neMiddle East. Gweta Rezvekutengeserana ane makore anopfuura gumi ruzivo rwekuvandudza bhizinesi, akabatana neTrans-Atlantic Sports kushambadzira semunhu aidzidzira basa muna 10 uye muna 1998 akava nebasa rekumiririra tarenda mumisika dzakasiyana seLebanon, Italy, Lithuania neFrance. Kuongorora mutambi, timu uye hukama hwevezvenhau, uye kuyedza kwake kwakaita kuti vatambi vakwanise kupinda munzvimbo dzisingazivikanwe uye kuraira fizi yehunyanzvi.
Abi akatungamira chikamu chevakadzi cheTASM, yekutanga yerudzi rwayo muEurope. Nekwaniso yekuona mikana mitsva uye kushuvira kugona kweAfrican Basketball, Abi akazvimisikidza semurevereri wevatengesi vepasirese anotarisa kubasketball kukondinendi yeAfrica. Muna 2006, hunyanzvi hwaAbhi hwakadaidzwa neOlimpiki Goridhe Medalist, Tessa Sanderson kuti ape hunyanzvi hwezvemutemo nekutengesa kune achangogadzira mitambo yemitambo yemitambo yeLondon 2012. Iye zvino ari Director we Africa kuDiamondAir International.
Vachitaura nezvechiitiko ichi, Deji Ajomale-McWord, Mutungamiri weAfrican Sports Tourism Vhiki, akati "chinangwa chedu ndechekuwedzera zvigadzirwa zvemumba zvemarudzi eAfrica, kuburikidza nemitambo yemitambo yakasununguka uye zororo remitambo. Nhabvu dzinogona kungogoneswa zvirinani kuburikidza nezvinoitika zvinongogadzirirwa kugamuchira vaeni nekushanya.
Tichave tichienda kune dzakasiyana nyika dze Africa, gore rimwe nerimwe kunze, kuitisa muchato wemitambo uye wekushanya, uye tichitarisa kudanana kwavo kuve nechokwadi kuti chinoburitsa vana vehupfumi hwemagariro. Dingindira redu regore rino nderekuti 'Kubatanidza Zvekushanya Kwemitambo neZvisungo Zvekusimudzira' uye tichange tichikurukura mimwe misoro iri kunetsa pakubhidha, nei Africa isiri kukwezva zviitiko zvemitambo zvakakwana uye kugadzirisa zororo remitambo muAfrica ”.
Paakabvunzwa nezve mibairo, Deji anodzokorodza kuti "kunyangwe ichiita kutanga kwayo mu2019, African Sports Destination Awards yaunganidza kufarira mukondinendi yose. Tourism mabhodhi uye mabhureki mumitambo yemitambo kukoshesa cheni dzakabatanidzwa zvine mutsindo mukugadzwa nekuvhota.
Iyo yekuvhota portal ikozvino yakavharwa uye vanokunda vanotsanangurwa nemavhoti kubva kuruzhinji nejuri. Tichave tichipinzawo rimwe zita mu'Shamwari dzeMitambo Yekushanya 'horo yemukurumbira, kirasi yakasarudzika yemhando, masisitimu uye vanhu vamwe vanotsigira chinangwa chekukurudzira uye kukurudzira vanhu kuti vasiye dzimba dzavo uye vaende kune dzimwe nzvimbo pasi redu, zvemitambo zvinangwa.
"Chinangwa chedu ndechekumisikidza vatambi vari mumaindasitiri ezvekushanyirwa, uye nekubatanidza Africa kuburikidza nemitambo pamwe nekushanya."


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Mupata
Muchidzidzo cheTaranyika, mupata (valley) ishoko rinoreva nzvimbo iri pakaderera inotevedza rwizi. Nzizi dzinoyerera dzichitevedza nhika saka idzo nhika idzi ndidzo dzinonzi mupata.
MuZimbabwe hova dzine mipata inotaurwa kunyanya dzinosanganisira: Zambezi Valley; Mazowe Valley; Save Valley neOdzi Valley. Izvi hazvirevi kuti dzimwe nzizi hadzifambe nemupata asi kuti vanhu vakapfumbidza mazita aya chete.
Mitauro yeBantu[chinja | edit source]
- VaChewa vanoti mpata kana mipata (a valley). VaMambwe vanoti mpata (a pass in mountain range, a gorge, ravine) kureva mupata.
- VaYao vanoti chapata (a gate or entrance ; a pass or road between mountains).
- VaGungu vanoti kihanga (n. valley) kureva mupata. VaGungu vanoisa h pamwe patinoisa p kuChiShona. Sokuti kuliha vachireva kuripa.


text: CLW dzakateerana ivhu / simende inosanganisa chirimwa CLW dzakateerana ivhu / simende kusanganisa chirimwa chakanakira zvivakwa zvekuvaka mapurojekiti senge Expressway, mugwagwa nendege. Iyo ine zvinotevera maficha: akanaka anochinjika zvinhu, akawanda madosi, compact dhizaini uye inonzwisisika dhizaini, yakakwira kutendeseka, nezvimwewo Kugona kunobva ku350t / h kusvika ku600t / h. ■ Yakashongedzerwa neakakwira kuita kusanganisa sisitimu, yunifomu kusanganisa, kugadzikana kuita, kugona kwepamusoro kugadzira ■ Inogona kusanganisa mhando dzakasiyana dzeyakagadzikana ivhu musanganiswa ...


text:
- Ndege kubva kuMoscow kuenda kuReykjavik, Iceland uye kubva kuMoscow kuenda kuValletta, Malta dzichange dzichishanda kaviri pasvondo
- ndege kubva kuMoscow kuenda kuCancun, Mexico, Lisbon, Portugal neJeddah, Saudi Arabia ichave ichishanda katatu pavhiki
- Ndege kubva kuGrozny, Russia neMakhachkala, Russia kuenda kuJeddah, Saudi Arabia ichave ichishanda kamwechete pasvondo
Russian mashandiro makuru ekurwisa kupararira kwe COVID-19 akazivisa kuti Russia ichatangazve basa remhepo neIceland, Malta, Mexico, Portugal neSaudi Arabia musi wa25 Chivabvu.
Vols kubva Moscow kuenda kuReykjavik, Iceland uye kubva kuMoscow kuenda kuValletta, Malta ichange ichishanda kaviri pasvondo, uye nendege kubva kuMoscow kuenda kuCancun, Mexico, Lisbon, Portugal neJeddah, Saudi Arabia - katatu pasvondo.
Uye zvakare, nendege kubva kuGrozny, Russia neMakhachkala, Russia kuenda kuJeddah, Saudi Arabia ichave ichishanda kamwechete pasvondo.
Zvakare, kubva Chivabvu 25, ndege dzevapfuuri dzinoenda kune dzimwe nyika dzichatangwazve kubva kunhandare dzenyika dzeOmsk, Syktyvkar, Chelyabinsk, Magnitogorsk neUlan-Ude.
Kuwedzera kwenhamba dzendege dzese kubva kuRussia Federation kuenda kuSouth Korea, Finland, Japan kwakaziviswa zvakare.


text:
Dichlormid, CAS 37764-25-3
Chigadzirwa Chigadzirwa
Chigadzirwa Mateki
Chigadzirwa Chigadzirwa
CAS Nha. 37764-25-3
Mazita:Dichlormid
MF: C8H11Cl2NO
EINECS Nha. 253-658-8
Kuchena: 97% min
Kushanda: Agrochemical Intermediates
Chitarisiko: Chiedza yeyero mvura
MW: 208.09
Nzvimbo yakanyunguduka: 5.0-6.5 ° C
Nzvimbo yekubikira: 118 ° C / 2mmHg
v250KG / DRUM
Mharidzo: Inowanikwa
Chigadzirwa Chiitiko
DichlormidInogona kuvandudza kuramba kwechibage kune thiocarbamate sora. Iyo inodzivirira chaiyo chibage kudzivirira chibage kubva mukukuvadza chibage ne dimethyl uye acetochlor.Inogona kushandiswa pakupfekedza mbeu pamwe nekumwaya nemushonga wekurapa wevhu. Kazhinji, kunwa pamumwe kuri 1,4-1.7g.Inogona zvakare kuchengetedza mupunga uye gorosi kubva kumishonga yesora, senge mishonga yesora, senge mishonga yekuuraya shefu, senge mishonga yekuuraya shefu, yakadai semishonga yekuuraya sora, yakadai semishonga yekuuraya sora, dzakadai semishonga yesora.
Kuiswa kwe Dichlormid CAS HERE. 37764-25-3 Dichlormid
Iyo yakajairwa imwe pasuru yeDichlormidis 25kg / dhiramu kana 200kg / dhiramu. Asi isu tinogona zvakare kuiisa pasi zvinoenderana nezvinodiwa nevatengi vedu.Sakadai 1kg / dhiramu, 5kg / dhiramu, 10kg / dhiramu, nezvimwe.
Kazhinji, kune zvidiki zvidiki, iyo mvura yeDichlormid icharongedzwa mumadhiramu epurasitiki akavharirwa, uye vozovharirwa mumabhokisi emabhokisi. kana isu taigona kuputira madhiramu ne bubble sheet uye tobva tadziisa mubhokisi remabhokisi. Kuhuwandu hukuru, inowanzoita 200 litres / dhiramu, uyezve 4drum imwe pallet, kana 1000liters paIBC dhiramu. Kunze kwezvo, isu tinogona kupa zvakanyanya kudzivirirwa kune izvo zvinhu sekuda kwevatengi vedu.
KUDZIDZISWA kweDichlormid CAS HERE. 37764-25-3 Dichlormid
Dichlormidinogona kununurwa neyekutakura, mweya kana negungwa.
Kwe1 ~ 100kg, tinokurudzira kuti titumire nekambani, inova inokurumidza uye iri nyore. Chii chimwe, . Uye zvinhu zvacho zvaigona kufuratirwa musuo nesuo.
Kweanopfuura 100kg, zvinhu zvacho zvinogona kutumirwa nendege kana negungwa, uye zviri kwauri. Asi isu tinopa mhinduro dzakakwana kune yako mareferensi.


text:
Liquid Trap Magnets ane Flangle Kubatanidza Rudzi
Tsananguro Pfupi:
Magnetic musungo unogadzirwa kubva kune magnetic chubhu boka uye hombe isina simbi chubhu imba. Seimwe yemhando yemagineti firita kana yemagineti akaparadzanisa, inoshandiswa zvakanyanya mumakemikari, chikafu, Pharma nemaindasitiri anoda kunatswa padanho repamusoro.
Chigadzirwa Chigadzirwa
Chigadzirwa Mateki
Liquid Musungo Magnets neFlangle Kubatanidza kunoitwa nemagineti chubhu akaparadzanisa mapoka uye isina simbi dzimba dzekunze. Inlet uye nzira yekubuda inoita kuti zvikwanisike kubatana nepo iripo yekugadzirisa tambo kuburikidza neflangle yekubatanidza mhando. Magnetic Liquid Misungo yakagadzirirwa kuburitsa iyo ferrous zvinhu kubva pamvura, semi-mvura uye nemhepo inoendesa hupfu kuitira kuchenesa izvo zvinhu mukugadzira maitiro. Simba magineti machubhu mukati meimba anodurura kuyerera uye otora simbi isingadiwe. Iyo yuniti inongokwidziridzwa kune iyo iripo pombi kuburikidza neaflanged kana akapetwa magumo. Kuwana nyore kunogoneka zvakare nekukurumidza kusunungura kiramba
Magnetic Filter Inesarudzo maficha:
1. Iko shell zvinhu: SS304, SS316, SS316L;
2. Magineti esimba giredhi: 8000Gs, 10000Gs, 12000Gs;
3. Kushanda tembiricha giredhi: 80, 100, 120, 150, 180, 200degree Celsius;
4. Dhizaini dzakasiyana dziripo: Rudzi rwakachena rwakajeka, pombi mumutsetse mhando, bhachi dhizaini;
5. Compress kuramba: 6 kilograms (0.6Mpa) nekukurumidza kuburitsa kiramba nepo 10 kilograms (1.0Mpa) ine flange.
6. Uyezve inotora zvigadzirwa zvevatengi.


text:
Nzwisisika Sumo pane "Lung Cancer Muurayi" Gefitinib
- Gefitinib Ongororo
- Gefitinib Maitiro ekuita
- Gefitinib Shandisa MuNyika
- Side Migumisiro yeGefitinib
- Gefitinib Kuchengetedza
- More Rearch: "Lung Cancer Muurayi" Gefitinib
Gefitinib tsananguro
Iyo kemikari zita re gefitinib iri 4-Quinazolinamine N- (3-chloro-4-fluorophenyl) -7-methoxy-6- [3- (4-morpholinyl) propoxy]. Gefitinib ine molecular fomula C22H24ClFN4O3. , iri hama mamorekuru mashoma e446.9 dalton uye iri chena-chena poda. Gefitinib inzvimbo yemahara. Morekuru rine pKas ye5.4 uye 7.2. Gefitinib inogona kutsanangurwa seyakanyungudika zvishoma paPH 1, asi haina kunyungudika pamusoro pH 7, nekunyungudika kuri kudzikira zvakanyanya pakati pH 4 uye pH 6.Mune isina-aqueous solvents, gefitinib inosununguka zvakasununguka mune glacial acetic acid uye dimethyl sulfoxide, yakasviba mu pyridine, zvishoma zvinogadziriswa mu tetrahydrofuran, uye zvishoma kusungunuka mu methanol, ethanol (99.5%), ethyl acetate, propan-2-ol uye acetonitrile.
Mahwendefa eGefitinib anowanikwa semapiritsi akasviba-akaputirwa nefirimu, ane 250 mg ye gefitinib powder, yekutungamira kwemuromo. Izvo zvisingaite zvigadzirwa zvehwendefa piritsi re IRESSA mahwendefa anonzi lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, povidone, sodium lauryl sulfate uye magnesium stearate. Iyo piritsi yekunamatira inoumbwa ne hypromellose, polyethylene glycol 300, titanium dioxide, tsvuku ferric oxide uye yero ferric oxide.
Technical Information:
Gefitinib inoshandiswa kurapa isiri-diki kenza yemapapu kenza iyo yakapararira kune zvimwe zvikamu zvemuviri mune vanhu vane mamwe marudzi emamota. Gefitinib iri mukirasi yemishonga inonzi kinase inhibitors. Izvo zvinoshanda nekudzivirira chiito chechimwe chinhu chinowanzoitika chinogona kudikanwa kubatsira kenza masero anowanda.
Gefitinib Mechanism of action
Gefitinib is inhibitor yeiyo epidermal kukura factor receptor (EGFR) tyrosine kinase inosunga kune adenosine triphosphate (ATP) - inosunga saiti yeiyo enzyme. EGFR inowanzo kuratidzwa kuve yakanyanyisa kuratidzwa mune mamwe maseru evanhu ecarcinoma, senge mapapu uye zamu kenza masero. Kunyanyisa kuwedzera kunotungamira mukusimudzira mashandisiro eanopokana-apoptotic Ras chiratidzo kutapurirana macashure, zvichizoguma nekuwedzera kupona kwemaseru ekenza uye kusadzora kuwanda kwesero. Gefitinib ndiyo yekutanga inosarudza inhibitor yeEGFR tyrosine kinase iyo inonziwo Her1 kana ErbB-1. Nekudzivirira EGFR tyrosine kinase, iyo yekudzika yekuisa chiratidzo macascades aka dzivirirwawo, zvichikonzera kudzivirirwa kwakaipisisa kwemasero kuwanda.
Gefitinib Shandisa Munyika
Gefitinib parizvino iri kutengeswa munyika dzinopfuura makumi matanhatu nematanhatu. Gefitinib yakagamuchirwa uye yakatengeswa kubva muna Chikunguru 64 kuJapan, ichiita nyika yekutanga kupinza mushonga.
The FDA yakatenderwa gefitinib muna Chivabvu 2003 yekenza isiri-diki yemukenza yemapapu (NSCLC) Yakagamuchirwa semonotherapy kurapwa kwevarwere vane yemuno yepamusoro kana metastatic NSCLC mushure mekundikana kweplatinum-based uye docetaxel chemotherapies, seyechitatu-mutsetse kurapwa.
MunaJune 2005 iyo FDA yakabvisa mvumo yekushandisa muvarwere vatsva nekuda kwekushayikwa kweuchapupu hwekuti yakawedzera hupenyu.
MuEurope gefitinib inoratidzirwa kubvira 2009 mune yepamusoro NSCLC mumitsara yese yekurapa kwevarwere vanochengeta shanduko yeEGFR. Chikwata ichi chakapihwa mushure mekuratidzwa kwegefitinib semutsara wekutanga kurapwa kunatsiridza kufambira mberi-kwemahara kurarama pamwe neplatinamu huviri hutongi muvarwere vanochengeta shanduko dzakadai. IPASS yave iri yekutanga yechina yechikamu chechitatu miedzo kuve yakasimbisa gefitinib ukuru mune iyi varwere varwere.
Mune mazhinji eimwe nyika uko gefitinib iri kutengeswa parizvino inogamuchirwa kune varwere vane advanced NSCLC avo vakagamuchira kanenge kamwe kamberi chemotherapy hurumende. Zvisinei, mafomu ekuwedzera zita rayo sechirapa chekutanga mune varwere vanochengeta shanduko yeEGFR parizvino irikuitwa zvichibva pauchapupu hwazvino hwesainzi. EGFR shanduko yevasina ruzivo munharaunda yemhando yepamusoro kana metastatic, isingagadzirisike NSCLC. Izvi zvakabhadharwa pachena kune yekutanga mwedzi-mina temu uye kuvandudzwa kana pasina kufambira mberi.Pana Chikunguru 2012, 4, iyo FDA yakabvumidza gefitinib semutsara wekutanga kurapwa kweNSCLC.
Side Migumisiro ye Gefitinib
Zvinhu zvakakosha zvekurangarira nezve mhedzisiro ye gefitinib:
♦ Vanhu vazhinji havawani ese emhedzisiro akanyorwa.
♦ Mhedzisiro inowanzo fungidzirwa maererano nekutanga kwavo uye nguva.
♦ Mhedzisiro inowanzo kuve inodzoserwa uye inozopera mushure mekurapwa kwapera.
Pane mikana yakawanda yekubatsira kudzikisira kana kudzivirira mhedzisiro.
Is Hapana hukama pakati pekuvapo kana kuomarara kwemhedzisiro uye kugona kwemushonga.
Iyi inotevera mhedzisiro yakajairika (inoitika mune yakakura kupfuura 30%) yevarwere vanotora gefitinib:
♦ Manyoka
Reaction Kugadzirwa kweganda (mapundu, acne)
Iyi mhedzisiro haina kujairika mhedzisiro (inoitika mune ingangoita 10-29%) yevarwere vanowana gefitinib:
Ause Nausea
♦ Kusvipa
Ching Itching
Kusadya zvakanaka
Kushatirwa kwemaziso
Kazhinji kesi (inenge 1%) yechakakomba divi mhedzisiro yechirwere chemapapu chemukati (pneumonia, kana kuzvimba kwemapapu pasina hutachiona). Kana iri divi mhedzisiro rikaitika, raiwanzoperekedzwa nekufema kunetseka nekukosora kana fivhiri yepasi-inoda inoda kuiswa muchipatara. 1/3 yemakesi anga atungamira kurufu. Kana kamwe kamwe kwekutanga kwekufema kwekufema, kukosora uye / kana fever kunoitika uchitora gefitinib, zivisa nyanzvi yako yehutano.
Kukwidziridzwa kwechiropa basa bvunzo (transaminase, bilirubin, uye alkaline phosphatase) yakaonekwa kune varwere vanorapwa negefitinib. Aya kukwidziridzwa aisaperekedzwa nezviratidzo zvehuturu hwechiropa. Nekudaro, wako wehutano wezvehutano anogona kutarisa bvunzo dzeropa kuti utarise chiropa chako chinoshanda nguva nenguva, paunenge uchitora gefitinib.
Haasi ese mhedzisiro akanyorwa pamusoro. Zvimwe izvo zvisingawanzoitika (zvinoitika mune isingasviki gumi muzana yevarwere) hazvina kunyorwa pano. Nekudaro, iwe unofanirwa kugara uchizivisa mupi wako wezvehutano kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchiona zviratidzo
Gefitinib chengetedzo
Chengeta gefitinib mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).
Isina kudiwa gefitinib inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, uye nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa iyi gefitinib pasi pechimbuzi. Panzvimbo iyoyo, nzira yakanakisa yekurasa yako gefitinib iri kuburikidza neyekurapa-kudzosera chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Zvakachengeteka Kubviswa kweMishonga webhusaiti kuti uwane rumwe ruzivo kana iwe usina mukana wekutora kudzoka chirongwa.
Zvakakosha kuchengetedza mishonga yose isingaoneki uye kusvika kune vana semiti yakawanda (yakadai sepiritsi yevhiki nevhiki uye yeavo madonhe emeso, makemikari, makanda, uye inhalers) haisi vana vasingagoneki uye vana vaduku vanogona kuvhura nyore nyore. Kuchengetedza vana vaduku kubva muchetura, nguva dzose chengetedza kuchengetedzwa kwekuchengetedza uye pakarepo ita mishonga munzvimbo yakachengeteka - imwe yakasimuka uye kure uye isati yavaona uye inosvika.
More Rearch: "Lung Cancer Muurayi" Gefitinib
Gefitinib inyaya yakanangwa kurapwa iyo inotitisa iyo tyrosine kinase chiitiko cheiyo epidermal yekukura factor receptor nekukwikwidza kuvhara iyo ATP inosunga saiti. Mune prelinical zvidzidzo gefitinib yakaratidza chiitiko chakasimba mune akati wandei mamota mamodheru, kusanganisira akati wandei kenza yemapapu maseru mitsara uye xenografts. Zvidzidzo zviviri zvakakura zveChitatu II (IDEAL 1 uye IDEAL 2) mune yakafungidzirwa isiri-diki kenza yemapapu yemapapu yakashuma chiyero chekupindura chinosvika makumi maviri muzana mune yechipiri-varwere varwere uye ∼20% mune avo vanofungidzirwa nemaviri kana anopfuura emakemikari marimeni. Kupona kwepakati mune izvi zviviri zvidzidzo kwakasvika pamwedzi 10-6. Sekutanga-mutsara wekurapa, gefitinib yakaongororwa pamwe chete nemaviri akasiyana chemotherapy regimens mune mbiri huru dzakasarudzika zvidzidzo (INTACT 8 uye INTACT 1). Zvese zvidzidzo zvakatadza kuratidza kuvandudzwa kwekupona pane yakazara murwere yakawedzera ye> 2 varwere mune yega yega kudzidza. Mamwe maperero ekupedzisira (semuenzaniso, nguva yekufambira mberi uye yekupindura mwero) zvakare haina kuvandudzwa nekuwedzera kwegefitinib. Zvimwe zvidzidzo zvinoratidzwa kuti zviongorore zvinogona kuita gefitinib mukuchengetedza kwevarwere vakagamuchira chemotherapy kana chemoradiotherapy. Zvidzidzo zvichiongorora gefitinib seyekutanga-mutsara monotherapy zvakare inodikanwa.
Ruzhinji rwevarwere vane isina-diki sero kenza yemapapu (NSCLC) inozopedzisira yaita chirwere chemastastatic kana chirwere chisingagone kurapwa kwese chete uye vanogona kukwikwidza kurapa kwehurongwa. Kunyangwe chemotherapy ichigona kuvandudza kupona kwevarwere vane chirwere chemberi, mukana wacho unongova ∼2 mwedzi pamusoro pekuchengetwa kwakanyanya, uye izvi zviri pamutengo wemhedzisiro. Kutsvaga kwevamiririri vatsva ayo angangoita senge chemotherapy asi zvirinani kubvumidzwa ndiko kwakanyanya kukosha. Huwandu hwevanoverengeka vamiririri vanoita zvakanangana nekusarudza zvinangwa zviripo kenza masero, senge epidermal kukura factor receptor (EGFR), ari kuyedzwa mune yepamusoro NSCLC. Parizvino, kunyanya varwere vane advanced NSCLC vakaongororwa, asi pane chikonzero chakanaka chekuongorora akati wandei eava vamiririri muzvirongwa zvekutanga zvechirwere, uko zvimwe zvezvakanangana nemagene zvisizvo zviripo.
EGFR inonyanya kuratidzwa mumhando dzakasiyana dzemamota akasimba, kusanganisira NSCLC. EGFR inonyatsoratidzwa mune mazhinji (∼80%) mapapu squamous cell carcinomas, uye ingangoita hafu yemapapu adenocarcinomas uye makuru-maseru carcinomas. Kushanda kweEGFR mumasero emukenza kwakaratidzirwa kusimudzira maitiro anobatanidzwa mune bundu sero kuwanda, angiogenesis, kupinda, uye metastasis, uye kudzivirira apoptosis. EGFR (erbB1 kana HER1) inhengo yemhuri yeerbB yekugamuchira, iyo inosanganisirawo erbB2 (HER2), erbB3 (HER3), uye erbB4 (HER4). Iyo transmembrane glycoprotein inoumbwa nedhiraina-rinosunga dura-rinosunga dura, dura rekuturikidzana, uye chinzvimbo chemukati chesaina-chinodhinda dhizaini ine tyrosine kinase chiitiko. Mushure mekusunga kweiyo yemuviri ligand senge epidermal yekukura chinhu, iyo EGFR inoyerera nechero imwe EGFR monomer kana imwe nhengo yemhuri yeerbB. Izvi zvinotungamira mukumisikidzwa kwe tyrosine kinase, autophosphorylation ye tyrosine, uye kutanga kwekusaina macascades ayo anozopedzisira aunza mhinduro dzakasiyana siyana dzakadzika senge kuwanda kwesero. Uyezve, kutaura kweEGFR mumamota kwave kuchisanganiswa nemhinduro isina kunaka kurapa, kusimudzira kwecytotoxic drug kuramba, kufambira mberi kwezvirwere, uye kurarama kwakashata. Dzimwe nzira dzekuwedzera EGFR chiratidzo chinogona kuve chakabatanidzwa mune bundu sero kuwanda kunosanganisira kuwedzera mazinga e extracellular ligand, heterodimerization yeEGFR, uye EGFR mutation. Iyo yakajairika fomu yekuchinja mutsi EGFR mumamota iEGFRvIII, iyo inowanikwa inosvika makumi matatu nepfumbamwe muzana yeNSCLC kesi. EGFRvIII inotakura deletion mutation kubva kuamino acids 39 kusvika 6 mune yekuwedzera maseru inosunga domain uye inoratidzira inogadzira tyrosine kinase chiitiko icho chakazvimiririra kune yekunze maselular ligand inosunga.
Reference
[1] Rukazenkov Y, Taura G, Marshall G, et al. Epidermal kukura chinhu receptor tyrosine kinase inhibitors: zvakafanana asi zvakasiyana? Anticancer Zvinodhaka 2009; 20: 856-866.
[2] Woodburn JR Iyo epidermal yekukura factor receptor uye yayo inhibition mune cancer cancer. Pharmacol Ther 1999; 82: 241–250.
[3] Isiri-diki Cell Lung Cancer Inobatana Boka. Chemotherapy mune isiri-diki kenza yemapapu kenza: meta-ongororo ichishandisa yakagadziriswa dhata pane mumwe murwere kubva makumi mashanu nemaviri emakiriniki ekuedzwa. BMJ 52; 1995: 311-899.
[4] Douillard JY, Kim ES, Hirsh V, et al. Gefitinib (IRESSA) maringe nedetaetaxel mune varwere vane kenza yemunzvimbo yepamusoro kana metastatic isina-diki kenza yemapapu inotarisirwa kurapwa neplatinamu-yakavakirwa chemotherapy: yakasarudzika, yakavhurika-yekushambadzira chikamu chechitatu kudzidza (INTEREST). J Thoracic Oncol 2007; 2: PRS-02–
[5] Fukuoka M, Wu Y, Thongprasert S, et al. Biomarker inoongorora kubva muchikamu chechitatu, chakasarudzika, chakavhurika-chita, yekutanga-mutsara kudzidza kwe gefitinib (G) maringe ne carboplatin / paclitaxel (C / P) mune varwere vakasarudzwa kiriniki (pts) vane epamberi isiri-diki kenza yemapapu kenza (NSCLC) mu Asia (IPASS). J Clin Oncol 2009; 27 Suppl. 15: 8006–.
[6] Reck MA yakakosha nhanho kune yakasarudzika kurapwa kwekenza yemapapu negefitinib: iyo IPASS kuyedzwa uye kupfuura. Nyanzvi Rev Anticancer Ther 2010; 10: 955-965.
[7] Barker, AJ Zvidzidzo zvinotungamira mukuzivikanwa kweZD1839 (IRESSA): inoshanda nemuromo, inosarudzika epidermal kukura chinhu receptor tyrosine kinase inhibitor yakanangana nekurapa kenza. Bioorg. Med. Chem. Lett. 11, 1911-1914 (2001).
[8] Wakeling, AE et al. ZD1839 (Iressa): muromo unoshanda inhibitor wepidermal kukura chinhu chinoratidzira nekwaniso yekenza kurapwa. Cancer Res. 62, 5749-5754 (2002).
[9] Yarden, Y. & Sliwkowski, MX Kubvisa iyo ErbB yekuratidzira network. Zvisikwa Rev. Mol. Cell Biol. 2, 127-137 (2001).
[10] Cersosimo, RJ Kenza yemapapu: ongororo. Ndiri. J. Hutano Syst. Pharm. 59, 611-642 (2002).


text:
CHK-16A Otomatiki Nucleic Acid Kubvisa System
Chigadzirwa Chigadzirwa
Chigadzirwa Mateki
Chigadzirwa sumo
Chuangkun Biotech's CHK-16A ndeye yepamusoro yepamusoro yakazara otomatiki nucleic acid kuburitsa-system,diki muhukuru, uye inogona kuiswa pabhenji rakachena kana mumotokari yekuyedza nhare; inogona kuendeswa nebhatiri rekunze kwekuyedza-saiti;inouya neUV sterilization uye Yakakwira-inoshanda filtration system inogona kubvisa zvinobudirira kusvibiswa kweaerosol; magineti ekuparadzanisa tekinoroji inogona kuwana yakachena-kuchena nucleic acid kubva kune akasiyana masampuli senge ropa, nyama, uye maseru; nyore kushanda, nekukurumidza uye kwakakwira-kuburitsa; yakakwira magnetic bead yekudzorera mwero, kuburitsa Iyo mhando yeiyo nucleic acid yakanaka, uye ndiyo yako yakanyanya kunaka sarudzo yeiyo nucleic acid kuburitsa.
Zvigadzirwa zveChigadzirwa
A.Big screen maviri mutauro mashandiro
B. Mahara chirongwa
C. Kurumidza kuburitsa
D. Kuchena kwakanyanya uye kushanda kwakanyanya
E.Stable mhedzisiro
F. Kuzvichenesa
Kudzora kusvibiswa
H.Safe uye yakavimbika
Technical Parameter
Kufananidza kitsi yekubvisa (Magnetic Bead Nzira)
Shanghai Chuangkun Biotech Inc.
Nzvimbo A, Floor 2, Kuvaka 5, Chenxiang Road, Jiading Dunhu, Shanghai, China
Nhare: + 86-60296318 + 86-21-400-079-6006
Webhusaiti: www.chkbio.cn E-mail: admin@chkbio.com


text:
Honye Gear Set
Diki gonye bhokisi
Worm gear bhokisi musangano
Our Services
honye gearbox inowana yakakwira kukurumidza kuderedza ratios kubva
3: 1 gearbox kuenda kumusoro, isu tinemutengo wakaderera wehonye giya bhokisi gungano kubva kumugadziri, kune diki honye gearbox uye rakakura giya, magiya ehonye mudzimba akagadzirwa neTin (Stannum) Bronze, hombe huwandu hweyakajairwa & yakakosha magiya giya. seti, Right Angle Cast Iron worm giya rinodzora, Varitron worm giya rinodzora akateedzera akateedzera base pamakore mazhinji ezviitiko anoshandisa akagadzirwa mazino kumusoro neasinga pfuuridzwe torque kuchinjisa kuita.
Hunhu hwehonye inofamba
Sei Tichifanira Kusarudza Ife?
Tine pamusoro pe100 inyanzvi ye worm drive gearbox technical design mainjiniya kuti ave nechokwadi chekuti isu tinogona kupa mhinduro kwayo kune zvisingaenzanisike zvikumbiro. Kunze kwemhando dzakajairika dzehonye gear bhokisi kusangana, tinokwanisawo kupa service yakagadzirirwa zvinoenderana nezvaunoda chaizvo.
Isu tinopa ese emakambani emabhizimusi ane akadzika dunhu zivo uye chinangwa-chakavakirwa zvishandiso chakagadzirirwa honye drive mabhokisi ekuti uite zvaunoda.
Kune vashandisi vekupedzisira, Kana iwe uchida yakakwana, yakabatana uye inoshanda indasitiri yekutapira mhinduro, ndapota uyai kwatiri;
Kune vatengesi, kana iwe uchida mugadziri akavimbika nehunhu hwakanaka uye sevhisi yakakwana, tapota uyai kwatiri.
20 + Makore
ruzivo
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Nyanzvi
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maitiro
Tine timu yakanyanya kutsenga yekutenga yekuchengeta yakakwira mhando yezvikamu zvakadai sekubereka, zvisimbiso zvemafuta, screws nezvose zvakanaka uye mutengo wemakwikwi.


text:
Anogara Magnet DC mota
Permanent magineti DC Motors inogona rakakamurwa zvachose magineti brushless DC Motors uye zvechigarire magineti sokusingaitiki DC Motors kana pasina brushes. Permanent magineti DC Motors vari zvinowanzoshandiswa siyana inotakurika zvemagetsi kana namano midziyo yemagetsi, dzakaita serekodhi, VCD vatambi, vatambi vemateki, massager emagetsi, uye matoyi akasiyana siyana, uye zvakare anoshandiswa zvakanyanya mumotokari, midhudhudhudhudhudhu, maomarara emagetsi, mabhasiketi emagetsi, uye mabatiji emotokari, zvengarava, zvemitambo, zvemuchina uye zvimwe maindasitiri zvakawandisa rakashandiswa vamwe soro-mugumo akaoma zvigadzirwa, akadai mavhidhiyo copiers, makamera, mobile phones, zvakarurama muchina maturusi bhengi mari counter, uye mari bundling michina.


text:
Yakashongedzwa chakra inonhuhwirira makenduru e soya nemakristani arimo
Chigadzirwa Chigadzirwa
Vhidhiyo
Chigadzirwa Mateki
Crystal marble Soy Wax Aromatherapy Maketi Maketi mune yakasarudzika yakajeka girazi mudziyo
Kwete chete iyo yakakwana yekuchenesa imba yako uye nekupa mweya mutsva, asiwo yezvipo zvemuchato, mapato, kudya kwemanheru uye chipo cheKisimusi, kushongedzwa kweKisimusi. Zvakare yakanaka kune iyo yoga uye aromatherapy.
Ongorora: Usambofa wakasiya kenduru rinotsva risina kutarisirwa. Zvichengetedze pasingasviki nevana uye mhuka dzinovaraidza. Usapise makenduru pane kana padyo nechero chinhu chingabatira moto. Inogona chete kuiswa pane isina kupisa, isina moto. Dzivisa kushandisa nzvimbo dzinotonhora dzakadai segirazi kana machena.
Kunhuwirira uye kurongedza zvese zvinogona kuve zvakagadzirwa !!!
Basa rekuenzanisira rinogona kupihwa.
Chekutanga, isu tine iyo chitupa pasi peiyo Euro chiyero. Makenduru edu akakwana kusvika kuEurope chiyero, saka haufanire kunetseka nezvehunhu hwemakenduru edu. Zvigadzirwa zvedu zvinotumirwa kune dzakawanda nyika nenzvimbo, senge United inoti, Russia, Europe, Southeast, nezvimwewo Uye zvinogamuchirwa nevatengi kumba nekune dzimwe nyika.
Chechipiri nezve izvo zvigadzirwa, tinoshandisa wakisi weparafini, wakisi yesoya, wakisi nyuchi uye imwe yakisi yemiti semidziyo yemakenduru. Wakisi yesoy inogona kutakura zvakanyanya se10% yemafuta akakosha uye ichipa hwema hwakanakisa kukanda. Uye wakisi yesoya haina makemikari ekuwedzera kana dhayi.
Yetatu yekunhuhwirira, tinoshandisa zvinopfuura zana mhando yezvinonhuwira zvakasarudzwa zvemakenduru. Isu hwekunhuhwirira vatengesi ndivo veCPL hwema uye Firmenich. Ivo vese vari pamusoro mhando dzevanopa hwema munyika. Izvi zvinonhuwira zvinowanikwa kuburikidza nekunhuhwirira pamwe nemafuta akakosha, uye zvinokubatsira iwe kugadzira anonyaradza ambiance. Kune hwema, isu tinogona kupa akasiyana anonhuwirira sezvaunoda. Kana iwe uchida kunhuwa kwakasimba, unogona kusarudza 10% mafuta mukenduru; kana iwe uchida kunhuwirira, unogona kusarudza 5% mafuta mukenduru.
Uyezve, isu tine yedu dhizaini uye tinokudziridza dhipatimendi, uye isu tinogona kupa ODM neOEM sevhisi kune vatengi. Isu tinopa sevhisi yakazara kubva padanho rekutanga kune zvigadzirwa zvekupedzisira zvinogamuchirwa. Vagadziri vedu vehunyanzvi vachakubatsira iwe kuzadzisa chinangwa chako.
Mufananidzo wakadzama


text:
Ducati Monster 1200 R ndeimwe murwi wemugwagwa kubva kugadziri weItaly. Iyo modhi yatora zvese zvekambani ruzivo rwekutora chikamu mumijaho yemota, nekuda kwekuti dhizaini yazvino inowedzeredzwa neakanakisa kuita kwesimba remagetsi. Iyo yakasarudzika mudhudhudhu ichapa yakawanda yakawanda yakanaka manzwiro kunyangwe kune ane ruzivo ruzivo mutasvi.
Mwoyo webhasikoro ndeye 1.2-litre mapatya-humburumbira injini. Inovandudza 160 hp, iyo inokwira pa 9250 rpm, uye 131.4 Nm yekusunda (inowanikwa pa7750 rpm). Iyo mota inochengeterwa mufuremu chimiro chakagadzirwa senge kambani superbike furemu. Iyo grille yakasungirirwa yakanangana neinjini uye nekudaro inoshanda senhengo yechimiro.
Mufananidzo wekuunganidza Ducati Monster 1200 R
Chassis / mabhureki
Chimiro
Kumiswa
Brake system
Technical specifications
Kuyera
Injini
Transmission
Package Zviri mukati
Magira
Zvimwe
LATEST MOTO TEST DZEMAHARA Ducati Monster 1200 R
Hapana chinyorwa chakawanikwa


text:
Anogona Kugadziridza Meso eGirazi
$13.95
Mudura
- Ramba uchichinjika
- Inogadzirisa 90% yezvakatsetseka zvikanganiso
- Zvinogadziriswa zvepedyo kana kure kuona
- Great back up pair yemota, Nighttand, kufamba kana chero kwaunoenda
- Kurera uremu uye kusimba.
YEDU YEDU
Isu tinoita zvatinokwanisa kuti tigadzire zvigadzirwa zvakasarudzika uye zvitsva zvatinogona kuwana, uye kuve nechokwadi chekuti iwe, mutengi wedu, unogara uine ruzivo rwakanyanya paunotenga nesu.
Kana nekuda kwechimwe chikonzero iwe usina ruzivo rwakanaka nesu, tapota tizivise uye tichaita chero zvatingagona kuona kuti uri 100% kugutsikana nekutenga kwako.
Kutenga online kunogona kutyisa, asi isu tiri pano kuti zvinhu zvive nyore.
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text:
- Ndege yeRussia Emergency Ministry yaAntonov An-26 ndege yakanyangarika kubva kumaradhi enhandare pedyo neKhabarovsk.
- Ndege yaive nevashandisi vendege vatanhatu vevanhu uye yakanga ichiita ndege yehunyanzvi.
- Kutsvaga kwakaomeswa nerima uye mamiriro ekunze asina kunaka, sekureva kwehushumiro hwevashandi.
Vezvenhau veRusgency emergency Ministry yeRussia vakasimbisa kuti ndege yayo yeAn-26 yakanyangarika kubva kumarairari ekubhururuka makiromita makumi matatu nemasere (38 mamaira) kubva kuKhabarovsk airport airport, kutenderedza nzvimbo yeKhekhtsir Nature Reserve mudunhu reKhabarovsk kuFar East yeRussia.
Ndege yaive nevashandi vekubhururuka vevanhu vatanhatu vaive muchikepe uye vaiita zvehunyanzvi kutiza, sekureva kwepepanhau basa.
"Panguva dza11: 45 kuMoscow nguva, Crisis Management Center yeRussia yeEmergency Ministry mudunhu reKhabarovsk yakagamuchira meseji yekuti Antonov An-2Ndege nhanhatu dzakanyangarika kubva kumarairari ekubhururuka 6 km kubva kuKhabarovsk airport airport, pamwe munzvimbo yeKhekhtsir Nature Reserve. Zvinoenderana nedatha rekutanga, paive nevashandi vekufamba nendege vevanhu vatanhatu, "akadaro musangano wevatori venhau, vachiwedzera kuti ndege iyi yanga ichiita nendege yehunyanzvi.
"Kutsvaga kwakaomeswa nenguva yerima yezuva uye mamiriro ekunze asina kunaka," hushumiro hwakawedzera.
Vanopfuura vanunuri makumi manomwe uye neherikoputa yekuona yakanga yaendeswa kunzvimbo yekufungidzirwa yekuparara.
Njodzi dzinosanganisira ndege dzakasakara musango reRussia uye kure Far East zvichiri zvakajairika.
Muna Nyamavhuvhu, vanhu vasere vakaurayiwa apo Mi-8 helikopta, iine vanhu gumi nevatanhatu, yakarovera mudziva pamupendero weKamchatka peninsula nekuda kwekusaonekwa zvakanaka.
Muna Chikunguru, imwe ndege ine vafambi makumi maviri nevaviri nevashandi vatanhatu vari mungarava yakarova sezvo yanga yave kuda kumhara muKamchatka, isina kusiya kana akapona.
Antonov An-26 (NATO inoshuma zita: Curl) ipatya-injini turboprop yemauto nemauto ekufambisa ndege, yakagadzirirwa uye inogadzirwa muSoviet Union kubva 1969 kusvika 1986.
Iyo An-26 inogadzirwawo pasina rezinesi chibvumirano kuChina neXian Ndege fekitori seY-14, yakazoshandurwa kuverengerwa muXian Y7 akateedzana.


text:
Hurumende yeMajorca nezvitsuwa zvakavakidzana nazvo inoramba ichingwarira kusvika padenda iri uye iri kusimudzira tariro yekuti kufamba kuchadzoka nekukurumidza. "Tinogona kuona dambudziko richipera", akadaro Francina Armengol, Gurukota-Mutungamiriri weBalearics, achitaura kubva pachikuva chengarava chePalma. Izvo zvinogara zvakadzikira hutachiona huwandu pazvitsuwa zveMajorca, Menorca, Ibiza, uye Formentera zvakapa chikonzero chetariro.
Gurukota rezvekushanyirwa, Iago Neugueruela akati: “Tinoda makoridho ekufambisa akachengeteka evashanyi vedu vanobva kuGerman - tichiona kuchengetedzeka kukuru kwevafambi nevanhu vemuno. "Muna 2020 maBalearic Islands akange aratidza kuti vaikwanisa kukunda dambudziko", akadaro Neugueruela. “Tine mamiriro akachengetedzeka uye nehutano hwakanaka muMediterranean. "Tine chivimbo chekuti bhizinesi rekufamba richadzoka."
Pamusoro pekuyedza kwekuyedza uye pfungwa dzekuongorora, vashanyi veBalearics vaitarisira kufambira mberi kunoitwa kubaya vanhu nevashanyi, Francina Armengol akawedzera kuti, indasitiri yezvekushanya. "Zvitsuwa zveBalearic zvaizozvipira senzvimbo yekuyedza yekudzivirira kwekuSpain. Nekudaro, zvaive zvakakosha kuronga maratidziro nedzimwe nyika. "Hakuchina kufamba kunze kwekuchengeteka kwehutano," akadaro gurukota rezvekushanya. Kugara uchigadzirisa kunogona kuwanikwa pawebhusaiti pa www.makemuru.travel/de/baleares.
Neugueruela akasimbisa kuti denda iri raidawo kuongororazve zano rezvehupfumi reBalearic Islands, iro raive rakabatana nekushanya. Pfungwa dzezvemagariro, dzemari, uye dzekushanyirana dzakazvimirira dzezvakatipoteredza dzaive dzakakosha kupfuura nakare kose kuti pagadzikane mukana pakati pebhizimusi nekushanya, chengetedzo, zvivakwa zvehutano, uye nekuvandudza mabasa.
Majorca inoda kuti vashanyi vekuEurope vadzoke
Mallorca ndiyo Spain inonyanya kukosha nzvimbo dzekufamba kune vashanyi vazhinji vekuEurope. Iyo nharaunda inoramba yakangwarira uye inotsanangurira kune vateereri vari kuenda kune chaicho ITB bhizinesi show.


text:
Tsaona
Tsaona (accident or incident) zvinoreva chiitiko chinoonekwa kana njodzi yasanangana nemunhu, muchina, zvivakwa kana nzvimbo dzakakomberedza. Sokuti mumhu akadhumiwa nebhazi inenge iri tsaona. Tsaona chinhu chisangadiwe chinoitika chisiri kutarisirwa.
Njodzi yokuti munhu anokwanisa kurohwa nebhazi achifamba pamugwagwa iripo nguva dzose asi njodzi haisiri iyo tsaona. Vanoongorora zvenjodzi netsaona vanoti tsaona zhinji dzinokwanisa kudzivirirwa.
Mitauro yeBantu[chinja | edit source]
- VaTumbuka vanoti ngozi (accident) vachireva tsaona. VaGungu vanoti butandwa (accident) vachireva tsaona.
- MaZulu vanoti pewu (ideo. of capsizing, overturning) inyaudzosingwi inodudza kubheuka.
- MaZulu vanoti pewuka (v. Capsize, tum over, fall over) kureva kubhewuka. Mamwe mazwi: pewula (v.tr. Capsize, overturn; push over) kureva kubhewura.


text:
Kingstone Mapupu VARIMI vekunzvimbo yakagariswa vanhu patsva yeNyamatani, kuMuzvezve kudunhu reSanyati vari kurumbidza ...
Muchaneta Chimuka VERUZHINJI vanokurudzirwa kudyara miti sezvo iine basa guru rinosanganisira kupa michero, kudzivirira ...
Muchaneta Chimuka BHINDAUKO rekupfuya mbudzi rinowanza kutorerwa pasi nevanhu vazhinji zvisinei nekuti rine mikana ...
Muchaneta Chimuka VADZIDZI 65 avo vakabudirira kupedza zvidzidzo zvavo zvekurima paChibero College of Agriculture svondo ...
Patrick Chitumba PANGUVA iyo chirwere cheCovid-19 chiri kukonzera matambudziko munyika muno nepasi rose, anosanganisira ...
Muchaneta Chimuka BHINDAUKO rekupfuya huku dzenyama nedzemazai rinonzi riri kusimukira zvikuru panguva ino apo nyika ...
Muchaneta Chimuka ZVICHITEVERA kukanganiswa kweraramo yevechidiki vakawanda nekuda kwechirwere cheCovid-19 apo vamwe ...
Kingstone Mapupu NYANZVI munyaya dzekupfuya tsuro muHarare inoti yave kuvaka nzvimbo yekuuraira tsuro, nyama yacho ...
Muchaneta Chimuka VARIMI vedonje vekumaruwa vari kupembedza chirongwa chePfumvudza nechePresidential Input Scheme ...
Muchaneta Chimuka VARIMI vanokurudzirwa kuti varambe vachidhibhisa mombe dzavo kudzivirira zvirwere zvinokonzerwa ...
Muchaneta Chimuka HURUMENDE yeIndia yotsigira sangano reUnited Nations World Food Programme (WFP) muZimbabwe neUS$1 ...
Muchaneta Chimuka GURUKOTA rezveminda, kurima, hove, mvura nekusimudzirwa kwevagari vekumaruwa – Dr Anxious Masuka – ...
Muchaneta Chimuka CHIRONGWA cheZimbabwe Agricutural Show che111 Edition gore rino chichaitwa kutanga nomusi wa27 Gunyana ...
Muchaneta Chimuka VARIMI vanokurudzirwa kuti varambe vachidhibhisa mombe dzavo kudzivirira zvirwere zvinokonzerwa ...
Muchaneta Chimuka GORE rino varimi vakawana goho guru rechibage, nyimo, nzungu, maringazuva, mapfunde nezvimwe ...
Muchaneta Chimuka HURUMENDE iri kuedza kusimudzira kurimwa kwezvekudya zvinovaka muviri uye chikafu chinokwanirana ...
Muchaneta Chimuka GURUKOTA rezveMinda, Kurima, Hove, Mvura Nekugariswa Kwevanhu Kumaruwa, Dr Anxious Masuka, svondo ...
Kingstone Mapupu SANGANO revarimi reZimbabwe Farmers Union (ZFU) rinoyambira nhengo dzaro kuti dzimbomira mabasa anoita ...
Muchaneta Chimuka MWAKA wekutengeswa kwefodya wasvika kumagumo apo misika ichavhara nemusi weChitatu svondo rino uye ...
Kingstone Mapupu SANGANO reZimbabwe Farmers Union (ZFU) rinoti rasimbaradza matanho ekurwisa Covid-19 munzvimbo ...
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text:
R akateedzana helical giya rinodzora rine hunhu hwediki saizi, kurema uremu, kukwirira kutakura kugona, kushanda kwakanyanya, hupenyu hurefu hwebasa, kuisirwa kumisikidza, yakafara mota simba renji uye kupatsanura kwakanaka kwekutapudza ratio.Can inogona kushandiswa zvakanyanya mumidziyo inoda kuve yakadzikiswa mumaindasitiri akasiyana siyana. Yese Yakakwira Torque application inotsanangura iyo Inline Helical giya mota uye inline inodzora inopihwa imwechete, yakapetwa uye yekudzora-rwendo.
Uwandu hwemagetsi: 0.12-200KW
Yekuendesa miganho yemhando: 1.3-33000
Panobuda torque (Kn.m): pamusoro kusvika makumi mashanu
Chigadzirwa chigadzirwa: Varitron Helical Gear mota Reducers Dhizaina maficha ane yakazara yakazara dhizaini. Kubudirira kwepamusoro, Helical giya, Inline, mota, ac, Foot Mount.
(1) Yakakwira magetsi geji inotapudza yakaenzana neSEW
(2) Yakadzika magetsi geji inotapudza inosanganisira ese matatu chikamu uye imwe chikamu
Simba: kudzika kusvika 0.3w, 0.12kw 0.18kw 0.25kw 0.37kw 0.55kw 0.75kw 1.1kw 1.5kw 2.2kw 3kw 4kw 5.5kw 7.5kw 9.2kw 11kw 15kw 18.5kw kumusoro 22kw
Simba remabhiza: 0.2hp 0.25hp 0.35hp 0.5hp 0.75hp 1hp 1.5hp 2hp 3hp 4hp 5.5hp 7.5hp 10hp 12hp 15hp 20hp 25hp 30hp kukwira 350hp
Voltage: 3v 6v 12v 24v 48v 90v 110v 115v 120v 200v 220v 230v 380v 400v 415v 660v etc.
1. R yakatevedzana helical gear inogadzirisa yega rational dhizaini, komputa kuvaka, diki saizi kupfuura X kana B akateedzera cycloidal gearmotor pane imwechete inotenderwa torque.
2. Diki kudzikisira uye ruzha ruzha, ine yakanyanya kutapurirana kushanda.
3. Izvo zvigadzirwa zvakanyanyo shandiswa mumashini emakemikari, simendi agitator muchina, kudhinda uye kurongedza muchina, mugodhi nemagetsi ekufambisa muchina, simbi nezvimwe
R yakatevedzana helical gear inogadzirisa, inosanganiswa neenyika dzepamhepo zvinodiwa, ine yakakwira tekinoroji yezvinhu, inochengetedza nzvimbo, yakavimbika uye yakasimba, inomira pamusoro pekuremerwa simba b, simba rinosvika 132Kw, kuderedzwa kwesimba, kugona kwakanyanya, kuderedza simba kusvika 95% Pamusoro, kudzika vibration, kudzika ruzha, yakakwirira simba kuchengetedza, yakakwirira-yakagadzirirwa simbi zvinhu, simbi yakakandwa simbi bhokisi muviri, giya kumusoro mushure mekutakura nekudzima, kunyatsojekesa machining, kuverengera shaft chiyero uye chinzvimbo chinotakura chinodiwa, kugadzira giya kutenderera musangano deceleration Machine, neese mhando dzemota dzinoverengerwa pamwe nesarudzo yemagetsi, kusimbisa zvizere kunaka kwechigadzirwa.
Iyi nhevedzano yekombiki, inorema-basa inline shaft helical gear minimers inowanikwa mune imwe chete, mbiri, uye katatu kudzokorora. Mhando dzakasiyana dzeMODEL Inopinda Flanges ine Solid Input Shaft Couple ine mota LHF LVF MHF MVF RXHF LHD LVD MHD. Isu tinopa yakakwirira chaiyo inline gear inodzika kuti ive yakakosha. Yedu helical gear kudzorera inopa yakavimbika simba kuendesa kune general applicationaton yakadai sekurapa kwemvura, muchina wekutakura chikafu, chigayo, simendi simiti, mugodhi wekutakura.
Tsanangudzo yeiyo helical geared mota:
Iyo helical gear minimer ndeyeinovhiringidza magiya. Kugamuchira iyo optimization, iyo yekumberi dhizaini yekugadzira module yekubatanidza ine maitiro ehukuru hudiki, uremu huremu, hombe yekuparadzira torque, yakagadzikana kutanga, kurongeka kwakanaka kwekutapurirana ratio, nezvimwewo, uye inogona kubatana zvinoenderana nezvinodiwa nemushandisi uye kusiyiwa kwakasiyana. chinzvimbo. Iyo yakagadzirwa neyemhando yepamusoro-yakasimba alloy simbi ine pasi carburizing uye kuomesa kurapwa. Iyo ine yakasimba kubereka kugona uye kusimba.
2, chengetedza nzvimbo, yakavimbika uye yakasimba, iine huwandu hwakawandisa hwekuremerwa, simba kusvika ku132KW;
3, Kushandiswa kwesimba kwakaderera, kushanda kwakanyanya, kugona kweiyo inotapudza kwakanyanya kunge 95% kana kudarika
5, kusarudzwa kwemhando yepamusoro yakagadzirwa simbi zvinhu, simbi yakakanda simbi bhokisi, pamusoro peiyo giya mushure mekukwirira-kwakawanda kupisa kurapwa;
R akateedzana giya rinodzora technical data
Helical Gear bhokisi inogona modular kunyora pamwe nemamwe anoderedza uye musiyano, tora yakakura yekudzikisa ratio drive uye mutsauko. Naizvozvo inoiswa kunzvimbo dzakawanda dzeindasitiri, senge Metallological mine, kukwidza zvifambiso, kuvaka petrochemical, machira, zvakatipoteredza, magetsi emagetsi, muchina wepurasitiki, michina yekupaka nezvimwe.
Sogears R yakatevedzana yakaoma Helical helical gear inotapudza (giya yakazara yekugeda)
tsananguro yechigadzirwa:
Nyaya dzakateedzana helical yokuderedza yakagadzirwa uye inogadzirwa pachishandiswa modular musanganiswa system. Kune akawanda mota dzinosanganiswa, mafomu ekuisa uye zvimisikidzo zvehurongwa. Chikamu chekutapurira chakapedzeredzwa kumanikidzwa kusangana nemamiriro ekunze akasiyana, ziva kusangana kwemagetsi, kukwirisa zvakanyanya uye kushomeka kwesimba. Kuita kwepamusoro. Iyo yakaoma mazino ejasi girazi yakagadzirwa neyemhando yepamusoro alloy simbi, iyo nzvimbo yakaomeswa nekutakura uye kudzima, meno ekugedza akaomeswa, kupatsanurika kwakagadzikana, ruzha rwakaderera, uye kugona kubereka kwakakura. Kupisa kwakadzika kusimuka uye hupenyu hwakareba. Inoshandiswa zvakanyanya mumaindasitiri akawanda, senge simbi, kurapwa kwemahombekombe, makemikari, mishonga uye zvimwe maindasitiri.
Matatu: zvakanakira
Inokodzera simba rakakwirira
Hupenyu hwakareba dhizaini
R37-R167 komputa yakasarudzika yemhando
RM akatevedzana minimader yakarongerwa chaizvo kusanganisa michina
zvina:
Shanu: Chigadzirwa paramende:
Simba: 0.18-160KW
Panobuda torque: Kusvikira 18000N.m
Yekunze kumhanya: 0.16-1028 RPM
Kuisa fomu: pasi kona yekuisa / flange kumisikidza
Kuendeswa kwehunyanzvi: 2 (chikamu: 5-24.8): 96%, 3 (chiyero: 27.2-264): 94%
chimiro chechimiro:
R: Shaft-mhando tsoka inokwidza RF: Flange inokwira
R ... F: Tsoka flange kukwira RM: Flange inokwira nedzimba dzakawedzera kubereka
RX: Imwe nhanho tsoka inokwira RXF: Imwe nhanho flange kukwira
Mhando huru dzeR dzakatevedzana dzakaomeswa helical gear minimer ndeidzi:
R / RF17, R / RF27, R / RF37, R / RF47, R / RF57, R / RF67, R / RF77, R / RF87, R / RF97, R / RF107, R / RF137, R / RF147, R / RF167
Mhando huru dzeR dzakatevedzana-dzakaoma helical gear rekudzora imwe-nhanho inotapudza ndeiyi:
RX / RXF37, RX / RXF47, RX / RXF57, RX / RXF67, RX / RXF77, RX / RXF87, RX / RXF97, RX / RXF107, RX / RXF127, RX / RXF157
Tigashire iwe unondibata kana uchifarira chigadzirwa chedu.
Chikwata chedu chinotsigira chero chinodiwa chaungave nacho.
FAQ
1 Q: Ndeipi infomation yandinofanira kukuudza kuti usimbise iyo gear inotapudza?
A: Muenzaniso / Saizi B: Magetsi simba C: Kuburitsa kumhanya D: Sevhisi chinhu.
2 Q: Ko kana ndisingazive kuti ndeyipi gear kudzora yandinoda?
A: Usanetseka, Tumira ruzivo rwakawanda sezvaunokwanisa, timu yedu ichakubatsira iwe kuti uwane iyo chaiyo iwe yauri kutsvaga.
3 Q: Inguva yakareba sei yandinofanira kumirira mhinduro mushure mekunge ndatumira kubvunza?
A: Mukati maawa gumi nemaviri.
4 Q: Ndeipi nguva yako yehondo yegeji inotapudza?
A: Tinopa gore rimwe chete warrenty kubva musi wekubva kwechikepe chakasiya China.
5 Q: Ndezvipi maindasitiri ari giya rako redanho rinoshandiswa?
A: Yedu gearbox mabhokisi anoshandiswa zvakanyanya munzvimbo dzesimende, machira, kugadzira chikafu, chinwiwa, indasitiri yemakemikari, escalator, otomatiki chengetedza michina, simbi
A: Negungwa - Mutengi anogadza anotungamira, kana timu yedu yekutengesa inowana yakanakira kumberi kune vatengi.
Nemhepo - Mutengi anopa kuunganidza akajeka account, kana yedu yekutengesa timu inowana yakakodzera expression kune vatengi. (Kunyanya muyenzaniso)
Vamwe - Isu tinoronga kuendesa zvinhu kune imwe nzvimbo muChina yakagadzwa nevatengi.
7. Kana iwe ukaisa odha, timu yedu inozosimbisa newe nezveruvara, pasuru, nzira yekubhadhara uye kuendesa, ipapo chibvumirano chekutengesa chinotumirwa kwauri kuti usimbise.
Iyo yakanakisa sevhisi kubva kune yedu yekufambisa dhiraivha nyanzvi kune yako inbox zvakananga.
NER GROUP CO., LIMITED
ANo.5 Wanshoushan Road Yantai, Shandong, China
T + 86 535 6330966
W + 86 185 63806647


text:
Mukomana
Mukomana (boy) zvinoreva mukono wemunhu achiri mudiki; kana ari mukuru anonzi murume. Asi shoko rokuti murume rinoshandiswazve kutaura chero mukono wemunhu zvisinei kuti ane makore mangani ekuzvarwa.
Kuyaruka kwemukomana[chinja | edit source]
- Dzvito (Puberty for male) - apa kureva kusvika pazera rekuyaruka panotanga kushanduka muviri, izwi richibhesera, vhudzi richimera muhapwa, huronyo huchitanga kuuya.
- Kudzvita (Reach puberty male). vamwe vanoti kupundudza kana kuputudza.
- Dzvita apa kureva munhu asvika pakudzvitura.
- Dandaringo kana matandaringo pahuwandu (1. Long pole 2. Tall, strong person). Idandaringo repwere: that child is much too big for his age.
Mitauro yeBantu[chinja | edit source]
- VaTonga vanoti bulombe kana malombe (n. boyhood) vachireva hukomana. VaTonga vanoti mulombe (boy) kureva mukomana.
- VaTonga vanoti kalombe (small boy) kureva kakomana.
- VaNyungwe vanoti mulumbwana kana alumbwana (boy/s) kureva mukomana.
- VaShambala vanoti mgoshi (n. male) kureva munhurume. VaShambala vanoti kagoshi (n. boy, lad) kureva mukomana.


text:
Aya ndiwo mamiriro asingawanzo, asi haugone kutongwa kunze: rimwe zuva unogona kunge wakanganisa - kana kutomisikidza - zvisirizvo paunenge waisa imwe yematairi ako. Chii chauri kuisa panjodzi mune iyi kesi? Ndezvipi zvinovhiringidza?
Iyi tsaona iyo vamwe venyu vangave makatosangana nayo: matai ari pamudhudhudhu wenyu apidigurwa! Zvinotaridza sezvisingabvumirwe, asi pane dzimwe mota dzine madhisiki maviri uye marimu akaenzana (kazhinji Harley-Davidson Tourers), inogona kunge iri tsaona, kana kuregeredza kwetirita fitter inomuka zvakaipa kumwana.
Matai emazuva ano emidhudhudhu akagadzirwa nemazvo, akasimbiswa nezero tambo yesimbi tambo (kumashure), uye iyo plies yakamiswa chaizvo mumutumbi. Iyi dhizaini inofungidzira kuti vhiri rinomhanya nenzira yakatarwa.
Saka fungidziro iyi ingakanganisa sei maitiro emudhudhudhu wako? Heano mhinduro, nekuda kwekutungamirwa kubva kuCCI Le Mans vanodzidzisa kuchovha uye emidhudhudhu uye nyanzvi dzeBridgestone.
Yakaoma:
Tayi repamberi rakachinjika rinogona kukonzera kuti sitiringi ifambe. Kana matai ese ari maviri akatsikitsira pasi, chinoitika chinokatyamadza chinogona kuitika.
Pamugwagwa wakanyorova:
Rimwe rebasa rematai ekutsika ndiko kudhonza mvura. Nenzira iyi, matairi akachinjika anogona kuchengetedza mvura, izvo zvinowedzera mukana we aquaplaning.
Christoph Le Mao, mufananidzo naMehdi Bermani


text:
Nanchang Weiti Technology Co, Ltd.
Iyi Kalocils Runako brand kubva kuNanchang Weiti Technology Co, Ltd inozivikanwa pakugadzira eyelashes dzenhema, eyeliner, lip gloss, eyeshadow, mascara etc.Variety runako zvigadzirwa zvigadzirwa zvinogona kusarudzwa kubva kwatiri. Kalocils Runako mhando yakasimbiswa 2019, asi isu tine makore gumi gumi ekugadzirwa kwekugadzira uye kutumira kunze ruzivo.Zvezvino, isu tine dzakatenderedza 3000 mativi mita yemusangano uye vanopfuura zana vakagadzika vashandi. Yedu yegore yekutengesa kukosha inodarika US $ 3000,000. Ndinovimba tinogona kusimbisa kwenguva yakareba bhizinesi hukama uye kuita kuti tese kubatsirana kuzadzike.
Kubatsira kwedu
Tine yakakwana yekugadzira tambo uye nzvimbo yekusangana nekwanisi yekugadzira uye yedu nyanzvi yekuongorora timu kune yakasimba yemhando control.OEM & ODM sevhisi inowanikwa uye yedu dhizaini timu inogona kukubatsira iwe kugadzirisa yako yakavanzika chitaridzi. Yedu yekutengesa timu ichave maawa makumi maviri nemana achipindura mibvunzo yako uye kugadzirisa matambudziko ako. Zvekutakura, isu tine chibvumirano neDHL, FEDEX, UPS, EMS, SF, TNT yemari iri nani yekutakura uye garandi yekufambisa.
Yedu Warranty
Hunhu ndiyo musimboti, sevhisi ndiyo injini. Isu tinotarisana nekupa vatengi vedu zvigadzirwa zvemhando yepamusoro pamwe neyakanakisa masevhisi.Zvose zvigadzirwa zvakarairwa kubva kwatiri zvinonakidzwa nekudzoka kana kudzoreredzwa mukati memazuva manomwe ekushanda kana paine chero matambudziko ehunhu uye kutakurwa kukuvara.Panguva imwecheteyo, yedu yekutengesa-timu ino zvirokwazvo gadzirisa dambudziko rako mukati memaawa makumi maviri nemana.
Vatengi vedu
Parizvino, isu takashandira vatengi vanobva kunyika makumi mashanu pasi rese, uye makumi masere muzana akapa chiyero chepamusoro chekucherechedzwa nekutenda chigadzirwa chedu uye sevhisi, uye vakati vacharamba vachichengetedza hukama hwakabatana pamwe nesu. Pakati pavo, vatengi vedu vanosanganisira vatengi vekambani, vagoveri, zvitoro zvepamhepo uye zvitoro zvepamhepo, nezvimwe.
Chiono chedu
Takazvipira kushandira vatengi vedu uye nekupa zvigadzirwa zvemhando yepamusoro, tinotarisira kufambira mberi uye kukura pamwe nevatengi vedu. Isu tinodawo kuchengetedza hurefu uye hwakagadzikana kudyidzana hukama nevatengi vedu. Kuburikidza nekuenderera mberi nekuvandudzwa kwehunhu hwechigadzirwa uye sevhisi, tinogona kuita kuti vatengi vedu vanzwe zviri nyore uye kuve nechokwadi chekushandira pamwe nesu, nokudaro tichiwana yekuhwina-kuhwina mamiriro. Pamatambudziko evatengi, isu tinopa kubvunza uye mhinduro nekukurumidza sezvazvinogona, kuitira kuti vatengi vasazonetseke.


text:
Yakavharwa -loop Control System
Zvakareruka uye intuitive mashandiro akavhara-chiuno kudziya tembiricha kudzora, pane-saiti kushanda voltage kuratidza chaiyo-nguva yekutarisisa yekushanda parameter.
Yakakwira torque kufambisa system
Iyo yakakwira-torque mota yakagadzirirwa neyakajeka-maviri-mapoka ekufambisa mashandiro, ayo anogona nyore kuwana yakakura yakakura materu ekutsvanzvadzira uye neyakaomarara mamiriro ekuvaka.
Kufuridzira Kugadziridza Sisitimu
Yepamberi T-yakaumbwa cantilever musoro dhizaini uye yekumanikidza yekugadzirisa mashandiro anoona kuti iyo yekuruboshwe uye kurudyi weld bead kumanikidza kune mwero uye iyo weld musono iri yunifomu, uye iyo yekutenderera yekumanikidza iri kuenderera ichigadziriswa.
Pressure Roller
Yakakosha simbi yekutsikirira vhiri, yakasimba yekumanikidza simba pasina kutsvedza, yakasimba
Ichangobva kuvandudzwa Heating System
Iyo inopisa wedge mamiriro yakanyanya kusimba uye inogona kuwedzera iyo yekubatana nzvimbo ine yekunamatira zvinhu, izvo zvinowedzera iyo yekushisa kugona ne30%.
HDPE (2.0mm) Geomembrane, dongo rakazara marara
LST900


text:
Product Description
Epacadostat (INCB024360) video yepoda
Epacadostat (INCB024360) powder Mifananidzo
Epacadostat (INCB024360) poda mukushandiswa
Mazita
Epacadostat powder; IDO inhibitor 1; INCB 024360; 1204669-58-8; 1204669-37-3 INCB-024360
Epacadostat powder Usage
Epacadostat powder iyi inowanika mumuromo inonzi hydroxyamidine uye inhibitor ye indoleamine 2,3-dioxygenase (IDO1), ine simba rekuita immunomodulating uye antiineoplastic mabasa. Epacadostat targets zvinosungirwa uye inosunga ku IDO1, inzyme inokonzera kusvibiswa kwe tryptophan mujinrenine. Nokudzivisa IDO1 uye kuderedza kynurenine mumatomu masero, INCB024360 inowedzera uye inodzorera kupararira nekushandiswa kwemasero ezvirwere zvakasiyana-siyana, kusanganisira dendritic cells (DCs), NK cells, uye T-lymphocytes, uyewo interferon (IFN) uye kuderedza mumakumbo anokonzerwa nekutonga T masero (Tregs). Kushanda kwemuviri wemuviri, iyo inodzingwa mumakondomu akawanda, inogona kudzivisa kukura kweDOO-NUMX-kuratidza tumarara masero. IDO1 inonyanyisa kunzwisiswa nemhando dzakasiyana-siyana dzechirwere chema cell uye DCs.
INCB024360 powder yakashandiswa mumisungo yekudzidza kurapwa kweHL, Melanoma, Glioblastoma, Mucosal Melanoma, uye Ovarian Carcinoma, pakati pevamwe.
Warning on INCB024360 powder
Iyo data inopa chikwereti kune Incyte yekutenda mune nzira yekuita kweEpacadostat powder. Mishonga inogadzirisa dhizii inonzi IDO1 kuti idzivirire maitiro ezvirwere zvemuviri. Epacadostat powder inhibits enzyme iyi kuti idimbure pasi ichi kuitika, zvichibatsira maitiro ezvirwere zvekuzvidzivirira kuti arove chiremera nemasimba ayo ose. Nepo mamwe mashoko akadikanwa kuti asimbise hypothesis, izvo zvinogona kuva nechinangwa chekutengesa kwemashamba emuno-oncology.
Incyte's data yakanyatsotarisana nekusanganiswa kweBristol-Myers 'Opdivo neJervoy, iyo yakakunda FDA kugamuchirwa pakutanga kwegore rapera pamusoro pesimba rePSS reZ11.5 mwedzi yevarwere vane melanoma yakakura.
Pane zvikonzero zvekufunga kuti musiyano mutsva pakati pePFS inowanikwa kubva mumakiriniki ekuedzwa achazopedzisira ashandura muganhu weIncyte. Chiitiko chaBristol-Myers chakanyoresa varwere-vasingatendi, asi zvimwe zvidzidzo muIncyte kudzidza zvakamboshandiswa. Incyte's treatment-naive kushandiswa kwekare kunosvika kune imwe yenyika yePFS asi iyo inowanikwa pamatanhatu, 12 uye 18 mwedzi inoratidza kuti iri munzira yekuvandudza mhinduro yeOpdivo-Yervoy.
Incyte inogonawo kuratidza kuchengeteka kwe data kuti iite nharo yekubatana kwayo inogona kunge iri nani yeBristol-Myers. Ikozvino chiitiko chakashumwa kuti 17% yevarwere vakatambura chikamu chechitatu kana zvakanyanya kuitika zviitiko zvakashata zvine chokuita nemishonga. Iko inofananidzwa nemigumisiro yakagadzirwa neBristol-Myers 'kusanganiswa, iyo, mumushumo kutanga kwegore rino, yakabatanidzwa kune 58% muzana wegiredhi yechitatu kana yechina zviitiko zvakashata.
Mamwe mirayiridzo
Epacadostat powder inhibitor ye indoleamine 2,3-dioxygenase 1 (IDO1) ine IC50 kukosha kwe7.1 nM muHeLa masero ayo anoratidzira zvishomanana kuita zvinopesana nemakemikari anonzi IDO2 kana tryptophan 2,3-dioxygenase (TDO) .1 Yakaratidzwa kukurudzira T uye kuurayiwa kwechisikigo-sekukura, kuwedzera kukwidziridzwa kweFNN-Y, uye kuderedza kutendeuka kumatare anonzi T (Treg) akafanana-siyana mumararamiro emhando yevanhu allogeneic lymphocytes ane dendritic masero kana tumarara masero.1 Epacadostat powder inogonawo kudzivisa tumarara kukura mumagunha anoremara mumarara mumararamiro anonzi lymphocyte.
Chirevo chinowanikwa mumumuromo chinonzi hydroxyamidine uye inhibitor ye indoleamine 2,3-dioxygenase (IDO1), ine simba rekudzivirira immunomodulating uye antiineoplastic mabasa. INCB024360 zvinokonzerwa nehupfu uye anosunga kuDIDO1, enzyme inokonzera kusvibiswa kwe tryptophan mujinrenine. Nokudzivisa IDO1 uye kuderedza kynurenine mumatomu masero, kuwedzera kweEpacadostat powder uye kunodzokorora kupararira uye kushandiswa kwemasero ezvirwere zvakasiyana-siyana, kusanganisira dendritic cells (DCs), NK cells, uye T-lymphocytes, pamwe ne-interferon (IFN), uye kuderedza kuora-kunobatanidza kutungamirira T cells (Tregs). Kushanda kwemuviri wemuviri, iyo inodzingwa mumakondomu akawanda, inogona kudzivisa kukura kweDOO-NUMX-kuratidza tumarara masero. IDO1 inonyanyisa kunzwisiswa nemhando dzakasiyana-siyana dzechirwere chema cell uye DCs. Chengetera kwekushanda kwekliniki inoshandisa uchishandiswa ichi.
Indoleamine 2,3-dioxygenase 1 (IDO1) ndiyo inofanirwa kukura maitiro ekurwisa mutezo ekudzivirira zvirwere zvekudzivirirwa kwemasimba nekusimudzira mutemo wechidiki chetachiona uye chekudzivirira chiremera chechidiki, zvichiita kuti chiremera chiwedzere kuburikidza nekubvumira mishonga yemukenza kuti irege kudzivirirwa. Epacadostat powder ipfungwa, yakanyanyisa uye inosarudza muromo inhibitor weDNA inokonzera chirwere chemune microenvironment, nokudaro inodzorera kugadzirisa kushanda kwemapurisa emune. Mune zvidzidzo zvese-ruoko, kusanganiswa kwe INCB1 powder uye immune checkpoint inhibitors yakaratidza uchapupu-hwe-pfungwa mune varwere vane mararaoma asingagoneki kana asingagadziriswi. Mune zvidzidzo izvi, INCB024360 powder pamwe chete neCCTLA-024360 inhibitor ipilimumab kana kuti PD-4 inhibitor KEYTRUDA inowedzera maitiro ekupindura kana ichienzaniswa neongororo yezvidzivirira zvekuzvidzivirira muzvirwere zvekuzvidzivirira inhibitor chete.
Kubatanidza IDO inhibitor Epacadostat powder neikvolumab (Opdivo) yakaratidza zviratidzo zvinokurudzira zvebasa kune varwere vane squamous cell carcinoma yemusoro nemutsipa (SCCHC) nevaya vane melanoma, maererano nezvakawanikwa kubva muchikamu I / II ECHO-204 kuongororwa pa iyo 2017 ASCO Annual Meeting.
Kubatanidzwa kwakaratidza kuti chinangwa chekuita chirongwa (ORR) che63% uye kupindura kwakakwana (CR) chiyero che5% kune varwere vane chirwere-naive melanoma, mumuviri-ruoko, yakazarura-mavara. Mune avo vane SCCHC, ORR yakanga iri 23% uye CR iyo yaive 3%. Kubatanidzwa kwakanga kusingabatsiri pakusarudzwa nevarwere vane kenza yemaovari uye cheraireal cancer (CRC).
"INCB024360 powder pamwe nivolumab yaishanda muchikamu II melanoma uye squamous cell carcinoma yemusoro neyemitsipa cohorts," akadaro coauthor kudzidza Karl D. Lewis, MD, purofesa anofambidzana, Dhipatimendi reMedical Oncology, University of Colorado Anschutz Medical Campus. "Mhinduro yakawonekwa zvisinei nemataurirwo ePD-L1 uye chinzvimbo cheHPV. Mhinduro dzese dzaienderera mberi pakudimburwa kwedata. "
Muchitsauko I chikamu chekudzidza, Epacadostat powder dose yakakura kubva ku25 mg kaviri zuva rimwe nerimwe ku 300 mg kaviri zuva rimwe nerimwe. Muchikamu chechipiri chikamu, varwere vakagamuchira 100 mg kaviri zuva rimwe nerimwe uye 300 mg kaviri zuva rega rega yeEpacadostat powder. Nivolumab pakutanga yaitarisirwa ku3 mg / kg mavhiki e2 ose, ayo akachinjwa ku 240 mg IV mavhiki ose e2 muchikamu chechipiri chechidzidzo. Zvakawanikwa zvakataurwa pa ASCO nokuda kwekuchengeteka zvakabva kune zvikamu zviviri zvekudzidza apo kushanda kwakakosha kwakabva kune boka reboka rechipiri.
Kune varwere vane melanoma isina kubatwa (N = 40), iyo ORR ine chirwere che 100-mg (n = 6) ye INCB024360 poda yaiva 100%, iyo yakave nemhinduro dzakakwana. Neyo 300-mg dose (n = 34), iyo ORR yaiva 56% uye CR iyo yaive 6%. Chirwere chekushaya chirwere (DCR; ORR pamwe nechirwere chakagadzikana) chaiva 85%. Muavo vane PD-L1-positive tumor (n = 7), iOrR yaiva 71% kusvika ku29% muboka re PD-L1-negative (n = 7). Mhinduro dzose dzakanga dzichienderera mberi, nehuwandu hwemasvondo e16 +.
Muchikwata cheCSCN, umo varwere vakanga vagamuchira ≤2 mitsara yapamusoro yerapi, iyo ORR ine chirongwa che 100-mg (n = 7) yeEpacadostat powder yaiva 14%, pakanga pasina CR, uye DCR yaiva 61%. Muchikamu che 300-mg (n = 24), iyo ORR yaiva 25%, ine 1 CR uye DCR ye71%. Varwere vane tumorama PD-L1-positive (n = 10) vane ORR ye30% uye avo vane zvirwere zvisina kunaka (n = 8) vane ORR ye13%. Mhinduro dzose dzakapfuurira pakuongororwa, pamwe nemakore makuru kupfuura mavhiki e24.
Muna 29 vakaongororwa varwere vane kenza yevana, iyo ORR yaiva 14% uye DCR yaiva 31%. Paiva na 1 CR mumurwere ane kurapa neive, BRCA-negative, PD-L1-positive chirwere. Muchirwere cheC26 neCRC, avo vane microsatellite kusagadzikana (MSI) vane ORR ye25% uye avo vane zvirwere zvakasimba zve microsatellite havana kuwana mhinduro.
"INCB024360 powder pamwe nivolumab haina kuratidza chiratidzo chekushanda muvanhu vasina kusarudzwa vegomarara reovarian ovancer uye varwere veCRC," akadaro Lewis nezve mhedzisiro. Nezve kuferefetwa kweramangwana, akataura kuti "kwekutanga kuchengetedzeka uye kushanda kwemhedzisiro kunotsigira kumwe kuongorora kwe nivolumab uye Epacadostat poda mukurapa-vasina ruzivo varwere vane melanoma uye nevarwere vane SCCHN."
Epacadostat Raw Powder
Min order 10grams.
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INCB024360 powder Marketing
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Nzira yekutenga Epacadostat powder: kutenga INCB024360 poda kubva kuAASraw
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