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Lachinayi pa Julayi 21, 2011, mwana wanga wamwamuna wazaka makumi awiri adasiya ntchito molawirira ndipo sanabwereko kunyumba. Thupi lake likapezedwa patatha masiku asanu ndi limodzi kudera lakutali lomwe likuyang'ana Sweetwater Canyon, chilonda chodziponyera kumutu, ndipo moyo wanga sudzakhalanso chimodzimodzi.
zatha bwanji pachibwenzi
Chaka chimodzi pambuyo pake, mkazi wanga adadzipha.
Amanditcha wopulumuka kudzipha, koma kodi ndili? Masiku ambiri, sindikutsimikiza kuti ndidapulumuka konse. Ine sindine munthu yemweyo momwe ndinaliri ndisanadziphe mwana wanga wamwamuna ndi mkazi wanga. Kufuna kupeza tanthauzo m'moyo wanga pambuyo podzipha kwakhala kovuta. Tsiku lina ndimamva ngati ndikuyamba kumvetsetsa za moyo wanga, tsiku lotsatira zonse zimabwerera ku chisokonezo.
Aliyense amalimbana ndi chisokonezo mdziko lomwe limawoneka ngati lopanda pake, koma kuzunzika kwa kudzipha kumawunikira. Albert Camus analemba kuti, 'Pali vuto limodzi lokha lalikulu kwambiri lafilosofi ndipo ndikudzipha.'
Mwanjira yopanda tanthauzo, kudzipha kumayankha funso lomwe likupezeka: kodi tikuyang'anira miyoyo yathu ? Kudzipha kumatipatsa ulamuliro. Icho chikhoza kukhala chinthu chokha chomwe chimachita. Kuti tithe kuwongolera miyoyo yathu, tiyenera kuvomereza imfa yathu . Koma zimafunikira zoposa kuvomereza kosavuta kuti tidzafa, kumafunikanso kukhulupirira kuti tidzapeza njira zomveka zoyendetsera zopusa za moyo. Kuti tikhale omasuka ku lingaliro lopanda pake, tiyenera kuvomereza.
Mwa kutontholetsa phokoso, kudzipha ndi njira imodzi yoyanjanitsira moyo wamunthu ndi kusowa chiyembekezo kwake komanso kupusa kwake.
Koma kodi ndiyo njira yokhayo?
Sindikuganiza choncho.
Kuti ndilandire udindo wanga ngati wopulumuka za kudzipha, ndipo kuti ndipeze chifukwa chokankhira, ndiyenera kupeza mphamvu zoyanjanitsa zopusa za moyo ndi chifuniro changa chokhala ndi moyo. Bwanji mupitirire kukhala m'dziko lopanda pake ndi kusatsimikizika? Ngati sindingayanjane ndi zopanda pake, sindidzakhala womasuka ku izo. Ndipo izi ndi zomwe tonse tatsatira, sichoncho? Ufulu. Mwaufulu timapeza mtendere. Chinyengo ndikupeza ufulu ndikukhala ndi moyo.
M'zaka zisanu ndi chimodzi kuchokera pomwe mwana wanga adadzipha, ndakhala ndikudzidzimutsa, chilichonse chosonyeza zopanda pake. Mkati mwa chaka mwana wanga atadzipha, mkazi wanga analimbana ndi mdima, ngakhale kufufuza njira zodzipha. Ndidampempha, ndikuyesera kuti ndimutsimikizire kuti pali nyali kumapeto kwa mumphangayo.
Sanathe kuziwona ...
Ndinamuuza kuti kudzipha kudzakhala komweko kwa iye, koma pakadali pano, ikani m'thumba lakumbuyo, sanafunikire kusewera khadi imeneyo. Ndinkayembekeza kuti apeza chitonthozo podziwa ngati zinthu zikhala zosapiririka, nthawi zonse amakhala ndi njira yopulumukira, koma pakadali pano, amafunika kukhala ndi moyo kuti alemekeze moyo wamfupi wamwamuna wathu, kuti apereke tanthauzo la moyo wake.
Munthu sangathe kufafaniza moyo monga choncho. Tsiku lina adabwera, tsiku lotsatira adachoka. Koma adalipo m'makumbukiro athu. Monga zopweteka monga momwe zimamuganizira m'mbuyomu, tifunika kuti tisunge zikumbukiro.
Chimodzi mwazinthu zodabwitsa zodzipha ndichikhulupiliro cha munthu amene akuganiza zodzipha kuti wasandulika cholemetsa kwa okondedwa ake ndipo kudzera mwa kudzipha kwake, adzamasula okondedwa ake pamtengowu, pamene kwenikweni, palibe chomwe chingakhale chopitilira chowonadi. Palibe munthu amene wapulumuka chifukwa chodzipha. M'malo mwake, amangomva kupwetekedwa mtima ndi kuwonongeka.
Mwana wanga wamwamuna sanafune kuvulaza wina aliyense podzipha. Koma iye anatero.
Usiku usanachitike chaka chimodzi chakumapeto kwa kudzipha kwa mwana wathu wamwamuna, ndinkachita mantha ndi malingaliro osalimba a mkazi wanga, koma adawoneka wolimba komanso wotsimikiza, akundiuza kuti atsimikiza mtima kuti izi zitheke. Amakwera masitepe m'mawa mwake monganso momwe mwana wathu wamwamuna adachita pomaliza kumuwona.
M'mawa wa tsiku lomwe adasowa, adachedwa kugwira ntchito, ndipo mkazi wanga adaseka pomwe mwana wathu wamwamuna adakwera masitepe chifukwa chakupuma. Adamuuza kuti sichinthu chachikulu, kupumula, kukhala pansi, kumwa khofi, moyo umamudikirira.
Inde, moyo umadikirira.
Zotsatira zake, zimadikirira kwamuyaya. Sanangokwera masitepe m'mawa uja, koma nthawi ina madzulo, atakhala yekha paphiri lamiyala moyang'anizana ndi Sweetwater Canyon mtunda wamakilomita zana kuchokera kunyumba, adapita kumalo osadziwika.
Kodi anali kuganiza chiyani m'maola omaliza aja, mphindi zomaliza, masekondi omaliza a moyo wake? (Kodi mungasankhe bwanji kuti ino ndi nthawi yokoka?) Kodi zinthu zikadasintha mosiyana ndikadamvera langizo lake kuti mupumule, mupume kambiri, sichinthu chachikulu, moyo nthawi zonse umatiyembekezera?
Mwinanso mungakonde (nkhani ikupitirira pansipa):
- Kukhumudwa Kwomwe Kungakhalepo: Momwe Mungagonjetsere Kumva Kwanu Kwachabechabe
- Kodi Mukuyang'ana Tanthauzo La Moyo Pamalo Olakwika?
- Njira 9 Gulu Lamakono Likuyambitsa Kutulutsa Komwe Kungakhalepo
- Mukamadzakhumudwa, Ingonena Mawu 4 Awa
- M'malo mongonena kuti 'Pepani chifukwa cha kutayika kwanu,' onetsani mawu anu achisoni ndi mawu awa
- Kupyola Masiku Omwe Mutasowa Wina Amene Mwataya
Palibe aliyense wa ife amene angaganize kuti moyo nthawi zonse umatiyembekezera. Tsiku lililonse, mwanjira ina kapena inzake, timadula mosadziwika. Nthawi zambiri, timakhala amoyo kumapeto kwa tsiku. Koma tsiku lina sizidzakhala choncho. Mwanjira imeneyi, tonse ndife opulumuka, tikuvutika kuti tifike kumapeto kwa tsikulo. Kodi timamvetsetsa bwanji? Kodi timapitiliza bwanji tikakumana ndi kusatsimikizika komanso chisokonezo? Nthawi zonse ndimakumbukira zakudzipha kwa mwana wanga wamwamuna ndi mkazi wanga, funso ili limandiyang'ana kwambiri.
Popeza ndilibe mayankho a mafunso awa, nazi zomwe ndasankha ndikuyenera kuchita kuti apite. Ndidzakhala wankhondo. Kodi kumatanthauza chiyani kukhala wankhondo? Zinthu ziwiri: kulanga ndipo chipiriro. Ndiyenera kufikira nthawi ina m'moyo wanga pomwe ndikukhulupirira kuti ndili ndi ufulu wokhala pano. Ngati moyo uli wodzaza ndi kusatsimikizika, zikhale chomwecho, ndatsimikiza mtima kuti ndidzakhazikika ndikuyang'anitsitsa, ndikudalira mphamvu zanga kuti ndipirire mulimonsemo.
Kupatula apo, ndi chinthu choipa chiti chomwe chingachitike?
Pachikumbutso cha mwana wanga wamwamuna, ndinauza mnzanga, bambo wa m'modzi mwa amnzanga a mwana wanga, kuti sindidzaopanso. Popeza ndinali nditavutika kale ndi chinthu choyipa kwambiri chomwe ndingaganizire, chifukwa chake, ndinalibe china choti nditaye, sindinalinso ndi chilichonse choopa. Kuyambira nthawi imeneyo, sindingakhale wopambana.
Zotsatira zake, komabe, sindinali wopambana.
Pamene masiku anali kupita, ndinamva kuti ndagonjetsedwa, ndikumakhala wosatetezeka komanso wofewa. Zinandivuta kupeza chifukwa chilichonse chopitilira. Ndinawonjezera kusokonezeka ndi kusokonezeka chifukwa cha khalidwe langa losasamala. Palibe chomveka, chifukwa chake ndidachita zopanda nzeru. Koma panali zotulukapo pazomwe ndidachita. Anthu ena adapwetekedwa, anthu omwe adatenga nawo gawo m'moyo wanga, anthu omwe amasamala za ine, anthu omwe adatero kugwa mchikondi ndi ine.
Popeza ndinamva kuwawa kwambiri, chinthu chomaliza padziko lapansi chomwe ndinkafuna ndikumvulaza wina aliyense. Ngakhale lingaliro lakukhumudwitsa wina aliyense linali lomvetsa chisoni kwa ine, ndimalakalaka kukondedwa komanso kucheza nawo, ndikudziwa bwino kuthekera koti sindingathe kudzipereka kuubwenzi wanthawi yayitali.
Pomaliza, ndazindikira kuti kuti ndithetse izi kudziwononga wekha , komanso kuti ndipewe kuyambitsa mavuto enanso kwa wina aliyense, ndiyenera kupeza mphamvu kuti ndipirire ndikamakumana ndi mavuto anga. Ndiyenera kukhala a opirira wankhondo, wamphamvu ndi wodekha komanso woganizira. Ndiyenera kufunafuna mtendere wamumtima . Ndikakhazika pansi malingaliro anga m'pamene ndimayamba kuwona njira yomwe ndiyenera kutsatira kuti ndikhale moyo wowona mtima komanso wowona.
wwe shawn micheals theme song
Kuwona mtima ndi chowonadi ndizovuta kwambiri kuzizindikira mdziko la chisokonezo ndi zopanda pake. Kodi timawazindikira bwanji? Sititero. Chifukwa chake, zili kwa aliyense wa ife kupanga malingaliro ake kuona mtima ndi choonadi. Tiyenera kuthetsa kusamvana kwathu pakuvomereza mfundo yosavuta iyi: kuwona mtima ndi chowonadi sizipezeka mu chisokonezo cha tsiku ndi tsiku, koma zimapangidwa mkati mwa aliyense wa ife kuti zigwirizane ndi zosowa zathu.
Timapanga zoonadi zathu. Izi ndi zowonadi zomwe titha kutsatira, zina zonse ndizopanda pake.
Aliyense wa ife ayenera kupeza mtundu wake wankhondo. Ndipokhapo pomwe atha kuyambitsa bata chisokonezo ndikupewa funso lokhazikika, 'Kodi timapanga bwanji moyo?' Sikuli kwa ife kuti tipeze yankho ku funso lachinyengo ili kwa ife kupeza yankho la funso lina: ndi chiyani kwa ife? Pokhapokha titakhala ndi chikhulupiliro mu chowonadi chathu komanso kuwona mtima komwe tidzatha kuyika chidwi ndikukonzekera kumenya nkhondo yabwino.
Chiyambireni kudzipha ndi mkazi wanga ndi mwana wanga, ndakhala ndikudziimba mlandu ndikudziona kuti ndine wolephera. Pazidziwitso, ndikudziwa kuti sindinachite cholakwika chilichonse, koma pa msinkhu wosazindikira , Sindingathe kupeza malongosoledwe ena chifukwa chake mwana wanga wamwamuna ndi mkazi wanga adamva kufuna kuchoka, kupatula kuti ndinawalephera.
Kuvutika ndi chipulumutso changa, ngakhale ndikudziwa kuti ndikudziwononga ndekha. Ndiyenera kudzikhululukira ndekha ndikupeza mphamvu mchowonadi china. Kuvutika ndi chowonadi chovuta komanso chosakhutiritsa mwanjira ina. Sindiyenera kutsimikizira kwa wina aliyense kuti sindinachite cholakwika chilichonse ndiyenera kutsimikizira ndekha.
Kuti ndidziwe kukhulupirika kwanga ndi chowonadi ndiye gawo loyamba lankhondo. Pambuyo povomereza chowonadi changa ndiyomwe ndidzayamba ulendo womwe ungandimasule.


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2. Wodabwitsa wa Nicotinamide Mononucleotide (NMN)
3. Nicotinamide Mononucleotide ndi NAD +
4. Kafukufuku waposachedwa wa Nicotinamide Mononucleotide Work pa Makoswe
5. Ubwino Wochokera ku Nicotinamide Mononucleotide (NMN)
6. Kodi Nicotinamide Mononucleotide (NMN) Imagwiradi Ntchito Pa Anthu?
7. Momwe Mungagwiritsire Ntchito Nicotinamide Mononucleotide (NMN) Poletsa Kukalamba?
8. Zotsatira za Nicotinamide Mononucleotide Muyenera Kudziwa
9. Kodi Ndingapeze Kuti Mankhwala Oletsa Kukalamba-Nicotinamide Mononucleotide (NMN)?
10. Chidule
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WikipediaZosungidwa zolemekezeka kwambiri zochokera ku National Institutes of Health
Pitani ku gwero
Introduction
Kukalamba sikungapeweke. Komabe, pali zotheka kubwezeretsa ukalamba pogwiritsa ntchito Nicotinamide Mononucleotide. Gwiritsani mahatchi anu chifukwa ndikupatsani inu zambiri zokhudza momwe zamatsenga zimagwirira ntchito m'maselo aumunthu.
Tsitsi lofanana ndi nzeru!
Chikhulupiliro chimenechi ndi chinthu chabwino kwambiri chimene munganene kuti chikhale chachikulu. Komabe, kumwetulira kwanu kudzakhala kanthawi kochepa mukayamba kuzindikira makwinya pa khungu lanu lonse. Komanso, ukalamba umakhudza zonse zomwe zimagwira ntchito komanso zamaganizo.
Tivomerezane. Pulogalamu ya odana ndi ukalamba zodzoladzola kumaso ndi maopaleshoni okongoletsa zakhala zikupezeka m'zaka zaposachedwa. Zomwe muyenera kudziwa ndikuti njirazi ndizofupikitsa ndipo zimatha kuyambitsa zovuta.Kwenikweni, muyenera kuthana ndi ukalamba pomvetsetsa kaye ma cell ndi ma physiological process omwe amatenga gawo pazokhudzana ndi zaka. Pambuyo pake, zimakhala zosavuta kuzindikira njira zolimbana ndi senescence. Nicotinamide Mononucleotide yoletsa kukalamba imathandizira kubwezeretsa unyamata.
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PubMed CentralZosungidwa zolemekezeka kwambiri zochokera ku National Institutes of Health
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Tonsefe tikufuna kusinthana bwino, chabwino? Chabwino, izi zikhoza kukhala zosatheka pamene thupi lanu likupitirizabe kufooketsa, ndipo mumatha kukhala maginito a matenda amtundu wanji, Alzheimer's, kukumbukira kukumbukira, ndi zina zambiri.
Wodabwitsa Nicotinamide Mononucleotide (NMN)
Kotero, kodi vuto lonse la Nicotinamide Mononucleotide ndi lotani? Ndiloleni ndifotokoze.
NMN ilipo m'ma alpha (a) ndi ma beta (B) mawonekedwe. Komabe, B-NMN ndi mawonekedwe omwe amagwira ntchito kwambiri. Nucleotide imeneyi imakhala pakati pa biosynthesis ya nicotinamide adenine dinucleotide kapena NAD +.
Izi zimakhala mwachibadwa m'magayala, tomato, nkhaka, cabbages, broccoli, ndi ng'ombe yaiwisi. Mu labotale, imapezeka ngati nicotinamide mononucleotide poda wambiri.
Mu mawonekedwe ake opangira, amadziwika ndi nambala ya CAS, 1094-61-7. Kuphatikizikaku kumabwera kuchokera ku zomwe zimachitika pakati pa nucleoside, monga nicotinamide riboside ndi gulu la phosphate.M'maphunziro a preclinical, Nicotinamide Mononucleotide ntchito pa mbewa yakhala yothandiza pazochitika zama cell biochemical, kasamalidwe ka matenda a Alzheimer's, matenda a shuga okhudzana ndi ukalamba, zovuta zomwe zimabwera chifukwa cha kunenepa kwambiri, komanso kuteteza mtima. Ngakhale izi zonse zachipatala zomwe zimagwirizanitsidwa ndi Nicotinamide Mononucleotide, zomwe zatulukira kwambiri ndizochita nawo ntchito zolimbana ndi ukalamba.
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PubMed CentralZosungidwa zolemekezeka kwambiri zochokera ku National Institutes of Health
Pitani ku gwero
Mu thupi la munthu, NMN ndiye gwero lalikulu la mphamvu mkati mwa maselo. Pamene mukukalamba, mphamvu zamagetsi zimachepetsa chifukwa cha nicotinamide mononucleotide ndi kuchepa kwa NAD +. Kulamulira NMN kudzasinthira ndondomekoyi ndi kulipira malire.
(1) Kodi NMN ndi yodabwitsa bwanji?
Mankhwala olimbana ndi ukalambawa amayenda ngati mphezi kuchokera m'matumbo kulowa m'magazi. Mu mphindi zochepa, adzakhala atatengedwa kupita m'magazi. Pachifukwa ichi, zikuwonekeratu kuti mwina sipangakhale zochitika zamankhwala zam'magazi zomwe zimachitika panjira yama molekyulu.
Kuthamanga kodabwitsa kumeneku kwapangitsa ochita kafukufuku kuzindikira kuti kuthekera konyamula, komwe kumathandizira kupatsira mafuta kwama cell. Mwachitsanzo, Imai ndi mnzake adayamba kupeza yankho kudzera mu kafukufuku wake waposachedwa wofalitsidwa pa Januware 7, 2019.
Ndikukalamba, thupi limagwiritsa ntchito NAD + kuposa momwe limapangira. Ngakhale mumagwiritsa ntchito nicotinamide mononucleotide, njirayi ikhalabe kuwononga nthawi bola kulibe molekyulu yothandizira mayendedwe ake. Pitilizani kupukusa kuti mumvetsetse wotumiza wodabwitsa yemwe angathetse 90% yazovuta zakukalamba.
(2) Nicotinamide Mononucleotide Structure Form
(3) Malingaliro a Nicotinamide Mononucleotide
Nicotinamide Mononucleotide ndi NAD +
onse Nicotinamide Mononucleotide ndi NAD + ndizomwe zimakhala zofunikira kwambiri m'mafakitale a mafuta.
NMN ili pakati pa biosynthesis ya Nicotinamide adenine dinucleotide (NAD +). Thupi limakhala ngati gawo lapansi la michere yeniyeni monga nicotinamide mononucleotide adenylyltransferase, yomwe imatembenukira ku NAD + mu thupi laumunthu. Powonongeka, gawoli limasintha ku nicotinamide. Pambuyo pake, izi zimagwirizananso ndi nicotinamide phosphoribosyltransferase (NAMPT) yopanga NMN.
Mamolekyu awiriwa ndi ogwirizana kotero kuti kusowa kwa aliyense wa iwo kudzakhudza wina. Mwachitsanzo, taganizirani pamene ma NMN akugwera pansi, mwina chifukwa cha senescence, kuchuluka kwa NAD + kudzatha.
Pamene mukukalamba, ntchito zina zowonjezera mavitamini zimakonda kudya NAD + kuposa thupi limene lingathe kupanga mafuta. The Sirtu, NADase, ndi poly-ADP-ribose polymerase (PARP) ndi mbali ya michere, yomwe imatentha NAD + kutsogolera kuyambanso.Komabe, kuchepa kwa mafuta a ma apulosi sikungokhala mosavuta. Mwachitsanzo, taganizirani zomwe zimachitika pothandizira pulojekiti zomwe zimaphatikizapo thandizo la PARP pokonza DNA yoonongeka. Komanso, timititi imathandizira kwambiri pakukonza kagetsi ka maselo.
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Pitani ku gwero
Ngakhale pali ubale wamankhwala pakati pa akatswiri awiriwa, simungathe kupereka NAD + mwachindunji m'dongosolo lino. Momwe njirayi ingathere, zotsatirapo zake sizikhala zovuta. Mwachitsanzo, mlingo waukulu umadziwika ndi kutopa, nkhawa, ndi kusowa tulo. Kuphatikiza apo, pompopompo silingaloledwe kulowa kudzera m'mitsempha yamagazi.
(1) Njira Yokometsera
The Nicotinamide Mononucleotideilipo ngati mankhwala osokoneza bongo. Kutentha kwake kupyolera mu matope a m'matope ndi mu kayendedwe ka kayendetsedwe kake kumayambira pafupi maminiti atatu. Ndi 15th min, zonse zidzakhala zitatengedwa. Kafukufuku wochuluka wa Imai ndi omwe adafufuza nawo akuwona kuti pali puloteni yomwe imathandizira kuthamanga kwakanthawi.
Pogwiritsa ntchito mankhwalawa, NMN imasintha mosavuta ku NAD + kuti isungidwe bwino. Njira ya metabolism ikhoza kutenga theka la ora. NAD + imakhala yambiri m'matumbo, minofu yoyera, chiwindi, ndi cortex. Komabe, kulamulira kwa nthawi yaitali kwa Nicotinamide Mononucleotide kunapitirira msinkhu wa NAD + mu ziwalo zina monga minofu yofiira adipose.
(2) NMN Biosynthetic Njira
M'maselo a mammalia, pali njira zitatu zosiyana zedi zamagetsi zomwe zimaperekera kufooka kwa NAD +.
①De Novo Pathway
De Novo ndi mawu otchedwa "Lain", omwe amatanthauza "kuyambira pachiyambi." Pano, nucleotide imachokera ku tryptophan kapena nicotinic acid, yomwe imachokera ku zakudya za NMN.
Panjirayi, momwe zinthu zimagwirira ntchito zimayambitsa mapangidwe a nicotinic acid mononucleotide, nicotinic acid adenine dinucleotide, ndipo potsirizira pake kuyembekezera kwambiri NAD +. De Novo imapanga pafupifupi 15% ya mafuta onse.
②Njira ya Salvage
Apa, njirayo imapezanso nucleosides pamene DNA imatha. Zimapanga zoposa 80% za chiwerengero cha NAD +, chimene thupi la munthu limafuna ntchito zapulogalamu. Njirayo imagwiritsira ntchito nicotinic asidi ndi nicotinamide kuti apange NAD yatsopano.
Nthenda yotchedwa phosphoribosyltransferase imathandizira kupanga mapangidwe a nicotinic acid mononucleotide kuchokera ku nicotinic acid. Pambuyo pake, nicotinamide mononucleotide adenylyltransferase 1 imapangitsa kuti adenylation iwonongeke kwa mankhwalawa ndi nicotinic acid adenine mononucleotide, ndipo potsiriza ku NAD +.
Ntchito ya NMN pamunthu imadalira njirayi.
③NR Conversion
Nicotinamide Riboside ndi wotsutsa wina wa NAD +. Pa phosphorylation pamaso pa nicotinamide riboside kinase, biomarker imapereka NMN musanayambe kukhala ndi enzymatic kutembenuzidwa kukhala NAD +.
Mbiri ya NAD + ndi NMN mu Research
Kwa zaka zambiri, phunziroli ndi njira zothandizira za nicotinamide adenine dinucleotide ndi zotsatila zake zakhala zikupsya mtima. Komabe, muyenera kuzindikira kuti izi anti-aging supplements akhala akugwiritsidwa ntchito mufukufuku kuyambira pakati pa 1900s.Mu 1906, akatswiri oyamba adanena kuti NAD + imachepetsa kuchulukitsa kwa yisiti. Pambuyo pake, akatswiri a sayansi ya sayansi ya zakuthambo anatsatizana ndi kuikonza kuti ikhale nucleotide.
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PubMed CentralZosungidwa zolemekezeka kwambiri zochokera ku National Institutes of Health
Pitani ku gwero
Kupyolera mufukufuku wake mu 1937, Conrad Elvehjem adapeza kuti nicotinamide ndi nicotinic ndi mavitamini ndi zowonongeka za NAD +. Patapita nthawi, anapeza kuti awiriwa akhoza kuchepetsa agalu. Chifukwa chake ndi chakuti ma nicotinic acid ndi nicotinamide anali otsika kwambiri kwa anthu omwe akudwala matendawa.
Mu 1963, gulu la asayansi lidakhazikitsa kuti Nicotinamide Mononucleotide imagwira mbewa zimathandizira ma enzyme omwe amadalira DNA, omwe anali othandiza pakupititsa patsogolo ma cell. Patadutsa zaka ziwiri, ofufuza ena adatulutsa njira za NAD + zamagetsi zama tryptophan ndi nicotinic acid.
Kuchokera nthawi imeneyo, akatswiri a sayansi ya zakuthambo akhala akupitiriza kusonyeza chidwi pa NMN ndi NAD + kafukufuku. Mu nthawi ino, chofunika kwambiri ndi kufunikira kwa izi mankhwala osokoneza bongo kukhala ndi moyo wautali komanso kuchepetsa mavuto okalamba.
Kafukufuku watsopano wa Nicotinamide Mononucleotide amagwira ntchito pa mbewa
Pali mitundu yambiri yophunzirira pazithunzi zamakono zomwe zimasonyeza ubwino wa mankhwala a Nicotinamide Mononucleotide (1094-61-7).
Tiye tikambirane ochepa chabe, omwe athandizidwa ndi kusintha kwa chilengedwe.
(1) Malingana ndi Sinclair, NAD + ndi Kasupe wa Achinyamata
Dr. Sinclair ndi anzake achita kafukufuku angapo ponena za ubwino wa nicotinamide mononucleotide ndi NAD + potembenuza kukalamba. Malingana ndi kafukufuku wake wa 2013, Sinclair ndi gulu adapeza kuti mbewa za 22 zamwezi zomwe zimatenga NMN kwa masiku asanu ndi limodzi zinasonyeza kusintha kwa minofu, kuchepa kwa thupi, ndi chipiriro.
Pambuyo pake pa pepala la kafukufuku wa 2016, gululo linatsimikizira kuti NMN inali ndi mapindu omwewo monga kuchita. M'malo mothamanga tsiku lililonse, mutha kukhala ndi zotsatira zofanana mukamagwiritsira ntchito mankhwala a Nicotinamide Mononucleotide m'malo mwake.
Malingana ndi Harvard Geneticist, a NMN imagwira ntchito pa anthu Zimayendera kuzungulira magazi pa okalamba ndi othamanga othamanga.
(2) Mphero Zimatsimikizira kuti NMN imachepetsanso kuchepa kwa thupi kwa azimuna okalamba
Ponena za kafukufuku wa 2016, Mills et al. adapeza kuti chithandizo cha NMN chingathane ndi kuchepa kwa magwiridwe antchito amthupi ndi ammunological mu mbewa zakale. Pamapeto pa kafukufuku wowonjezera wa NMN, makoswe adalembetsa kuwonjezeka kwa ma cell a chitetezo chamthupi, kuchuluka kwa ma lymphocytic, ndi kuchepa kwa neutrophils.
M'mbuyomu, mu 2011, Mills, Yoshino, ndi Imai adagwiritsa ntchito mbewa kuti atsimikizire udindo wa NAD + pochiza matenda ashuga obwera chifukwa cha zakudya. Pakafukufuku wina wa 2016, adalumikizana ndi ofufuza ena omwe adatsimikiza kuti kuwonjezera kwa NMN kuthana ndi kupsinjika kwa oxidative komanso kusokonekera kwa mitsempha mu mbewa zakale.
(3) Matenda a NMN a Alzheimer (AD) mu Murine Models
Mu 2015, Long et al. adasanthula momwe NMN imathandizira pakuchepa kwa kupuma kwa mitochondrial pa mbewa ndi matenda a Alzheimer's. Gululi lidazindikira kuti chithandizo cha NMN chidatha kuthana ndi zamatsenga za AD, kuphatikiza otsika OCR (kuchuluka kwama oxygen), NAD + falloff, ndi zovuta za mitochondria.
Mu 2016, Wang ndi anzawo adasindikiza kafukufuku wawo, pomaliza kuti awa odana ndi ukalamba Mankhwala osokoneza bongo amalimbana ndi kuwonongeka kwazindikiritso ndi mitsempha, zomwe zimachokera ku ig-amyloid (AB) oligomer. Puloteni iyi ya AB ndi neurotoxic ndipo imayambitsa mapangidwe a zolengeza muubongo wa odwala AD. Wang et al. adamaliza kuti kayendetsedwe ka NMN mu mbewa zidapangitsa kuchepa kwa AB oligomers, potero kulimbitsa magwiridwe antchito.Kutsatira kafukufuku wa 2017, Hou ndi anzake adapeza kuti NAD + supplementation inachepetsa kupanga B-amyloid oligomers. Patatha chaka chimodzi, Yao ndi gulu lake adakhazikitsa kuti Nicotinamide Mononucleotide amachepetsa kusonkhanitsa kwa AB ndi kutayika kwa synaptic mu AD-Tg murine zitsanzo.
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(4) NMN ndi Cardio-chitetezo
Malinga ndi zomwe 2014 Yamamoto ndi anzawo adalemba mu XNUMX, NMN amateteza mtima ku kuvulala kwa ischemic ndikubwezeretsanso. Asanaphunzire izi, Yamamoto anali mgulu la 2012, lomwe lidapeza kuti NAD + imawerengera kunenepa kwambiri kwama mbewa.
Mu 2016, De Picciotto et al. ndipo amzake amzake amaphunzira momwe mphamvu ya NMN imathandizira pakamagwira mbewa zokalamba. Kuchokera pamalingaliro, nicotinamide mononucleotide idakhala yothandiza pothetsa kuchepa kwa mitsempha, kupsinjika kwa oxidative, ndikuchepetsa elastin.
(5) Kupeza Kwa Njira Yatsopano ya Mafuta Akutumizidwa ndi Shin-Ichiro Imai
Mu kafukufuku waposachedwapa, gulu la asayansi motsogoleredwa ndi Imai adapeza ndipo adasula nthumwi yodabwitsa ya NMN m'maselo.
Kafukufukuyu wa NMN supplement poyamba anapezeka mu January 2019 mkati Chilengedwe cha Metabolism. Imai anakhazikitsa kuti puloteni inayake, Slc12a8, ndi yomwe imayambitsa kutembenuka kwa NMN kwa NAD + mofulumira ndikuyendetsa mu selo. Enzyme imeneyi imakhala yaikulu kwa anthu akale osati achinyamata kapena thanzi labwino.
M'maphunziro onse am'mbuyomu, asayansi ofufuza amatha kusungunula ufa wambiri m'madzi asanawapatse mbewa.
Ubwino wa Nicotinamide Mononucleotide (NMN)
NMN ili ndi ntchito zambiri zochizira komanso zotsatira zamankhwala pathupi la munthu. Pasanathe zaka khumi, asayansi apereka nthawi yawo kuti aphunzire zonse za Nicotinamide Mononucleotide kuphatikizapo njira zomwe zimafotokozera ukalamba ndi matenda okhudzana ndi ukalamba.
Tiyeni tiwunikire maubwino ampangidwe wa makina amunthu.
(1) Kutsegula Mitundu ya Zamoyo
Kufikira kuyambika kwa 21st zaka zapitazi, akatswiri anali ndi zifukwa zokwanira zowonetsera ukalamba ngati njira yosasinthika. Komabe, lingaliro limeneli lakhala lopanda kanthu chifukwa cha kufufuza kwapadera anti-aging supplements monga Nicotinamide Mononucleotide.
NMN imachitika mwachibadwa m'maselo aumunthu ndipo imayambitsa biosynthesis ya NAD + ndi kupanga mphamvu. Pamene mukukalamba, izi zimakhala zochepa kwambiri zomwe zimayambitsa matenda a maselo. Kumbukirani, magulu ogwira ntchitowa amafunikira mafuta okwanira okwanira nthawi zonse, choncho, kugwa kumachepetsa msinkhu wa moyo wa maselo.
Kuwongolera mankhwala ogwira ntchito odana ndi ukalamba monga NMN idzasinthira ndondomeko ndi kuchepetsa ukalamba.
(2) Kulimbikitsa Maselo Achinyamata Achinyamata
Chiyambi chachikulu cha matenda ambiri okhudzana ndi ukalamba ndi wocheperachepera mpaka pamaselo a ma selo. Kuchepa kwa kupanga mphamvu m'kati mwa maselo ndizo zikuluzikulu zowonjezera zizindikiro za ukalamba.Pokhala chithunzithunzi cha NAD +, NMN ili ndi gawo lomwe liyenera kuthandizira kusunga mphamvu zamagetsi za mitochondria. Kukalamba kumapangitsa kuchepa kwa NAD +. Chifukwa chaichi, ukalamba umatenga nthawi pang'ono kuti ukhale ndi matenda okalamba.
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Dontho m'magulu a mphamvu zam'manja mkati mwa ziwalo zofunikira monga minofu, mitsempha ya magazi, impso, chiwindi, kapena mphukira nthawi zonse zimasokoneza thanzi labwino ndi thanzi. Ndi chifukwa chake matenda omwe amatchedwa ischemia, matenda a mtima, impso, matenda osokoneza bongo, ndi ena akuwombera.
Yankho langwiro ndilowonjezera thupi Nicotinamide mononucleotide ndi NAD+ yokhala ndi chithandizo chakunja cha NMN. Mankhwala oletsa kukalamba awa amapereka moyo watsopano kwa maselo okalamba, omwe amavala mawonekedwe aunyamata.
(3) Kupititsa patsogolo Kuthamanga kwa Magazi
Chimodzi mwa kusintha komwe kumachitika nthawi yakale ndi kuchepa kwa mitsempha ya magazi mkati mwa thupi la mamamia. Choncho, ma circulatory system imakumana ndi mavuto ambiri pakanyamula zakudya, mpweya, kutentha, kapena kuchotsa zida kuchokera ku ziwalo. Popeza kuti zinthu zikupitirirabe, zimaipiraipira patapita nthawi kuti zizindikiro za matenda a nthawi yaitali zichitike.
Nicotinamide Mononucleotide ndiyomwe imayambitsa kupanga mitsempha ya magazi. Ndiloleni ndifotokoze. Pulogalamuyi imapanga NAD +, yomwe imathandizanso puloteni ya Sirir deacetylase (SIRT1).
Mosiyana ndi zimenezi, SIRT1 imapangitsanso mabwinja a lysine omwe amathandiza kupanga mpweya wabwino wa oxygen. Njirayi imamenyana ndi zovuta zowonjezera zowonjezereka, kutsekemera, kapena kuvulala kwa kasupe. Nthawi zambiri, thupi lomwelo lidzagonjetsa ischemia ndi zochitika zogwirizana ndi ischemic preconditioning (IPC). IPC idzachitapo kanthu pofuna kulimbikitsa kupanga SIRT1.
Mukhoza kupereka NMN musanachitike chochitika chachilendo kapena panthawi yake. Zisanachitike, kampaniyi imapereka chitetezo cha cardio popititsa patsogolo ATP kupanga kudzera mwa glycolysis.
Pankhani ya Ischemia, mutha kugwiritsabe ntchito Nicotinamide Mononucleotide chifukwa ingayambitse acidosis ndikupangitsa kusowa kwa mitochondrial; chifukwa chake, kutsimikizira kutetezedwa kwa dongosolo la mtima.
(4) Muscle Endurance
Mukuyembekezera chiyani magazi akuchepa? Boma litsogolera kutayika kwa minofu. Sitikukayika kuti mudzawona kuti anthu akale amakhala ndi magwiridwe antchito, kupirira pang'ono, kusayenda, komanso otopa kwambiri nthawi zonse.
Chimodzi mwazinthu zodziwika bwino zomwe a Dr. Sinclair adachita ndichakuti mphamvu ya NMN ikuthandizira kulimbikitsa minofu. Malinga ndi kafukufuku wake wa 2013 komanso 2018 yaposachedwa, mbewa zakale zomwe zidapatsidwa mankhwala a masiku asanu ndi awiri a NMN zidakhala zolimbitsa thupi komanso zolimba ngati anzawo achichepere.
Mphamvu ya minofu ndi kupirira kwa mbewa zakale kwambiri (miyezi 30) zinali zofanana ndi za mwana wa miyezi isanu. Mibadwo imeneyi ikufanana ndi zaka pafupifupi 70 ndi 20 mwa anthu. Kuchokera pazomwe zapeza, mutha kunena kuti NMN imagwira ntchito pa anthu ngati imfa.
(5) Kulimbana ndi Matenda a Neurodegenerative
Ubongo uli ngati mphamvu ya dongosolo lanu. Izi zikhoza kukhala chifukwa chomwe madokotala amakhulupirira nthawi zonse pa ubongo pamene akulengeza nthawi ya imfa.Kuchepetsa chiwerengero cha NAD + mu ubongo kumayambitsa thanzi labwino pakati pa okalamba. Ulamuliro wa NMN ukufulumizitsa kupanga NAD +, motero, kuteteza ntchito za neural.
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Kafukufuku wambiri amatsimikizira kuti Nicotinamide Mononucleotide imapindulitsa kuzindikira, sitiroko, komanso kulepheretsa kukumbukira kukumbukira, komwe kumakhala kofala ndi ukalamba. Mwachidule, izi odana ndi ukalamba zowonjezerazo ndizoyang'anira ma neuron.
NMN imalunjika makamaka pamalingaliro amtundu uliwonse wamanjenje. Mwachitsanzo, Alzheimer's Matendawa amapezeka chifukwa cha kuchepa kwa NAD +, kugwiritsidwa ntchito kocheperako kwa mpweya muubongo, komanso zovuta za mitochondrial. Kuchulukitsa kuchuluka kwa NMN mthupi kuwerengera zotsatirazi.
Malinga ndi kafukufuku wofalitsidwa mu 2012, Nicotinamide Mononucleotide idzawongolera kuwonongeka kwa ubongo, komwe kumayambitsa sitiroko. Mbewa zakale zomwe zinali pansi pa kuchuluka kwa NMN zidalembetsa kusintha kwakukulu pakupanga kwa NAD +. Mitundu yofufuzayi inali ndi chitetezo chokwanira motsutsana ndi kupwetekedwa kwa ischemic, kufa kwa neural, ndi kutupa kwamitsempha.
(6) Kusintha Metabolism mu Ukalamba
Ofufuza ambiri afufuza ndi kutsimikizira kuti NMN imayambitsa kulekerera kwa glucose pamene imapangitsa kuti shuga yambiri isamakhale ndi zakudya zambiri. Phunziroli likugwiranso ntchito kwa anthu okalamba omwe amayamba shuga kapena chifukwa cha shuga kapena zakudya zoperewera. Kuonjezera apo, kudya zakudya zochuluka kumawonjezera insulini kukana.
Nicotinamide Mononucleotide ili ndi chiwerengero chachikulu cha NAD +, zomwe zimachepetsanso kutupa kwa zaka zomwe zimapangitsa kuti thupi likhale ndi mafuta ambiri.
(7) Kuchiza kwa Shuga
Anthu omwe ali ndi matenda ashuga amtundu wachiwiri nthawi zonse amakhala osagwirizana ndi insulin. Khalidwe ili chifukwa chakugwa mu NAD +. Zotsatira zake, maselowo amakhala ndi nkhawa ya oxidative komanso kutupa. Ngati mudakali achichepere, thupi limadzilimbitsa lokha mwazinthu zina zakuthupi. Komabe, ndi ukalamba, milingo ya NAD + imachepa m'ziwalo zothandizira moyo monga mafupa, chiwindi, ubongo, ndi kapamba.
Chinanso chimene chimayambitsa matenda a shuga ndicho kudya zakudya zamafuta ambiri. Mafuta osakwanira okwanira amalepheretsa biosynthesis ya NAD +. Pofuna kutsimikizira kuti Nicotinamide Mononucleotide imathandiza bwanji pochiza matenda ashuga okhudzana ndi msinkhu komanso zakudya, Yoshino ndi anzawo adagwiritsa ntchito mbewa ziwiri.
Pambuyo popereka mlingo wa tsiku ndi tsiku wa NMN kwa masiku pafupifupi 10, ophunzirawo adatsimikiza kuti mbewa, zomwe zimadya mafuta ambiri, zidalembetsa kusagwirizana kwa insulin. Kumbali inayi, mbewa za matenda ashuga zimawonetsa kusintha kwakukulu kwa hyperlipidemia.
(8) Kusintha Kukalamba
Zovuta zaumoyo nthawi zonse zimayendera limodzi ndi ukalamba. Pamene thupi likumana ndi kusintha kwambiri kwa thupi, ntchito zina zimagwera kubwerera. Mwachitsanzo, taganizirani kuti nicotinamide adenine dinucleotide imachepa mu ziwalo zingapo, zomwe zimapangitsa kuchepa kwa mphamvu za magetsi pogwiritsa ntchito mitochondrion ya selo.Kukalamba kumayambitsa zinthu zosiyanasiyana monga kuwonongeka kwa DNA chifukwa cha mamolekyu osatulutsidwa, kupsinjika kwa magazi, ndi mavuto ena. Kodi mukudziwa zomwe zimachitika? Chabwino, pali DNA yokonza mapuloteni (PARP1) mu dongosolo laumunthu. Pankhani ya kuwonongeka kwa DNA, NAD + idzayambitsa mapuloteniwa kuti akonze selo yogwidwa.
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Maphunziro angapo abwera ndi ubwino wa nicotinamide mononucleotide pakukalamba. Mwachitsanzo, Mills ndi anzake adagwiritsa ntchito mbewa kuti afufuze zotsatira za kuchepa kwa thupi chifukwa cha zaka za NMN.
Phunziroli, ochita kafukufuku adanena kuti nthawi yayitali chithandizo cha mankhwalachi chinapangitsa kuti kuwonjezeka kwa majeremusi osokonezeka mu chiwindi, mitsempha, ndi minofu. Kuwonjezera pamenepo, zomwe anapezazi zinatsimikizira kuti maselo a chitetezo cha m'magulu, chitetezo cha ma lymphocytes, ndi kuchititsidwa kwa leukocyte.
Chinthu china cha ukalamba ndi kukhalapo kwa mawanga owala mu thumba la maso. Matendawa kuphatikizapo kuperewera kwa mafupa kufooka komanso kulephera kubweretsa misozi kwawerengedwa bwino pa makoswe. Asayansi ananena kuti mbewa, zomwe zinayikidwa pa chithandizo cha mwezi wa XMUMX wa NMN, zinasintha zinthu zonsezi.
Zaka zambiri ndizo chifukwa chokha chomwe anthu amachitira Gulani Nicotinamide Mononucleotide.
(9) Kuchiza kwa Kunenepa Kwambiri
Kwa okalamba, NMN ikhoza kuchepetsa mpaka 10% ya kulemera kwa thupi koyamba popanda kupeza pakati pakati pa njala ndi kukula. Zomwe zimayambitsa kunenepa kwambiri ndi shuga zimagwirizana. Maseŵera a NAD + otsika amachititsa kulephera kwa mitochondrial; chotero, kuchepa kwa kupanga ATP.
Kunenepa kumachepetsa mphamvu ya mitochondria pakupanga ATP mphamvu kwa maselo. Mukapereka Nicotinamide Mononucleotide, mankhwalawa amachititsa kusagwirizana kwa shuga ndi ntchito zina zamagetsi zokhudzana ndi kunenepa kwambiri.
Zikafika pakukweza magazi, NMN yokhudza kunenepa kwambiri imachitanso chimodzimodzi ndi kuchita masewera olimbitsa thupi. Piritsi limodzi lingakhale lofanana ndi kugwiritsa ntchito chopondera tsiku lililonse. Komabe, kusiyana kumabwera m'magulu azomwe zili ndi NAD + m'ziwalo zathupi. Pomwe Nicotinamide Mononucleotide imakulitsa NAD + m'chiwindi ndi minofu yamphamvu, kuchita masewera olimbitsa thupi kumangomangika pakapangidwe kake mkati mwa minofu.
Kodi Nicotinamide Mononucleotide (NMN) Ikugwira Ntchito Pa Munthu?
Mwina ili ndi funso lomwe likupezeka m'mutu mwanu. Mulimonsemo, kafukufuku ndi Preclinical kafukufuku wokhazikika pa Nicotinamide mononucleotide ndi NAD + akhala akuwongolera mitundu ya murine.
Ngati muli ndi zosungira za momwe NMN ikugwirira ntchito paumunthu, ndizo zonse zomwe mukuyenera kuzidziwa. Dr. David Sinclair, wofufuza kapamwamba, ndi geneticist ku Harvard University ndi mmodzi mwa omwe adalandira NMN.Sinclair avomereza kuti amatenga chowonjezera. Pakadali pano, wophunzirayo sanalembe zotsatira zoyipa za nicotinamide mononucleotide. M'malo mwake, akunena kuti amadzimva wachichepere wokhala ndi malingaliro owoneka bwino. Zobisalira ndi jet lags tsopano ndi nthawi yapitayi kwa iye. Ananenanso kuti abambo ake, omwe ali kumapeto kwa zaka makumi asanu ndi awiri, amatenganso chowonjezera.
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Kuwonjezera apo, Dr. Sinclair wakhala akugwiritsa ntchito mankhwalawa monga oyambirira ku Brigham ndi Women's Hospital. Ali ndi ndondomeko zowonjezeretsa kuyesa kwa okalamba omwe ali ndi thanzi labwino. Ngakhale kuti phunziro lake limodzi ndi lathunthu, adakalibe buku lovomerezeka. Sinclair adayamba gawo lachiwiri lachipatala ichi NMN supplement kafukufuku mu 2018.
chipatala Mayesero
Phunziro lachipatala lomwe limayenera ku 1st June 2020, ofufuza akuyang'ana kuti asinthe kusintha kwa mphamvu ndi beta-selo ikugwira ntchito ndi NMN supplementation mwa anthu. Ophunzirawo akuchokera ku Sunivesite ya Washington University of Medicine ndi Keio University School of Medicine ku Tokyo.
Mu kuyesedwa kwaumunthu komwe kunayamba ku 2016 ku Keio University, akatswiriwa anali kuyang'ana kuti aone ngati NMN ndi otetezeka kwambiri. Mu gawo lachiŵiri lopitirira, bungwe lomwelo, lotsogoleredwa ndi Shin-Ichiro, likufufuza kafukufuku wa NMN wa nthawi yayitali. Zowonjezerapo, gululi likufuna kufufuza njira zokhudzana ndi matenda opatsirana pogonana, NMN kinetics, ndi mankhwala omwe amachititsa kuti shuga isamagwiritsidwe ntchito.
Mu phunziro lachipatala la 2017 ndi University of Washington, ophunzirawo anali ndi akazi a 50 a zaka 55 mpaka zaka 75. Gululi linaikidwa pa mlingo wa tsiku ndi tsiku wa 250mg wa NMN kwa masabata asanu ndi atatu. Ngakhale kuti anali a thanzi labwino, akaziwa anali ndi shuga kwambiri, triglyceride, ndi BMI. Phunziro silinamalire.
Pakadali pano, palibe zofalitsa zomwe zimatsimikizira kuti NMN imagwira ntchito pa anthu. Komabe, muyenera kuyimilira chifukwa china chake chikuphika ndipo mayesero azachipatala atha kukhala olonjeza.
Mmene Mungagwiritsire ntchito Nicotinamide Mononucleotide (NMN) Yotsutsa Kukula?
Ngati mukuyang'ana kugula nicotinamide mononucleotide, pali zinthu zingapo zomwe muyenera kudziwa.
Mungathe kutenga mankhwala monga chakudya chowonjezera chifukwa sanalandire mgwirizano womaliza wa FDA kukhala mankhwala osokoneza bongo.
Mlingo uli pakati pa 25mg ndi 300mg malingana ndi ubwino wa thanzi lomwe mukufuna kuti mukwaniritse. Komabe, anthu ena amavomereza kutenga 1000mg patsiku. Tenga Mwachitsanzo, Dr. Sinclair amatenga 750mg / tsiku. Kuphatikiza apo, akuwonjezera mphamvuyi ndi resveratrol ndi metformin.
Mu mayesero a chipatala a NMN, ambiri ofufuza adzaika maphunziro awo pamtundu wa 100mg kwa 250mg.
Mvetserani pamagulu osiyana
Ngati mukufuna kupititsa patsogolo mankhwalawa, muyenera kugula mapiritsi a Nicotinamide Mononucleotide kuti muwongolera. Kugwiritsa ntchito mankhwalawa kumachepetsa kuchepetsa ndalama zomwe zimalowa m'matumbo. Chifukwa chake n'chakuti imayambitsa matenda ndi kuchepa pamene imadutsa m'magazi ndi chiwindi.NMN yamagulu amodzi mwachindunji alowa mwazi popanda zitsulo zilizonse. Kuchuluka kwake kwa njira iyi yobereka ndi pafupifupi kasanu kuposa kulamulira komlomo. Pachifukwa ichi, mufunika kuwonjezera mlingo kuti mupange choyamba chamagetsi pachiwindi. Tiyerekeze kuti mukufufuza, mungafunikire ufa wochuluka wa nicotinamide mononucleotide kuti mutsirize phunzirolo.
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Zotsatira Zake za Nicotinamide Mononucleotide Muyenera Kudziwa
Zofananira ndizofanana ndi zomwe zimawonetsedwa ndi niacinamide ndi zina za vitamini B3 komposionotinamide mononucleotide zoyipa s. Komabe, anthu ambiri samaziwona nkomwe. Mwachitsanzo, wasayansi wamkulu wofufuza ku Harvard University avomereza kuti atenga NMN, koma sanazindikire zovuta zilizonse.
Pakalipano, mu Nicotinamide Mononucleotide yomwe ilipo ikugwira ntchito pa mbewa, palibe deta yomwe imasonyeza kuti pali zotsatirapo zina zomwe zimayambitsa maonekedwe a murine. Palibe wofufuza amene adalemba chizindikiro choipa pafupipafupi komanso kwa nthawi yaitali NMN administration.
Anthu ena amatha kuona zotsatirazi zoipa;
- nseru
- kusanza
- chizungulire
- Mimba imakhumudwitsidwa
- kutsekula
- Zomwe zimayambitsa matendawa monga itchiness, mng'oma, kapena misampha
Nthawi zambiri, zotsatira za nicotinamide mononucleotide zikhoza kukhala zovuta kwambiri kuti mufunse kufufuza mwamsanga. Kutchula zochepa, zovuta kupuma, kupweteka mtima kwa mtima, kusanza kosalekeza, khungu la chikasu, ndi kusowa kwa njala ndi zina mwa zizindikiro zovuta.
Contraindications
Pakadali pano, mayesero a zachipatala amangokhala akuluakulu okalamba mu zaka za 45 mpaka zaka 75. Pa chifukwa ichi, magulu otsatirawa ayenera kukhala osamala asanayambe kuwonjezera zowonjezera kupirira kwa NMN.
- Amayi oyembekezera ndi oyamwitsa
- Anthu omwe ali ndi mbiri ya hypersensitivity kwa NMN
- Odwala amamwa mankhwala odwala matenda aakulu
Kodi Ndingapeze Kuti Mankhwala Osokoneza Bongo-Nicotinamide Mononucleotide (NMN)?
(1) NMN Zakudya Zakudya
Mwinamwake mukukangana kuti ndi chifukwa chiyani muyenera kugula Nicotinamide Mononucleotide pamene mungapeze mosavuta zakudya zina. Ndiloleni ndikufotokozere mwachidule chifukwa chake izi zowonjezera ndizofunikira.Monga NAD + imachepa m'thupi chifukwa cha kukalamba, maselo sangathe kulimbana ndi zotsatira zake. Panthawi imeneyi, kusankha kwanu kokha kungakhale kugwiritsa ntchito NMN supplements. Madokotala amakulimbikitsani kutenga zakudya za NMN monga broccoli, bowa, edamame, kapena shrimp. Komabe, zakudya izi zidzangopereka zosakwana 5% za zomwe thupi lanu limafuna.
(11)↗
PubMed CentralZosungidwa zolemekezeka kwambiri zochokera ku National Institutes of Health
Pitani ku gwero
FDA ikuvomereza kuti munthu aliyense akusowa pafupifupi 560mg ya NMN patsiku. Tiyerekeze kuti mutenga mafuta kuchokera ku broccoli, mudzadya mapepala a 1500 ofanana.
(2) Zotsatira za NMN
The nicotinamide mononucleotide ufa wambiri ilipo kugulitsidwa m'masitolo ambiri a mankhwala ndi mankhwala kapena ma laboratories. Ngati mukufuna zina pa kafukufuku wanu, mukhoza kupanga ndondomeko yowonjezera, yomwe imabwera ndi mitengo yotsika mtengo ndi zoperekera pazitsamba zotsatsira.
Kugula pa intaneti kwa NMN sikungopulumutsa nthawi yanu komanso kumapereka nsanja yabwino kwambiri yofananizira mitengo yosiyanasiyana. Ngati simuli wofufuza, mutha kugulabe Nicotinamide Mononucleotidesupplements kuti mugwiritse ntchito nokha. Musanayambe kuyitanitsa, onetsetsani kuti ndi chakudya chamagulu.
Chidule
Zikumveka zosamveka kunena kuti NMN imawonjezera nthawi ya moyo wa anthu. Komabe, izi zikutsimikiziridwa. Chifukwa cha imfa pakati pa okalamba ndi chifukwa cha matenda omwe amachititsa zaka zambiri, zomwe zimachitika chifukwa cha ntchito zamagulu osauka.
The anti-aging Nicotinamide Mononucleotide imangowonjezera kupititsa patsogolo mafuta a cell komanso kulimbikitsa magwiridwe antchito a ma cell. Imachita ndikuwongolera NAD +, yomwe imakonda kuchepa tikamakalamba.Kugwiritsira ntchito mankhwala okalamba, kusungunuka, dzuwa, kapena kuchita masewera olimbitsa thupi pa zakudya zabwino kungangosintha nkhope yanu. Komabe, muyenera kumvetsa chomwe chimayambitsa mavuto okalamba omwe angawachitire. Nicotinamide mononucleotide imasintha ukalamba pokonzanso DNA yowonongeka, kuteteza ubongo, mapulogalamu a mtima, kupangitsa minofu kugwira ntchito, ndi kuwonjezera chipiriro.
(12)↗
PubMed CentralZosungidwa zolemekezeka kwambiri zochokera ku National Institutes of Health
Pitani ku gwero
Ngati mukufuna nicotinamide mononucleotide ufa wambiri, fufuzani ndi ife ndipo muzisangalala ndi mtengo wabwino.
Zothandizira
- Mphero, KF, Yoshino, J., Yoshida, S., et al. (2016). Kulamulira kwa Nthaŵi Zakale za Nicotinamide Mononucleotide Zimasintha Mitengo ya Kusagwirizana Kwambiri M'magulu. Cell Metabolism.
- Yoshino, J., Mills, KF, Imai, SI, ndi Yoon, MJ (2011). Nicotinamide Mononucleotide, chofunika kwambiri cha NAD + Chokhazikika, Amachiza Pathophysiology Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chakudya Chamakono Cell Metabolism.
- Yamamoto, T., Byun, J., Zhai P., Ikeda, Y., Oka, S., ndi Sadoshima, J. (2014). Nicotinamide Mononucleotide, Wopakatikati wa NAD + Synthesis, Amateteza Mtima ku Ischemia ndi Reperfusion.
- Sinclair, DA, Uddin, GM, Youngson, NA, ndi Morris, MJ (2016). Mutu kupita ku Mutu Kufanizitsa Chithandizo cha Nthawi Yachidule ndi Chotsutsa NAD + Chotsatira Nicotinamide Mononucleotide (NMN) ndi Ma sabata asanu ndi limodzi a Kuchita Zozizira M'magulu Okazi Amuna.
- Imai, S., Yoshino, J., Mills, KF, Grozio, A., et al. (2019) Slc12a8 ndi Nicotinamide Mononucleotide Transporter. Chilengedwe cha Metabolism.
- De Picciotto, NE, Mills, KF, Imai, S., Gano, LB, et al. (2016). Nicotinamide Mononucleotide Amatsitsimutsa Matenda Osavuta ndi Mavuto Osokoneza Bongo ndi Amphawi Okalamba.
- Yao, Z., Gao, Z., Yang, W., ndi Jia, P. (2017). Nicotinamide Mononucleotide Imaletsa JNK Kukonzekera Kuti Muthane ndi Matenda a Alzheimer.
- Hou, Y., Wang, Y., Zhang, Y., Lautrup, S., et al. (2018). NAD + Zowonjezeretsa Zomwe Zimapangitsa Makhalidwe Aakulu a Alzheimer ndi DNA Kuwonongeka Mayankho mu New AD Mouse Model ndi Kutulutsidwa DNA Kukonza Kufooka.
- NTHAWI NICOTINAMIDE MONONUCLEOTIDE (NMN) UTHO (1094-61-7).

robotstxt: allowed

filter: keep


text:
Ndalama zamchere zamchere, nyali zoyima, nyali zamchere, nyali zowonetsera nyali, nyali zamatchi, nyali zamchere, himalayan nyali zamchere, nyali zamchere za himalayan, nyali zamchere zamchere, himalaya nyali zamchere, nyali yamchere, mchere wamchere, nyali zamwala , ion air purifier, ma air purifiers ionizers, nyali yamchere ya mchere, nyali zamchere, nyali yamwala, mpweya wa mchere wa mchere, nyali ya mchere wa himalayan, nyali zamchere zamchere, nyali zamchere zamchere, zamchere zamchere za ionic, nyali zamtengo wapatali zamagetsi nyali zonunkhira, nyali yamchere ya mchere, nyali yamchere ya mchere, nyali zoyipa za ion
Nyali iliyonse yomwe mukufuna kuipezerapo ilipo 2-3, 3-4, 4-6, 6-8, 8-10, 10-12 ndigram yowonjezeranso nyali zazikulu 50 kg, 100 kg, 150 kg, 200 makilogalamu, etc. .
Nyali yamchere ya Himalayan
Ndalama zamchere zamchere, nyali zoyima, nyali zamchere, nyali zowonetsera nyali, nyali zamatchi, nyali zamchere, himalayan nyali zamchere, nyali zamchere za himalayan, nyali zamchere zamchere, himalaya nyali zamchere, nyali yamchere, mchere wamchere, nyali zamwala , ion air purifier, ma air purifiers ionizers, nyali yamchere ya mchere, nyali zamchere, nyali yamwala, mpweya wa mchere wa mchere, nyali ya mchere wa himalayan, nyali zamchere zamchere, nyali zamchere zamchere, zamchere zamchere za ionic, nyali zamtengo wapatali zamagetsi nyali zonunkhira, nyali yamchere ya mchere, nyali yamchere ya mchere, nyali zoyipa za ion


text:
Khosi Massager 3D Wanzeru Zamagetsi Khosi Massager
Mankhwala Mwatsatanetsatane
Zogulitsa
* Mitundu isanu ndi umodzi, milingo 15 yamphamvu ingasinthidwe mwakufuna kwawo.
* Kutentha kwa TENS, kutsanzira kutikita minofu yachikhalidwe yaku China.
* Nthawi zonse kutentha kwanzeru kuyang'anira kutentha.
* Kuwulutsa mawu, anzeru kutali
* 6 modes of massage and 15 intensity levels: Ubetter Intelligent Pulse Neck Massager ili ndi mitundu 6 ya kutikita minofu ndi milingo 15 yolimba. Akupatseni mitundu yosangalala kwambiri yamisili
* Pewani bwino kupweteka kwa khosi: gwiritsani ntchito khungu lokoma, yopumira yopepuka ya silicone kuti muwonetsetse kukhazikika kwa khosi. Kugwiritsa ntchito mankhwala ochepetsa kutentha kwapafupipafupi sikungathandize kuthana ndi kupweteka kwa khosi, komanso kumalimbikitsa kuyenda kwa magazi.
* Kupanga kofanana ndi U komanso kapangidwe kake konyamula .
* 4-point kutentha kwapompopompopompo - Kokhala ndi 107.6 ° F kutentha kosalekeza komanso kutentha kwa compress, pogwiritsa ntchito mawonekedwe amakono ndi kuzindikira kutentha, kumatha kuyendetsa molondola kutentha ndikupewa kutenthedwa.
* Batire yayikulu yamagetsi komanso nthawi yochenjera - Gwiritsani ntchito batri la lithiamu la 1200mAh kulipiritsa kwa maola awiri, itha kugwiritsidwa ntchito kwa maola 6 mosalekeza. Nthawi yomweyo, ili ndi mphindi 15 zokha yotseka ntchito kuti iteteze chitetezo chanu.
* Chidziwitso cha miyezi 24 & malingaliro obwerera masiku 30. Osagwiritsa ntchito mukakhazikitsa opanga zida. Chonde moisten khosi limatha kupanga ma elekitirodi kukhudzana ndi khosi kwathunthu.
Chojambula → Nkhungu → jekeseni → zinthu mopupuluma Kumaliza → yosindikiza → Waya kumulowetsa → Assembly → Quality kasamalidwe → atanyamula
Europe, America, Nouth America, South America, Middle East, Asia
* Iliyonse kubokosi lamitundu, lokhala ndi IFU
* Kukula kwa Bokosi: 17.5x16.5x5.7cm,
* Kukula kwa Ctn: 36.5x34x36cm
* 24pcs / ctn
* Mtengo wa 20 '': 13320pcs
* Mtengo wa 40 ``: 30384pcs
* Mtengo wa 40HQ: 35712pcs
* FOB Port: Ningbo
* Nthawi Yotsogolera: Masiku 35- 45
Njira Yolipira: Pofika 30% T / T pasadakhale komanso ndalama zolipiridwa motsutsana ndi B / L, PayPal, L / C ..
Kutumiza Tsatanetsatane: mkati 30-45days pambuyo kutsimikizira kuti.


text:
vesi 1:
Ndi chinachake pa lingaliro langa chiyani inu muli kamphindi?
bokosi la sopo kudzikoka, Ine ndangokhala pa izo
Ine ndakhala mu unyolo izi ndi ine ndatopa izo
(phokoso Car) Ine ndikudziwa inu akumva matayala izi akusisita
Screeching msewu, yenera achoke
I akufuna zondithawitsa, Ine ndikuganiza izi tsiku
Chifukwa Ine ndiri mu ukapolo kuchita mabodza ake mwachinyengo
Anayesera kuti ndisiye koma sanali oyenerera
Pezani he mkulu, kupeza he mkulu, kupeza he mkulu
Novacane mu thupi langa, palibe Ine m'malo mabodza
Iwo amati ndine mchere ndi iwo akhoza kutsutsa
Koma ine ndikuwapempherera kupha, sangathe kudikira kutha ake
Musanayambe kulilira, ndi kuwauza anthuwo ine ndikangochoka
Ine ndikuyankhula podwala woluza Lusifara, inu mukudziwa iye zolakwika
Ine ndikudziwa iwe anafunsa kuti awononge pa foni
Kodi n'kulakwa ngati ine ndikupita mu nyimbo?
mbedza:
Ndikumva zomwe inu mukunena, koma ine sindikukhulupirira kuti inu
Chifukwa inu basi kumanama, ndipo Sindifuna inu
Ine ndiri ndi Ambuye latsopano, Ine ndikudziwa ine sindikuwona inu
Koma I kuona kudutsa inu, kotero ine ndikuyenera kuchoka inu
(Bwerezani 2X)
vesi 2:
Kangati kodi ine ndikuyenera
Uzani y'all kuti Ine akana kuchita
Kuti zambiri zoipa, chifukwa wakale mbuye Opha
Undiitane Harriet ine ndikuyesera kuti inu mu munda
Ine ndikuyankhula podwala Satana, Iye ndikuganiza iye ndi munthu
Kumachita monga iye akuthamanga zinthu, Ine ngakhale akusewera
Koma kumuuza Sindifuna mabodza ake onse pa ine
Ngakhale ine ndikudziwa kuti iye ali maso ake onse pa ine
Iye ndiye tate wa mabodza
Iye anafika ana ochuluka omwe si anadabwa
Pambuyo bambo kuyenda kwa iwo kuwonongedwa
Iwo sakanakhoza kuyenda kuchoka kwa mwenimweni mwa phiri limeneli ngati iye anatsegula maso awo, ife ndikuyenera nyamuka
utali iye anali pa izo, mukuganiza kwenikweni amphamvu?
Kumachita ngati inu mu zone ya, iye wakhala akugona zonse pamodzi
Ife tikusowa champ kugogoda iye ndi Lizani
Iye anachita izo, zaka zambiri zapitazo, kotero
mbedza (2X)


text:
Mu Shadow Wathu: Zauzimu Kupempherera Ansembe
-dinani PANO pa tsamba la buku.
Dinani PANO kugula pa Amazon.
Mu Shadow Wathu-Zauzimu Kupempherera Ansembe ndi chitsogozo kwa amayi, kuwalowetsa mkati mozama ndikusinkhasinkha za ubale wapakati pa Dona Wathu ndi Yesu, Wansembe Wamkulu Wamuyaya. Zikuwoneka pakukula kwa ubale wawo - kuyambira paubwana Wake (monga 'Yesu Wam'ng'ono Wopachikidwa'), kudzera mu Utumiki Wake ndi Chisoni (komwe Amayi Athu Anali Omthandiza Ndi Mphatso), ku Kuuka Kwake ndi kukhala ndi Iye kwamuyaya. Kupyolera mu kusinkhasinkha uku, owerenga samangodziwa mozama za ubale wa Mariya ndi Mwana Wake, komanso udindo wake pothandiza amuna onse oitanidwa kuunsembe. Mwa kulowa mu uzimu wa Amayi Athu opempherera ansembe, owerenga amaphunzitsidwa njira yabwino kwambiri yoperekera ansembe mwauzimu ngati mayi wauzimu, mlongo, mwana wamkazi, komanso bwenzi.
"Pomwe mapemphero a Saint Monica a mwana wake wopulupudza adathandiza Augustine kukhala woyera kwambiri, mapemphero a azimayi amathandizanso ansembe kukula mchiyero, kuyitanidwa kwathu konse kudamveka nthawi iliyonse yomwe timakondwerera Misa ndikuwerenga limodzi ndi kwayala ya kumwamba. 'Woyera, Woyera, Woyera Ambuye Mulungu Wamakamu.' Mulole amayi ambiri alimbikitsidwe ndi bukuli kupempherera chiyero cha ansembe athu. ” - A Rev. Peter Samuel Kucer, MSA, wolemba A Brief Historical Survey of Marian Devotion and Theology
"Buku la Mary Kloska mu In Our Lady's Shadow - The Spirituality of Praying for ansembe ndi limodzi mwamabuku achikatolika olimbikitsa kwambiri omwe ndidawerengapo. Munthawi yamavuto ino mu Mpingo, ndikofunikira kwambiri kuti tikupempherera ansembe mozama kwambiri kuposa kale. Werengani! Ikhoza kupititsa patsogolo moyo wanu wauzimu m'njira yomwe simungadziwe. ” - Ronda Chervin, Ph.D., Pulofesa Wachikatolika Wopuma pantchito, wolemba mabuku ambiri, komanso wowonetsa pa EWTN ndi Catholic Radio
"Lofalitsidwa pa Tsiku Ladziko Lonse la Akazi, buku latsopano la a Mary Kloska… MU OAD LADY's SHADOW: Zauzimu Kupempherera Ansembe… zikuwonetsa panthawi yake za ntchito yokongola yomwe amayi makamaka ali nayo yopempherera ansembe. Nthawi yomwe azimayi ambiri amasokonezeka chifukwa cha ntchito yawo mdera lawo komanso malo awo mu Mpingo… Thupi la Khristu… wolemba akufotokoza za mphatso yapadera ya umayi ya umayi ndi uzimu wabwino womwe umachokera ku chowonadi ichi. Wolemba amakumbutsa azimayi kuti, mosiyana ndi malingaliro wamba, ndi "kuchepa" komwe kumapangitsa kusiyana kwakukulu padziko lino lapansi. " - Bambo. Lawrence Edward Tucker, SOLT… wolemba buku la The Prayer of Jesus Crucified ; Zopatsa Chisangalalo Cha Atate! ; Yemwe Mtima Unasankha Kukonda ; Kuwomboledwa kwa San Isidro .
“Zinali zotonthoza kwa Yesu chotani nanga kukhala ndi Amayi Ake achifundo kumeneko kuti amuthandize ndi chikondi chawo chonse ndi mapemphero m'moyo wake wonse wansembe, makamaka popita ku Kalvari. Nanga ana ake ena a ansembe okondedwa amafunikiranso bwanji Amayi awa a chitonthozo ndi chifundo kutsagana nawo pamene akukwaniritsa udindo wawo waunsembe. Ndikukhulupirira bukhu ili, "Mu dona lathu: Zauzimu zopempherera ansembe" zidzawalimbikitsa, iwo omwe amawerenga, kuti akwaniritse pempho lathu lachangu loti apempherere ansembe mu mzimu wa Maria, amayi a Yesu, Amayi a ansembe ndi Mfumukazi ya atumwi. Chikondi chonse m'mitima ya Yesu, Mariya ndi Yosefe chidzaze mitima ya wansembe aliyense kusefukira! ” - Bob Cantoni, wolandila Bob Carter wa WCAT Radio "Ngati Mumamudziwa Maria, Ndiye Kuti Mumamudziwa Yesu"
“Bukuli ndichothandiza kwambiri kwa anyamata omwe akuphunzira za unsembe, wansembe wokondedwa wa parishi kapena bwenzi la wansembe, komanso aliyense amene angakopeke ndikupempherera ansembe. Ndi chuma chambiri chomvetsetsa komanso mgodi wolimbikitsira wa golide, wofunikira kwambiri mdziko lamakonoli. ” - Theresa Thomas, Wolemba Mabanja, Amayi a asanu ndi anayi, komanso wolemba Big Hearted (Ndodo)
"Monga mayi wa ana ang'onoang'ono komanso wina wopatulira nthawi yopemphera kwa sabata sabata lililonse kwa ansembe, bukuli limandithandiza kukonda kwambiri mapembedzedwe a ansembe komanso momwe amafunira mapemphero athu. Ndine wokondwa kukhala ndi chitsogozo. Ndi buku lapadera kwambiri! ” - Amelia Colone, mkazi, amayi komanso membala wa Seven Sisters Apostolate wopembedza ansembe sabata iliyonse


text:
10 iPhone Music anasamutsidwa kwa mazenera ndi Mac
Pali softwares ndi zida zimene zinayenera Music anasamutsidwa kwa mazenera ndi Mac popanda osasowa iTunes. Zida ndi softwares ndi yosavuta kugwiritsa ntchito ndi pakati yabwino kumsika. Nawu mndandanda anthu softwares zochokera mu gulu la nsanja, mawindo, Macs ndi ena.
5 iPhone nyimbo anasamutsidwa kwa Mawindo
Pakuti nsanja, mawindo, pamwamba 5 softwares osankhidwa ndi awa:
PodTrans
Mapulogalamu, kukula ndi chida chachikulu kwa yoyenera kutengerapo a nyimbo iPod kuti Mawindo! Monga dzina zikusonyeza, ntchito za PodTrans Ia chachikulu popanda osasowa aliyense iTunes thandizo.
Mapulogalamu: Immobile Inc.
Mfungulo Mbali
- • ziwiri iPod Music Choka
- • Ntchito onse pa Mawindo ndi Mac
- • mokwanira amathandiza onse zitsanzo za iPod ngati nano, Sewerani, iPod tingachipeze powerenga ndi iTouch
Free kapena amalipira: Free Mlandu ($ 29.99)
Download URL: http://www.imobie.com/podtrans/download.htm
Chithunzi:
Wina mapulogalamu kwa cholinga chomwecho ndi dzina lalikulu chimodzimodzi inuyo mumakonda, amene akutumikira monga lalikulu nyimbo kasamalidwe dongosolo.
Mapulogalamu: Immobile Inc.
Mfungulo Mbali
- • Chimafunika iPhone waluso kusewera mitundu yonse ya mavidiyo
- • Ali ndi mphamvu kusamutsa owona ngakhale iTunes kubwerera kamodzi
- • Great kusamalira nyimbo ndi ena, ngakhale zoposa iTunes
Free kapena amalipira: Free Mlandu ($ 39.99)
Download URL: http://www.imobie.com/anytrans/download.htm
Chithunzi:
iTools
A zodabwitsa ufulu njira chida iTunes, itools ndi zodabwitsa mtendere kwa Mac ndi Mawindo Ogwiritsa.
Mapulogalamu: Thinksky
Mfungulo Mbali
- • Free ntchito
- • Wangwiro njira iTunes ndipo angagwiritsidwe ntchito kwa kung'anima pagalimoto popanda unsembe
- • Great Chida kugwiritsa ntchito zipangizo zonse iOS
Free kapena amalipira: Free
Download URL: http://itools.en.uptodown.com/
Chithunzi:
DiskAid kapena iMazing
Kale ankatchedwa DishAid, iMazing chachikulu Kuwonjezera pa mndandanda. Ndi ntchito zake zosiyanasiyana thandizo mbali ndi mkulu khalidwe misonkhano ndi zinthu, ali ngati lalikulu mapulogalamu kwa owerenga zinayenera ntchito zake zosiyanasiyana.
Mapulogalamu: DigiDNA SARL
Mfungulo mbali
- • Ntchito zodabwitsa basi 2 masitepe
- • Waluso kulenga zonse Backups ndi kuwabwezeretsa ku chifuniro
- • Ntchito ndi malire iOS zipangizo
Free kapena analipira: $29.90
Download URL: www.imazing.com/download
Chithunzi:
SynciOS
SynciOS ndi yosavuta kugwiritsa ntchito pulogalamu, amene ali imapanga kulenga lalikulu playlist ngakhale popanda kum'dula choyambirira nyimbo laibulale
Mapulogalamu: Anvsoft Inc.
Mfungulo mbali
- • A zodabwitsa njira kwa Mawindo ndi Mac
- • 100% yogwirizana ndi zipangizo zatsopano m'badwo
- • M'manja onse iOS zipangizo zambiri kusiyana iTunes
Free kapena analipira: Free
Download ulalo: www.syncios.com/download.html
Chithunzi:
3 iPhone nyimbo anasamutsidwa chifukwa Mac
Nawu mndandanda wa pamwamba 3 iPhone nyimbo anasamutsidwa mapulogalamu Mac.
iSkysoft TunesOver
A wamkulu mapulogalamu zinayenera cholinga cha Ogwiritsa ankaona kuti Mac, iSkysoft TunesOver ndi dziko lonse wothandiza mapulogalamu, amene ali itune njira kwa Mac.
Mapulogalamu: iskysoft situdiyo
Mfungulo mbali
- • Magalimoto azindikire wapamwamba mtundu, basi kutembenuza nyimbo owona ndipo motero, sitiyenera kudandaula za mtundu wapamwamba
- • No thandizo la iTunes anafunika
- • osiyanasiyana TV thandizo ndi wapamwamba kudya liwiro ndi ziro khalidwe imfa
Free kapena analipira: Free ($ 29.95)
Download ulalo: http://www.iskysoft.com/tunesover-for-mac.html
Chithunzi
SharePod
Ofunsira cholinga cha kusewera nyimbo ndi anasamutsidwa wa wapamwamba kwa Mac owerenga!
Mapulogalamu: Macroplant
Mfungulo mbali
- • Small kukula mapulogalamu
- • malo a kukopera ndi achire nyimbo ndi playlists chilichonse iPod, iPad, kapena iPhone kuti kompyuta ndi mu iTunes.
- • Great mapulogalamu Kusewera nyimbo
Free kapena analipira: Free Mlandu ($ 20)
Download ulalo: https://www.macroplant.com/downloads?_ga=1.132314254.1037637007.1432744083
Chithunzi
Floola
Floola, limene lakonzedwa kwa cholinga cha iPod, Motorola foni kutengerapo ndi kasamalidwe, pa Intaneti angathe kusamutsa nyimbo iPod popanda iTunes pa Mac, Mawindo ndi Linux nsanja.
Mapulogalamu: Floola
Mfungulo mbali
- • Free ndi cholinga posamutsa nyimbo ndi playlist kuti iPod ndi zina Mobiles
- • Kuwonjezera nyimbo chilichonse makompyuta (kuphatikizapo anzanu makompyuta) anu iPod
- • Easy Kokani ndi dontho malo akupezeka
Free kapena analipira: Free
Download ulalo: http://www.floola.com/home/download_mac/
Chithunzi
2 iPhone nyimbo tranfer app
Air Choka
Ndi yosavuta nsanja osiyanasiyana owona ndi chikalata kugawana pakati pa PC ndi iPhone.
Mapulogalamu: Dong hyung SEO
Mfungulo mbali
- • The losavuta njira kusamutsa owona pakati PC ndi iPhone / iPad
- • Zambiri Kokani Dontho malo
- • Background Kwezani njira likupezeka Lite Baibulo
Free kapena analipira: Free
Download ulalo: https://itunes.apple.com/in/app/air-transfer-easy-file-document/id521595136?mt=8
Chithunzithunzi:
iRip
iRip chachikulu app zinayenera Choka nyimbo yanu iPod kapena iPhone kuti Mac kapena PC.
Mapulogalamu: The Little App Factory Pty. Ltd
Mfungulo Mbali
- • Mungasankhe wina pitani achire zilipo ndi iRip
- • playlist mosavuta anamanga ndi limodzi pitani
- • Kodi kutengera zili iPhone kapena iPod kuti PC ndi Mac ndi limodzi pitani
Free kapena analipira: $24.95
Download ulalo: http://thelittleappfactory.com/irip/index_irip1.php
Chithunzithunzi:


text:
Mawerengedwe a zitsime kapena maenje a cylindrical mawonekedwe
Nenani miyeso mu mamita
D1
- Upper awiri zitsime
D2
- ndi awiri a pansi pa bwino
H
- Kuzama
Komanso, inu mukhoza mwachindunji mtengo wa kukumba chitsime ndi mtengo wa kuchotsedwa kwa nthaka.
Mawerengedwe a
Pali zitatu zimene mungachite kuti madzi a m'nyumba. Mukhoza kubowola dzenje nokha, inu mukhoza ganyu akatswiri Mwaichi, koma inu mukhoza kukumba chitsime pa malo. Onse njira nazo zonse ubwino ndi kuipa.
Ambiri amakonda kukonza malo bwino, chifukwa ndi wotsika mtengo, ungagwire ntchito kwa zaka zoposa 50 ndi kuyeretsa yomanga imeneyi chophweka kwambiri kuposa bwino. Kuwonjezera kukumba zitsime sikutanthauza wapadera chilolezo.
Komabe, kukumba chitsime pa malo anu, muyenera ena kuwerengetsera. Apa mudzathandiza wathu mawerengedwe pulogalamu. Muyenera kuchita ndi kulowa mu yoyenera minda pakuya bwino, pamwamba ndi pansi m'mimba mwake ndi mtengo wa kukumba m'dera lanu, ndiye pulogalamu kuwerengera buku la bwino ndi pafupifupi ndalama kukumba.
Chabwino-akumira
Choyamba m'mabuku kukumba zitsime ndi kusankha malo iye. Nkofunika kutseka izo mwa utali wozungulira 50 mamita panali manyowa storages ndi zina zosafunika kuti zingakhudzire madzi khalidwe. Sikuti kusunga bwino kwambiri kuposa 5 mamita m'nyumba. Mwinamwake pali chiopsezo cha kuwonongeka kwa maziko a nyumba chifukwa cha leaching dothi.
M'pofunikanso kudziwa akuya bwino. Zimenezi kuzindikira kuzama kwa ofanana ndi Zikhalidwe moyandikana zigawo kapena chisanadze mokhomerera dzenje.
Onani kuti inu simungakhoze kukumba chitsime nthawi iliyonse pachaka. Ndi bwino yoti imeneyi kuchokera June kuti September. Pa nthawi iyi, aquifer zachepa, kutanthauza kuti simungathe kulowa mu kulakwa kwa chapamwamba zigawo za madzi kuti chikhalebe pambuyo m'chaka madzi osefukira.
Chinthu chotsatira muyenera nkhawa ndi mmene zingalimbitse makoma a bwino. Apa pali zingapo zimene mungachite. Izi matabwa yoyendera monolithic konkire ndi njerwa. Aliyense ya njira Zolimbikitsa lili ndi ubwino wake. Mwachitsanzo, yotsika mtengo matabwa chimango. Koma pochita zimenezi iye nthaŵi yochepa. Ake akuti utumiki osati oposa zaka 15. Komanso, ziyenera kutsukidwa chaka chilichonse kuchokera sludge. Komanso pa kukumba dzenje la makoma kulimbikitsa, kuchititsa ngozi za kugwa kwa dziko lapansi.
Monolithic konkire zabwino kuti amakonda zimaonekera madzi kulowa bwino. Koma bwino kwambiri kochepa, ndalama kwambiri zodula. Apa muli yachiwiriyo. Ukakoma konkire mitundu kumveketsa makoma nokha kapena kulipira. Pamaso mwaganiza mmene Zitatero, chonde onani kuti fakitare ya analimbitsa konkire mphete wamphamvu kuposa amene mukhoza kudzipereka. Koma, ndithudi, ndipo ndalama zambiri.
Chabwino yomanga njerwa kumafuna luso ndi mosalekeza maphunziro. Walls ayenera chitetezo, ndi njerwa kumanga maziko. Koma, ngati konkire, njerwa salola kusalola padziko madzi ku chitsime.
Pambuyo bwino ndi wokonzeka
Iliyonse mtundu wa chipangizo mwasankha bwino, nthawi lifunika kupopera mankhwala. Kukonza zizichitidwa osachepera kawiri pa chaka ndipo kawirikawiri ngati mlendo zinthu kugwera mu bwino.
Kukonza bwino mothandizidwa ndi madzi mpope amawapopa. Ndiye, ife tikupita uko, timapanga zofunika mankhwala njira. Pamene yachilendo zinthu, matopewo, mchenga ndi litsiro kuchotsedwa pansi makoma a bwino, mankhwala. Kuti tichite zimenezi, makoma a bwino ntchito tsache kapena burashi ndi yaitali kugona utsi ndi zothetsa kuthimbirira.
Pamene bwino yodzala madzi kachiwiri, iwo ayenera kuwonjezera zothetsa kuthimbirira mu kuchuluka kwa 150 mg pa 1 lita imodzi ya madzi. Water ndipo analimbikitsa bwino, yokutidwa ndi chivindikiro, anapitiriza kwa maola awiri. Madzi ndiye kachiwiri amawapopa ndi osambitsidwa ndi madzi oyera bwino. Ndondomeko mobwerezabwereza mpaka chlorine fungo kusiyiratu.


text:
Kupinda chimango squat rack
Tsatanetsatane wa Zamalonda
Zogulitsa Tags
Kufotokozera za mankhwala
Iron squat rack imakhala ndi mpando wachitsulo ndi chubu chachitsulo chokhala ndi kutalika kosinthika, Squatting rack ndi chida chapadera chopumira mmwamba minofu yamyendo pamapewa a ma barbell.
Ma squats ndi njira yochitira masewera olimbitsa thupi, squat yokhazikika ndikusunga msana wanu wowongoka, cholumikizira cha ntchafu chimakhala pansi kenako bondo.olakwika luso kayendedwe kungayambitse kuwonongeka kwa bondo olowa.
Monga aliyense akudziwa, squats ndi lipenga la ntchito minofu ya ntchafu, Squats, kumbali ina, ndizomwe zimafuna mphamvu zambiri za mapapu ndi mtima wamphamvu.Kuumirira kuchita Kuwonjezera akadali ndi zotsatira kuti kuonda.
Mu maphunziro a mphamvu, squat ndi chigawo, thupi lonse, Imagwira ntchafu, matako, ntchafu zam'mbuyo.Zimalimbitsanso mitsempha ya fupa ndi tendons kudutsa m'munsi mwa thupi.Squats amaganiziridwa kuti amawonjezera mphamvu ndi kuzungulira kwa miyendo ndi chiuno.Ndipo masewera olimbitsa thupi ofunikira kukulitsa mphamvu yapakati,Mukudumpha kwa isometric, mukamakwinya moyenera, tsitsani minyewa yam'mimba yam'mimba, ndi minofu ya intercostal.Komanso mapewa ndi manja ndizofunikira pakuchita izi.
Chiyambi cha Kampani


text:
- 1997
ADA Yakhazikitsidwa.ADA ndi m'modzi mwa oyambitsa komanso akatswiri oyeretsa mpweya ku China.
- 2001
Dipatimenti Yotsatsa Padziko Lonse idakhazikitsidwa kuti ipange bizinesi yotumiza kunja.Anakhazikitsa choyamba choyeretsa mpweya chothandizira zithunzi.
- 2002
Anakhazikitsa mini protable ionizer air purifier.
- 2003
Mliri wa SARS, udayambitsa makina oyeretsera mpweya waku China.
- 2004
Anakhazikitsa woyamba solar energy galimoto mpweya oyeretsa.
- 2006
Tidakhazikitsa choyeretsa choyamba chamagetsi a solar energy ndi AQI yanzeru.
- 2007
Galimoto Yotsuka Msika Wogawira Nambala 1 ku China (Kuchokera ku hc360.com).Nov 2007, ADA inasamutsa fakitale yatsopano ku Haicang Industrial Zone.
- 2010
Anakhazikitsa njira yoyamba yowonda kwambiri yolumikizira mpweya wophatikiza ndi gawo loyeretsa mpweya.
- 2012
Oyeretsa Mpweya Opambana 10 ku China(Kuchokera chinabidding.com.cn).
- 2013
Yakhazikitsa makina oyeretsera mpweya wa digito.
- 2014
Anakhazikitsa njira ya digito yowonetsera mwanzeru khoma yopumira mpweya.
- 2016
Anakhazikitsa 3.0 smart air purifier.
- 2017
Amalemekezedwa ndi mabizinesi apamwamba kwambiri a Xiamen.
- 2019
Amalemekezedwa ndi mabizinesi apamwamba kwambiri a National.
- 2021
Chomera 2 chinakhazikitsidwa ku Longhai, Zhangzhou


text:
Pofika pano ambiri a inu mukudziwa kale kuti Apple ili ndi gawo lapadera la zopatsa ophunzira aku yunivesite. Mkati mwazoperekazi timapeza kuti zilipo kuchotsera kwa 10% pazinthu zambiri zamakompyuta zamakampani ndi kuchotsera kwina kosangalatsa.
M’lingaliro limeneli, n’kutheka kuti ambiri a inu munamvapo kale zimenezi Apple ikupereka kwa ophunzira aku koleji, koma tiyenera kukumbukira kuti izi ndizothandizanso kwa achibale a ophunzira, aphunzitsi kapena ogwira nawo ntchito.
Zimapezeka kwa ophunzira omwe adalembetsa kapena kuvomerezedwa ku yunivesite, makolo omwe amagulira ophunzira aku yunivesite, aphunzitsi kapena ogwira ntchito pamaphunziro.. Kuti muyambe, onani ngati mukukwaniritsa zofunikira. Ndi zinthu zoyenera za Apple, mutha kukwaniritsa chilichonse chomwe mungafune. Ndipo kukuthandizani, Apple imapereka mitengo yapadera pagawo la maphunziro
Zotsatira
- 1 Kukhala ndi akaunti ya UNiDAYS ndikofunikira
- 2 Kuchotsera komwe kwakhala kwazaka zambiri
- 3 Ntchito zikuphatikizidwanso muzochotsera izi
- 4 Momwe Mungagulire Mac kapena iPad pa Kuchotsera kwa Ophunzira pa intaneti
- 5 Momwe Mungagulire Mac kapena iPad pa Kuchotsera kwa Ophunzira pa intaneti
Kukhala ndi akaunti ya UNiDAYS ndikofunikira
Mwachiwonekere, kuti mupeze zochotsera izi, chofunikira chofunikira chikufunika, khalani ndi akaunti ya UNiDAYS. Kuti muchite izi muyenera kulowa patsamba la Apple komwe zimatitengera mwachindunji kupanga akauntiyi, timagawana ulalo kuti mulembetse ku UNiDAYS.
Izi zikachitika, tiyenera kuganiziranso mbali zina monga, mwachitsanzo, kuchuluka kwa zida zomwe mungathe kuzipeza ndizochepaKuphatikiza apo, muyenera kuvomereza zachinsinsi ndikulola UNiDAYS yokha, osati Apple, kusunga, kuwongolera ndi kukonza zomwe mumapereka. Ngati simukufuna kuti UNiDAYS ikhale ndi deta yanu, gwiritsani ntchito njira zina zotsimikizira.
Kumbali inayi, ndikofunikira kunena kuti tilinso ndi kuchotsera pa mapulogalamu a Apple ndi zolembetsa. Zina mwazo mwachiwonekere ndi Apple Music, Apple TV, Apple One ndi mautumiki ena onse zomwe Apple ikupereka pano.
Kuchotsera komwe kumachitika 10% pazogula chaka chonse
Ogwiritsa ntchito ambiri amaganiza kuti zoperekedwazi zili ndi tsiku lotha ntchito, koma pankhani yogula ku yunivesite, alibe. Ogwiritsa akhoza kusangalala ndi izi 10% kuchotsera pamtundu uliwonse wazinthu chaka chonse, popanda masiku enieni. Izi zimapangitsa kukhala kosangalatsa kwambiri kuti ophunzira agule chinthu ndi imodzi mwamaakaunti awa, chifukwa kungolembetsa timatha kusangalala ndi kuchotsera pa malonda, ntchito, ndi zina.
Kugulidwa kwa MacBook yatsopano, iMac yatsopano, kapena iPad iliyonse kapena chowonjezera ya kampani ya Cupertino ikhoza kukhala yotsika mtengo chifukwa cha kulembetsa kwa UNiDAYS. Izi zikugwira ntchito pakali pano pitilizani nazo.
Kuchotsera komwe kwakhala kwazaka zambiri
Ambiri a inu omenyera nkhondo mumakumbukira pomwe mudauza wogulitsayo mwachindunji kapena patsamba la Apple mudawonetsa kuti mukufuna kuchotsera ophunzira popanda kupitirira apo. Zimenezi zikanatheka zaka zingapo zapitazo. palibe akaunti ya UNiDAYS kapena china chilichonse chofunikira kuti mupindule ndi kuchotsera 10% pamtengo wazinthu za Apple.
Zomveka, ogwiritsa ntchito ambiri omwe amadziwa za kuchotsera kumeneku kwa ophunzira adatengerapo mwayi. Popanda kukhala ophunzira, adapempha kuchotsera ndi pamapeto pake Apple idasiya "kudalira kwambiri" ndikusankha kugwiritsa ntchito chitsimikiziro ichi kudzera mu UNiDAYS kuti ndendende chinthu chokha chomwe chimachita ndikuwunika ngati tili ndi akaunti ya ophunzira ku yunivesite kapena kusukulu.
Ntchito zikuphatikizidwanso muzochotsera izi
Kwa onse omwe akufuna kusangalala ndi kuchotsera pakulembetsa kwa Apple Music, Apple TV +, Apple Fitness +, Apple One ndi ntchito zina zonse zoperekedwa ndi Apple limodzi kapena padera, atha kupindula ndi kuchotsera kwa ophunzira.
Mwachitsanzo, kuti tipeze kuchotsera pakulembetsa kwa Apple Music, tiyenera kutsatira izi:
- Tsegulani pulogalamu ya Nyimbo kapena iTunes ndikudina Mverani kapena Kwa Inu
- Dinani kapena dinani zoyeserera (imodzi pa munthu kapena banja)
- Sankhani Wophunzira, kenako dinani kapena dinani "Chongani Zofunikira"
- Mudzatumizidwa ku webusayiti ya UNiDAYS, komwe mudzayenera kutsatira malangizo apakanema kuti mutsimikizire kulembetsa kwanu. UNiDAYS ikatsimikizira kuti ndinu wophunzira, mudzatumizidwa ku pulogalamu ya Music kapena iTunes
- Lowani ndi ID ya Apple ndi mawu achinsinsi omwe mumagwiritsa ntchito pogula. Ngati mulibe ID ya Apple, sankhani Pangani ID Yatsopano ya Apple ndikutsata njirazi. Ngati simukutsimikiza ngati muli ndi ID ya Apple, titha kukuthandizani kuti mudziwe.
- Tsimikizirani zambiri zamabilu ndikuwonjezera njira yolipirira yolondola
- Dinani kapena dinani Lowani
Izi ndizomwe zimachitika mwachindunji pazantchito zonse za Apple ndipo kugula chinthu ndikofanana. Njirayi ndi yophweka komanso yodabwitsa, simudzakhala ndi vuto lililonse, zomwe muyenera kuchita ndikupita ku gawo linalake kuti ophunzira agule.
Pezani UNiDAYS ndipo sangalalani ndi kuchotsera uku pazinthu za Apple.
Momwe Mungagulire Mac kapena iPad pa Kuchotsera kwa Ophunzira pa intaneti
Kuchotsera kumasiyanasiyana kutengera zomwe zagulitsidwa, koma pa Mac ndi 10% kuchotsera pamtengo wawo. Mu iPad iwo amachokera ku 6 mpaka 8% kutengera mtundu wosankhidwa ndipo muzowonjezera zimachitika mochulukirapo kapena mochepera. Mtengo wa MacBook yotsika mtengo kwambiri m'sitolo ya ophunzira ndi ma euro 1016. Zida zolowera zomwe zimawonjezera Apple M1 chip, 8 CPU cores, ndi 7 GPU cores. Pankhani ya chitsanzo chapamwamba (chomwe chiri chovomerezeka) mtengo umakhalabe pa 1.260,15 euro, ndipo izi ndizomwe zimawonjezera 8-core GPU ndi 8-core CPU komanso.
Kuti mugule pogwiritsa ntchito UNiDAYS, tsatirani izi.
- Lowani mwachindunji mu tsamba la maphunziro a apulo ndikudina Chongani ndi UNiDAYS njira
- Pangani akaunti yathu yatsopano ngati tilibe kale pogwiritsa ntchito imelo ndi mawu achinsinsi
- Akaunti yanu ikapangidwa, muyenera kutsimikizira kuti ndinu wophunzira potsatira njirazi
- Chophimba chikuwonekera pomwe mungasaka mwachindunji ku yunivesite kapena koleji yanu yomwe mudzalembetse
- Mukachipeza, mutha kulembetsa ndikulowetsanso Apple Store kuti muphunzire mwakupeza kuchotsera
Momwe Mungagulire Mac kapena iPad pa Kuchotsera kwa Ophunzira pa intaneti
Kwa onse omwe ali ndi sitolo ya Apple pafupi ndi kwawo kapena amatha kupita kumodzi, ndizothekanso kugwiritsa ntchito kuchotsera kwa UNiDAYS mwachindunji mwa iwo. Kuchotsera uku sikumasintha ngakhale mutagula pa intaneti kapena m'sitolo.
Mukafika ku sitolo muyenera kuwonetsa chikalata chilichonse chimene chimatsimikizira mwachindunji kuti ndinu wophunzira, mphunzitsi kapena ndodo ya malo maphunziro. M'sitolo adzatsimikizira deta ndi kuchotsera komweko komwe timapeza mu gawo la Online Store pa maphunziro kudzaperekedwa.


text:
Ichi chinali chimodzi mwazinthu zomwe ndimafunitsitsadi kujambula zithunzi ndikugawana mayina ... koma ndiyesetsa kuwapatsa mwayi kukayika awa. Tikukhulupirira siamisala amisili omwe adachokera pomwe anali ndi tsiku loyipa. Chowonadi ndichakuti ndikutopa ndi zanema ndipo ndikuwononga nthawi yocheperako pazokambirana pamenepo. Chifukwa chiyani? Kugawana malingaliro, malingaliro ndi zokambirana mwaulemu zikutha.
Ena mwa anthu omwe ali pa Facebook ndiwodabwitsa kwambiri kotero kuti akamagawira Facebook, palibe chifukwa chotsutsana, kukulitsa zokambirana, kapena kupereka malingaliro ena. Anthuwa ndi anzeru kwambiri kwakuti amadodometsedwa pomwe wina… awalozera ku Lembani Ndemanga danga… amalemba zolemba zawo.
Ayenera kusinthira Facebook ndikudzaza mwachangu ndi zina zomveka bwino.
Kumayambiriro kwa chaka chino, ndinali ndi mnzanga yemwe adanditumiziranso mauthenga achinsinsi kuti ndisiye kuyankha pazomwe adalemba - uthenga wotsutsana womwe umafotokoza malingaliro ake pamutu wophatikizira ndi kunyoza aliyense amene angavomereze. Sindidagwirizane… ndipo ndidamuwuza adziwe. Anandiuzadi kuti ndisiye kuyankhapo lake zosintha. Mpaka nthawiyo, sindinadziwe kuti zokambiranazo zomwe zimapezeka patsamba la anthu onse ndi zake komanso malingaliro onse omwe amatsatira. Ndidakakamizidwa kokha nditapereka ndemanga.
Chokwanira kungoti zosintha zake sizikuonekanso my Mtsinje wa Facebook. Ndimakonda kucheza ndi anthu wamba ngati ine omwe sakhulupirira kuti tazindikira zonse.
Mungaganize kuti anthu omwe ali anzeru kwambiri safunika kutenga nawo mbali pagulu lapa Facebook. Pali zifukwa ziwiri zokha zomwe ndingaganizire chifukwa chomwe amapitilira. Mwina amawona ngati malo omwe angaphunzitse enafe osayankhula. Kapena mwina ndi malo omwe amafunikira kuti azisisitidwa.
Sindikudziwa. Sindinayang'anepo pazanema mwanjira imeneyi. Nthawi zambiri ndimanena za mutu kuti ndimvetsere malingaliro ena. Nthawi zina, nthawi zambiri ndimakhala ngati wogwirizira ndikupereka malingaliro ena. Nthawi zambiri ndimaphunzira kuchokera pazinthu zonse ziwiri. Ndikuganiza kuti sindine wanzeru ngati anthu omwe amadziwa kale zonsezi.
Usikuuno, ndinali ndi awiri olemba zanema pazosintha zosiyana ndikonzeni. Wina adandiuza kuti atopa kwambiri kuti asateteze malingaliro awo pamutu. Mwanjira ina, "Yawn… achoke munthu wosalankhula.". Wina adandiuza kuti, pomwe ndemanga yanga idapereka mfundo zomveka, zidachoka pamutu woyambirira. Wow… zikomo kwambiri adandiuza zidziwitsozi. Zindipanga kukhala munthu wabwino mtsogolo. Ndikhala wotsimikiza kuyesera kupitilizabe lake mutu mosasamala komwe kukambirana kumapita.
Awa ndi malingaliro anga chabe, koma ngati muli anzeru kwambiri kotero kuti anthu sangathe kuyankhulana nanu pa intaneti, bwanji osalankhula kwambiri kuti mugawane nawo izi pagulu la anthu wamba? Mwazindikira zonse ndiye mukutifunira chiyani? Mwina mungakhale anthu anzeru kwambiri opusa omwe ndidakumanapo nawo.
Nayi malangizo anga:


text:
Nayi nkhani yokhudza SEO (yomwe ndidayambiranso sabata ino): Ma subdomains.
Alangizi ambiri a SEO amanyoza ma subdomain. Amafuna chilichonse pamalo amodzi osamalika kuti azitha kupititsa patsogolo mosavuta ndikulingalira zakupeza olamulira amenewo. Ngati tsamba lanu lili ndi magawo angapo, limachulukitsa ntchito yomwe limafunika. Mwanjira ina, ngati mudzatchova juga… akufuna mutchova juga pamanja. Apa pali vuto… nthawi zina zimakhala zomveka kugonjera tsamba lanu.
M'malo mwake, zina mwazinthu zomwe zapezeka ku Google yotchuka Kusintha kwa Panda adatembenukira kumagawo ang'onoang'ono. Imodzi mwamasamba amenewo inali Ma Hubpages. Kugwiritsa ntchito Semrush, tidasanthula kuchuluka kwa mawu omwe a Hubpages anali nawo kale komanso pambuyo pa kugunda kwa Panda ndikusunthira kwawo kumagawo ang'onoang'ono.
Ngati muika pambali mawu onse osinthidwa, masanjidwe apamwamba a Hubpages tsopano onse ali pamafunso ofunikira! Nazi zokambirana pa izi:
- Google Imati "Lolani Trillioni Subdomains Bloom"
- Panda Fix kuchokera ku Hubpages
- Subdomains: Hubpages Way Out Google Panda Purigatoriya?
Kodi mudawonapo aliyense pazinthu izi akukambirana kutembenuka mitengo or zotsatira zamabizinesi? Inde… inenso.
Sikuti ndimafamu okhutira ndi Panda zokha. Magawo ang'onoang'ono amalola kulekanitsa bwino tsamba lanu, kumveketsa bwino ndikuwunika zomwe zili pamenepo. Mukadula ndikudula tsamba lanu kukhala ma subdomain, inu nditero mwina tengani pamndandanda pomwe mukusunthira zomwe mukuyenera ndikuyenera kulozetsa magalimoto. Koma m'kupita kwanthawi, mudzatero pezani bwino pamawu ofunikira, kuyendetsa magalimoto ambiri ndizosavuta kudzera patsamba lanu, ndikupatsanso mwayi wogwiritsa ntchito owunikira omwe amawerengera owerenga anu bwino ndikuwongolera kutembenuka konse.
Subdomains sizoyipa pa SEO, atha kukhala osangalatsa chifukwa… ngati mukukhulupirira kuti SEO ikufuna kupeza zotsatira zamabizinesi. Koma pogwiritsa ntchito ma subdomain, alangizi a SEO amadziwa kuti akukankha zovutazo panjira. Ndiye… apanga chisankho chomwe chikhala ndi zotsatira posachedwa kapena zabwino mtsogolo? Ngati akufuna kupitiliza kulipidwa, atenga njira yosavuta.
Kutsata ndi njira yotsatsa yabwino yomwe imagwiritsidwa ntchito m'makampani onse. Tikuwona mphepo zosintha, komabe. Google imadziwa kuti zofunikira kwambiri, zomwe zilipo ndizofunikira kwambiri pamachitidwe abwino… ndi zomwe injini zawo zosakira zidamangidwapo. Zosintha zowonjezerapo za 600 zomwe amapanga pachaka zikuthandizira kupitilizabe kuyang'ana.
Ndiye bwanji mungachite china chomwe amapewa kutsata zomwe zikuwonetsedwa komanso kulumikizana kwa ogwiritsa ntchito?
Chitsanzo china ndicho kuwukira kwa infographics zomwe ziri kalikonse kuchita ndi bizinesi yeniyeni. Amuna a SEO amakonda infographic yayikulu chifukwa izitha kukhala yovuta ndipo kampaniyo ipeza matani a backlinks ndipo iwonjezera kuchuluka ndi kuchuluka kwa anthu.
Kupambana.
Kapena zinali ...
Tsopano muli ndi kuchuluka kwa magalimoto osasintha. Ziphuphu zimakwera, kutembenuka kwatsika… koma mukukhala bwino - makamaka pagulu la mawu omwe alibe chochita ndi bizinesi yanu.
M'malingaliro mwanga, mwango kuwonongeka kusaka kwanu pakusaka ndi kukhathamiritsa chifukwa mwasokoneza makina osakira ndikuganiza kuti tsamba lanu mwina sichotheka. Ndikadakhala kuti ndikalandiridwa mwachikondi ndi infographic yamakampani kuposa infographic ya virus yomwe ilibe ntchito. Chifukwa chiyani? chifukwa imafotokoza zaulamuliro wanga komanso mbiri yanga m'makampani anga. Tsamba lomwe mukufuna kuwonongera nthawi zonse limaposa lomwe aliyense… ndipo sindingathenso kupita kukakhala pagulu.
Ngati kasitomala wanga ali ndi mitu yambiri yomwe mwina singagwirizane mwachindunji, ndibwino kuti ndiwalangize kuti asamukire kumagawo ang'onoang'ono, kuti amenye, ndikupanga njira yolunjika kwambiri pamakampani, malonda ndi ntchito zawo. Ngati zonse zomwe mwatsata ndizoyang'anira komanso kuchuluka kwama traffic, ma subdomains mwina ndi pariah. Koma ngati mwatsatira zotsatira zamabizinesi, mungafune kuyang'ananso kachiwiri.
Omwe tili mumakampani omwe amagwira ntchito kuti makasitomala asinthe amatimvetsetsa zomwe angathe kuchita. Mungafune kupereka madera ena mwayi wina.


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1Jude, the servant of Jesus Christ, and brother of James, to them that are sanctified by God the Father, and preserved in Jesus Christ, and called: 2Mercy unto you, and peace, and love, be multiplied.
3Beloved, when I gave all diligence to write unto you of the common salvation, it was needful for me to write unto you, and exhort you that ye should earnestly contend for the faith which was once delivered unto the saints. 4For there are certain men crept in unawares, who were before of old ordained to this condemnation, ungodly men, turning the grace of our God into lasciviousness, and denying the only Lord God, and our Lord Jesus Christ. 5I will therefore put you in remembrance, though ye once knew this, how that the Lord, having saved the people out of the land of Egypt, afterward destroyed them that believed not. 6And the angels which kept not their first estate, but left their own habitation, he hath reserved in everlasting chains under darkness unto the judgment of the great day. 7Even as Sodom and Gomorrha, and the cities about them in like manner, giving themselves over to fornication, and going after strange flesh, are set forth for an example, suffering the vengeance of eternal fire. 8Likewise also these filthy dreamers defile the flesh, despise dominion, and speak evil of dignities. 9Yet Michael the archangel, when contending with the devil he disputed about the body of Moses, durst not bring against him a railing accusation, but said, The Lord rebuke thee. 10But these speak evil of those things which they know not: but what they know naturally, as brute beasts, in those things they corrupt themselves. 11Woe unto them! for they have gone in the way of Cain, and ran greedily after the error of Balaam for reward, and perished in the gainsaying of Core. 12These are spots in your feasts of charity, when they feast with you, feeding themselves without fear: clouds they are without water, carried about of winds; trees whose fruit withereth, without fruit, twice dead, plucked up by the roots; 13Raging waves of the sea, foaming out their own shame; wandering stars, to whom is reserved the blackness of darkness for ever. 14And Enoch also, the seventh from Adam, prophesied of these, saying, Behold, the Lord cometh with ten thousands of his saints, 15To execute judgment upon all, and to convince all that are ungodly among them of all their ungodly deeds which they have ungodly committed, and of all their hard speeches which ungodly sinners have spoken against him. 16These are murmurers, complainers, walking after their own lusts; and their mouth speaketh great swelling words, having men’s persons in admiration because of advantage.
17But, beloved, remember ye the words which were spoken before of the apostles of our Lord Jesus Christ; 18How that they told you there should be mockers in the last time, who should walk after their own ungodly lusts. 19These be they who separate themselves, sensual, having not the Spirit. 20But ye, beloved, building up yourselves on your most holy faith, praying in the Holy Ghost, 21Keep yourselves in the love of God, looking for the mercy of our Lord Jesus Christ unto eternal life. 22And of some have compassion, making a difference: 23And others save with fear, pulling them out of the fire; hating even the garment spotted by the flesh.
24Now unto him that is able to keep you from falling, and to present you faultless before the presence of his glory with exceeding joy, 25To the only wise God our Saviour, be glory and majesty, dominion and power, both now and ever. Amen.
1Ndine Yuda, mtumiki wa Yesu Khristu, komanso mʼbale wake wa Yakobo.
Kwa inu amene Mulungu Atate anakuyitanani, amene amakukondani ndikukusungani mwa Yesu Khristu.
2Chifundo, mtendere ndi chikondi zikhale nanu mochuluka.
Tchimo ndi Kuwonongeka kwa Osapembedza
3Okondedwa, ngakhale ndinkafunitsitsa kukulemberani za chipulumutso cha tonsefe, ndakakamizidwa kuti ndikulembereni ndi kukupemphani kolimba kuti mumenye ndithu nkhondo yotchinjiriza chikhulupiriro chimene Mulungu anachipereka kamodzi kokha kwa anthu onse oyera mtima. 4Pakuti anthu ena amene za chilango chawo zinalembedwa kale, alowa mobisika pakati panu. Amenewa ndi anthu osapembedza Mulungu, amene amapotoza chisomo cha Mulungu wathu kuchisandutsa ufulu ochitira zonyansa ndiponso amakana Yesu Khristu amene Iye ndiye Mbuye ndi Mfumu yathu.
5Ngakhale munazidziwa kale zonsezi, ndafuna kuti ndikukumbutseni kuti Ambuye anapulumutsa anthu ake ndi kuwatulutsa mʼdziko la Igupto, koma pambuyo pake anawononga amene sanakhulupirire. 6Ndipo mukumbukire angelo amene sanakhutire ndi maudindo awo, koma anasiya malo awo. Angelo amenewa Mulungu anawamanga ndi maunyolo osatha, ndipo akuwasunga mʼmalo a mdima mpaka tsiku lalikulu lachiweruzo. 7Musayiwale mizinda ya Sodomu ndi Gomora ija, ndi mizinda yoyandikana nayo. Anthu mʼmenemo anadziperekanso kuchita zadama ndi kuchita zonyansa zachilendo. Mizinda imeneyi yakhala ngati chitsanzo cha amene adzalangidwa ndi moto wosatha.
8Nʼchimodzimodzinso zimene akuchita anthu amenewa potsata maloto awo, amadetsa matupi awo, amakana ulamuliro wa Mulungu ndiponso amachitira chipongwe angelo akumwamba. 9Koma ngakhale mkulu wa angelo Mikayeli, pamene ankalimbana ndi Mdierekezi za mtembo wa Mose, sanamunene kuti wachipongwe, koma anati, “Ambuye akudzudzule iwe!” 10Koma anthu awa amachita chipongwe zinthu zimene sakuzidziwa. Ndipo zinthu zimene amazidziwa ndi nzeru zachibadwa, monga za nyama, ndizo zimene zimawawononga.
11Tsoka kwa iwo chifukwa anatsatira njira ya Kaini. Iwo athamangira phindu, nʼchifukwa chake anagwa mʼtchimo la Baalamu. Iwo anawonongedwa chifukwa chowukira monga anachitira Kora.
12Anthu amenewa ndiwo amayipitsa maphwando anu achikondi. Amadya nanu mopanda manyazi ndipo ali ngati abusa amene amangodzidyetsa okha. Anthuwa ali ngati mitambo yowuluzika ndi mphepo, yopanda mvula. Ali ngati mitengo ya nthawi ya masika, yopanda zipatso, yozuka mizu, mitengo yoferatu. 13Iwowa ali ngati mafunde awukali apanyanja, amene amatulutsa thovu la zonyansa zawo. Amenewa ali ngati nyenyezi zosochera, ndipo Mulungu akuwasungira mdima wandiweyani mpaka muyaya.
14Enoki, wachisanu ndi chiwiri kuyambira pa Adamu, ananeneratu za anthu amenewa kuti, “Onani, Ambuye akubwera ndi oyera ake osawerengeka 15kuti adzaweruze aliyense, ndi kudzagamula kuti onse osapembedza ndi olakwa, chifukwa cha ntchito zawo zosalungama zimene anachita mʼmoyo wawo osaopa Mulungu. Adzawatsutsa chifukwa cha mawu onse achipongwe amene osapembedzawa ananyoza nawo Ambuye.” 16Anthu amenewa amangʼungʼudza ndi kudandaula. Amatsatira zilakolako zawo zoyipa. Amayankhula zodzitamandira ndipo amanamiza ena pofuna kupeza phindu.
Awalimbikitsa kuti Apirire
17Koma okondedwa, kumbukirani zimene atumwi a Ambuye athu Yesu Khristu ananeneratu. 18Iwo anakuwuzani kuti, “Mʼmasiku otsiriza kudzafika anthu onyoza, otsatira zofuna zawo zoyipa.” 19Anthu amenewa ndi amene akubweretsa mipatuko pakati panu, amatsatira nzeru zachibadwa ndipo alibe Mzimu Woyera.
20Koma inu okondedwa, muthandizane kuti mukule pa chikhulupiriro chanu choyera, ndipo muzipemphera ndi mphamvu ya Mzimu Woyera. 21Khalani mʼchikondi cha Mulungu pamene mukudikira chifundo cha Ambuye athu Yesu Khristu kuti akubweretsereni moyo wosatha.
22Muwachitire chifundo amene akukayika. 23Ena muwapulumutse powalanditsa ku moto. Enanso muwachitire chifundo, koma mwa mantha, ndipo muzidana ngakhale ndi mwinjiro yomwe yayipitsidwa ndi machimo.
Mawu Olemekeza Mulungu
24Kwa Iye amene angathe kukusungani kuti mungagwe mʼmachimo, ndiponso amene angathenso kukufikitsani pamaso pake pa ulemerero wopanda cholakwa muli okondwa, 25kwa Mulungu yekhayo, Mpulumutsi wathu, kwa Iye kukhale ulemerero, ukulu, mphamvu ndi ulamuliro, mwa Yesu Khristu Ambuye athu, kuyambira isanayambe nthawi, tsopano mpaka muyaya. Ameni.


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Malingaliro a kampani Xuzhou Chens-lift Machinery Co., Ltd.idakhazikitsidwa mu 2008 ndipo ili ndi zaka zopitilira 12 zopanga, zogulitsa ndi zogulitsa kunja.Takhala ndi "National AAA Credit Enterprise" nthawi zambiri, tilinso ndi dongosolo lathunthu loyang'anira zopanga ndipo tadutsa chiphaso cha ISO9001 ndi chiphaso cha CE.Gulu lazamalonda lapadziko lonse lapansi limapereka mayankho amunthu malinga ndi zosowa zosiyanasiyana za makasitomala, ndipo timathandizira ntchito zosiyanasiyana zosinthidwa makonda.
Amagwira ntchito zosiyanasiyana zamakina aulimi: monga chopunthira, chotuta, chobzala, rotary tiller, laser land leveler, chotola miyala, galimoto ya feteleza, sprayer, chotola mtedza, windrower, ndi zina zotero. Zogulitsa zathu sizimagulitsidwa mdziko lonse lapansi, komanso zimatumizidwa kunja. kumayiko opitilira 20 monga Europe, America, Africa, Middle East, Southeast Asia.Makamaka, mankhwala ophera mbewu akhala akugwirizana ndi Unduna wa Zamalonda nthawi zambiri ndikuchita nawo ntchito zothandizira zakunja, zomwe zayamikiridwa kwambiri.
Xuzhou Chens-lift Construction Machinery Co., Ltd. ikutsatira lingaliro la "kuwongolera umphumphu, khalidwe loyamba" ndi malo a "ziro zowonongeka ndi ntchito zamtunda ziro".Onse ogulitsa malonda akunja ali ndi madigiri aku yunivesite ndipo amadziwa zilankhulo zingapo.Kuti musavutike ndi kulankhulana chinenero.
Kupanga zinthu zotsogola ndikumanga mtundu wapamwamba kwambiri padziko lonse lapansi ndimasomphenya athu akampani.Apa mutha kupeza makina aliwonse aulimi omwe mukufuna.Malingana ngati mukufunikira, timakhalapo nthawi zonse.
Satifiketi Yolemekezeka


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Mapangidwe aukadaulo aku Europe, mawonekedwe amphamvu
Khalani ndi kukana kwanyengo
Kukana kukokoloka ndi kukana kusintha kwa kutentha
Kupaka utoto wolimba, luso lomatira lamphamvu, zokutira za ufa zopangidwa mwachizolowezi
mwachangu ntchito katundu ndi selectivity
Chipata chachikulu chachitsulo chotchipa, zipata zachitsulo pafupi ndi ine, kapangidwe ka zipata zachitsulo, chipata chachitsulo, chipata cha driveway garden, chipata cholowera mwachizolowezi, zipata zakale za ebay, zipata zachitetezo, ma swing amakono, zipata zotsetsereka za aluminiyamu, zipata zachitsulo zosapanga dzimbiri.


text:
Pali misonkhano yambiri yoti mutengere tsiku lanu ndipo mulibe nthawi yokwanira yolembera mfundo zofunikazi. Ngakhale mliri usanachitike, magulu ogulitsa ndi otsatsa amakhala ndi misonkhano yakunja yopitilira 9 patsiku ndipo tsopano okhala ndi zofunda zakutali komanso zosakanizidwa kwa nthawi yayitali, misonkhano ikukwera. Kusunga zolemba zolondola za misonkhanoyi kuti zitsimikizire kuti maubwenzi akuleredwa komanso deta yokhudzana ndi zofunikira sizitayika yakhala ntchito yovuta komanso yowononga nthawi, ndipo ndipamene mayankho a mawu ku CRM angakugulireni nthawi, kuthandizira mbadwo wotsogolera ndikusunga mphamvu zanu.
Hei DAN Voice to CRM Assistant
Voice to CRM wothandizira Pa DAN imalemba misonkhano ndikuyika zidziwitso zolumikizirana ndikumakumana ndi zotengera mosavutikira muzosunga zobwezeretsera za CRM. Wokondedwa wa Fortune 500, wothandizira mawu uyu amagwira ntchito ndi CRM iliyonse, kuphatikiza Salesforce, Zithunzi za MS Dynamicsndipo HubSpot. Imawongolera kutengera kwa CRM, imawonjezera mtundu wa data ndi 200%, ndipo imapereka pafupifupi maola 4-6 pa sabata yanthawi yowonjezera yogulitsa. Ndi cholinga chowongolera zidziwitso zamakasitomala ndikuchotsa kulemedwa ndi oyang'anira, ili ndi magwiridwe antchito a pulogalamuyo ndi ndondomeko yokhazikika yachitetezo kuti ijambule nthawi yomweyo zolemba zapamsonkhano, makhadi abizinesi, kukonza zotsatila ndikuwongolera zowonongera.
Kodi Mawu Angatani Kuti Akhale Olondola pa CRM pa Hey DAN Support Lead Generation?
Kuwonetsetsa kuti kutsatiridwa kumapangidwa kwa munthu woyenera pa nthawi yoyenera ndipo magulu ogulitsa ali ndi zida zanzeru zakumbuyo, ndizofunikira kwambiri panjira yogulitsa bwino. Pa DANKafukufuku akuwonetsa kuti ngati woyimira malonda adikirira tsiku limodzi lokha asanalembe zolemba zapamsonkhano mu CRM system, mpaka 40% yazambiri za zomwe zikuchitika zimatayika. Kupatsa mphamvu magulu ogulitsa kuti achite zomwe akuchita bwino, kumanga ndi kulimbikitsa maubwenzi opindulitsa onse, kulowetsa deta ya CRM yolondola komanso munthawi yake ndikofunikira. Pulogalamu ya Voice to CRM imapereka yankho pompopompo komanso lolondola.
Pazaka khumi zapitazi, ntchito zolembera misonkho zama database a CRM zachoka pantchito zothandizidwa ndi anthu kupita kwa othandizira ma robotiki. Chosangalatsa ndichakuti, ngakhale kuti ndiatsopano pamasewerawa, ma bots awa amathanso kulondola kwambiri.
Tawona kulondola kwa mawu ku CRM kukuyenda bwino kwambiri pazaka zingapo zapitazi, pomwe zolakwika zikutsika kuchokera pa 19% mu 2019 mpaka 12% mu 2021. Mayankho a Voice to CRM akuwongolera pang'onopang'ono ma aligorivimu ndipo gulu lathu lolemba limapereka cheke chowonjezera onetsetsani kuti zolakwika zotulutsa zimachepetsedwa mpaka 1% - kuphatikiza kwamphamvu kumeneku ndichifukwa chake makampani a Fortune 500 amatikhulupirira. Kukwatirana ndi ukadaulo ndi anthu ndikokwanira bwino pakati pakuchita bwino ndikuchita bwino.
Kate Zeid, Growth & Operations SVP ku Hey Dan
Kupulumutsa nthawi yonseyi ndikujambula kolondola kwa deta kungagwiritsidwe ntchito kujambula chithunzi chomveka bwino cha chiyembekezo ndikukonzekeretsa magulu ogulitsa kuti atenge njira yokwanira yotseka mgwirizano. Deta yamphamvu imatha kuyambitsa kulumikizana kwamatsenga, monga kuzindikira chidziwitso cha asymmetry pakati pa zomwe kasitomala akufuna kuphunzira ndi zomwe gulu lamalonda limadziwa za chinthu. Zitha kuthandiza magulu kuti azitha kudziwa momwe kutsogola kulili kotentha ndikuyambiranso pa nthawi yoyenera komanso m'njira yabwino kwambiri. Kusanthula kwa data pamlingo waukulu kungayambitsenso kuwona momwe makasitomala akufunira ndikudziwitsanso gawo lotsatira lazogulitsa kapena ntchito.
Kupanga Kupitiliza kwa Gulu Logulitsa
Kuchepetsa kwamagulu ogulitsa kungakhale kovuta, m'mafakitale ambiri ogulitsa ntchito amatha kukhala osakwana zaka ziwiri. Pamodzi ndikuyang'anira mutu wolembera munthu wochita masewera olimbitsa thupi, ndikupweteketsa mtima komwe kungathe kutaya ubale wamakasitomala womwe adaupanga pakapita nthawi komanso mtengo womwe ungawononge bizinesi yawo.
Kukumbukira zolondola komanso zozama za msonkhano ndiye chinsinsi chokonzekera zotsatizana. Powonetsetsa kuti tsatanetsatane wa msonkhano wamakasitomala, kuchokera ku manambala omwe angagwirizane nawo Zoom mpaka kukumbukira kuyamikira woyambitsa bizinesi yake, akhazikitsidwa nthawi yomweyo komanso momveka bwino mu nkhokwe ya CRM mwapeza bwino tsogolo la ubalewo.
At Pa DAN mawu athu ku pulogalamu ya CRM alemba misonkhano yopitilira 1 miliyoni, kuyimira mphindi zopitilira 620,000 zamawu. Kupereka kukumbukira kwamabungwe popereka chidziwitso chanzeru kwa magulu ogulitsa onse a Fortune 500 ndi zovala zazing'ono zamabizinesi, zimatsimikizira kupitiliza kwa ubale ndipo pamapeto pake zimayendetsa malonda.
Kate Zeid, Growth & Operations SVP ku Hey Dan
Pulogalamu yotsimikizika ya CRM, Pa DAN, ikhoza kuchepetsa kuchepa kwa nthawi kukumbukira zambiri za misonkhano yambiri yomwe inachitika pa tsiku lotanganidwa. Ndizolimbikitsanso kuti mawu osinthikawa kuukadaulo wa CRM akupitilirabe kuwongolera mbiri yake yolondola, pomwe ma algorithms akupitiliza kutseka kusiyana pakati pa kukumbukira kwamunthu ndi luso la bot.