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Introduction
Ndimkonda ana. Chimodzi mwa zifukwa Ndimkonda ana ndi chifukwa akutionetsa tokha. Iwo ali ngati kalirole pang'ono. Ndiroleni ine ndikuuzeni inu chimene ine ndikutanthauza. Kids ndi wokongola kwambiri zonse za mavuto omwewo tili, koma mavuto amene ali basi kwambiri zoonekeratu kwambiri chifukwa sindikudziwa momwe kuwabisa yet. Iyi ndi bwino achinyamata kuchita zinthu zimene iwo sakuyenera kuchita.
Kodi munamuonapo mwana kukhudza chinachake iwo sanafunike kukhudza? Iwo kuti ndione ngati inu mukuyang'ana. Iwo sindikusamala ngati mwana wina akuyang'ana; iwo safuna akuluakulu kapena makolo kuona. N'chifukwa chiyani iwo amachita izo, Komabe? Chifukwa iwo akudziwa inu kuyang'anira, ndipo sindikufuna kudziwa chifukwa ndikudziwa ndinu munthu ali ndi mlandu ndi.
Akuluakulu njira yomweyo. Kawirikawiri ife tiri Chabwino ndi kuchita zinthu ife ayenera kuchita, malingana ngati munthuyo ife adzayankha kwa si tikupeza. Inu okondwa mofulumira mpaka inu mukuona apolisi patsogolo. Mwina ndife okondwa kuti asiye ntchito ya bola ngati bwana wathu si tikupeza. Mwinamwake ena a ife amaonera mayeso malingana ngati pulofesa sichitipeza ife. Sitikudziwa zambiri kaya anthu ndikudziwa ife kuchita chinachake cholakwika, pokhapokha ndi ulamuliro ife adzayankha kwa.
mu 1 Samuel 2, Hannah akupemphera poyankha kubadwa kwa mwana wake Samuel. Ndipo mu pemphero, iye anachenjeza anthu ena kuti tchimo limodzi lokha, chifukwa Woweruza wawo akuwaona. Tembenuzani ndi ine 1 Samuel mutu 2, ndime 3.
Musakhale akuyankhula kwambiri monyadira kapena tiyeni pakamwa pako kulankhula N'chimodzimodzinso, pakuti Yehova ndiye Mulungu amene adziwa, ndi iye zochita tikakumana.
(1 Samuel 2:3)
M'lembali, Hannah amaticenjeza kulankhula wonyada, chifukwa Mulungu adzapeza ndi Iye muigwire ife chifukwa cha izo. Ndicho chimene ine ndikuganiza mfundo yaikulu ya ndime ili ndi: Ngati mulankhula monyadira, inu muyenera kuyankha kwa Mulungu chifukwa.
Tikhoza kuyesedwa kuganiza mawu athu wonyada sindiri kanthu kwambiri. Koma ngati mukuganiza mawu anu wonyada ziribe kanthu, Ine ndikuwopa kuti inu. Iwo ayenera kanthu kwa inu, chifukwa wofunika kwa Mulungu, ndipo Iye ali Mmodzi muyenera kuyankha. Ife sitikhala potsiriza kuyankha kwa makolo athu, kapena anzathu, kapena abusa athu, koma kwa Mulungu.
Poganizira, Ine ndikufuna kufunsa mafunso angapo kumvetsa lemba bwino.
funso 1: Kodi kumatanthauza Kambiranani monyadira?
Kumatanthauza ntchito mawu anu anatamanda nokha.
Background
Tsopano ambiri ife tingaganize mawu modzitukumula monga chabe basi kudzitama za kudabwitsa tili, koma pali njira zambiri kulankhula monyadira. Ndipo ine ndikuganiza mmodzi mwa zimene Hannah akuganiza ndi zimene taona m'chaputala 1.
Hannah anali mkazi wa munthu wina dzina lake Elikana. Iye sanali mkazi wake yekha kuti. Iye anali mkazi mmodzi wina dzina lake Penina. Penina anali ndi ana, Hana anali wosabereka. Ndipo Penina kodi kwenikweni kudzatonza Hannah za izo. Ndipo chifukwa cha vuto lakeli ndipo izi Hannah kutsutsa udawawa ndipo anali kulira.
Ine ndikuganiza Penina ndi chitsanzo cha mawu wonyada Hannah amaticenjeza. Penina anali osati pofotokoza mfundo yakuti iye anali ana. Iye sanali mongoyesa kukumbutsa Hannah mfundo. Iye anali kutsutsa kwake, kudzitamanda pa iye, akundizunza wake.
Izo zikumveka ngati iye kukhala zikutanthauza. bwanji kulankhula monyadira? Chabwino izo zikuwoneka ngati Penina anali kugwiritsa ntchito njira kunena yekha pa Hannah. Zikuoneka ngati iye poganiza kuti pena zimakhudza wake wa ana chinamupangitsa kuposa Hannah, amene sanali owona. Lemba limanena momveka bwino kuti ana ndi mphatso yochokera kwa Yehova. Penina anali kuyankhula monyadira, ndipo iye adzayankha kwa Mulungu chifukwa.
Njira timakambirana monyadira
Ngati timazindikira kapena ayi, tonse kulankhula monyadira kulankhula ndi kudzikuza mu zosiyanasiyana:
1. Chodziŵikiratu njira ndi modzitamandira ndi zinthu zimene wathu. Nthawizina ife sitingakhoze kudikira kuuza ena zimene tili ndi chimene ife chakwaniritsidwa. Koma ife si kutamanda Mulungu chifukwa; Cholinga cha kudzipereka kuyang'ana bwino. I mwagwira ndekha zimenezi nthawi zambiri. Mwina kukumana ndi mnzake wakale ndipo amandifunsa ndachita. Ine ndikhoza kunena rapping, koma ine kulibwino amatchula mphoto kapena zochita zina.
2. Kapena mmene zinthu tikunena za ena? Nthawizina ife mabodza ena. Tikufuna kujambula iwo mu kuwala zoipa, kotero ife kuyang'ana zabwino. Mwina pa ntchito timawauza kuti makamaka co-wantchito wokongola aulesi, kuti anthu adzaona kusiyana inu awiri. Kapena mwina m'malo ndi wachisomo ndi ena, ife tiri odzilungamitsa. Ife tikuima monga woweruza iwo, chifukwa kumatipangitsa kumva bwino bwanji zinthu zimene wathu wauzimu. Kuti ndi wonyada kulankhula.
3. Kapena nthawi zina pamene ife zabwino. Mwinamwake ndi umboni pa Lamlungu usiku. Izo zikhoza kukhala nkhani yosangalatsa za ntchito ya Mulungu mu moyo mnzake, koma zolinga zanu zikhoza kukhala ulemerero wanu m'malo Mulungu. Kapena kulola munthu wina mwakhala kuwapempherera iwo. Kapena kuphunzitsa Sunday School kalasi. Ngakhale zinthu zabwino ayenera kunyadira kulankhula ngati cholinga chanu ndi kumukweza nokha.
Zitsanzo za izi ndi zoonekeratu kuposa ena. Kotero kodi mukudziwa ngati? Chimene chimatisiyanitsa kulankhula kunyada kwa kunena zoona? Kulankhula monyadira ndi pamene inu musati kuvomereza Mulungu amene ali yekha ndi woyenera ulemerero, mu mtima kapena mawu okha. Ndipo tinali, timaona ulemerero wa Mulungu.
mawu anu kuvomereza Mulungu, Koma kodi mtima wanu? anthu ena sangathe kuuza kusiyana, koma Hannah limatikumbutsa kuti Yehova ndi Mulungu amene adziwa. Ndipo ngati mawu athu anatamanda tokha, ife adzayankha kwa Iye chifukwa.
M'lembali Hannah limatiuza kulankhula monyadira, ndiyeno iye amatiuza chifukwa: chifukwa Yehova ndiye Mulungu amene akudziwa ndi akulemera ntchito.
funso 2: N'chifukwa Chiyani kuyankha kwa Mulungu Kulankhula Chathu?
Chifukwa ndi kuukira ulemerero Wake.
Ngati munthu mmodzi yekha pa mawu awiri otsiriza zinalili, izo zikhoza kusintha kwambiri. Ngati Mulungu ankadziwa, koma sanali woweruza, kapena ngati Mulungu anali woweruza koma sankadziwa. Koma mwangwiro basi Woweruza ndi onse kudziwa Mulungu. Osati Mulungu tikupeza, Iye akumvetsera. Mulungu nthawi zonse anatsekula chilichonse kukambirana zimene zikuchitika. Pafupifupi monga Iye ali ndi kuchuluka wopandamalire makamera chitetezo anaikidwa aliyense phazi lalikulu la dziko lapansi. Iye amadziwa. Ndipo ngati ife kumenyana ulemerero Wake ndi mawu wonyada, Adzazindikira.
kufunkha Mulungu
Ngati ine ndinali kupita nkhani zanu banki, ndi ndalama ndi ntchito kwa ine, ndi kuti kuba? Indedi. Ine ndikutenga chinachake wa inu, ndi kugwiritsa ntchito ndekha. Ine sindingakhoze ndekha iliyonse ya ndalama asanatenge kwa inu. Ndipo izo ziri zolakwika chifukwa cha inu.
Pamene anthu kuyesera kupereka okha ulemerero, iwo adzalanda za Mulungu Ake. Inu simungakhoze kuperekedwa wekha matamando ndi ulemerero, popanda kubera Mulungu. Kunyada kuukira ulemerero wa Mulungu. chifukwa? Chifukwa kudziŵerengera kopambanitsa zimachokera ku underestimation wa Mulungu. Ndiroleni ine ndinene izo kachiwiri: kudziŵerengera kopambanitsa zimachokera ku underestimation wa Mulungu. Ndipo pamene ife tikuwona mu 1 Samuel 1, izi underestimation wa Mulungu, Komanso kumachititsa underestimation ena. Motero poganiza kuti ndife ofunika kwambiri amachokera kuganiza kwambiri onyozeka a Mulungu, ndipo kumabweretsa kuganiza kwambiri onyozeka a ena.
Penina anali olakwika. Tamarayo kukambapo mwa kuika yekha pa mpando wachifumu Wamkulu, ngati zobereka yake. Ndipo ife tiri zambiri yolakwa mofanana. Ife ndikuganiza ife amene ayenera kutenga ngongole pantchito kuti, kapena ana akhalidwe labwino, kapena ndalama zomwe tinali. inde, Mulungu adzakulipirani ntchito mwakhama, koma sizitanthauza kanthu. chifuniro cha Mulungu ndi chinthu chenicheni kusankha nthawi zonse. Kodi chofunika potsiriza si mphamvu zathu, nzeru zathu, kapena kukhulupirika kwathu.
wonyada Kulankhula
Choncho kunyada ndi cholakwika. Tonsefe tili ndi ena kunyada mu mitima yathu kuti tiyenera kulimbana. Pamene mukuganiza mu mtima mwanu kuti mufunika ulemerero, kuti pawokha ndi tchimo. Koma mawu wonyada ukuchitika kwa mlingo wina. Kodi tingatsanzire, anthu ochimwa, ulemu, osati kuganiza kuti ndife woyenera ulemerero wa Mulungu, koma makamaka aipereke kuti njira ena? Kuyesa kutsimikizira ena kutipatsa ulemerero wa Mulungu wokha. Kulankhula monyadira ali ngati osati kufunkha munthu, koma kuuza aliyense za icho ndi kuwalimbikitsa yemweyo.
Chinthu chokha ndi, Mulungu safuna kanema kanema kudziwa ndinu olakwa. Mulungu sadzalekerera anthu akuyesera kulanda Iye ulemerero Wake ndi kulimbikitsa ena kuchita chimodzimodzi. Amene chifukwa Hannah anati tiyenera kuchita izo.
mawu wonyada ndi kutola kumenyana ndi Mulungu, nchifukwa chake ziri zowoneka zodabwitsa ndi moyo wa okhulupirira. Pamene tinamva mmawa uno, "Mulungu amatsutsa odzikweza, koma apatsa chisomo kwa odzichepetsa. "
ntchito Kulemedwa
Ngati ife sitiri mwa Khristu, mawu athu wonyada, adzakhala chifukwa chinanso Mulungu kuti atipatse chilango. zochita zathu zoipa adzapitiriza kuthandiza nkhani kwabasi nafe. Ngati inu simuli mwa Khristu, palibe mantha kuposa Woweruza Wodziwa. Kotero ngati inu muli pano usikuuno ndi inu simutero Yesu, Chonde kudziwa Iye. Kusiya machimo anu, ndipo wekha pa chifundo Chake. Iye anali amazipanga odzichepetsa odzichepetsa kufa kuti ochimwa monga inu ndi ine moyo. Iye anawuka kuchokera mmanda ndi mphamvu zonse, ndi kuyitana anthu kumtewera. Ife tikanati amakonda kulankhula kwambiri za izo kenako.
Koma monga Akristu, kodi zimatanthauza kuti zochita zathu kuti ingalemetsedwe? Wokhulupirira aliyense mu chipinda ichi kuyankha kwa Mulungu nthawi iliyonse Timawanyadira kulankhula, koma chiweruzo chathu chasintha. Khristu kale machimo athu pa mtanda. Koma chenjezo akhale zimakhudzira mmene timakhalira. Pamene ife tikuyima pamaso pa Mulungu, zochita zathu mwina umboni chakuti ife anakhulupirira mwa Khristu kapena kuti ife amanyadira kwambiri kukhulupirira Khristu yekha.
komanso, tikufuna kusangalatsa Atate. Kumene amasangalala nafe mwa Khristu, koma tikufuna Iye kusangalala ntchito zathu zabwino akutuluka chikhulupiriro mwa Khristu. Tikufuna kusangalatsa Mulungu wathu wachikondi.
Tisalole mawu amwano kubwera kuchokera mkamwa mwathu. Ndipo ngakhale ife tiyenera kuyankha kwa Mulungu zolankhula zathu wonyada, tiyenera kutamanda Mulungu kuti machimo athu ali mu pulogalamu Khristu.
Choncho ngati tikufuna kuti Mulungu alemekezedwe mwa zolankhula zathu, kodi ife nkhondo imeneyi nkhani wamwano?
funso 3: Kodi Timathandiza Nkhondo Chathu Kulankhula?
Timachita ndi kukondwera mwa Mulungu.
Tiyenera kuonera timalankhula, koma sikokwanira. Ziri ngati kufotokozera munthu ndi chimfine njira basi kugwira kuyetsemula awo. No, matenda ndi zoyenera anaukira.
Mtima wonyada amakondwera palokha. Koma mtima wodzichepetsa amasangalala Mulungu. Yang'anani pa mawu oyamba a pemphero Hannah m'vesi 1: "Mtima wanga ukukondwera mwa Ambuye." Hannah akutionetsa yankho yoyenera dalitso la Ambuye. Osati kukondwera mwa Ambuye andipatsa, koma Wopatsa Yekha. yankho lathu lingakhale wonyada, koma uyenera kudzichepetsa ife, chifukwa ife kulandira mphatso yochokera kwa Mulungu
Mulungu amapereka nachotsa. Mulungu kugawira ndi Sasonyeza. Koma Iye amachita izo zonse kuti tipindule ndi ulemerero Wake. Ife ukuyenda bwino pamene tidzayamba kudalira zinthu kwambiri. Kukondwera Mulungu amapha onse kunyada ndi chiyembekezo.
Kodi mumasangalala Mulungu? Kuchita izo zimatengera kudzikumbutsa amene ali kumbuyo chirichonse. Kutamanda Mulungu pamene mwalandira cheke. Ichi ndi chifukwa chake ife tiyamika Mulungu pamaso chakudya. Kukumbukira kuti ndi amwano kuganiza zolinga zathu nthawi zonse amapita. Kunena Ambuye akalola. Alemekeze Mulungu pamene ena kudzamuthokoza inu pa mwakwanitsa. Musati kwa miniti kulola mtima wanu kutenga ngongole. Penyani mawu anu wonyada. Pezani mizu ya kunyada mu mtima wanu.
Kutsiliza
Aliyense single wa ife wapatsidwa mwayi chidwi ndi liwu lililonse tikulankhula. Ife tikufika ku ntchito mawu athu kulemekeza Mulungu yemwe anatilenga. Ife tikufika ku ntchito mawu athu kuthandiza ena Mulungu mwa Ambuye wa ulemerero umene Iye ali.
Chilimbikitso changa si ntchito mawu anu anatamanda nokha. m'malo, ntchito zimene inuyo zinalengedwa kuchita alemekeze Mulungu. Izo zonse ziri za Iye mulimonse.
Tiyeni tipemphere.


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Mkuntho "Nibert" wagunda m'chigawo cha Fujian molimba-Shenzhen Lehui Optoelectronics Lighting Support
Mvula yamkuntho No. 1 ya 2016 "Nibert" idagwa ku Shishi City, Quanzhou City, m'chigawo cha Fujian nthawi ya 13:45 pa Julayi 9, ndimvula yambiri yosokonekera komanso kusefukira kwamadzi m'malo ambiri m'chigawo cha Fujian, zomwe zidapangitsa kuwonongeka kwachuma komanso kuwonongeka ku Fujian Chigawo.
Chifukwa cha kusokonekera kwa misewu, kulumikizana ndi magetsi mdera latsokalo kwa masiku angapo, malowo anali ovuta ndipo panali milu yambiri, zomwe zidapangitsa kuti kusaka ndi kupulumutsa anthu ndikutsimikizira kuti ndi ndani ntchito yovuta kwambiri. Fujian Provincial Power Supply Company idafika kutsogolo kwa kukonza magetsi mwadzidzidzi mdera lomwe lakhudzidwa nthawi yoyamba. Shenzhen Lehui Optoelectronics Co., Ltd. mwachangu adakonza gulu lopulumutsa ataphunzira za tsokalo ndikugawa zida zambiri zoyatsira mafoni ndi nyumba zazikulu zowunikira kuti zigwirizane ndi Fujian Provincial Power Supply Company kuti ikonze ndikupereka thandizo kuunikira ku gulu lopulumutsa usiku.
Panthawi yopulumutsa, kampani yathu sikuti imangounikira magetsi oyatsa magetsi a KLT-8000, komanso imapatsanso mpope wathu watsopano wopanga zida zadzidzidzi zodzipulumutsira kuti zithandizire kupulumutsa ngalande zadzidzidzi m'malo amadzi osefukira. Pampu yamadzi iyi imapangidwa ndi kampani yathu, yomwe ndi yosiyana kwambiri ndi mapampu ena pamsika. Pampu yotereyi imakhala ndi mawonekedwe ang'onoang'ono, kulemera pang'ono komanso kuyenda kosavuta. Pakayendedwe, sikusowa thandizo la kireni, koma imatha kuzindikira kuti ikutsitsa ndikutsitsa pagalimoto yaying'ono podalira njira zawo zokhazokha ndi zotsitsira, zomwe zimathandiza kwambiri kupulumutsa ntchito ndikupulumutsa kwambiri nthawi yothamanga.
Post nthawi: Mar-05-2021

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Basharul Haafi rahimahu Allah anati:
“Yemwe amakonda kuti azifunsidwa (za deen), sali oyenera kufunsidwa”
قال بشر الحافي رحمه الله تعالى: مَن أحبَّ أن
يُسْأَلَ، فَليسَ بِأَهْلٍ لِأَنْ يُسْألَ.
Mau awa ndi akuya zedi. Allah atipatse kumvesetsa
Phunziro:
Kuitanira kuti uzifunsidwa za deen ponena kuti “ngati mukufuna kudziwa za deen muzindifunsa ine…” ndiko kukonda kufunsidwa. Kuyankhula koteroko kumasonyeza kuti ukudzionetsera kuti ndiwe wozindikira kwambiri kuposa ena, ndipo anthu sakuyenera kufunsa kwa ena koma iwe wekha.
Zotsatira zake ndizoti anthu amayamba kukuona kuti iwe ndiwe wozindikira kwambiri kuposa aliyense pakati pawo; palibe wina yemwe ali ndi ‘ilm kuposa iweyo poti wadzilengezetsa.
Ndiye zimapezeka kuti munthu woteroyo akafunsidwa zinthu zoti sakudziwa, amachita manyazi kunena kuti sakudziwa, mapeto ake amangoyankha zakezake nkumasocheretsa anthu, poti anthuwo sangamutsutsenso. Komanso sangapite kwa ma Sheikh ena kuti akaonjezere maphunziro poti anthu akumudziwa kuti ndi ozindikira kuposa onse.
Zofunika kwa omwe Allah awadalitsa ndi maphunziro pa deen, akadziwidwa kuti akuzindikirapo zinthu, asadzikweze pamwamba ena ena onse… adzichepetse… akafunsidwa aziyankha zomwe akudziwa, ndipo kumapetoko azinena kuti ‘Allah ndiye mwini kudziwa konse’ kapena mau ena ofanana ndi amenewa… kupatula ngati waiwala. Ngati sakudziwa anene kuti sakudziwa, ngati angakwanitae kufufuza, anene kuti ‘ndidikireni ndifufuze’.
Izi sichikakamizo, koma ndinjira imodzi ya kudzichepetsera pamaso pa Wodziwa Zonse (Allah) komanso zimapangitsa kuti Allah akudalitse ndi maphunziro oonjezera.


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- Ngakhale pali katemera wambiri omwe alipo, kuchuluka kwa anthu odwala matenda atsopano ndi kumwalira kukupitilirabe padziko lonse lapansi.
- Ziwerengerozi zimakhudzidwa makamaka ndi kusiyanasiyana kwa Delta chifukwa chazomwe zimafalikira kwambiri.
- Ngakhale kuti aliyense amangokhalira kunena za kutetezedwa kwa ziweto, Woyang'anira Dipatimenti ya Katemera ku WHO adati palibe "nambala yamatsenga."
Ananenanso kuti kuneneratu ndi mawu am'munsi kuti manambalawa ndiwotsika kwambiri ndipo chilichonse chothana ndi vutoli chichitapo kanthu mwamphamvu.
Tedros adati, "Tonse tili mgulu ili, koma dziko lapansi silikuchita monga choncho."
Adadandaula kuti ngakhale pali katemera wambiri, kuchuluka kwa anthu odwala matenda opatsirana mwatsopano ndikufa kukukulirakulira, makamaka chifukwa cha kuchepa kwa Delta ndi zomwe zimafalikira.
Ngakhale aliyense amangokhalira kulankhula za kutetezedwa kwa ziweto, Director of the World Health Organization Dipatimenti ya Katemera, akuti palibe "nambala yamatsenga." Iye anafotokoza kuti: “Zimakhudzadi mmene kachilomboka kamafalitsira. Zomwe zakhala zikuchitika ndi coronavirus… ndikuti popeza mitundu ikukula ndipo imafalikira, zikutanthauza kuti kachigawo kakang'ono ka anthu amafunika katemera kuti athe kukwaniritsa ziweto zawo. Asayansi sakayikira pankhani imeneyi. ”
Mwachitsanzo, chikuku chimafala kwambiri kotero kuti pafupifupi 95% ya anthu akuyenera kuteteza kapena katemera kuti asafalikire. Ngakhale timavomereza kwathunthu kulandira katemera wa chikuku mpaka mwachitsanzo ku America makanda amatemera katemera ali ndi miyezi khumi ndi iwiri, zatsopano za COVID-12 zikuwapangitsa anthu kukhala opanda mantha kapena amantha kapena onse awiri. Pali ambiri omwe sakhulupirira kuti sakugwiritsidwa ntchito ngati nkhumba kuti ayese "katemera watsopanoyu". Pakadali pano, Chiwerengero cha omwalira padziko lonse lapansi kuchokera ku COVID-19 yafika 4,333,094 lero.
Kwa iwo omwe amatenga kachilomboka, chiyembekezo chili poti akuluakulu a WHO anena kuti kafukufuku wambiri akuchita pa chithandizo cha COVID-19. Chiyeso chomwe sichinachitikepo chamayiko ambiri chotchedwa Solidarity Plus chiziwona momwe mankhwala atsopano atatu akugwirira ntchito m'maiko 3.


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Lero Amazon Kindle Amakhala ma eReaders odziwika kwambiri kapena mabuku amagetsi pamsika, chifukwa cha kapangidwe kake kopitilira muyeso, mawonekedwe ndi malongosoledwe awo, koma koposa zonse ndipo nthawi zambiri chifukwa cha mtengo wawo. Pakadali pano pamsika pali banja lalikulu lazida zomwe zilipo, zopezeka kwa aliyense wogwiritsa ntchito ndipo zili ndi ntchito zosiyanasiyana zomwe mungasankhe malinga ndi kuthekera kwanu.
Ngati muli ndi Kindle Oasis, a Kindle Voyage, a Kindle Paperwhite, a Kindle oyambira kapena amodzi mwa mtundu wina womwe Amazon yakhazikitsa m'mbiri yake, lero tikuwonetsani Zizolowezi zosangalatsa zisanu kuti mupindule kwambiri ndi Kukoma mtima kwanu kuchokera ku Amazon, ndikuti mutha kugwiritsanso ntchito bwino, osati kungowerenga mabuku osiyanasiyana a digito.
Zotsatira
Tumizani tsamba lililonse patsamba lanu
Popeza ndidagula chida changa cha Kindle zaka zingapo zapitazo, imodzi mwanjira zomwe ndimakonda kwambiri ndikutha tumizani tsamba lililonse patsamba langa la Amazon, kuchokera pa foni yanga ya m'manja kapena ngakhale kompyuta yanga, kuti awerenge pambuyo pake.
Nthawi zambiri masana ndimatumiza nkhani zomwe zimandisangalatsa kuti ndiwerenge ndikamagona pa sofa usiku uliwonse komanso komwe ndimawerenga bwino osasiya maso anga, koposa zonse ndi bata.
Kuti mugwiritse ntchito tsenga, zonse muyenera kuchita ndikukhazikitsa zowonjezera Tumizani ku Kindle mu msakatuli wanu wa Google Chrome. Zachidziwikire, kuti muzitha kuwerenga zolemba zomwe zatumizidwa ku Kindle yanu, muyenera kukhala kuti zidalumikizidwa ndi netiweki zamakalata ndikuzilumikiza kuti zizilandira nkhani tsiku lililonse.
Tsitsani - Tumizani ku Kindle
Tumizani buku ladijito ku Kindle yanu kudzera pa imelo
Amazon Kindle ndi chimodzi mwazida zochepa pamsika zomwe sizigwiritsa ntchito mtundu wa epub wamabuku a digito, kusankha kuyambira kale kwambiri pa AZQ. Izi zikuphatikiza zovuta zakusintha ma eBooks nthawi zambiri kuti muzitha kusangalala nawo pachida chathu kuchokera ku kampani yomwe idatsogoleredwa ndi Jeff Bezos.
Kuti muchite izi, pali zosankha zambiri monga Caliber, komanso kuthekera koti mutumize buku kapena chikalata chilichonse kudzera mu imelo yathu, kuchilandira kale kuti chikhale chosinthika ndi mtundu wathu. Ngati mukufuna kuchita izi, muyenera kungozilumikiza ndi kuzitumiza ku imelo yomwe Mtundu uliwonse wakupatsani komanso zomwe mungapeze mu chida chanu kapena patsamba la Amazon, komwe mungayang'anire zipangizo.
Perekani buku ladijito kwa aliyense amene mukufuna
Ngati mungaganize kuti chifukwa mudakhala ndi Mtundu simukanatha kusiya ma eBooks kwa mnzanu kapena abale anu, mtundu womwe sikukubwezerani mabukuwo kapena kukubwezerani zaka mutabwereka iwo, mukulakwitsa kwambiri. Ndipo ndizo kuchokera ku Amazon e-book iliyonse titha kubwereketsa buku ladijito kwa mnzathu kapena wachibale, popanda vuto lililonse, ngakhale kuti sizovuta kwenikweni ngati kuti ndi buku looneka.
Kuti mubwereke bukhu, liyenera kuphatikizidwa pamndandanda womwe Amazon ilipo kwa aliyense wogwiritsa ntchito komanso wophatikizidwa muutumiki wa «Kubwereketsa Wowonjezera». Buku lililonse lomwe lili ndi uthengawu limatha kubwerekedwa kwa milungu iwiri ndipo kwaulere. Ndalama zimapangidwa kuchokera patsamba Sinthani Amazon Kindle yanu, pomwe muyenera kungonena buku lomwe mukufuna kubwereketsa komanso kwa yemwe mukufuna kumusiyira milungu ingapo.
Amazon yalengeza kale kuti ikugwira ntchito yopanga mabuku ake onse adijito kwa abwenzi kapena abale, ngakhale pakadali pano zikuwoneka kuti padakali nthawi yayitali kuti izi zichitike, mwanjira yovomerezeka.
Tengani chithunzi pa Kindle yanu
Chimodzi mwazinthu zosangalatsa kwambiri zomwe tili nazo pa Kindle yathu, komanso kuti ogwiritsa ntchito ambiri sakudziwa, ndikutenga chithunzi chomwe chimatilola ife, mwachitsanzo, kusunga tsamba la buku lomwe tikuwerenga kwanthawizonse.
Kutengera mtundu wa Kindle womwe tili nawo, zojambulazo zimachitidwa mwanjira ina. Mwachidule mawonekedwe pansipa tikuwonetsani momwe mungatengere chithunzi pamitundu yosiyanasiyana ya Amazon eReader;
- Kindle Yoyambirira, Kindle 2, Kindle DX, ndi Kindle ndi kiyibodi: kuti titenge chithunzicho tiyenera kugwiritsira pa kiyibodi Alt-Shift-G
- Mtundu 4: akanikizire ndi kugwira batani lapanyumba ndi batani la kiyibodi nthawi imodzi
- Kukhudza Kwachikondi: choyamba tiyenera kugwiritsira batani loyambira kenako ndikukhudza zenera kuti tipeze skrini pazenera
- Mtundu wa PaperwhiteZachikondi (2014)Zipangizo ziwirizi zilibe batani lililonse kotero Amazon amayenera kuganizira njira ina yojambulira. Ngati tikufuna chithunzi cha zomwe tikuwona pazenera, zidzakhala zokwanira kusindikiza nthawi imodzi pazenera
- Ulendo wachifundo: Titha kutenga skrini monga mu Paperwhite panthawi imodzimodziyo kukhudza ngodya ziwiri zowonekera pazenera
- Mtsinje wokoma: chithunzicho chimachitika monga paulendowu pogogoda zenera ziwiri nthawi yomweyo
Bwezeretsani kauntala wa nthawi yotsalayo wa bukuli
Chimodzi mwazabwino zoperekedwa ndimabuku ambiri amagetsi pamsika, kuphatikiza Kindle, ndi kutha kuwona nthawi zonse komanso pamene tikuwerenga, nthawi ndi masamba omwe tikufunikira kumaliza bukuli. Kuwonetsa masamba omwe tikufunikira kuti timalize bukulo sizovuta kwenikweni kwa chida chilichonse, koma kuwerengera nthawi yomwe tikufunika kulimaliza sichinthu chophweka.
Kukoma mtima kotiwonetsa nthawi ino kutengera kuthamanga kwa kuwerenga komanso njira zina zomwe palibe amene angazimvetse, kupatula ngati tikuganiza wopanga makina osamvetseka a Amazon. Tsoka ilo, sizimagwiranso ntchito bwino m'ma eBook ena, makamaka omwe amagulidwa kunja kwa Amazon.
Mwamwayi, palibe zovuta zambiri zoyambiranso akauntiyi kuyambira nthawi yomwe tatsala kuti tifike kumapeto kwa bukuli. Kuti tichite izi tiyenera kutsegula makina osakira a Kindle athu kuti ngati simunawagwiritse ntchito ali pamwamba pazenera, ndipo lembani "; ReadingTimeReset" yokhudzana ndi semicolon yoyamba ndi zilembo zazikulu.
Osadandaula kuti palibe uthenga kapena zotsatira zomwe zidzawonekere, chifukwa palibe chomwe chiziwonetsedwa koma kauntala idzasinthidwa, zomwe ndi zomwe timafuna kuchita.
Kodi zina mwa zidulezi zakuthandizani kufinya pang'ono ngati chida chanu cha Kindle chikukwanira?.


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- Ntchito Zokopa Padziko Lonse zimafunikira thandizo ndipo Saudi Arabia ilinso komwe ikusowa pa United States Yokopa alendo, mokometsera mbendera ya Saudi mkulu ndi yotchuka.
- Saudi Arabia ili panjira to kusamutsa UNWTO kuchokera ku Madrid kupita ku Riyadh Kukhala wolandila likulu latsopano la World Tourism Organisation (UNWTO), koma ndiomwe alandila a Bungwe la World Travel and Tourism Council (WTTC) ofesi yamchigawo komanso zochitika zina zingapo padziko lonse lapansi.
- Kenya idayitanitsa nthumwi kumsonkhano womwe ukubwera ku Africa Tourism Recovery Lachisanu kudziko lino la East Africa. Ambiri mwa nthumwizo akuyembekezera kukumana ndi Nduna Yowona Zoyendera ku Saudi Arabia Ahmed Al Khateeb, yemwe ayenera kukhala nyenyezi yowala kwambiri pamwambowu.
Secretary of Tourism ku Kenya, Najib Balala, alinso mtsogoleri wapadziko lonse lapansi omwe akhala akuchita nawo zochitika zambiri padziko lonse lapansi, kuphatikiza a eTurboNews-thandizidwa World Tourism Network ndi Bungwe la African Tourism Board. Pamodzi ndi Minister of Tourism ku Jamaica, Hon. Edmund Bartlett, Balala adapangidwa a Ngwazi Zokopa alendo WTN chaka chatha.
Minister a Tourism ku Jamaica a Bartlett afika ku Kenya ndipo ayankhula pamsonkhanowu ngati mtsogoleri wolemekezeka padziko lonse lapansi pankhani yothana ndi kuchepa kwa ntchito zokopa alendo. Adzakhala akukamba nkhani yake yayikulu pamsonkhano waku Africa.
Ali ku Kenya, Minister wa Jamaica asaina MOU ndi satellite ya Global Tourism Resilience & Crisis Management Center (GTRCMC) ku Kenyatta University pambuyo paulendo wake Lachinayi.
Mtsogoleri wa Kenya Kenyatta akutumikira monga Wapampando Wolemekezeka (woimira Africa) wa GTRCMC limodzi ndi Prime Minister waku Jamaica Andrew Holness ndi a Marie-Louise Coleiro Preca, Purezidenti wakale wa Malta.
Chofunika kwambiri paulendo wa Bartlett ku Kenya kungakhale kupitiliza zokambirana ndi Minister of Tourism ku Saudi Arabia, Ahmed Al-Khateeb, yomwe idayamba mwalamulo mu Juni pomwe msonkhano woyamba wapakati pa Jamaica ndi Saudi Arabia umayang'ana kwambiri za ndalama zakunja kuti zithandizire Kukula kwachuma ndikupanga ntchito zatsopano zakunyumba yake ya Caribbean.
Bartlett ndi Al Khateeb atawoneka ngati gulu losintha, zinali zowonekeratu kuti Saudi Arabia yasintha ndipo ikupitilizabe kusintha mwachangu - mabiliyoni akuthandiza kusintha uku.
Panthawiyo, Minister Al Khateeb adatsogolera nthumwi zapamwamba paulendo wawo waposachedwa ku Jamaica, kuphatikiza omwe adapezekapo, a Abdurahman Bakir, Wachiwiri kwa Purezidenti wa Investment Attraction and Development ku Ministry of Investment ku Saudi Arabia, ndi a Hammad Al-Balawi, General Woyang'anira Investment Management ndi Oyang'anira mu Ministry of Tourism ya Saudi.
Balala, Bartlett, ndi Al Khateeb atha kukhala opambana ndi atsogoleri akumaloko ndi njira yapadziko lonse lapansi yobweretsa chiyembekezo ku Africa komwe kukuvulaza mayendedwe ndi zokopa alendo.
Cuthbert Ncube, Wapampando wa Bungwe la African Tourism Board, komanso wotsogolera Project Hope motsogozedwa ndi Secretary General wakale wa UNWTO Dr. Taleb Rifai, adati: "African Tourism Board ikuyimilira ndipo ndiwokonzeka kuthandizira ndikugwirizanitsa ntchito iliyonse yomwe ingatuluke pazokambirana zofunika izi Kubwezeretsa Ulendo waku Africa Kukhazikika sikofunikira kokha pakukhazikitsanso makampani omwe amafunikira kuyenda komanso zokopa alendo mdziko lathu, komanso kukhazikika ndi chitetezo m'maiko athu ambiri. ”
Mtumiki wa Saudi Arabia Al Khateeb, Yemwe ndi Wapampando wa ndalama zankhaninkhani ku Saudi Fund for Development, awonetsa masomphenya olimbikitsa kukula kwa bizinesi yaku Saudi Arabia padziko lapansi.
Msonkhano Wobwezeretsa Ntchito Zokopa Anthu unachitikira ku Riyadh, Saudia Arabia, mu Meyi chaka chino. Inayang'ana kwambiri pa nyengo yatsopano yomwe zokopa alendo zimalowa ndikufufuza njira zomanganso gawo la zokopa alendo ku Africa lomwe layambitsidwa ndi mliri wa COVID-19.
Msonkhano waku Kenya ukuyembekezeka kuwunika mwayi wamgwirizano pakati pa mayiko aku Africa ndi Kingdom of Saudi Arabia, ndikuchepetsa zovuta za mliriwu ndikulimbikitsa kupirira.


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- Mabwato awiri okwera adakumana ku India.
- Chombo chaching'ono chonyamula anthu chimagundika ku India kugundana.
- Wokwera bwato m'modzi waphedwa pamavuto.
Mabwato awiri onyamula okwera omwe amayenda mbali zosiyana agundana pamtsinje wa Brahmaputra kumpoto kwa mzinda wa Jorhat, womwe uli kumpoto chakum'mawa kwa Assam, India.
Akuti panali anthu opitilira 100 m'mabwatowa, ambiri mwa iwo anali akusowa ndikuopa kufa.
Zithunzi zomwe zikuyenda pa intaneti zikuwonetsa boti lalikulu, lolemera, lomwe limanyamula okwera komanso magalimoto angapo, likuphwanya boti laling'ono lonyamula.
Zing'onozing'ono chombo inagubuduzika atangogundana, ndikupita m'madzi pasanathe mphindi zingapo, kanema wosokoneza yemwe akuwombedwa ndi wokwera pazowonetsa zazikulu za bwato. Anthu adathamanga kutuluka m'chombo chomwe chimamira, katundu wawo akuyandama.
Palibe chidziwitso chazomwe zitha kuwonongeka chomwe chidapezeka nthawi yomweyo.
Zipatso zimagwiritsidwa ntchito poyendera mu India. Ngozi zapamadzi ndizofala chifukwa chodzaza anthu pafupipafupi komanso kusamalira bwino komanso chitetezo.


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Lero tiyenera kukambirana nkhani yosuntha. Aka si koyamba kuti ukadaulo upulumutse moyo wa munthu, koma ana ang'ono atakhala nawo, nkhaniyi ndi yodabwitsa kwambiri. Tonsefe omwe tili ndi ana timadziwa kuti ukadaulo ndi chinthu chomwe amakonda ndipo nthawi iliyonse yomwe angathe, amayesetsa kutero ndi foni yathu kapena piritsi kuti tisangalale ndi makanema a YouTube kapena masewera omwe amakonda. Chochitika chaposachedwa chokhudzana ndi othandizira ma smartphone imatiwonetsa momwe mwana wazaka zinayi zokha adakwanitsira kupulumutsa moyo wa amayi ake chifukwa cha Siri, omwe adalumikiza othandizira.
Monga tikuwonera, Roman wachichepere mnyumbamo adapeza amayi ake atakomoka pansi, ndikuwuza othandizira kuti wamwalira, osapuma. Roman adapereka adilesi yakunyumba kuti mphindi khumi ndi zitatu pambuyo pake ambulansi imatha kupita mwachangu mnyumbayo ndikumutsitsanso mayiyo kuti pambuyo pake amsamutsire kuchipatala. Tiyenera kudziwa kuti umphumphu womwe Roman wachichepere amawonetsa poyankha mafunso onse omwe woyendetsa amayenera kumufunsa modekha kuti adziwe zomwe zikuchitika komanso komwe anali.
Zomwe chochitikachi chikuwonetsanso ife ndikuti kakang'ono kwambiri mnyumba ayenera kuyamba kugwiritsa ntchito ukadaulo mosamala, Zachidziwikire, popeza chifukwa cha iwo atha kupulumutsa miyoyo yathu, monga momwe nkhani yomalizayi ikusonyezera. China chofunikira ndikuti adziwe nthawi zonse nambala yafoni yadzidzidzi, adilesi yakunyumba kwathu ndipo ngati zingatheke nambala yafoni ya makolo kapena omwe akuwasamalira.


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Top 5 Free antivayirasi kuyeretsa HIV ndi gunpoder kuchokera Android foni
Monga umisiri zapita patsogolo kwambiri kuchita hackers amene konse kupeza njira circumvent kachitidwe. Chiwerengero cha hackers ndi pa kuwuka kutanthauza osati kokha kompyuta Intaneti komanso mafoni ogwiritsa ayenera kukhala osamala wa asamale ndi awa hackers. Virus ndi gunpoder ndi ambiri njiru kuukira zachilendo android mafoni. M'nkhaniyi tiona tione zina zabwino antivayirasi ntchito kuti ntchito mwapadera bwino android foni ya Intaneti
- Avast Mobile Security
- Wotchipa poyerekeza ena mapulogalamu
- Iwo ali wasenza mbali
- Sagwira ntchito bwino wakale mafoni
- 360 chitetezo Anti-kachilombo
- Ndi ufulu
- Kodi kuyeretsa onse owona anatsala wakale mapulogalamu
- Lilinso ndi deta polojekiti
- Ndi ankhanza pa angathe kumuopseza
- Iwo akhoza m'mbuyo wakale mafoni
- AVG antivayirasi
- Ndi ufulu
- iwo ali zambiri mbali
- Timatha app loko, app kubwerera kamodzi ndi SIM loko
- Izo si yapafupi kugwiritsa
- Iwo amapereka pamwamba chitetezo kwa Stock Android msakatuli koma osati mochuluka ena asakatuli
- Bitdefender antivayirasi
- yosavuta kugwiritsa ntchito
- Ntchito bwino wakale android mafoni
- Iwo amapereka kwambiri chitetezo
- Iwo ali yosavuta mbali
- McAfee Mobile Security
- Free
- Easy Kugwiritsa Ntchito
- Ilo liri ndi mbali
- Iwo amadya zambiri mphamvu
Avast ndi kampani wapanga mbiri mu PC dziko ndipo izo zikuwoneka ngati iwo ali kuchikhomera pansi pa mafoni dziko. Izi antivayirasi amapereka wasenza mbali kwa owerenga kuyambira watetezeka yaumbanda kwa odana ndi kuba functionalities. Ndi avast, chitetezo cha zipangizo kwapangidwa chachikulu anapatsidwa kuti app imapereka ukonde chishango, maukonde bwana ndi pulogalamu bwana kugula android owerenga pamwamba chitetezo. Mu ufumu wa odana ndi kuba, pulogalamuyi amalola owerenga younikira, pezani ndi kusintha kubedwa zipangizo paradaiso. Ngakhale zikuphatikizapo makhoma oteteza masanjidwe kwa mizu android Intaneti. The kukongola kuti ntchito kwambiri angakwanitse-mmodzi angathe kutenga utumiki mbali pa $ 15 pa chaka.
Ubwino:
Kuipa:
Ili ndi umodzi chida kuti lakonzedwa kuti aziyankha chipangizo imathamanga pamene kusasamala pa chilichonse yaumbanda kuti mwina kupatsira ake dongosolo. Kumbali ya liwiro, pulogalamuyi ndi bwino kukonza mmwamba zonenepetsa owona ngati posungira owona ndi RAM. The chida lili mulingo woyenera chitetezo mwa kupanga sikani yokumbukira malo ndi mapulogalamu ndi ambiri kwa tsiku magwiridwe. Zilibe ndi chidwi odana ndi kuba mbali limodzi ndi zachinsinsi kuteteza zofunika deta owona kuti kufika ndi wosaloleka anthu.
Ubwino:
Kuipa:
AVG chinanso antivayirasi imene yakhala Linatithandiza mu PC msika chifukwa cha khalidwe la misonkhano izo amapereka kwa PC Intaneti. Mu android dziko ake kapamwamba wakhalanso anapereka kwambiri ndi ntchito kuti oveteredwa pakati yabwino antivayirasi mapulogalamu m'dzikoli. Choncho, chimene kuti izi app kwambiri pochikhumba? Chinthu choyamba chomwe wokongola ndi kuti ufulu tanthauzo kuti inu mosavuta kulumikiza izo popanda ndisunse mu matumba mwathu. Ndi multifunctional app amene amapereka chitetezo ngakhale imathandiza kwa njiru mapologalamu mapulogalamu ndi mu ukonde. Pulogalamuyi makamaka kwambiri zinchito popereka ukonde chitetezo monga lakonzedwa kuti aone Websites ndi maulalo kwa kumuopseza. Pamwamba pa izi, pulogalamuyi Inunso zabwino kupereka anzeru odana ndi kuba mbali kuchepetsa mwayi inu kutaya zinthu zanu zachinsinsi pa foni kuba. Izi kuiwala kuti app chilinso mbali kuti athe Intaneti sintha chitetezo pa foni deta monga app maloko pakati ena.
Ubwino:
Kuipa:
Tsopano, ngati inu simuli kompyuta novice, ndiye bitdefender si chatsopano mawu kwa inu. Ngati yotsirizira zakale, izi antivayirasi amadziwika PC owerenga ndipo anakafika madera kwa android m'manja. Antivayirasi ndi wotchuka chifukwa chake yosavuta kugwiritsa ntchito mawonekedwe kuti amalola ngakhale newbies kuyenda mosavuta. Zilibe naperewera zimaonetsa kuti izo amapereka pazipita yaumbanda chitetezo ndi zodziwikiratu dongosolo mapanga sikani kuphatikiza izo ali odana ndi kuba ndi zachinsinsi mbali. Komanso kukupatsani chitetezo asakatuli monga Chrome, zisudzo mini pakati ena
Ubwino:
Kuipa:
Ili ndi antivayirasi kuti wakhala bespoke sanangopeka kupereka munthu amasiya shopu zake owerenga m'lingaliro kuti ali ndi mndandanda wa functionalities. Ndi chida chomwe aone pafupifupi kulikonse mkati foni kunja kwa inu ndi chitetezo inu amakhumba kuti. Pulogalamuyi ali ndi chida chomwe zosavuta kusamalira chitetezo mthupi limodzi lokha malo. Komanso chimathandiza pa odana ndi kuba mbali ndi zachinsinsi-ali khumi ndi awiri a ziwiri blended pamodzi zothetsera kupeza chitetezo Intaneti chosonyeza.
Ubwino:
Kuipa:
Nsonga kusapita malwares
Kupewa yaumbanda matenda tiona zinthu zina mungathe kuchita:
- Kukhazikitsa ndi antivayirasi-Chinthu choyamba muyenera kuchita ndi kuonetsetsa kuti muli ndi antivayirasi kuti zingakuthandizeni kugwiritsa ntchito chitetezo ntchito foni yanu.
- Muyenera kufufuza bwinobwino zimene mukufuna download. Komanso kukopera zinthu kuchokera anakhulupirira magwero. Mwachitsanzo, mukhoza kukopera mapulogalamu anu ku mapulogalamu magwero osati gulu lina Intaneti.
- Ntchito atsopano Android Version-Izi ndi kuonetsetsa kuti muli ndi Os kuti atakhazikitsa aliyense nsikidzi mwina ntchito molakwika ndi njiru zida ndi anthu.
Wondershare SafeEraser - Kuteteza Nokha Information
- Kalekale kufufuta Anu Android & iPhone
- Chotsani fufutidwa owona pa iOS zipangizo
- Chotsani wamba Data pa iOS zipangizo
- Free Up Space ndi kufulumizitsa iDevices
- Support iPhone (iOS 6.1.6 ndi apamwamba) ndi Android zipangizo (kuchokera Android 2.1 kuti Android 6.0).


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3D Video
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2 3D Video Mlengi
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3 3D Video Player
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4 3D Video Converter
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5 2D kuti 3D
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6 3D Movie
Kusewera 3D Movies ndi VLC
VLC Ndithu wotchuka kanema wosewera mpira, chifukwa chake chomasuka ntchito ndi kusinthasintha. Ndi lotseguka gwero pulogalamu akuthamanga ena ambiri kanema akamagwiritsa, kuphatikizapo .flv, mmene mtundu inu mudzapeza pa Vimeo ndi YouTube. Mukhoza kugwiritsa ntchito ndi osavuta zosintha kusewera mafilimu mu 3D.
Amalangiza Mankhwala
Amamasula Anu Music - Transer, Download, Record, bwana, M'moto Music Chida
- Kusamutsa nyimbo pakati aliyense zipangizo.
- Ntchito iTunes ndi Android.
- Koperani nyimbo YouTube / ena nyimbo Intaneti.
- Downlaod nyimbo anamanga-pamwamba playlists.
- Kulemba nyimbo kapena playlist mungapeze pa intaneti.
- Kukonza nyimbo Tags, chimakwirira ndi winawake Zobwerezedwa.
- Sinthani nyimbo popanda iTunes malamulo.
- Mwangwiro kubwerera kamodzi / kubwezeretsa iTunes laibulale.
- Pangani wanu mwambo mixtape CD mosavuta!
- Professional nyimbo wosewera mpira / nyimbo nawo chida.
Apa mmene kusewera 3D mafilimu pa VLC. Yambani ndi kutsegula VLC wosewera mpira, ndiye n'kosavuta Zida pa mlaba wazida.
Kenako, alemba pa Zotsatirapo ndi Zosefera. Kuyambira menyu, alemba Video Zotsatirapo.
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text:
UTHENGA OCHOKERA KU MEC
Uthenga wochokera kwa wa pampando wa bungwe loyendetsa zisankho la Malawi Electoral Commission, Justice Dr. Chifundo Kachale
Moni a Malawi anzanga.
Ndikuthokoza Mulungu chifukwa chotipatsa nthawi yabwino ino kuti tikambirane nkhani zokhudza kuponya voti pa zisankho zapadera zomwe zichitike lachiwiri pa 10 November, 2020 ku madera awa:
• Karonga Central Constituency
• Lilongwe North West Constituency
• Makhwira South Ward ya ku Chikwawa East Constituency
Pachifukwa chimenechi ndikufuna kupereka uthenga wapedera ku dziko lonse, makamaka anthu amene ali m’madera omwe muchitike chisankho chapaderachi. Ndondomeko yonse ili motere:
Ndondomeko yoponyera voti
Malo oponyera voti adzatsegulidwa nthawi ya 6 koloko m’mawa ndikutsekedwa 6 koloko madzulo. Ngati pofika nthawi yotseka padzakhalebe anthu pa mzere, amenewo adzaloledwa kuponya voti, sadzabwezedwa.
Bungwe loyendetsa zisankho likukumbutsa anthu onse kuti, popita kukavota ndikoletsedwa kuvala, kunyamula kapena kupachika makaka aliwonse a chipani kapena a opikisana nawo pa chisankho. Mkulu oyang’anira malo oponyera voti wapatsidwa mphamvu mwa lamulo yochotsetsa wina aliyense opezeka atavala makaka a chipani ngati munthuyo sakuchotsa yekha. Amene adzapite kovota atavala za chipani adzabwezedwa kuti akasinthe ndi kubweranso bwino.
Mukafika kumalo oponyera voti mudzakhala pa mzere. Malo onse oponyera voti komwe kuli anthu oposera 1,000 m’kaundula adzakhala ndi mizere yoposera umodzi. Chonde kaonetsetseni kuti mwayima pa mzere oyenera. Ngati muli ndichikaiko, funsani oyendetsa chisankho kuti akulozereni mzere woti muyime. Nthawi yanu ikafika kuti mukaponye voti, ngati njira imodzi yopewera mlili wa Covid-19, zasambeni m’manja ndi sopo pamalo osambira m’manja omwe bungwe loyendetsa zisankho layika pafupi ndi tebulo loyamba.
Mukafika pa kalaliki woyamba adzakupemphani kuti muonetse chiphaso chanu chovotera. Pofuna kupewa ndi kuchepetsa kufalikira kwa matenda a korona, chiphaso chanucho muzangomuonetsa kalalikiyu ndipo iyeyu adzawerenge chili m’manja mwanu. Kenako kalaliki adzayang’ana dzina lanu mkaundula wavoti. Dzina lanu likadzapezeka mkaundula wavoti, kalalikiyo adzayitana dzina lanu mokweza kuti anthu onse pamodzi ndi oyimira zipani adziwe amene akukavota.
Pamenepo mudzapita pa kalaliki wachiwiri pamene mukabviike chala chanu chankomba phala chakumanja mu inki ndi kupukuta bwinobwino. Inki imeneyi siyowopsya ku moyo wa munthu ndipo ndi chizindikiro chakuti munthu waponya voti.
Mukatero mudzapita pa kalaliki wachitatu pamene akakupatseni pepala lovotera (ballot paper). Ogwira ntchito ya chisankho adzakufotokozerani ndondomeko ya kavotedwe komanso kukuuzani mayina a anthu amene akupikisana nawo pa chisankho. Kuchoka apa mudzapita mu kachipinda komata m’mene mukakhalemo nokha kuti mukasankhe opikisana nawo wa ku mtima kwanu.
Kusankha opikisana nawo pa chisankho
Kuponya voti ndi kwa chinsinsi kotero musaope kapena kuopsyezedwa kuti mudzasankhe munthu amene simukumufuna. Posankha munthu mudzakhala nokha mu kanyumba komata ndipo palibe amene adzadziwe amene mwamusankha.
Kuti musankhe opikisana nawo muyenera kuchonga mu kabokosi kali kumanja kwa chizindikiro cha munthu amene mukumufuna. Onetsetsani kuti chochonga chanu chisatulukire kunja kwa bokosi limeneli. Ngati simungachonge muyenera kudinda ndi chala mkati mwa bokosi limeneli. Onetsetsani kuti musalipake inki pepala limeneli malo ena kupatulapo pamene mwadindapo. Ngati mwangozi inki yapakika malo ena osati amene mumafuna, dziwitsani ogwira ntchito pamalowo kuti akupatseni chipepala china chovotera ndipo choonongekacho muzabweza.
Mukasankha munthu amene mukumufuna, pindani pakati pepala la voti kuonetsetsa kuti mbali yovotera ili mkati. Pindaninso kachiwiri kenako ndi kukayiponya mu bokosi loponyera voti. Mukatero mwamaliza ndondomeko yonse yovota, sambaninso mmanja ndi sopo ndipo nyamukani mudzipita kunyumba kuti mukadikire zotsatira. Simukuloledwa kucheza kapena kumangozungulira pamalo oponyera voti.
Dziwaninso kuti ndikulakwira malamulo kuwulula munthu amene mukufuna kumuvotera kapena mwamuvotera chifukwa voti yanu ndi yachinsinsi. Simukuyeneranso kuonetsa kapena kupanga zizindikiro zoonetsa chipani chimene mumachikonda kapena opikisana nawo pa chisankho amene mumamukonda.
Komanso ndikulakwira lamulo kuwumiriza kapena kunyengerera munthu kuti awulule munthu amene wamuvotera. Aliyense akupemphedwa kuti adziwe za lamulo limeneli.
Kaponyedwe ka voti kwa olumala
Anthu onse olumala adzathandizidwa mwachangu ndipo sakuyenera kuyima nawo pa mzere. Anthuwa akafika pamalo oponyera voti akuyenera akadzionetse kwa oyendetsa chisankho amene adzawathandize kukawakhazika patsogolo.
Chimodzimodzinso kwa amayi oyembekezera, anthu okalamba ndi odwala onse adzathandizidwa msanga. Kwa anthu olumala amene amayenda panjinga asade nkhawa popeza adzathandizidwa kuti aponye voti popanda kutsika pa njinga zawo. Chisankho chikachitikira pabwalo choncho akatha kufikira ndondomeko yonse ya chisankho popanda kufunika kutsika pa njinga.
Kwa olumala m’njira zosiyanasiyana monga kumva kapena kupenya: lamulo likuti anthu oterewo adzabwere ndi munthu amene akumukhulupirira komanso akhale wakuti analembetsa nkaundula wa voti. Munthu ameneyu ndi amene adzawathandize kuponya voti. Ngati sabwera ndi munthu owathandiza, lamulo limanena kuti: mkulu woyang’anira chisankho pa malopo atha kumuthandiza munthu oteroyo.
Pamenepa ndikupempha ma “monitala” onse kuti adzathe kumvetsetsa ndi kutsatira zimene lamulo limanena. Nthawi zina pamakhala kusamvetsetsa kukabwera munthu otereyo chifukwa ma monitala amafuna kuti akaone nawo kuti akumusankhira molondola kapena ayi. Izi zimafafaniza chinsinsi chavoti ndipo ndizoletsedwa m’malamulo.
Pambali pa zimene malamulo akunena, bungwe loyendetsa zisankho lapanga chikombole chomwe chidzathandize kuti anthu amene ali ndi vuto lopenya avote osathandizidwa ndi munthu wina. Pogwiritsa nchito chikombole chimenechi anthu osaona adzatha kusankha wopikisana nawo pa chisankho wakumtima kwawo pogwiritsa ntchito zala zawo. Anthu awa akadzafika polandira mapepala ovotera, kalaliki adzawapatsanso chikombole chimenechi ndi kuwafotokozera m’mene angakagwiritsire ntchito kuti avote. Akatero adzatsogoleredwa kukanyumba komata komwe adzakasankhe munthu wa kumtima kwawo mwa iwo wokha.
Ngati chiphaso cha voti chatayika kapena kuonengeka
Aliyense okavota akupemphedwa kuti adzakumbukire kunyamula chiphaso chovotera. Kwa amene adataya ziphaso zawo, kaya kubedwa, kaya kuonongeka, kapena kulandidwa, ali ololedwa kuponya voti ku malo amene adalembetsera mayina awo mkaundula wa voti.
Akakafika pamalo ovotera ayenera kukadziwitsa oyendetsa chisankho kuti anataya chiphaso chawo. Pamenepo dzina lawo lidzafufuzidwa mkaundula wavoti. Ngati lapezeka adzaloledwa kuvota. Ngati dzina lawo lasowa, sadzaloledwa kuponya voti chifukwa umboni owonetsa kuti analembetsa palibe.
Chitetezo pa malo oponyera voti
Bungwe la MEC lakhazikitsa chitetezo chokwanira. Kumalo onse oponyera voti kudzakhala a Polisi omwe ntchito yawo ndi kusungitsa bata ndi mtendere, pamene chisankho chikuchitika.
Ndichenjeze wina aliyense amene angakhale ndi maganizo ofuna kusokoneza zisankho pamene zili mkati; A Polisi adzakhala tcheru ndipo adzathana ndi wina aliyense oyambitsa ziwawa.
Pempho kwa atsogoleri
Mafumu ndi atsogoleri onse muli ndi udindo waukulu olimbikitsa anthu anu kuti adzapite kukaponya voti kuti adzasakhe munthu owayimirira.
Mafumu ndi atsogoleri amipingo musakondere chipani kapena wina aliyense amene akupikisana nawo pa chisankho.
Kwamakolo ndi aphunzitsi alimbikitseni ana anu omwe analembetsa kuti adzaponye voti yawo, pakuti ichi ndicho cholinga cholembetsera mkaundula wa voti.
Kwa olemba ntchito, ndikupempha mudzawalore anthu anu onse amene adalembetsa mkaundula kuti apite akaponye voti yawo monga njira imodzi yokwaniritsira ufulu wawo.
Pempho la bata ndi mtendere
Ndikulimbikitseni aMalawi amzanga kuti tisunge bata ndi mtendere pomwe mavoti adzakhale akuwerengedwa komanso zotsatira kuwulutsidwa. Ngati munthu adzakhale ndi dandaulo lirilonse lokhudzana ndi chisankho kaliperekeni kwa mkulu oyendetsa chisankho pa malo a voti omwe muli nao pafupi kapena kwa Bwana
Mkubwa wa boma lanu. Iwowa adzakuthandizani moyenera ndithu.
Kuwerenga mavoti
Kuwerengera mavoti kudzayambika nthawi imene kuponya mavoti kwatha. Palibe bokosi limene lidzachoke pa malopo lisanawerengedwe. Oyendetsa chisankho pa malowo ndi anthu okhawo amene adzaloledwe kuwerengera mavoti, ma monitala adzakhalepo panthawiyi kuti adzaonenerere kuwerenga kwa mavotiko.
Dziwani kuti mzere uli onse udzawerengera mavoti paokha ndipo pomaliza mkulu woyendetsa chisankho pa mzere umenewo adzanyamula zotsatira ndi kukapereka ku ofesi ya kwa Bwana Mkubwa wa boma limenelo.
“Monitala” aliyense ayenera kutsimikizira zosatira zonse za pa malopo posayinira ndipo ayenera kukhala ndi zotsatira zofanana ndizomwe zidzatumizidwe ku malo owonkhetsera mavoti. Zotsatirazi adzadzikhoma pamalo pamene voti inachitikira kuti anthu onse adzathe kuona momwe voti yayendera pa malo pamenepo.
Ndipemphe azipani ndi omwe akuyima nawo pazisankhozi kuti awayang’anire mamonitala bwino lomwe kuti adzadzipereke powagwirira ntchitoyi. Ma “monitalawa” alimbikitsidwe kuti asadzachoke pa malo oponya mavotiwa mpaka zotsatira zonse zitawerengedwa ndikusayinidwa. M’mbuyomu taonapo ma “monitala” akuchoka pamalo oponya mavoti pachifukwa choti munthu wawo sakuchita bwino pa chisankhocho. Titsindike kuti siudindo wa “monitala” kupambanitsa opikisana nawo, koma ntchito yake ndi kuonetsetsa kuti zonse zikuyenda mwa dongosolo.
Bungwe loyendetsa chisankho likuyembekeza kuti lidzaulutsa zotsatira lachitatu pa11 November, 2020 zonse zikayenda bwino.
Kupewa matenda a Covid 19
Bungwe loyendetsa zisankho likukumbutsa anthu onse kuti mlili wa
Covid 19 udakalipobe. Chonde pamene mukupita kukavota lachiwiri lino pa 10 November onetsetsani kuti mukutsatira ndondomeko zonse zodzitetezera kutenga ka chirombo ka korona. Njira zake nazi;
• Popita koponya voti onetsetsani kuti mwavala mask kapena chotchinga pakamwa ndi pamphuno. Ngati kuli kotheka zatengeni mankhwala opaka mmanja, kapena kuti hand sanitizer. Komanso ngati nkutheka tengani cholembela chanu.
• Mukafika pa malo oponyera voti onetsetsani kuti mwayima motalikirana mikono iwiri ndi ena. Musapereke moni wa pa manja pamene mwakumana ndi achibale kapena anzanu.
• Pa malo a voti pakakhala madzi osamba m’manja komanso sopo. Mukasamba m’manja onetsetsani kuti mwaumitsa bwinobwino.
• Chiphaso chanu musadzapereke kwa woyendetsa chisankho koma mudzamuonetse ndipo adzawerenge dzina lanu ndi kuona nkhope yanu mutachigwira nokha chiphasocho.
• Onetsetsani kuti pali mpata okwanira pakati pa inu ndi ogwira ntchito ya chisankho komanso oyang’anira chisankho.
• Mukaponya voti yanu kumbukirani kusamba m’manja.
Mulungu akudalitseni pomwe mukukaponya voti yanu la chiwiri lino pa 10 November, 2020.


text:
Mumakonda chokoleti? Ndi strawberries? Ndiye tili ndi kuphatikiza kwabwino. Froberries ndi zokutira za chokoleti okonda kwambiri. Ndipo ndichoncho ngati mukuganiza zopatsa mchere koma nthawi yomweyo zachikondi komanso zosintha makonda anu usiku wa Tsiku la Valentine, iyi ndi njira yomwe mungakonde kwambiri. Ndikukuwonetsani zina malingaliro owonetsera, koma mukudziwa kale…. Maganizo ku mphamvu !! Sakanizani ma chokoleti achikuda, chokoleti cha mkaka, zoyera kapena zoyera, ndikupanga mawonekedwe omwe mukufuna. Ngati mungayerekeze kuyika makalata, zonse ndizotheka.
Sangalalani ndi malingaliro achikondi awa pa Tsiku la Valentine !!
Mu Recetin: Msuzi wa chokoleti wa Tsiku la Valentine


text:
3 zosavuta kuti Muzu Nexus 6
Zifukwa muzu Nexus 6
Kwenikweni chodabwitsa kukhala Nexus 6 pafupi, osati ntchito ngati foni kuti mafoni, lemba anzake, komanso ngati piritsi masewera, kuwerenga eBooks, ngakhale view zikalata ntchito. Komabe, ngati simunakhala mizu yanu Nexus 6, mwina sadzaloledwa yochotsa chisanadze anaika mapulogalamu pa izo, kwabasi aliyense app mukufuna, kukhazikitsa atsopano kapena wokondedwa wanu Android Mabaibulo ndi aziyankha batire moyo.
Kodi kuchotsa Nexus 6
Chifukwa tangotchulawo zifukwa, mungafune kuchotsa Nexus 6. Zedi, pali kusagwirizana njira kuperekedwa pa Internet kuti inu muchite Nexus 6 rooting. Komabe, ambiri a iwo akuchita muzu kudzera lonyezimira latsopano AROMA anu Nexus 6, umene anu Nexus 6 mu ngozi, ninga bricked ndi kupewa chitsimikizo. Pamaso rooting wanu Nexus 6, inu mukuyenera kuganiza kawiri. Ine ndikhoza amati mumayesa otetezeka njira muzu Nexus 6 - ntchito imodzi-pitani Muzu Mbali Wondershare MobileGo. Pogwiritsa ntchito izo, inu sadzataya deta yanu pa Nexus 6, ika Nexus 6 mu njerwa, kapena Muyesa achabe ake chitsimikizo. Ndipo yekha amatenga inu 3 zosavuta kuti muzu Nexus 6. Fufuzani kunja zotsatirazi:
Gawo 1. Download MobileGo anu Mawindo PC ndi kukhazikitsa. Pakali pano, MobileGo amangogwira ntchito pa Mawindo ntchito dongosolo lawo PC. Ngati inu ntchito Mac, muyenera ntchito mu pafupifupi Mawindo opaleshoni dongosolo wanu Mac. Pambuyo ndiye, kuthamanga yomweyo.
Gawo 2. Ntchito USB chingwe kulumikiza wanu Nexus 6 ndi kompyuta. Kuti pulogalamu azindikire wanu Nexus 6, muyenera chimathandiza USB debugging wanu Nexus 6: Zikhazikiko> About foni> wapampopi kumanga nambala 7 zina. Mu Wolemba Mapulogalamu Mungasankhe, kuyatsa USB debugging ndi kumadula bwino. Pamene chikugwirizana bwino, mukuona windo la MobileGo zikuwoneka ngati chithunzi m'munsimu. Kapena mungayesere kulumikiza wanu Nexus 7 ndi MobileGo kudzera Wi-Fi.
Gawo 3. dinani 'Mmodzi-Dinani Muzu' batani kumanja pa zenera, kulola MobileGo kuchita Nexus 6 rooting kwa inu. Mu Pop-mmwamba zenera, alemba "Chabwino" kutsimikizira rooting. Kudzatenga inu maminiti pang'ono kuti muzu Nexus 6. Musadandaule! Monga kuleza mtima ndi khalani Nexus 6 chikugwirizana ndi kompyuta pa Nexus 6 rooting ndondomeko.
Onani mmene yosavuta ndi kuchotsa Nexus 6. Bwanji kukopera MobileGo kuyesa wekha.
Nkhani
Mankhwala a mafunso? Wolankhula wathu Support Team >>


text:
Sangakhoze kugula MP4 mu Final Dulani ovomereza? Anatsimikiza
MP4 Akonzi & Kutembenuka
- 1 MP4 Akonzi
-
- 1.1 MP4 kuti DVD Burner
- 1.2 Free Online avi kuti MP4 Converter
- 1.3 Free YouTube kuti MP4 Converters
- 1.4 MP4 kuti YouTube Converter
- 1.5 kung'anima kwa MP4 Converters
- 1.6 MP4 kuti gif Converters
- 1.7 MP4 kuti MP3 Converters
- 1.8 gif kuti MP4 Converter
- 1,9 SWF kuti MP4 Converter
- 1,10 Free MP4 kuti MP3 Converters
- 1,11 MP4 osema miyala / Splitters
- 1,12 MP4 Trimmers
- 2 MP4 Kutembenuka
-
- 2.1 Mukamawerenga avi kuti MP4
- 2.2 Mukamawerenga MOV kuti MP4
- 2.3 Mukamawerenga VOB kuti MP4
- 2.4 Mukamawerenga MP4 kuti VOB
- 2.5 Mukamawerenga DAT kuti MP4
- 2.6 Mukamawerenga MP4 kuti iPhone
- 2,7 Mukamawerenga MPG kuti MP4
- 2.8 Mukamawerenga MP4 kuti WAV
- 2.9 Nchito Mukamawerenga AVCHD kuti MP4
- 2,10 Convert MP4 kuti MOV
- 2,11 Mukamawerenga VRO kuti MP4
- 2,12 Convert Wmv kuti MP4
- 2,13 Convert nkhanza kwa MP4
- 2,14 Mukamawerenga VLC kuti MP4
- 2,15 Mukamawerenga MTS kuti MP4
- 2,16 Convert MP4 kuti avi
- 2,17 Convert DVR kuti MP4
- 2,18 Convert MXF kuti MP4
- 2,19 Convert M2TS kuti MP4
- 2,20 Convert MP4 kuti FCP
- 2,21 Convert MP4 kuti 3GP
- 2,22 Mukamawerenga WLMP kuti MP4
- 2,23 Convert MP4 kuti QuickTime MOV
- 2,24 Convert MP4 kuti Wmv
- 2,25 Convert MPEG kuti MP4
- 2,26 Convert MP4 kuti MKV
- 2,27 Convert MP4 kuti SWF
- 2,28 Convert M4V kuti MP4
- 2,29 Convert MP4 kuti M4V
- 2,30 Convert RMVB kuti MP4
- 2,31 Convert MP4 kuti iPad
- 2,32 Convert TS kuti MP4
- 2,33 Convert MP4 kuti iTunes
- 2,34 Convert MP4 kuti iPod
- 2,35 Convert Mawindo Movie Mlengi owona kuti MP4
- 2,36 Mukamawerenga mtsinje kuti MP4
- 2,37 Mukamawerenga BDMV kuti avi, MP4, MOV
- 2,38 Convert MP4 kuti XviD
- 2:39 Convert MKV kuti MP4
- 2,40 Convert MP4 kuti M4V
- 2,41 Mukamawerenga MSWMM owona kuti MP4
- 2:42 Mukamawerenga WTV kuti MP4
- 2,43 Convert MP4 ndi DVD Player
- 2,44 Convert MP4 kuti OGV
- 2,45 Convert flv kuti MP4
- 2,46 Convert HDV kuti MP4
- 2,47 Convert ASF kuti MP4
- 2,48 Convert MP4 kuti flv
- 2,49 Convert 2D kuti 3D MP4
- 2,50 Mukamawerenga yamakono kuti MP4
- 2,51 Convert MP4 kuti WebM
- 2,52 wotembenuka MP4 kuti MPEG / MPEG-1 / MPEG-2
- 2,53 Convert MPEG / MPEG-1 / MPEG-2 MP4
- 2,54 Convert MP3 kuti MP4
- 2,55 Convert VHS kuti MP4
- 2,56 Mukamawerenga IFO kuti MP4
- 2,57 Convert MP4 kuti MP4
- 2,58 Convert FLAC kuti MP4
- 2,59 Convert OGG kuti MP4
- 2,60 Convert MP4 kuti MPG
- 2,61 Convert MP4 kuti OGG
- 2,62 Convert MP4 kuti WebM
- 2,63 Convert MP4 kuti WMA
- 2,64 Convert VIDEO_TS kuti MP4
- 2,65 Mukamawerenga ARF kuti MP4
- 2,66 Mukamawerenga F4V kuti MP4
- 3 MP4 Nsonga & ndale
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- 3.1 Add SRT kuti MP4
- 3.2 Mukamawerenga ISO kuti MP4
- 3.3 Mukamawerenga iPhone Video MP4 kuti
- 3.4 wanga MP4 Fayilo Ali No Sound
- 3.5 Kodi MP4 mtundu
- 3.6 MP4 owona pa Xbox 360
- 3,7 kuchepetsa kukula kwa MP4
- 3.8 Sinthani wanga MP4 ndi kuyamba Adobe
- 3,9 Njira kuphatikiza / Combile MP4
- 3,10 iMovie Mfundo MP4 owona
- 3,11 Njira Zungulirani MP4
- 3,12 kulimba Tengani ndi katundu MP4
- 3,13 MP4 wolemba
- 3,14 Add MP4 zambiri zazidziwitso
- 3,15 Mfundo MP4 kuti WMM
- 3,16 Mfundo MP4 Video mu Adobe kuyamba ovomereza
- 3,17 kutentha MP4 pa Mawindo DVD Mlengi
- 3,18 Convert MP4 kuti iDVD kapena DVD
- 4 MP4 Resource & Download
Kodi chomaliza odulidwa ovomereza thandizo MP4? Kwenikweni, izo zinanenedwa kuti Final Dulani ovomereza amathandiza MP4, H.264, nkhanza, HDV, 3GP, etc. Ngati inu simungakhoze poyera ndi Sinthani MP4 owona pa Final Dulani ovomereza, izo zikhoza kukhala mtundu codec nkhani. Kuti vuto lanu, muyenera kupeza chida champhamvu chimene zakonzedwa kuti zithandize Final Dulani ovomereza.
Part 1: Best MP4 kuti Final Dulani ovomereza Converter
Kodi kutembenuza mavidiyo ndi MP4 kuti Final Dulani ovomereza Converter
The phunziro ili m'munsiyi zachokera Mac Os (Yosemite m'gulu). Ngati mukufuna kanema Converter kwa Mawindo (Mawindo 10 m'gulu), kungodinanso pano.
1. Add MP4 mavidiyo
Kachitidwe MP4 kuti FCP Converter. Dinani "Fayilo"> "Katundu Media owona ..." menyu kutsegula wanu MP4 mavidiyo kapena mwachindunji litenge ndi kusiya wanu MP4 owona mu pulogalamu ya pane. Pambuyo importing bwinobwino, mukhoza kudziwiratu zimene zidzachitike MP4 mavidiyo mwa kuwonekera kanema tizithunzi, kapena adzathe kukonza mavidiyo amenewa ndi mtima wonse kukokera chandamale kanema ku malo mukufuna.
Dziwani izi: Ngati owona ali segmented ndipo mukufuna kuphatikiza pamodzi mu chachikulu pamaso panu kuitanitsa owona mu FCP, pa nthawi ino, inu mukhoza kusinthana pa "kuphatikiza" lophimba pansi. Yomweyo, padzakhala unyolo pakati iwiri iliyonse mavidiyo.
2. Sankhani FCP monga linanena bungwe mtundu
Izi app atakupatsani wokometsedwa kwa mtundu FCP mu mtundu zenera, komanso ProRes, apulo Zokhwimirapo Codec ndi DNxHD options. Apa, mukhoza mwachindunji kusankha wokometsedwa preset monga linanena bungwe mtundu. Inde, mukhoza kusankha mbadwa codec kuti encode kompyuta kuti kusintha mu FCP.
Basi dinani pansi muvi batani pansi pa ichi pane kutsegula ake linanena bungwe mtundu zenera. Ndiye upite "Mukusintha" gulu> "Final Dulani ovomereza" kapena kusankha wina ProRes, apulo Zokhwimirapo Codec ndi DNxHDthe options.
3. Start MP4 kuti FCP kutembenuka
Pamene zonse zichitike, dinani "Mukamawerenga" batani pansi-pomwe ngodya kutsiriza kutembenuka. Mukudikira, ndi khofi kapena kutenga pang'ono ndiponso tiyeni Video Converter kuchita ntchito chapansipansi. Pambuyo kutembenuka, izi app mafano adzasunga kulumpha pa Dock.
Tsopano, inu mukhoza kuitanitsa linanena bungwe owona kuti Final Dulani ovomereza kusintha popanda vuto lirilonse. Ndipo linanena bungwe kanema sadzakhala kuchepa mu kanema khalidwe. Ndipo linanena bungwe njira kale amene ali pansi waukulu mawonekedwe. Mukhoza mwamsanga ndipo mosavuta kupeza linanena bungwe owona malinga ndi wapamwamba njira. Inde, mungathe kusintha wapamwamba njira wekha ngati kufunika.
Video Chitsanzo: Kodi kutembenuza MP4 kuti Final Dulani ovomereza ndi Video Converter Ultimate
Part 2: Free MP4 kuti Final Dulani ovomereza Converter
# 1. Free Video Converter: Wondershare Free MP4 Converter
Ndi ufulu kanema Converter kwa Final Dulani ovomereza, inu mosavuta kuitanitsa MP4 kuti Final Dulani ovomereza.
Ovomereza: Free, palibe owonjezera mlandu, mwachilengedwe mawonekedwe
Kuipa:
1. Ilibe presets kwa Final Dulani ovomereza. Inu simungakhoze atembenuke mwachindunji FCP.
2. Muyenera kusamala linanena bungwe kanema khalidwe.
3. Iwo salola inu kutentha DVD.
Chigawo 3: Online MP4 kuti Final Dulani ovomereza Converter
Mukhoza kugwiritsa ntchito ufulu Intaneti kanema Converter m'munsimu. Iwo otembenuka mavidiyo pafupifupi mtundu uliwonse.
Dziwani izi: Ndikufuna kuthetsa Video yako zosagwirizana nkhani efficiently ndi bwino? Basi kuyesa Video Converter Ultimate.
Kuwerenga Zipangizo
Nkhani
Mankhwala a mafunso? Wolankhula wathu Support Team >>


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Pazambiri zokhudzana ndi malonda athu kapena pricelist, chonde tisiyeni imelo yathu ndipo tidzalumikizana patatha maola 24.
Yiwu Sansandeng Trading Co, Ltd ili ku Yiwu City, m'chigawo cha Zhejiang, China. Ndife kampani yogulitsa mafakitale. Timakhala ndi mayendedwe abwino oyendera. Zogulitsa zathu zonse zimapangidwa ndi zida zapamwamba komanso njira zosamalitsa za QC kuti zitsimikizire kwambiri. Tikutsimikizira kupezeka kolimba, panthawi yake, mtundu wodalirika ndi ntchito yabwino. Zogulitsazo zimatumizidwa ku Europe, America, Japan, South Korea, Central Asia, Russia, Southeast Asia ndi maiko ena ndi zigawo. Amalandiridwa bwino ndi makasitomala. , Kapena mukufuna kuyitanitsa zinthu zogulitsa, kapena OEM, chonde tiuzeni. Zikomo kwambiri!Dziwani zambiri
Msika wa Laptop Bag umaphunziridwa kwambiri ndi olemba lipotili mwachidwi kwambiri pamawonekedwe a ogulitsa, kufutukula kwa zigawo, magawo otsogola, njira zowonjezereka ndi mwayi wofunikira, ndi maphunziro ena ofunikira. Lipotili likuwunikira zinthu zazikulu zomwe zikukulitsa ...
Kwa aliyense, "kuyenda" kuli ndi tanthauzo losiyana. Kwa ana osasamala, kuyenda kumatha kudya chakudya chokoma chomwe amayi amakhala ndi chikondi, ndipo amatha kusewera mosangalala ndi abwenzi, ndizosangalatsa kwambiri. Kwa iwo, tanthauzo laulendo akhoza kukhala "kusewera" ndi "kudya"! F ...


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Estradiol ufa (E2), amenenso amatchedwa oestradiol, ndi steroid, estrogen, ndi mahomoni achikazi apakati. Amatchulidwa ndipo ndi ofunika pa lamulo la maseŵero olimbitsa thupi omwe amabereka. Estradiol ndi ofunikira kuti chitukuko ndi kukonzanso ziwalo zoberekera za amayi monga mabere, chiberekero, ndi umayi pa nthawi ya kutha msinkhu, munthu wamkulu, ndi mimba, komanso imakhala ndi zotsatira zofunikira m'matenda ambiri, kuphatikizapo fupa, mafuta, khungu, chiwindi, ndi ubongo.
No mankhwala anapezeka zofanana kusankha.


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99% DMAA 1,3-dimethylamylamin HCL ufa CAS 105-41-9
Mankhwala Mwatsatanetsatane
Zogulitsa
DMAA, Ndi cholimbikitsira chomwe chimagwiritsidwa ntchito kuwonjezera mphamvu zolimbitsa thupi ndi nyonga. 1,3 dimethylamylamine imapezeka kwambiri pama preworkout supplements, monga Jack3d ndi SciVation Quake 10.0. Mphamvu zowonjezera kuchokera ku DMAA zimatha maola 35 osawonongeka kapena kutopa. Mosiyana ndi caffeine ndi zinthu zina zopatsa mphamvu, DMAA siyikusiyani inu mutatopa mutatha.
DMAAatha kupanga mankhwala. Zanenedwa kuti DMAA imapezekanso mwachilengedwe mumafuta a chomera cha geranium (Pelargonium tombolens). Pachikhalidwe, chomerachi chimakhala chofunikira pamsika wamafuta onunkhira. Komabe, malipoti ambiri akuwonetsa kuti DMAA kulibe mafuta a geranium ndipo DMAA yomwe ilipo muzowonjezera zowonjezera mwina ndizopanga.
Zowonjezera pazakudya, zowonjezera zowonjezera, zowonjezera zakudya, zowonjezera zowonjezera zakudya, zopangira mankhwala. zowonjezera masewera, zowonjezerapo masewera olimbitsa thupi, zowonjezera thupi.
1. Ndi mtundu wa zakudya zowonjezera.
2. Ikhoza kukonza kagayidwe kabwino ka minyewa ya minyewa komanso kulimbitsa kwambiri kupsinjika kwa minofu ndi kupirira kuchokera pazakudya zokha.
3. Itha kugwiritsidwa ntchito ngati chopatsa thanzi chopatsa thanzi.
4. Ndi chimodzi mwa zakudya zopatsa thanzi komanso zopatsa thanzi komanso chinthu chofunika kwambiri kwa omanga thupi.
5. Amagwiritsidwanso ntchito ndi othamanga ena, monga osewera mpira, osewera basketball ndi zina zotero.
1.Opanga pakati amankhwala, kaphatikizidwe kabwino ka mankhwala ndi chothandizira, mankhwala, ndi zina zambiri.
2. Wonjezerani mphamvu ndikusintha mphamvu ya thupi
3. Amagwiritsidwa ntchito m'kalasi lolemera momwe mungachepetsere chidwi chofuna kuponderezana ndi kutentha.
4. Komanso itha kugwiritsidwa ntchito ngati zinthu zina zopangira zakudya.


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Palibe chonga mbale supuni Pa nthawi ino ya chaka. Msuzi ndi nyemba za nyemba zikulakalaka koma sitikumbukira nthawi zonse kuthira nyemba kapena nandolo. Popeza izi zikachitika, pali njira lero: a nyemba nyemba zachangu msanga.
Tigwiritsa ntchito nyemba zamzitini koma sizitanthauza kuti zileka kukhala zolemera. Tiziwatumikira ndi mbatata zawo komanso kaloti. Kodi mukufuna kukhala osasinthasintha? Chabwino, onaninso chorizo, musazengereze.
Tsatirani zithunzi pang'onopang'ono, zomwe zingakuthandizeni kumvetsetsa momwe mungapangire.
- Mafuta owonjezera a maolivi
- 30 g anyezi
- Pafupifupi 120 g ya karoti
- Mbatata ziwiri (pafupifupi 250 g)
- 2 cloves wa adyo
- 800 g wa madzi kapena msuzi
- 720 g nyemba zoyera zamzitini (nyemba zakumwa kamodzi)
- chi- lengedwe
- Supuni 1 ya ufa
- Supuni 1 imodzi ya paprika
- Timakonza ndiwo zamasamba, nkuzisenda.
- Timadula anyezi.
- Timayika mafuta pang'ono mu poto ndikuwonjezera anyezi. Timalimbikitsa. Kenako timadula karoti ndikuwonjezera.
- Timadula mbatata.
- Timawonjezera pa mphodza.
- Timawonjezera madzi, adyo cloves ndi bay tsamba. Timalola ndiwo zamasamba kuphika. Pafupifupi mphindi 20 zikhala zokwanira.
- Timakhetsa nyemba ndi kuziyika pansi pamadzi ozizira.
- Timawaika mu phula, momwe timapezamo zotsalazo.
- Timalola zosakaniza zonse kuphika palimodzi kwa mphindi zochepa.
- Mu kasupe kakang'ono timathira supuni ziwiri zamafuta ndipo, zikatentha, timathira supuni ya ufa ndi imodzi ya paprika. Saute kwa mphindi.
- Timathira izi mu mphodza yathu ndikusiya ziphike, tonse pamodzi, kwa mphindi khumi.
- Timathirako mchere pang'ono ngati tiona kuti ndikofunikira.
- Timatumikira.
Zambiri - Lentili ndi chorizo


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by Admin | Nov 20, 2019 | IslamMaloto amachitika pamene munthu wagona tulo ndipo mzimu wake umachoka mthupi ndikupita kwina kumene atha kukakumana ndi mizimu ya anthu ena, omwalira kapena amoyo omwe ali mtulo ngati iyeyo. Choncho Allah amangosiya connection pakati pa thupi ndi mzimu wake, ndipo...
by Admin | Nov 11, 2019 | Featured, SalaatTiyeni titsegule page103 ya chitabu cha أحكام الجنائز وبدعها cha Allaamatu Sheikh Muhammad Naasirul-Deen Al Albaaniy, ndipo tiyambire pa mutu wa number 13 kumapita kutsogolo mmapage otsatira mu chitabuchi Zoyenera kuchita pa Janaaza Janaaza ndi mwambo wa maliro womwe...
by Admin | Oct 10, 2018 | IslamNkhani inachokera kwa al-Bara’ ibn ‘Aazib yemwe anati: “tinapita ndi Mtumiki (Mtendere ndi Madalitso zipite kwa Iye) kumwambo woika mmanda mmodzi wa ma Ansar (mzika ya mumzinda wa Madina), ndipo titafika pa manda, tinapeza kuti sadaikidwe ku mphanga la manda. Kenako...


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Nkhani
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Mkulu mphamvu, m'pamenenso laser mphamvu linanena bungwe, ndi chosavuta akuya chodetsa. Komabe, mphamvu yotulutsa iyenera kutsimikizika malinga ndi zomwe ipangidwe. Sikuti kukweza mphamvu, kumakhala bwino, bola ngati ikwaniritsa zofunikira zake, ndi makina omwe amagwira ntchito pansi pa h ...Werengani zambiri »
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Mbiri yakale ya vinyo m'mabwinja yakale imatha kubwereranso ku Mesopotamiya mu Neolithic Age 10,000 BC. Mu Neolithic Age pafupifupi zaka 9,000 zapitazo, tirigu ndi zipatso adagwiritsa ntchito kupanga vinyo. Ku Egypt wakale komanso nthawi yomweyo m'chigawo cha Mitsinje iwiri, zipatso ndi barele ...Werengani zambiri »
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Makina odulira laser ndi chida chofunikira pakupangira pepala. Kugwiritsa ntchito makina odulira laser ndichinthu chofunikira pakukonzanso moyo wawo. Chifukwa chake, titagula makina, tiyenera kudziwa momwe makina amagwirira ntchito moyenera komanso moyenera ...Werengani zambiri »
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Kudula molondola ndichinthu choyamba kuweruza mtundu wa makina odulira laser. Ndiroleni ndikufotokozereni zinthu zinayi zikuluzikulu zomwe zimakhudza kudula kolondola kwa makina odulira laser: 1.Laser aggregation kukula kwa jenereta ya laser: Ngati malo owala ndi ochepa kwambiri atatha kusonkhanitsa, kudula ...Werengani zambiri »
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Makina olembera laser a ZC Laser amagwiritsidwa ntchito kwambiri pamakampani opanga. Tsopano, ukadaulo wa laser wagwiritsidwa ntchito mwakhama kuma makampani opanga ma CD. Mwachitsanzo, ndudu za katoni kapena mapaketi a ndudu omwe amagwiritsidwa ntchito poyang'anira malonda amadziwika ndi ma code azithunzi ziwiri, matumba azachipatala ndi mar ...Werengani zambiri »
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Mliri wakunja ukukulirakulira, mitengo yazipangizo ndi katundu wanyanja zakula, ndipo gulu lazogulitsa padziko lonse lapansi likukumana ndi mayeso ovuta, zomwe zimapangitsa makampani aku China akunja akukumana ndi zovuta zomwe sizinachitikepo. Poyang'ana zovuta zamalonda zakunja ...Werengani zambiri »


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Patatha sabata limodzi tchuthi, gulu la iPhone News ndipo ndikuchokera ku Mac takumananso kuti tikambirane nkhani zaposachedwa zokhudzana ndi dziko la Apple. Chimodzi mwazofunikira kwambiri ndi kutsutsana kokhudzana ndi Masewera a Epic.
Kuphatikiza apo, mphekesera zokhudzana ndi iPhone 12 zimatiwonetsa momwe mbadwo watsopano wa iPhone ungathere khalani ndi chiwonetsero cha 120Hz. Tinakambirananso zama phukusi omwe Apple amatha kupereka kuyambira kugwa.
https://youtu.be/7oL7D_rTb7o
Podcast ya Actualidad ikhoza kutsatiridwa pompano kudzera pa njira yathu ya YouTube, pomwe mungathe nawo kudzera macheza ndi timu ya Podcast komanso owonera ena.
Tumizani ku njira yathu kuchokera pa YouTube ndikuyambitsa belu kuti landirani zidziwitso pamene kujambula kwapodcast kukuyamba, komanso tikamawonjezera makanema ena omwe timasindikiza.
Ikupezekanso pa iTunes kuti mutha mvetserani nthawi iliyonse yomwe mukufuna kugwiritsa ntchito Podcast yomwe mumakonda. Tikukulimbikitsani kuti mulembetse ku iTunes kuti magawowa atsitsidwe mosavuta akangopezeka motero tidzaphonya gawo lathu lililonse.
Podcast yathu nawonso ikupezeka pa Spotify, ndiye ngati mukugwiritsa ntchito izi nsanja yotsatsira nyimbo kumvera nyimbo zomwe mumakonda. Ndipo ngati sichoncho, inunso muli ndi mwayi kutimvera pa iVoox.


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Matani 2 wakhala pulogalamu yanga yoyang'anira clipboard kwanthawi yayitali. Pamenepo, Ndiwo okhawo omwe adatsiriza kugwiritsa ntchito Mac, chifukwa cha kapangidwe kake ndi kagwiritsidwe ntchito kake.
Pambuyo pakupambana pa Mac, adalengeza pulogalamu yawo ya iOS kalekale. Kuyambira pamenepo zakhala zikuyimira payokha beta, momwe ndidatenga nawo gawo, ndipo zidasiya zambiri zoti ndizifuna. Koma tsopano popeza ndi pulogalamu yofalitsidwa mu App Store, kuchuluka kwa zosintha kumakhala kosasintha ndipo kusintha kwake kuli kodabwitsa.
Dzulo yasintha pulogalamu yawo kuti igwirizane ndi iPad. Izi, pamodzi ndi kutsegulira kwaposachedwa kwamagwiritsidwe kudzera pa iCloud, zimapangitsa pulogalamu ya Paste 2 kuyamba kudziyimira yokha ngati ayenera-ndi kwa ogwiritsa ntchito zida zingapo za Apple, zikhale iPhone, iPad kapena Mac.
Ngakhale iCloud syncing ili akadali wobiriwira pang'ono, akugwirabe kale ntchito. M'malo mwanga, ndimafunikira kusintha mapulogalamuwa pa ma Mac anga kuti zinthu zolembedwazo ziwonekere pa iPhone.
Matani 2 amabwera ku iPad ndi chilichonse chomwe mukuyembekezera. Kokani ndikuponya, kugawa zenera, a widget,… Zonse pamodzi ndi kapangidwe kosavuta komanso kosavuta.
Pulogalamu ya iPhone ndi iPad ndi yaulere, koma tifunika kulipira, pogula mu-app, € 5,49 ngati kulipira kamodzi kuti mupeze mtundu wa Paste Pro. Mwanjira imeneyi titha kukhala ndi kulumikizana komanso kuchuluka kwama pinboards mumtundu wa iPad.
Recuerda que pulogalamu ya Mac ndi € 16,99 ngati malipiro amodzi, koma titha kuipeza ndikulembetsa ku Setapp. Ndi ntchito yomwe ndikulangiza kwambiri. Kugwiritsa ntchito kwake ndikuwonekera kwathunthu kwa wogwiritsa ntchito, mutha kubisanso chithunzi cha doko ndi bar ya menyu kwathunthu. Ndipo mukafuna, imatuluka ndi njira yachidule yosavuta.
Tsitsani | Matani


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Ndemanga ya Dacomitinib: Kodi Mungamuthandize Bwanji NSCLC?
- FDA ivomereza dacomitinib ya khansa yam'mapapo yam'mapapo osakhala yaying'ono
- Kodi Khansa Yam'mapapo Yomwe Sili Ying'ono Ndi Chiyani?
- Kugwiritsa ntchito kuchipatala kwa Dacomitinib mu khansa ya m'mapapo yosakhala yaying'ono
- Ndemanga ya Dacomitinib
- Njira ya Dacomitinib yogwirira ntchito
- Ntchito za Dacomitinib
- Zotsatira za Dacomitinib
- Chithandizo cha Khansa ya M'mapapo Yaying'ono: Dacomitinib VS Gefitinib
- Kodi Mungagule Bwanji Dacomitinib Powder pa intaneti?
FDA ivomereza dacomitinib ya khansa yam'mapapo yam'mapapo osakhala yaying'ono
Pa Seputembara 27, 2018, Food and Drug Administration idavomereza mapiritsi a dacomitinib (VIZIMPRO, Pfizer Pharmaceutical Company) yothandizira odwala oyamba omwe ali ndi metastatic khansa ya m'mapapo yosakhala yaying'ono (NSCLC) yokhala ndi epidermal grow factor receptor (EGFR) exon 19 kufufutidwa kapena exon 21 L858R m'malo osintha monga momwe zimadziwika ndi mayeso ovomerezeka a FDA.
Kuvomerezeka kutengera kuyesedwa kosasinthika, kosiyanasiyana, koyeserera, kuyeserera kogwira ntchito (ARCHER 1050; NCT01774721) kuyerekeza chitetezo ndi mphamvu ya dacomitinib ndi gefitinib mwa odwala 452 omwe ali ndi NSCLC yosasunthika. Odwala amafunikira kuti asalandire chithandizo chamatenda am'mimba kapena matenda obwerezabwereza osachepera miyezi 12 yopanda matenda akamaliza njira ya non-EGFR TKI; ntchito yaku Eastern Cooperative Oncology Group ya 0 kapena 1; ndi EGFR exon 19 kuchotsa kapena exon 21 L858R m'malo osintha. Odwala adasinthidwa mwachisawawa (1: 1) kuti alandire dacomitinib 45 mg pakamwa kamodzi tsiku lililonse kapena gefitinib 250 mg pakamwa kamodzi tsiku lililonse mpaka kukula kwa matenda kapena poizoni wosavomerezeka.
Mlanduwu udawonetsa kusintha kwakukuru pakupulumuka kopanda kupita patsogolo; palibe kusintha pamayankho onse kapena kupulumuka konse komwe kudawonetsedwa. Kupulumuka kwapakatikati kwapakatikati, kutsimikiziridwa ndi komiti yodziyimira payokha. anali miyezi 14.7 ndi 9.2 m'manja mwa dacomitinib ndi gefitinib, motsatana (chiopsezo cha 0.59; 95% CI: 0.47, 0.74; p <0.0001).
Malangizowa amakhala ndi machenjezo ndi zodzitetezera ku matenda am'mapapo am'mapapo (ILD), kutsegula m'mimba, komanso kusintha kwa dermatologic. Mwa odwala 394 omwe adalandira dacomitinib, zovuta zoyipa zidachitika mu 27%. Zovuta zomwe zimachitika chifukwa chosiya dacomitinib anali kutsegula m'mimba ndi ILD. Zotsatira zoyipa kwambiri (> 20%) za dacomitinib zinali zotsekula m'mimba, zotupa, paronychia, stomatitis, kuchepa kwa njala, khungu lowuma, kuchepa thupi, alopecia, chifuwa, ndi pruritus).
Kodi Khansa Yam'mapapo Yomwe Sili Ying'ono Ndi Chiyani?
Khansa ya m'mapapo ndi khansa yofala kwambiri padziko lonse lapansi, yomwe imapezeka ndi anthu opitilira 2018 miliyoni padziko lonse lapansi mu 85. Pafupifupi 75 peresenti ya khansa yonse yam'mapapo imadziwika kuti si khungu laling'ono, ndipo pafupifupi XNUMX% ya izi ndi metastatic, kapena kupita patsogolo, pakuzindikira .
EGFR ndi mapuloteni omwe amathandiza maselo kukula ndikugawana. Gulu la EGFR likasinthidwa limatha kupangitsa kuti puloteniyo igwire ntchito mopitilira muyeso ndikupangitsa kuti maselo a khansa apange. Kusintha kwa EGFR kumatha kupezeka mu 10 mpaka 35% ya zotupa za NSCLC padziko lonse lapansi, ndipo kusintha komwe kumachitika kwambiri ndikuchotsa exon 19 ndikutulutsa 21 L858R m'malo mwake, zomwe zimaphatikiza 80% yodziwika yosintha kusintha kwa EGFR. Matendawa amagwirizanitsidwa ndi kuchepa kwa kupulumuka ndipo kupitilira kwa matenda kumakhalabe kovuta.
AASraw ndiye katswiri wopanga Dacomitinib.
Chonde dinani apa kuti mumve zambiri: Ochezera ife
Kugwiritsa ntchito kuchipatala kwa Dacomitinib mu khansa ya m'mapapo yosakhala yaying'ono
Dacomitinib ndi m'badwo wachiwiri wa EGFR tyrosine kinase inhibitor (TKI) womwe umamangirira mosalekeza ndikuletsa EGFR / Her1, Her2 ndi Her4 subtypes mofanana ndi ma TKIs ena. Muyeso la ARCHER 1050, kupulumuka kopanda kupita patsogolo kunasintha ndi dacomitinib poyerekeza ndi gefitinib, yothandizira dacomitinib ngati njira yoyamba yothandizira khansa yaying'ono yamapapo yam'mapapo osasintha ndi kusintha kwa EGFR. Ponena za kuchuluka kwa zochitika zoyipa kwambiri, kuchepetsedwa kwa mlingo sikunachepetse mphamvu ya dacomitinib ndipo kumatha kuchepetsa kuchepa komanso kuwopsa kwa zochitika zoyipa. Poganizira momwe kusintha kwa khansa ya m'mapapo ya EGFR-mutant-cell yaying'ono, mutu wamtsogolo kuyerekezera pakati pa dacomitinib ndi osimertinib itha kupereka chidziwitso chofunikira kuti mudziwe nthawi yabwino yothandizira TKI.
Kuchuluka kwa khansa ya m'mapapo osakhala yaying'ono kwatikakamiza kuti tiganizire za njira zamankhwala, momwe tingapezere njira zabwino? Chidwi chithandizo chidzalimbikitsidwa kwa aliyense. Chotsatira, tiyeni tiwone Chidwi:
Ndemanga ya Dacomitinib
Dacomitinib, yopangidwa ngati (2E) -N-16-4- (piperidin-1-yl) koma-2-enamide, ndi gawo losankhidwa kwambiri la quinazalone m'chigawo chachiwiri cha tyrosine kinase inhibitors chomwe chimadziwika ndikumangika kosasinthika madera a ATP a madera a epidermal kukula factor receptor banja kinase. Dacomitinib ndi mankhwala ochizira non-cell-cell lung carcinoma (NSCLC). Ndi choletsa chosankha ndi chosasinthika cha EGFR.
Dacomitinib idapangidwa ndi Pfizer Inc ndikuvomerezedwa ndi a FDA pa Seputembara 27, 2018. Umboni wina m'mabukuwa ukuwonetsa kuthekera kwa kuchiritsa kwa dacomitinib mu mtundu wa khansa yamchiberekero ya epithelial, ngakhale kuli kofunikira kuti kufufuzanso kwina.
Pakadali pano, Dacomitinib ufa (CAS:1110813-31-4) atha kuperekedwa ndi AASraw ochokera ku China.
Njira ya Dacomitinib yogwirira ntchito
Dacomitinib ndi chosasinthika chaching'ono cha molekyulu choletsa zochitika za banja la epidermal grow factor receptor (EGFR) (EGFR / HER1, HER2, ndi HER4) tyrosine kinases. Imakwaniritsa choletsa chosasinthika kudzera kolumikizana kophatikizana ndi zotsalira za cysteine m'magawo othandizira a HER receptors. Chiyanjano cha dacomitinib chawonetsedwa kuti chili ndi IC50 ya 6 nmol / L.
Banja la ErbB kapena epidermal grow factor (EGF) limathandizira pakukula kwa chotupa, metastasis, komanso kukana chithandizo chamankhwala poyambitsa njira zosunthira kutsika monga Ras-Raf-MAPK, PLCgamma-PKC-NFkB ndi PI3K / AKT kudzera pa tyrosine phaseji ya kinase yomwe imayendetsedwa ndi carboxy-terminus.1 Pafupifupi 40% yamilandu ikuwonetsa kukulitsa kwa jini la EGFR ndipo 50% ya milanduyo ikuwonetsa kusintha kwa EGFRvIII komwe kumayimira kufufutidwa komwe kumapangitsa kuyambitsa kwa tyrosine kinase domain ya receptor.
Ntchito za Dacomitinib
Dacomitinib imavomerezedwa kuchiza: Khansa ya m'mapapo yosakhala yaying'ono (NSCLC) yomwe yasintha (kufalikira mbali zina za thupi). Amagwiritsidwa ntchito ngati chithandizo choyamba kwa odwala omwe zotupa zawo zimakhala ndi kusintha kwa majini a EGFR.
Dacomitinib akuwerengedwanso pochiza mitundu ina ya khansa.
Zotsatira za Dacomitinib
Zinthu zofunika kuzikumbukira pazotsatira zoyipa za dacomitinib:
▪ Anthu ambiri sangapeze zovuta zonse za dacomitinib zomwe zalembedwa apa.
▪ Zotsatira zoyipa za Dacomitinib nthawi zambiri zimadziwikiratu malinga ndi momwe zimayambira, kutalika kwake komanso kuuma kwake.
▪ Zotsatira zoyipa za Dacomitinib zidzayamba bwino mankhwala akamaliza.
▪ Zotsatira zoyipa za Dacomitinib zitha kukhala zotheka. Pali njira zambiri zochepetsera kapena kupewa zovuta za dacomitinib.
AASraw ndiye katswiri wopanga Dacomitinib.
Chonde dinani apa kuti mumve zambiri: Ochezera ife
Zotsatira zotsatirazi ndizofala (zomwe zimachitika kuposa 30%) kwa odwala omwe amatenga dacomitinib:
▪ Ziphuphu pakhungu
▪ Matenda a msomali abacteria kapena fungal (paronychia)
▪ Khungu louma
▪ Ochepera albumin
▪ Kashiamu wochepa
▪ Kuchuluka kwa shuga m'magazi
▪ Kutsekula m'mimba
▪ Zilonda za pakamwa
▪ Kuchepetsa njala
▪ Kuchepa kwa magazi m'thupi (hemoglobin yotsika)
▪ Kuchuluka kwa maselo oyera a magazi
▪ Kuchulukitsa michere ya chiwindi
Izi ndizotsatira zoyipa zochepa (zomwe zimachitika mu 10-29%) kwa odwala omwe alandila dacomitinib:
▪ Kupweteka pachifuwa
▪ Kusagona
▪ Tsitsi
▪ Kuyabwa
▪ Kufiira, kutupa, ndi kupweteka m'manja mwake kapena / kapena kupondera kwa mapazi
▪ Potaziyamu wambiri, magnesium ndi sodium
▪ Kuchepetsa thupi
▪ Nausea
▪ Kudzimbidwa
▪ Kupweteka kwa ziwalo
▪ Kumva kupweteka kwa mafupa ndi mafupa
▪ Kufooka / kusowa mphamvu
▪ Kutupa kapena matenda m'maso
▪ Kuchuluka kwa seramu creatinine
▪ Chifuwa, zizindikiro za m'mphuno, kuvutika kupuma komanso matenda am'mapapo
Sizovuta zonse zomwe zalembedwa pamwambapa. Zotsatira zoyipa zomwe zimapezeka kawirikawiri - zomwe zimachitika ochepera 10 peresenti ya odwala - sizinalembedwe pano. Koma nthawi zonse muyenera kudziwitsa omwe akukuthandizani ngati mukukumana ndi zachilendo.
Chithandizo cha Khansa ya M'mapapo Yaying'ono: Dacomitinib VS Gefitinib
Mwa odwala omwe ali ndi vuto la EGFR-positive, non-brain metastatic non-small cell lung cancer (NSCLC), mzere woyamba wa dacomitinib umapangitsa kupulumuka kopitilira patsogolo (PFS) pa gefitinib, malinga ndi kafukufuku wapa phase 3 wofalitsidwa mu The Lancet Oncology.
Mbadwo woyamba EGFR-tyrosine kinase inhibitors (TKIs), kuphatikiza gefitinib, amagwiritsidwa ntchito pamzere woyamba kwa odwala omwe ali ndi matenda a EGFR, omwe amakhala pakati pa 10% ndi 44% yamapapo adenocarcinomas onse. Kafukufuku wam'mbuyomu sanazindikire ngati m'badwo wachiwiri EGFR-TKIs ndi wapamwamba kuposa mitundu yoyamba.
Pamalemba otsegukawa, osasinthika (ARCHER 1050; Chidziwitso cha ClinicalTrials.gov: NCT01774721), yomwe olemba adalemba ndi gawo loyamba la 3 kufananizira m'badwo wachiwiri EGFR-TKI ndi m'badwo woyamba EGFR-TKI munthawi imeneyi. , ofufuza adalembetsa odwala 452 kuti alandire dacomitinib (odwala 227) kapena gefitinib (odwala 225). Odwala omwe ali ndi metastases yamaubongo sanali oyenerera.
Pakutsatira kwapakatikati kwa miyezi 22.1, PFS yapakatikati inali miyezi 14.7 ya dacomitinib vs 9.2 miyezi ya gefitinib; Kafukufuku wamagulu ang'onoang'ono adakondanso dacomitinib. Mayankho khumi ndi awiri athunthu adalembedwa mgulu la dacomitinib vs 4 pagulu la gefitinib. Mulingo woyankhira poyankha unali wofanana (75% ya dacomitinib ndi 72% ya gefitinib; P = .4234).
Odwala makumi awiri mphambu awiri omwe amalandira dacomitinib adakumana ndi vuto lalikulu lokhudzana ndi chithandizo (AE); Izi zinali choncho ndi odwala 10 omwe amalandira gefitinib. Imfa zokhudzana ndi chithandizo zidanenedwa kwa odwala 2 omwe amalandira dacomitinib vs 1 ya gefitinib.
Olembawo anamaliza kuti "chithandizo cha dacomitinib chinali choposa alireza mokhudzana ndi [PFS] komanso nthawi yayitali poyankha chithandizo cha mzere woyamba wa odwala omwe ali ndi EGFR-mutation-NSCLC ndipo ayenera kuwonedwa ngati njira yatsopano yothandizira anthuwa. ”
Kodi Mungagule Bwanji Dacomitinib Powder pa intaneti?
Pali ogulitsa / opanga ambiri a dacomitinib ufa pamsika, kupeza wowona ndikofunikira kwambiri kwa anthu onse omwe amafunikira izi mwachangu. Tikaganiza zogula ufa wa dacomitinib pamsika, tifunika kuphunzira zambiri za izi, kudziwa momwe tingagwiritsire ntchito ndi momwe amagwirira ntchito, zoopsa zilizonse tikatenga dacomitinib powder…. Kuphatikiza apo, mtengo ndi mtundu wake ziyenera kukhala nkhawa zathu tisanagule.
Titasanthula madata ochokera kumsika, poyerekeza ambiri ogulitsa, AASraw imawoneka ngati njira yabwino kwa anthu omwe akufuna kugula zambiri dacomitinib ufa, kupanga kwawo kumayang'aniridwa mosamalitsa pansi pa cGMP, mtunduwo ukhoza kutsatiridwa nthawi iliyonse ndipo atha kupereka malipoti onse oyesa mukamaitanitsa. Ponena za mtengo wa dacomitinib powder / mtengo, ziyenera kukhala zomveka, m'maso mwanga. Chifukwa ndili ndi mitengo yambiri kuchokera kwa ogulitsa osiyanasiyana, poyerekeza ndi mtundu, ndikuganiza kuti aasraw sikhala chisankho choyipa.
Reference
[1] Kobayashi Y, Fujino T, Nishino M, et al. Kusintha kwa EGFR T790M ndi C797S ngati njira zotsutsana ndi dacomitinib. J Thorac Oncol. 2018; 13 (5): 727-731. onetsani: 10.1016 / j.jtho.2018.01.009.
[2] Kris MG, Camidge DR, Giaccone G, ndi al. Kulimbana ndi kusokonekera kwa HER2 ngati oyendetsa khansa yam'mapapo: gawo lachiwiri kuyesedwa kwa pan-HER tyrosine kinase inhibitor dacomitinib mwa odwala HER2-mutant kapena amplified tumors. Ann Oncol. 2015; 26 (7): 1421–1427. onetsani: 10.1093 / annonc / mdv383.
[3] Paki K, Tan EH, O'Byrne K, et al. Afatinib motsutsana ndi gefitinib ngati chithandizo choyamba cha odwala omwe ali ndi khansa ya m'mapapo yam'mapapo (LUX-Lung 7): Lancet Oncol. 2; 2016 (17): 5-577. onetsani: 589 / S10.1016-1470 (2045) 16-X.
[4] Kuchotsa INE, Keefe DM, Sonis S, et al. Kafukufuku wachiwiri (ARCHER 1042) kuwunika mankhwala opatsirana a dacomitinib-omwe amachititsa dermatologic ndi m'mimba zochitika zovuta mu khansa yaying'ono yamapapo yam'mapapo. Ann Oncol. 2016; 27 (9): 1712-1718. onetsani: 10.1093 / annonc / mdw227.
[5] Reckamp KL, Giaccone G, Camidge DR, ndi al. Gawo lachiwiri la mayesero a dacomitinib (PF ‐ 2), poto wamlomo, wosasunthika-HER (human epidermal growth factor receptor) inhibitor, mwa odwala omwe ali ndi khansa yaying'ono yaying'ono yamapapo atalephera kugwiritsa ntchito chemotherapy ndi erlotinib. Khansa. 00299804; 2014 (120): 8–1145. onetsani: 1154 / cncr.10.1002.
[6] Engelman JA, Zejnullahu K, Mitsudomi T, ndi al. Kukulitsa kwa MET kumabweretsa gefitinib kukana khansa yamapapu poyambitsa kuwonetsa kwa ERBB3. Sayansi. 2007; 316 (5827): 1039-1043. onetsani: 10.1126 / science.1141478.
[7] [Nkhani yaulere ya PMC] [Adasankhidwa] Liu X, Wang P, Zhang C, et al. Epidermal growth factor receptor (EGFR): Nyenyezi yomwe ikukwera munthawi yachipatala cha khansa yamapapo. Chotsani. 2017; 8 (30): 50209-50220.
[8] Girard N. Kupititsa patsogolo zotsatira mu EGFR mutation-positive NSCLC: ndi tyrosine kinase inhibitor liti ndipo liti? Tsogolo la Oncol 2018.
[9] Inoue A, Kobayashi K, Maemondo M, et al. Zotsatira zomaliza zopulumuka za NEJ002, gawo lachitatu lofanizira gefitinib ndi carboplatin (CBDCA) kuphatikiza paclitaxel (TXL) ngati njira yoyamba yothandizira khansa yaying'ono yamapapo yam'mapapo (NSCLC) ndi kusintha kwa EGFR. J Clin Oncol 2011; 29: 7519 (Adasankhidwa)
[10] Lembani LV, Yang JC, Yamamoto N, et al. Gawo lachitatu la afatinib kapena cisplatin kuphatikiza pemetrexed mwa odwala metastatic lung adenocarcinoma ndi kusintha kwa EGFR. J Clin Oncol 2013; 31: 3327-34 (Adasankhidwa)
[11] Lin JJ, Cardarella S, Lydon CA, ndi al. Kupulumuka Zaka Zisanu mu EGFR-Mutant Metastatic Lung Adenocarcinoma Yothandizidwa ndi EGFR-TKIs. J Thorac Oncol. 2016; 11: 556-65. (Adasankhidwa)


text:
VLC Media Player
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Part 1: VLC Media Player
Company: VideoLAN
Koperani Link:
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